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Chinese Journal of Natural Medicines 2024年第5期22卷 385-386页

作者： chen qian FAN Xiaohui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

With the awarding of the 2015 Nobel Prize in Physiology or Medicine to Chinese pharmacologist Tu Youyou,and the significant contributions of traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),TCM has garnered increasing attention and interest globally.Although advanced research progress has been made in the efficacy research,mechanism elucidation and target prediction of TCM in recent years[1].

关键词： Protein interactome Traditional Chinese medicine Therapeutic effectiveness

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan chen qian WANG Yuan XING Yan-qing ZHENG Jun DUAN chen-chen chen Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

Matrix-Mediated Color-Tunable Ultralong Organic Room Temperature Phosphorescence of 7H-Benzo[c]carbazole Derivatives

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CCS Chemistry 2024年第3期6卷 798-811页

作者： chen qian Xue Zhang Zhimin Ma Xiaohua Fu Zewei Li Huiwen Jin Mingxing chen Hong Jiang Zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this work.Pure powders of BCz and its derivatives merely exhibit blue fluorescence at ambient condition.However,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room temperature.Moreover,the UORTP color can be tuned between green and yellow depending on the matrix.The ultralong phosphorescence originates from the generation of charge-separated states via radicals.The matrixes play a key role in both stabilizing charge-separated states and controlling UORTP color.More interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room temperature.Comparedwith Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical applications.This work gains a deeper insight into the mechanism of UORTP and paves a new approach to applying organic phosphorescent materials to underwater coating and imaging.

关键词： 7H-Benzo[c]carbazole ultralong organic room temperature phosphorescence ion radical matrix-mediated color tunning underwater application

Research progress on formation and suppression of crack defects in oxide eutectic ceramics by laser additive manufacturing

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AFM probe for measuring~10^(−5)ultra-low friction coefficient:Design and application

CAILIAO GONGchenG-JOURNAL OF MATERIALS ENGINEERING 2024年第5期52卷 34-45页

作者： Yao, Jiatong Su, Haijun Jiang, Hao chen, qian Shen, Zhonglin Yu, Minghui Zhang, Zhuo Guo, Min Northwestern Polytech Univ State Key Lab Solidificat Proc Xian 710072 Peoples R China Northwestern Polytech Univ Shenzhen Res Inst Shenzhen 518057 Guangdong Peoples R China

Oxide eutectic ceramics have excellent high specific strength , high temperature resistance , corrosion resistance , oxidation and creep resistance , and so on , which are considered to be the promising materials to be used in ultra -high temperature oxidation , corrosion and other extreme environments. It shows great application prospects in the new generation of high thrust -to -weight ratio aero-engine for hightemperature hot -end structural components. Laser additive manufacturing technology has become one of the most promising cutting -edge technologies for the preparation of high-performance complex structural components in recent years. Crack defect is easy to occur in the process of laser rapid solidification of ceramics , which seriously affects the quality and performance of the oxide eutectic ceramics components. So , it has become a key factor restricting the engineering application. Two typical laser additive manufacturing technologies for ceramics including laser engineered net shaping and laser power bed fusion were briefly summarized. The crack morphology characteristics of different shaped components formed by the above two technologies were analyzed and compared. The formation mechanism of cracks in laser additive manufacturing of oxide ceramics was explored from the perspectives of microstructure characteristics ,stress state. Further ,a systematic summary was presented focusing on the improvement of microstructures and the reduction of thermal stress to inhibit crack formation through optimization of process parameters ,compositional design ,and outfield assistance. Finally ,it is pointed out that the future development trends and breakthrough directions of oxide eutectic ceramics by laser additive manufacturing in terms of and factors ,and research.

关键词： oxide eutectic ceramic laser additive manufacturing crack defect formation mechanism crack suppression DIRECTED ENERGY DEPOSITION MECHANICAL-PROPERTIES PROCESS OPTIMIZATION ALUMINA CERAMICS MICROSTRUCTURE COMPOSITE ZIRCONIA COMPONENTS STRENGTH

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Friction 2024年第1期12卷 64-73页

作者： Yushan chen Liang JIANG Linmao qian Tribology Research Institute State Key Laboratory of Traction PowerSouthwest Jiaotong UniversityChengdu 610031China

Superlubricity provides a novel approach to addressing friction and wear issues in mechanical systems.However,little is known regarding improving the atomic force microscope(AFM)friction coefficient measurement resolution.Accordingly,this study established the theoretical formula for the AFM friction coefficient measurement and deduced the measurement resolution.Then,the formula was applied to the AFM probe with a rectangular cross-section cantilever.The measurement resolution is associated with the dimensional properties of the AFM probe,the mechanical properties of the cantilever material,the properties of the position-sensitive detector(PSD),and probably the anti-vibration performance of the AFM.It is feasible to make the cantilever as short as possible and the tip as high as possible to improve the measurement resolution.An AFM probe for measuring an ultra-low friction coefficient was designed and fabricated.The cantilever’s length,width,and thickness are 50,35,and 0.6μm,respectively.The tip height is 23μm.The measurement resolution can reach 7.1×10^(−6) under the maximum normal force.Moreover,the AFM probe was applied to measure the superlubricity between graphene layers.The friction coefficient is 0.00139 under 853.08 nN.This work provides a promising method for measuring a~10^(−5) friction coefficient of superlubricity.

关键词： atomic force microscope(AFM) superlubricity friction coefficientμ probe

Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation

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World Journal of Stem Cells 2024年第4期16卷 459-461页

作者： Yi Li qian-qian chen En-qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology First Medical Center of Chinese PLA General HospitalBeijing 100853China

Hypoxia can get more ability to inhibit inflammation.But how it impact on survival time of mesenchymal stem cells(MSCs)is confusing and how preconditioned MSCs inhibiting inflammation are partially known.Those issues ... 详细信息

关键词： Mesenchymal stem cell Hypoxia-inducible factor 1α Hypoxia Inflammation Macrophage

Emerging mechanisms of ferroptosis and its implications in lung cancer

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中华医学杂志(英文版) 2024年第7期137卷 818-829页

作者： Li qian Song Qibin Pei Huadong chen Yali USA State Key Laboratory of Medical Proteomics National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing 102206 Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology Georgetown Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington D.C. 20057

Lung cancer is one of the most common malignancies and has the highest number of deaths among all cancers. Despite continuous advances in medical strategies, the overall survival of lung cancer patients is still low, probably due to disease progression or drug resistance. Ferroptosis is an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides, and its dysregulation is implicated in cancer development. Preclinical evidence has shown that targeting the ferroptosis pathway could be a potential strategy for improving lung cancer treatment outcomes. In this review, we summarize the underlying mechanisms and regulatory networks of ferroptosis in lung cancer and highlight ferroptosis-targeting preclinical attempts to provide new insights for lung cancer treatment.

关键词： Lung cancer Ferroptosis Ferroptosis regulators Ferroptosis inducers Cancer treatment

Review on article of effects of tenofovir alafenamide and entecavir in chronic hepatitis B virus patients

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World Journal of Hepatology 2024年第1期16卷 109-111页

作者： Yu-Tong Sun qian-qian chen Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100193China

This letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published on World J Hepatol 2023 August 27.We review the related research content,topic selection,methodology,conclusions,strengths and weaknesses of this article.And evaluate it in relation to other published relevant articles.

关键词： Tenofovir alafenamide Entecavir Serum lipid levels Hepatitis B virus

Sex-specific facilitation and reproduction of the gynodioecious cushion plant Arenaria polytrichoides on the Himalaya-Hengduan mountains,SW China

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Plant Diversity 2024年第2期46卷 247-255页

作者： Xufang chen Yazhou Zhang Lishen qian Renyu Zhou Hang Sun Jianguo chen State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnanChina Yunnan Key Laboratory of Plateau Wetland Conservation Restoration and Ecological ServicesSouthwest Forestry UniversityKunmingYunnanChina

When benefiting other beneficiaries,cushion plants may reciprocally receive feedback effects.The feedback effects on different sex morphs,however,remains unclear.In this study,taking the gynodioecious Arenaria polytrichiodes as a model species,we aimed to assess the sex-specific facilitation intensity of cushion plant by measuring the beneficiary cover ratio,and to assess the potential costs in cushion reproductive functions by measuring the flower and fruit cover ratios.The total beneficiary cover ratio was similar between females and hermaphrodites.Females produced much less flowers but more fruits than hermaphrodites.These results suggested that females and hermaphrodites possess similar facilitation intensity,and female cushion A.polytrichoides may allocate more resources saved from pollen production to seed production,while hermaphrodites possibly allocate more resources to pollen production hence reducing seed production.The surface areas covered by beneficiaries produced less flowers and fruits than areas without beneficiaries.In addition,strong negative correlations between beneficiary cover and flower cover were detected for both females and hermaphrodites,but the correlation strength were similar for these two sex morphs.However,the correlation between beneficiary cover and fruit cover was only significantly negative for females,suggesting that beneficiary plants negatively affect fruit reproduction of females while have neutral effects on hermaphrodites.All the results suggest that to facilitate other beneficiaries can induce reproductive costs on cushion A.polytrichoides,with females possibly suffering greater cost than hermaphrodites.Such differentiation in reproductive costs between sex morphs,in long-term perspective,may imply sex imbalance in population dynamics.

关键词： Facilitation intensity Feedback effect Sex-specific facilitation Nurse plant Population dynamics Reproductive function

Diagnostic values of questionnaires of Convergence Insufficiency Symptom Survey and College of Optometrists Vision Development Quality of Life in the screening of convergence insufficiency

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 904-908页

作者： Ling Xiong qian chen Ye Wu Department of Ophthalmology West China HospitalSichuan University/Laboratory of Optometry and Vision ScienceWest China School of MedicineChengdu 610041Sichuan ProvinceChina Department of Clinical Research Management Center of BiostatisticsDesignMeasurement and EvaluationWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To compare and analyse the diagnostic efficacy of the College of Optometrists Vision Development Quality of Life Questionnaire(COVD-QOL)and the Convergence Insufficiency Symptom Survey(CISS)in detecting convergence insufficiency and to compare their diagnostic value in clinical applications.METHODS:Using the diagnostic test method,62 adult patients with convergence insufficiency(age:24.74±3.75y)and 62 normal participants(age:23.61±3.13y)who visited the Optometry Clinic of West China Hospital of Sichuan University from April 2021 to January 2023 were included.All subjects completed the CISS and COVD-QOL.Statistical analysis of the sensitivity and specificity of the CISS and COVD-QOL and comparison and joint experimental analysis of their diagnostic efficacy were performed.RESULTS:The sensitivity of the CISS and COVD-QOL for convergence insufficiency was 64.5%and 71.0%,respectively,while the specificity was 96.8%and 67.7%,respectively.Compared to the CISS alone,the combination of the CISS and COVD-QOL demonstrated lower sensitivity and specificity.The areas under the receiver operating characteristic curve of CISS,COVD-QOL and CISS combined with COVD-QOL were 0.806,0.694 and 0.782,respectively.CONCLUSION:Considering the low sensitivity of the CISS and the low specificity of the COVD-QOL,it is recommended to supplement these questionnaires with other screening tests for the detection of convergence insufficiency.

关键词： convergence insufficiency symptom survey College of Optometrists Vision Development Quality of Life Questionnaire convergence insufficiency asthenopia