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OsHemA gene, encoding glutamyl-tRNA reductase(GluTR) is essential for chlorophyll biosynthesis in rice(Oryza sativa)

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Journal of Integrative Agriculture 2020年第3期19卷 612-623页

作者： ZENG Zhao-qiong LIN Tian-zi ZHAO Jie-yu ZHENG Tian-hui XU Le-feng WANG Yi-hua LIU Ling-long JIANG Ling chen sai-hua WAN Jian-min State Key Laboratory for Crop Genetics&Germplasm Enhancement/Jiangsu Provincial Center of Plant Gene Engineering/College of Agriculture Nanjing Agricultural UniversityNanjing 210095P.R.China Nanchong Academy of Agricultural Sciences Nanchong 637000P.R.China Key Laboratory of Plant Functional Genomics Ministry of Education/CoInnovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhou 225009P.R.China

Chlorophyll(Chl) biosynthesis is essential for photosynthesis and plant ***-tRNA reductase(GluTR) catalyzes glutamyl-tRNA into glutamate-1-semialdehyde(GSA) and initiates the chlorophyll *** though the main role of GluTR has been established,the effects caused by natural variations in its corresponding gene remain largely ***,we characterized a spontaneous mutant in paddy field with Chl biosynthesis deficiency,designated as *** intact thylakoid lamellar structure,the cbd1 plant showed light green leaves and reduced Chl and carotenoids(Cars) content significantly compared to the wild *** map-based gene cloning,the mutation was restricted within a 57-kb region on chromosome 10,in which an mPingA miniature inverted-repeat transposable element(MITE) inserted in the promoter region of OsHemA *** leaf color and the pigment contents in cbd1 were recovered in a complementation test,confirming OsHemA was responsible for the mutant *** was uniquely predicted to encode GluTR and its expression level was dramatically repressed in *** transformation in protoplasts demonstrated that GluTR localized in chloroplasts and a signal peptide exists in its N-terminus.A majority of Chl biosynthesis genes,except for POR and CHLG,were down-regulated synchronously by the repression of OsHemA,suggesting that an attenuation occurred in the Chl biosynthesis ***,we found major agronomic traits involved in rice yield were statistically unaffected,except for the number of full grains per panicle was increased in ***,OsHemA plays an essential role in Chl biosynthesis in rice and its weak allele can adjust leaf color and Chls content without compromise to rice yield.

关键词： OsHemA GluTR chlorophyll biosynthesis

A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

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Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： sai-Nan Liu Jia-Hui Meng Li-Yun Cui hua chen Lin-Qi Shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

Goal-Oriented Control Systems(GOCS):From HOW to WHAT

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 816-819页

作者： Wen-hua chen the Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershireLE113TUU.K.

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced ***-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.

关键词： automated instru system

Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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Chinese Journal of Polymer Science 2024年第8期42卷 1217-1226页

作者： Fang-hua Luo Zhi-Tao Dong Guo-hua chen chen Ma huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials Science and Engineering Huaqiao UniversityXiamen 361000China School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties have attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films have obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

Effects of seepage pressure on the mechanical behaviors and microstructure of sandstone

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2033-2051页

作者： Xuewei Liu Juxiang chen Bin Liu sai Wang Quansheng Liu Jin Luo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Faculty of Engineering China University of GeosciencesWuhan430074China Key Laboratory of Safety for Geotechnical and Structural Engineering of Hubei Province School of Civil EngineeringWuhan UniversityWuhan430072China

Surrounding rocks of underground engineering are subjected to long-term seepage pressure,which can deteriorate the mechanical properties and cause serious *** order to understand the impact of seepage pressure on the mechanical property of sandstone,uniaxial compression tests,P-wave velocity measurements,and nuclear magnetic resonance(NMR)tests were conducted on saturated sandstone samples with varied seepage pressures(i.e.0 MPa,3 MPa,4 MPa,5 MPa,6 MPa,7 MPa).The results demonstrate that the mechanical parameters(uniaxial compressive strength,peak strain,elastic modulus,and brittleness index),total energy,elastic strain energy,as well as elastic strain energy ratio,decrease with increasing seepage pressure,while the dissipation energy and dissipation energy ratio ***,as seepage pressure increases,the micro-pores gradually transform into meso-pores and *** increases the cumulative porosity of sandstone and decreases P-wave *** numerical results indicate that as seepage pressure rises,the number of tensile cracks increases progressively,the angle range of microcracks is basically from 50-120to 80-100,and as a result,the failure mode transforms to the tensile-shear mixed failure ***,the effects of seepage pressure on mechanical properties were *** results show that decrease in the effective stress and cohesion under the action of seepage pressure could lead to deterioration of strength behaviors of sandstone.

关键词： Rock mechanics Mechanical property Seepage pressure Numerical simulation Microcracks

Perception-Driven Learning of High-Dynamic Jumping Motions for Single-Legged Robots

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Journal of Bionic Engineering 2024年第4期21卷 1733-1746页

作者： Nengxiang Sun Fei Meng sai Gu Botao Liu Xuechao chen Zhangguo Yu Qiang huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing100081China

Legged robots show great potential for high-dynamic motions in continuous interaction with the physical environment,yet achieving animal-like agility remains significant *** animals usually predict and plan their next locomotion by combining high-dimensional information from proprioception and exteroception,and adjust the stiffness of the body’s skeletal muscle system to adapt to the current *** control methods have limitations in handling high-dimensional state information or complex robot motion that are difficult to plan manually,and Deep Reinforcement Learning(DRL)algorithms provide new solutions to robot motioncontrol *** by biomimetics theory,we propose a perception-driven high-dynamic jump adaptive learning algorithm by combining DRL algorithms with Virtual Model Control(VMC)*** robot will be fully trained in simulation to explore its motion potential by learning the factors related to continuous jumping while knowing its real-time jumping *** policy trained in simulation is successfully deployed on the bio-inspired single-legged robot testing platform without further *** results show that the robot can achieve continuous and ideal vertical jumping motion through simple training.

关键词： Deep reinforcement learning High-dynamic jump Perception driven Single-legged robot

A Secure Mutual Authentication Protocol Based on Visual Cryptography Technique for IoT-Cloud

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Chinese Journal of Electronics 2024年第1期33卷 43-57页

作者： Brou Bernard Ehui chen chen Shirui WANG hua GUO Jianwei LIU School of Cyber Sciences and Technology Beihang University State Key Laboratory of Software Development Environment Beihang University Sino-French Engineering School Beihang University Beihang Hangzhou Innovation Institute Yuhang

Because of the increasing number of threats in the IoT cloud, an advanced security mechanism is needed to guard data against hacking or attacks. A user authentication mechanism is also required to authenticate the user accessing the cloud services. The conventional cryptographic algorithms used to provide security mechanisms in cloud networks are often vulnerable to various cyber-attacks and inefficient against new attacks. Therefore,developing new solutions based on different mechanisms from traditional cryptography methods is required to protect data and users’ privacy from attacks. Different from the conventional cryptography method, we suggest a secure mutual authentication protocol based on the visual cryptography technique in this paper. We use visual cryptography to encrypt and decrypt the secret images. The mutual authentication is based on two secret images and *** user requests the ticket from the authentication server(AS) to obtain the permission for accessing the cloud services. Three shared secret keys are used for encrypting and decrypting the authentication process. We analyze the protocol using the Barrows-Abadi-Needham(BAN)-logic method and the results show that the protocol is robust and can protect the user against various attacks. Also, it can provide a secure mutual authentication mechanism.

关键词： Visualization Cloud computing Data privacy Protocols Biometrics (access control) Authentication Resists

WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor (PSTT)

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Biomedical and Environmental Sciences 2024年第4期37卷 423-427页

作者： ZHANG sai chen Zhi Xian ZHANG Mo DU Yan ZHOU Jia Yi WU Jing YU Yin hua CAO Qi ZHAO Hong Bo Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关键词： chemotherapy diagnosis metastasis

Room temperature self-healing liquid metals:capabilities,applications and challenges

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International Journal of Smart and Nano Materials 2024年第3期15卷 469-501页

作者： chen hua Jianye Gao Jing Liu Key Lab of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijingChina School of Future Technology University of Chinese Academy of SciencesBeijingChina School of Biomedical Engineering Tsinghua UniversityBeijingChina

Self-healing materials span diverse application fields,including flexible electronics,soft robotics,and energy ***,conventional self-healing materials pose a challenge in achiev-ing the delicate balance between flexibility and electrical ***,they also suffer from prolonged healing times,incomplete healing,and high manufacturing *** metals possess excellent self-healing capabilities owing to their unique combination of fluidic and metallic properties,high surface tension,and reversible solid-liquid phase change at room temperature,offering an intriguing material option for addressing the challenges associated with flexibility and elec-trical *** this review article,we comprehensively examine the domain of self-healing liquid metals from the standpoint of typical mechanisms underlying self-healing pro-cesses,as well as practical strategies employed for achieving such ***,we explore representative applications that showcase the potential of these materials while aiming to provide a valuable reference for advancing and enhancing the field of self-healing *** pro-spect along this direction is made.

关键词： Self-healing Liquid metal Smart materials