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Intravitreal injection practice patterns among Chinese ophthalmologists

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1717-1722页

作者： Li Su Yin-chen Shen Hong Li Bo mou Kun Liu Xun Xu Department of Ophthalmology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai MicroCall Information Technology Co. Ltd.Shanghai 200436China

AIM:To describe the practice patterns of intravitreal injections(IVIs)among ophthalmologists in ***:This was a cross-sectional online *** who had performed accumulated more than 100 injections were contacted by the Brightness Center,a hospital-based national network,to complete an anonymous,24-question,internet-based *** were surveyed on practices in injection techniques,pre-,and post-injections ***:A total of 333 ophthalmologists from 28 provinces/municipalities/autonomous regions responded to the survey(50.68%response rate).The 91.29%of the respondents evaluated systemic risk factors by medical history,electrocardiogram(ECG)and blood *** the respondents used pre-injection prophylactic *** checked intraocular pressure(IOP,99.1%)and blood pressure(96.1%)before injections.A majority of the respondents performed injections in the operating room(98.8%),wore masks(99.7%),gloves(99.4%)and sterile surgical clothing(96.1%),performed topical anesthetics(97.9%),and applied povidone-iodine(95.8%)*** 61.26%of the respondents dilated *** half of the respondents(51.05%)performed bilateral injections in the same *** temporal quadrant(40.54%)was the most frequent site of *** three quarters used 30-gauge *** respondents(97.9%)measured the site of injection from *** than half(53.45%)performed conjunctiva displacement prior to *** 32.43%of the respondents checked IOP post-injection and 87.99%physicians checked hand motion(HM)or counting fingers(CF)after injection,while 36.94%observed optic nerve *** participants used topical antibiotics *** physicians(91.89%)reviewed patients on the following ***:This study provides a description of the real-world practice patterns in IVIs in China and offers critical information regarding education and training of ophthalmologists and amendment of local society guideli

关键词： intravitreal injections practice pattern topical antibiotics Chinese ophthalmologists

资源配置混杂Petri网的混杂系统生产过程动态调度

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控制理论与应用 2011年第2期28卷 173-178页

作者：杨欣陈谋费树岷南京航空航天大学自动化学院江苏南京210016 东南大学自动化学院江苏南京210096

为了增强混杂生产过程应对突发事件的能力,以一种新的混杂Petri网(资源配置混杂Petri网)为研究模型,给出了相应的使能和激发规则.并在资源配置混杂Petri网建立的仿真模型的基础上,融入事件逻辑网和逻辑规划,提出一种适用于混杂系统动态... 详细信息

为了增强混杂生产过程应对突发事件的能力,以一种新的混杂Petri网(资源配置混杂Petri网)为研究模型,给出了相应的使能和激发规则.并在资源配置混杂Petri网建立的仿真模型的基础上,融入事件逻辑网和逻辑规划,提出一种适用于混杂系统动态生产调度建模和优化的方法.以典型的混杂生产过程为例,研究混杂系统生产过程建模及优化.研究结果表明,资源配置混杂Petri网模型描述能力强,能够有效描述混杂系统生产过程,所提出的动态调度方案切实有效.

关键词：资源配置混杂Petri网混杂系统生产过程动态调度

Study on Microcrystaline Structure and Luminescence of ZnS Thin Film Devices

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厦门大学学报（自然科学版） 2002年第S1期41卷 176-177页

作者： WANG Yu-jiang, chen mou-zhi, SUN Zhen-ning, LIU Rui-ta ng, LI Jie, chen Shang-wei (Department of Physics, Xiamen University, Xiamen 361005, China)

The Electroluminescence thin films of zinc sulfide do ped with erbium, fabricated by thermal evaporation with two boats, are analyzed by the technology of X-ray diffraction (XRD) and X-ray photoelectron spectrosc opy (XPS). The relationship between electroluminescence brightness and microst ructure of the thin films is obtained. The analysis results of XRD indicate th at the fabricated zinc sulfide thin films belong to the blende structure and hav e a trend of preferential orientation. The XPS measurements reveal the surface m icrostructure states formed mainly by oxygen absorption and carbon absorption th at effect on the EL excitation and relaxation luminescence process. The maximum photoelectron peak corresponding to the doped erbium is detected at a depth of 1 35nm to 350nm that formed the activation layer in the films. Analysis shows that the high brightness of the film devices is attributed to the crystalline planes of growth orientated in the (311), (400). In explanation of this phenomenon, th e status of the substitute energy for Er 3+ replacing Zn 2+ in the hos t lattice of zinc sulfide is discussed. All results of describing above are referable in researching of the electroluminescence excitation machnism of the t hin film devices and in favor of fabricating the thin film devices with high qua lity.

关键词： electroluminescence ZnS thin film microstru cture

Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

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Chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： Ming-Zhong Guo Mei-Jin mou Zhuo chen Shao-Fei Ni Ming Li Li-Rong Wen Lin-Bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

Adaptive H~∞ Control of Nonlinear Systems with Neural Networks

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Chinese Journal of Aeronautics 2003年第1期16卷 36-41页

作者：姜长生陈谋 Automaton College Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The discussion is devoted to the adaptive H ∞ control method based on RBF neural networks for uncertain nonlinear systems in this paper. The controller consists of an equivalent controller and an H ∞ controller. The RBF neural networks are used to approximate the nonlinear functions and the approximation errors of the neural networks are used in the adaptive law to improve the performance of the systems. The H ∞ controller is designed for attenuating the influence of external disturbance and neural network approximation errors. The controller can not only guarantee stability of the nonlinear systems, but also attenuate the effect of the external disturbance and neural networks approximation errors to reach performance indexes. Finally, an example validates the effectiveness of this method.

关键词： neural networks nonlinear systems adaptive control H ∞ control

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing chen Wei-qing chen Fei-hua GONG mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

基于动态目标概率分布的核电站无人机航路强化学习规划

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中国科学：信息科学 2022年第9期52卷 1642-1655页

作者：周同乐陈谋南京航空航天大学自动化学院南京210016

针对核电站空中动态入侵目标,本文提出了一种基于动态目标概率分布的无人机航路强化学习规划算法,实现了对空中入侵目标的有效拦截.根据入侵目标的状态信息基于概率扩散原理计算目标的概率分布,推理目标可能出现的位置.在此基础上,设计... 详细信息

针对核电站空中动态入侵目标,本文提出了一种基于动态目标概率分布的无人机航路强化学习规划算法,实现了对空中入侵目标的有效拦截.根据入侵目标的状态信息基于概率扩散原理计算目标的概率分布,推理目标可能出现的位置.在此基础上,设计了基于航路点转移规则的行动空间和基于目标概率分布的报酬函数动态更新机制,通过Q-学习不断优化路径,构建了基于目标概率分布和强化学习的无人机航路规划框架,实现了无人机航路强化学习规划.仿真结果表明,该方法能够针对核电站空中入侵目标,实现目标点变化情况下无人机的自主航路规划.

关键词：无人机核电站航路规划动态目标概率分布强化学习

Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of Gastroenterology 2024年第5期30卷 440-449页

作者： Yue Deng Ya Jiang Tong Jiang Ling chen Hai-Jun mou Bi-Guang Tuo Guo-Qing Shi Department of Gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also *** were allocated to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was *** average cost and other related economic factors were g

关键词： Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

应用干扰观测器的导弹发射车起竖装置鲁棒控制

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应用科学学报 2014年第3期32卷 319-324页

作者：朱成陈谋南京航空航天大学自动化学院南京210016

针对现有垂直导弹发射车起竖装置的起竖平稳性不足和快速性不够的问题,对起竖装置的运动学部分和液压部分进行建模,在此基础上利用backstepping方法实现起竖角的精确控制.由于系统存在着建模不确定性误差和未知外部干扰,运用径向基神经... 详细信息

针对现有垂直导弹发射车起竖装置的起竖平稳性不足和快速性不够的问题,对起竖装置的运动学部分和液压部分进行建模,在此基础上利用backstepping方法实现起竖角的精确控制.由于系统存在着建模不确定性误差和未知外部干扰,运用径向基神经网络干扰观测器对其进行估计,并将估计输出应用于起竖角的控制,从而提高了系统控制精度.仿真结果表明,所设计的基于径向基神经网络干扰观测器导弹发射车起竖装置backstepping控制器具有良好的动态特性和强鲁棒性.

关键词：导弹发射车起竖装置神经网络干扰观测器 backstepping控制