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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan shuai chen Dan Liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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热塑性纤维素与PVA混溶性的分子动力学模拟

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原子与分子物理学报 2025年第3期42卷 149-158页

作者：冯彦洪陈帅杰孙航华南理工大学机械与汽车工程学院聚合物新型成型装备国家工程研究中心聚合物成型加工工程教育部重点实验室广东省高分子先进制造技术及装备重点实验室广州510000

首次提出了将氧化还原改性纤维素(Oxidation-reduction modified cellulose,ORC)与聚乙烯醇(Poly(vinyl alcohol),PVA)共混进行制备复合材料,并采用分子动力学模拟研究了ORC与PVA的混溶性.对分子链间相互作用能和氢键数量分析发现,随着... 详细信息

首次提出了将氧化还原改性纤维素(Oxidation-reduction modified cellulose,ORC)与聚乙烯醇(Poly(vinyl alcohol),PVA)共混进行制备复合材料,并采用分子动力学模拟研究了ORC与PVA的混溶性.对分子链间相互作用能和氢键数量分析发现,随着改性程度增加,ORC与PVA会产生更强烈的相互作用,这促进了组分间的混溶.当ORC的改性程度达到40%后,ORC与PVA的溶解度参数差值为2.02(J/cm^(3))^(1/2),达到混溶条件.根据Flory-Huggins理论确定了醇解度为88%和99%的PVA与ORC的混溶性,结果表明PVA(88%)与ORC的混溶性更好.对共混体系中形成氢键原子的径向分布函数分析发现,醋酸乙烯酯重复单元上的羰基更倾向与ORC形成分子链间氢键,而乙烯醇重复单元上的羟基更倾向形成分子链内氢键,这促使PVA(88%)/ORC共混体系中形成更多的分子链间氢键,从而混溶性更好.研究结果可为ORC/PVA复合材料的制备提供理论指导.

关键词：混溶性氧化还原改性纤维素分子动力学聚乙烯醇

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A dynamic PUF anti-aging authentication system based on restrict race code

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Science China(Information Sciences) 2016年第1期59卷 149-160页

作者： Bing LI shuai chen Southeast University School of Integrated Circuit

This paper presents a PUF(physical unclonable functions) authentication mechanism which can combat aging based on restrict race code(RRC). PUF provide a mechanism for identifying an integrated circuit based on the intrinsic variations of physical components uniquely and provide a cheap and secure alternative to random message storage on devices. However, due to its own characteristics, the chip-level PUF circuit reliability is easily affected by environment. The effect of reversible temporal noise on PUF is well studied and has obtained good effect(e.g. temperature, voltage), but sufficient attention has not been given so far to analyze the effect of the irreversible temporal variabilities(e.g. aging on PUF). This paper proposes a dynamic PUF authentication method, which is based on the RRC with two-ring strong characteristics structure. A combination of hardware and software system is used to improve the efficiency of authentication, and in an FPGA(field-programmable gate array)-based SRAM(static random access memory) PUF are used as an experimental object to verify the feasibility of this design. And this system can enhance the authentication system safety from the CVC(characteristic value challenge) randomness test.

关键词： aging PUF dynamically maintain RRC characteristic value

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RB-SLAM:visual SLAM based on rotated BEBLID feature point description

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The Journal of China Universities of Posts and Telecommunications 2023年第3期30卷 1-13页

作者： Fan Xinyue Wu Kai chen shuai School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

The extraction and description of image features are very important for visual simultaneous localization and mapping(V-SLAM).A rotated boosted efficient binary local image descriptor(BEBLID)SLAM(RB-SLAM)algorithm based on improved oriented fast and rotated brief(ORB)feature description is proposed in this paper,which can solve the problems of low localization accuracy and time efficiency of the current ORB-SLAM3 ***,it uses the BEBLID to replace the feature point description algorithm of the original ORB to enhance the expressiveness and description efficiency of the ***,it adds rotational invariance to the BEBLID using the orientation information of the feature *** also selects the rotationally stable bits in the BEBLID to further enhance the rotational invariance of the ***,it retrains the binary visual dictionary based on the BEBLID to reduce the cumulative error of V-SLAM and improve the loading speed of the visual *** show that the dictionary loading efficiency is improved by more than 10 *** RB-SLAM algorithm improves the trajectory accuracy by 24.75%on the TUM dataset and 26.25%on the EuRoC dataset compared to the ORB-SLAM3 algorithm.

关键词： visual simultaneous localization and mapping(V-SLAM) oriented fast and rotated brief(ORB) feature extraction boosted efficient binary local image descriptor(BEBLID) rotational invariance

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An improved PAAs countermeasure based on permutation tables and latch PUF

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Science China(Information Sciences) 2020年第3期63卷 243-253页

作者： Bing LI shuai chen Kai WANG Advanced Cloud-Systems Research Center School of Microelectronics Southeast University

Dear editor,Maintaining the secrecy of secret keys under the so-called power analysis attack(PAA) is challenging(the summary of PAAs countermeasure was shown in Appendix A). Prior studies have demonstrated that conven... 详细信息

关键词： XOR An improved PAAs countermeasure based on permutation tables and latch PUF

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The effect of temperature on phase equilibria of polyethylene glycol(PEG8000)-K_(2)SO_(4)-H_(2)O at T=(288.15,298.15,308.15)K

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3079-3085页

作者： shuai chen Niancu chen Hong Zheng Xudong Yu Ying Zeng College of Materials and Chemistry&Chemical Engineering Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education InstitutionChengdu University of TechnologyChengdu 610059China

The phase behavior of potassium sulfate(K_(2)SO_(4))in polyethylene glycol with molecular weight 8000(PEG8000)andwater(H_(2)O)mixed solvent at 288.15,298.15,and 308.15 Kwere *** to the results,when the temperature are 288.15 and 298.15 K,there is only a solid-liquid phase equilibrium relationship in the system,and the phase diagrams are both divided into three parts which respectively are the regions of unsaturated homogeneous liquid(L),one liquid and one solid K_(2)SO_(4)(L+S)and one liquid and twosolids K_(2)SO_(4) and PEG8000(L+2S).The solubility of K_(2)SO_(4) in PEG8000-H_(2)O mixed solvent decreased with the addition of the PEG8000 in the *** the diagrams of 288.15 and 298.15 K,the sizes of regions of(L)and(L+S)increased and that of(L+2S)decreased with the increase of *** at 308.15 K,solid-liquid and liquid-liquid equilibrium coexist,and there are six parts in the complete phase diagram at 308.15 K,adding the areas of one liquid and one solid K_(2)SO_(4)(L+S),two liquids(2 L),two liquids and one solid K_(2)SO_(4)(2 L+S).The equations developed by Merchuk,Hu,and Jayapalwere used to fit the binodal curves data of the systemat 308.15 K,meanwhile,the experimental tie-line data of the system at 308.15 K were correlated by Othmer-Tobias equation and Bancroft equation.

关键词： K2SO4 Phase diagram Solubility Mixed solvent Multitemperature

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Controlling Membrane Phase Separation of Polymersomes for Programmed Drug Release

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Chinese Journal of Polymer Science 2022年第9期40卷 1006-1015页

作者： shuai chen Erik Jan Cornel Jian-Zhong Du Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Programmed release of small molecular drugs from polymersomes is of great importance in drug delivery.A significant challenge is to adjust the membrane permeability in a well-controlled ***,we propose a strategy for controlling membrane phase separation by photo-cross-linking of the membrane-forming blocks with different molecular *** synthesized three amphiphilic block copolymers with different membrane-forming blocks,which are poly(ethylene oxide)_(43)-b-poly((ε-caprolactone)_(45)-stat-((α-(cinnamoyloxymethyl)-1,2,3-triazol)caprolactone)_(25))(PEO_(43)-b-P(CL_(45)-stat-CTCL_(25))),PEO_(43)-b-P(CL_(108)-stat-CTCL_(16)),and PEO_(43)-b-PCTCL_(4)-b-PCL_(79).These polymers were self-assembled into polymersomes using either a solvent-switch or powder rehydration method,and the obtained polymersomes were characterized by dynamic light scattering and transmission electron *** the phase separation patterns within the polymersome membranes were investigated by mesoscopic dynamics(MesoDyn)*** further confirm the change of the membrane permeability that resulted from the phase separation within the membrane,doxorubicin,as a small molecular drug,was loaded and released from the *** to the incompatibility between membrane-forming moieties(PCTCL and PCL),phase separation occurs and the release rate can be tuned by controlling the membrane phase pattern or by ***,besides the compacting effect by formation of chemical bonds in the membrane,the cross-linking process can act as a driving force to facilitate the rearrangement and re-orientation of the phase pattern,which also influences the drug release behavior by modulating the cross-membrane distribution of the amorphous PCTCL *** this way,the strategy of focusing on the membrane phase separation for the preparation of the polymersomes with finely tunable drug release rate can be envisioned and designed accordingly,which is of great signifi

关键词： Polymersome Drug delivery Phase separation Programmed drug release

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Chaotic block iterating method for pseudo-random sequence generator

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 45-48页

作者： chen shuai ZHONG Xian-xin Physics Department Huainan Normal University Huainan 232001 China Key Laboratory of Optoelectronic Technology and System of State Ministry ofEducation Chongqing University Chongqing 400030 China

A pseudo-random sequence generator is a basic tool for cryptography. To realize a pseudo-random sequence generator, a new block iterating method using shifter, multiplier, and adder operations has been introduced. By increasing the iteration of the counter and by performing calculations based on the initial value, an approximate pseudo-random sequence was obtained after exchanging bits. The algorithm and the complexity of the generator were introduced. The result obtained from the calculation shows that the self-correlation of the ＂m＂ block sequence is two-valued; the block field value is [0, 2^m - 1 ], and the block period is 2^m＋8 - 1.

关键词： pseudo-random sequence generator algorithm,calculation

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Hybrid π-conjugated polymers from dibenzo pentacyclic centers：precursor design,electrosynthesis and electrochromics

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Science China Chemistry 2017年第1期60卷 38-53页

作者： Kaiwen Lin shuai chen Baoyang Lu Jingkun Xu School of Pharmacy Jiangxi Science & Technology Normal University Nanchang 330013 China

π-Conjugated polymers(CPs)represent one of the quite important and rapidly growing branches of flexible electrochromic *** hybrid CPs employing dibenzo pentacycles(fluorenes,carbazoles,dibenzothiophenes,and dibenzofuran)as the backbones have received considerable attention owing to their special structures and interesting electrochromic *** studies show that polymers from these structures exhibit decent contrast ratios,favorable coloration efficiencies,low switching voltages,fast response time,excellent stability,and color ***,their electrochromic properties significantly depend on fine-tailoring of precursor monomer structures,and polymerization techniques and *** review devotes to showing a clear picture of the research progress of dibenzo pentacycle-centered CPs via electrochemical polymerization,including fluorenes,carbazoles,dibenzothiophenes,and dibenzofuran-based hybrid electrochromic *** influences of the tailored precursor structures on their electropolymerization and resultant polymer performances are highlighted,aiming at providing an insight for the development of novel fused ring-based polymer electrochromic materials.

关键词： fluorenes carbazoles dibenzothiophenes dibenzofuran polymer synthesis electrochemistry electrochromism

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Vibration-assisted vat photopolymerization for pixelated-aliasing-free surface fabrication

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International Journal of Extreme Manufacturing 2024年第3期6卷 440-456页

作者： Han Xu Renzhi Hu shuai chen Junhong Zhu Chi Zhou Yong chen Center for Advanced Manufacturing University of Southern CaliforniaLos AngelesCA 90007United States of America Daniel J.Epstein Department of Industrial and Systems Engineering University of Southern CaliforniaLos AngelesCA 90089United States of America Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089United States of America Department of Industrial and Systems Engineering University of BuffaloBuffaloNY 14260United States of America

Mask image projection-based vat photopolymerization(MIP-VPP)offers advantages like low cost,high resolution,and a wide material range,making it popular in industry and ***,MIP-VPP employing liquid crystal displays(LCDs)has gained traction,increasingly replacing digital micromirror devices,particularly among hobbyists and in educational settings,and is now beginning to be used in industrial ***,LCD-based MIP-VPPsuffers from pronounced pixelated aliasing arising from LCD’s discrete image pixels and itsdirect-contact configuration in MIP-VPP machines,leading to rough surfaces on the 3D-printed ***,we propose a vibration-assisted MIP-VPP method that utilizes a microscalevibration to uniformize the light intensity distribution of the LCD-based mask image on VPP’s building *** maintaining the same fabrication speed,our technique generates asmoother,non-pixelated mask image,reducing the roughness on flat surfaces and boundary segments of 3D-printed *** light intensity modeling and simulation,we derived an optimal vibration pattern for LCD mask images,subsequently validated by *** assessed the surface texture,boundary integrity,and dimensional accuracy of componentsproduced using the vibration-assisted *** notably smoother surfaces and improved boundary roughness enhance the printing quality of MIP-VPP,enabling its promisingapplications in sectors like the production of 3D-printed optical devices and others.

关键词： additive manufacturing vat photopolymerization piezo vibration sub-pixel resolution aliasing

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