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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo jiao Yan Wang Yue-Hua Zhang Ge chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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Non-Rigid Medical Image Registration with Joint Histogram Estimation Based on Mutual Information

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Transactions of Tianjin university 2007年第6期13卷 452-455页

作者：陆雪松张素苏和陈亚珠 department of Biomedical Engineering Shanghai Jiao Tong University

A mutual information-based non-rigid medical image registration algorithm is presented. An approximate function of Hanning windowed sinc is used as kernel function of partial volume (PV) interpolation to estimate the joint histogram, which is the key to calculating the mutual information. And a new method is proposed to compute the gradient of mutual information with respect to the model parameters. The transformation of object is modeled by a free-form deformation (FFD) based on B-splines. The experiments on 3D synthetic and real image data show that the algorithm can converge at the global optimum and restrain the emergency of local extreme.

关键词： non-rigid registration free-form deformation (FFD) Hanning windowed sinc partial volume (PV) interpolation

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Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2.)-dependent AMPK/mTOR pathway

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-Hui Huang jiao Lyu Sheng chen Ting-Yi Liang Yu-Qing Rao Ping Fei Jing Li Hai-Ying Jin Pei-Quan Zhao department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 2.0,300,400,500,or 600 mOsm for 6,12.18,2.h in *** chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein *** transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy *** electron microscopy was used to detect the existence of *** interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related *** cytometry was employed to test the apoptosis and intracellular Ca^(2.)*** membrane potential was measured by JC-1 *** cell counting kit-8 assay was used to calculate the cellular *** wound healing assay was used to evaluate the wound closure *** 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in *** 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression *** Ca^(2.)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early *** on this evidence,autophagy activation through the Ca^(2.)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic *** stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration *** of autophagy by ATG7 knockdown had sim

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

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Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activation

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Acta Pharmacologica Sinica 2019年第8期40卷 1040-1048页

作者： Yun-tian chen Yao Du Bo Zhao Li-xing Gan Kai-kai Yu Lei Sun Jian Wang Feng Qian department of Respiratory Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine department of Infectious Diseases The Fifth People’s Hospital of ShanghaiFudan University Engineering Research Center of Cell & Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong University

Staphylococcus aureus(***)infection leads to a severe inflammatory response and causes acute lung injury(ALI),eventually threatening human ***,it is of importance to find an agent to inhibit inflammation and reduce ***,we found that costunolide,a sesquiterpene lactone,displays anti-inflammatory effects and ameliorates heat-killed ***(HKSA)-induced *** treatment attenuated HKSA-induced murine ALI in which pulmonary neutrophil infiltration was inhibited,lung edema was decreased,and the production of pro-inflammatory cytokines was significantly *** addition,costunolide dose-dependently inhibited the generation of IL-6,TNF-α,IL-1β,and keratinocyte-derived cytokine(KC),as well as the expression of iNOS,in HKSA-induced ***,costunolide attenuated the phosphorylation of p38 MAPK and cAMP response element-binding protein(CREB).Collectively,our findings suggested that costunolide is a promising agent for alleviating bacterialinduced ALI via the inhibition of the MAPK signaling pathways.

关键词： Costunolide Staphylococcus aureus pneumonia macrophage MAPK signaling

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Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice

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Acta Pharmacologica Sinica 2019年第8期40卷 999-1009页

作者： Shu-qin chen Qiang Niu Li-ping Ju Miriayi Alimujiang Han Yan Ning-ning Bai Jun Xu Qi-chen Fang Jun-feng Han Ying Yang Wei-ping Jia shanghai Key Laboratory of Diabetes Shanghai Institute for DiabetesShanghai Clinical Medical Centre of DiabetesShanghai Key Clinical Centre of Metabolic DiseasesDepartment of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s Hospital National Engineering Research Center of Die and Mold CAD Shanghai Jiao Tong University department of Geriatrics Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Promoting white adipose tissue(WAT)browning and enhancing brown adipose tissue(BAT)activity are attractive therapeutic strategies for obesity and its metabolic *** sympathetic innervation in WAT and BAT represents a promising therapeutic ***,there are few reports on extracellular microenvironment remodeling,especially changes in nerve terminal *** the key molecules mediating the neuro-adipose synaptic junctions is a key *** this study,we used bioinformatics methods to identify the differentially expressed predicted secreted genes(DEPSGs)during WAT browning and BAT *** DEPSGs largely reflect changes of cytokines,extracellular matrix remodeling,vascularization,and adipocyteneuronal *** then performed functional enrichment and cellular distribution specificity *** upregulated and downregulated DEPDGs during WAT browning displayed a distinctive biological pattern and cellular *** listed a cluster of adipocyte-enriched DEPSGs,which might participate in the cross-talk between mature adipocytes and other cells;then identified a synaptogenic adhesion molecule,Clstn3,as the top gene expressed enriched in both mature white and brown *** Q-PCR and immunohistochemistry,we found significantly increased Clstn3 expression level during WAT browning and BAT activation in mice subjected to cold exposure(4℃).We further demonstrated that treatment with isoproterenol significantly increased Clstn3 and UCP1 expression in differentiated white and beige adipocytes in *** conclusion,our study demonstrates that the secretion pattern was somewhat different between WAT browning and BAT *** reveal that Clstn3 may be a key gene mediating the neuro-adipose junction formation or remodeling in WAT browning and BAT activation process.

关键词： WAT browning BAT activation Calsyntenin-3 neuro-adipose synapse isoproterenol obesity

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THE BEHAVIOUR OF1/2.112. SUPERLATTICE DISLOCATIONSIN POLYSY NTHETICALLY TWINNED CRYSTALS OF TiAl

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中国有色金属学会会刊：英文版 1999年第S1期9卷 81-86页

作者： Yi Liu 1,2., Dongliang Lin (T. L. Lin) 1, Shipu chen 1, Zhongguang Wang 2.and Zhiguo Liu 3 1 department of Materials Science, {2., shanghai 2.0030, china 2.State Key Laboratory for Fatigue and Fracture of Material

The behaviour of 1/2.112. superlattice dislocations in polysynthetically twinned (PST) crystals of TiAl at elevated temperatures have been investigated by transmission electron microscopy (TEM). The results showed that 1/2.112. superlattice dislocations play an important part in the deformation. At room temperature, 1/2.112. superlattice dislocations can be activated easily but are often dissociated into partials trailed by faulted dipoles with super extrinsic stacking faults (SESFs) and difficult to move. In situ heating observations on the faulted dipoles showed that annihilation of the partials bounding the SESFs of the faulted dipoles occurred and resulted in discontinuous stacking faults along the direction of the partials at about 500 ℃. The faulted dipoles disappeared completely at about 600 ℃. The temperature range of annihilation coincided with that of brittle to ductile transition of TiAl PST crystals reported by Inui et al (1995). At 850 ℃, they are often dissociated into partials including super intrinsic stacking faults (SISFs) and can move easily. The experimental observations suggest that the behaviors of 1/2.112. superlattice dislocations control the phenomenon of brittle to ductile transition of PST crystals of TiAl alloy.

关键词： PST crystals TiAl superlattice dislocations dissociation brittle to ductile transition

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Quadratic and cubic eddy-viscosity models in turbulent supercavitating flow computation

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Theoretical & Applied Mechanics Letters 2011年第3期1卷 66-70页

作者： Ying chen,~(1,a)) Chuanjing Lu,~(1,2. and Xin chen~1 1){2. of Engineering Mechanics,School of Naval Architecture,Ocean and Civil Engineering, shanghai jiao tong university,shanghai 2.02.0,china 2.State Key Laboratory of Ocean Engineering,shanghai jiao tong university,shanghai 2.02.0,china State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240 China

Quadratic and cubic non-linear eddy-viscosity turbulence models(NLEVM) with low Reynolds number(Re) correction were presented to provide better description of anisotropic turbulence stresses in the numerical prediction of supercavitating flows,which are accompanied with large density ratio and large-scaled swirling flow *** applications of the NLEVM were carried out through a self-developed cavitation codes,coupled with a cavitation model based on the transport equation of liquid *** NLEVM were verified capable of capturing more accurate macroscopic shape and hydrodynamic property of supercavity by the benchmark problems of supercavities over simple ***,the cubic NLEVM was further applied to the numerical prediction of supercavitating flow around a complex submerged *** corresponding cavitation behaviors were explored in detail to provide beneficial experience for further research.

关键词： supercavitating flow numerical simulation non-linear turbulence model

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Characteristics of Obesity and Its Related Disorders in china

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Biomedical and Environmental Sciences 2010年第1期23卷 4-11页

作者： WEI-PING JIA ,chen WANG,SHAN JIANG,AND JIE-MIN PAN department of Endocrinology and Metabolism,{2. Affiliated Sixth People’s Hospital,shanghai Diabetes Institute,shanghai Clinical Center of Diabetes,shanghai 2.02.3,china [a] department of Endocrinology Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Diabetes Institute Shanghai Clinical Center of Diabetes Shanghai 200233 China

Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences. Abdominal obesity, also known as central obesity, refers to the presence of excess fat in the abdominal area. Obesity, especially abdominal obesity, contributes to many metabolic disorders including metabolic syndrome （MetS）, type 2.diabetes （T2.M） and cardiovascular diseases （CVD）. The incidence of obesity has increased dramaticaUy in recent yeats worldwide. In china, more than one-third of adults are overweight or obese and 10%-2.% of all adults are affected by MetS. The pathogenesis underlying the abdominal obesity remains unclear. The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments （lifestyle changes, pharmacological interventions and surgical therapies） before a serious consequence becomes clinically apparent. In this review, we discuss the prevalence, pathogenesis and clinic features of obesity in china.

关键词： Obesity Metabolic syndrome Type 2.diabetes Cardiovascular disease

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Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin chen Jianhua Zhuang Jie Gao You Yin department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

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The nuclear symmetry energy and neutron skin thickness of finite nuclei

The nuclear symmetry energy and neutron skin thickness of fi...

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第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： Lie-Wen chen~(1 1)) 1(department of Physics,{2.,shanghai 2.02.0,china)

Heavy-ion reactions induced by neutron-rich nuclei and the neutron skin thickness of heavy nuclei provide a unique means to investigate the equation of state of isospin asymmetric nuclear matter,especially the density dependence of the nuclear symmetry *** review the recent progress on the determination of the density dependence of symmetry energy from both heavy ion reactions and nuclear *** particular,using a novel correlation analysis,which allows us to explore transparently the correlation between observables of finite nuclei and nuclear matter properties within the Skyrme-Hartree-Fock approach, we find that the existing neutron skin data of Sn isotopes can give important constraints on the value E（ρ） and its density slope L of the nuclear symmetry energy at saturation densityρ.Combining these constraints from nuclear structure with those from recent analyses of isospin diffusion and double neutron/proton ratio in heavy ion reactions at intermediate energies leads to a quite accurate value of L = 58±18 MeV approximately independent of E（ρ）.This result allows us to rule out a number of nuclear effective interactions and also has important ramifications in neutron star physics.

关键词： Equation of state of asymmetric nuclear matter the symmetry energy the neutron skin heavy ion collisions

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