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Pathogenesis of Demyelinating Encephalopathy in Dogs with Spontaneous Acute Canine Distemper

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Journal of Integrative Agriculture 2013年第2期12卷 334-343页

作者： PAN Yao-qian LIU Xing-you MENG Li-ping ZHU Guang-rui XIA Yin-ke chen jin-shan Yoshikawa Takashi Department of Veterinary Pathology College of Animal Sciences Henan Institute of Science and Technology Department of Microbiology and Immunology Northwestern University Feinberg Medical School Department of Veterinary Pathology School of Veterinary Medicine and Animal Science Kitasato University

So far, the pathogenesis of demyelination caused by canine distemper virus （CDV） in the central nervous system has remained unclear, although a lot of studies have been done extensively. To further investigate the relation of variety cells in brain to demyelination, this study was performed on 15 dogs with spontaneous acute canine distemper and 2 controls. According to anatomical relation, the brain was divided into cerebrum, cerebral stem and cerebellum. The sections with no, mild, moderate, or severe demyelinating lesions were selected respectively and stained by HE and immunohistochemistry. Immuno-localisation of CDV antigen was used to conftrm CDV infection. The brain was examined for co-localisation of the CDV antigen with either an astrocyte-specific marker, glial fibrillary acidic protein （GFAP）, or an oligodendrocyte-specific marker, galactocerebroside （GalC）. Apoptotic cell was detected by TdT-mediated nick end-labeling assay （TUNEL）. The results demonstrated that the local disturbance of blood circulation mainly included congestion, edema, thrombosis, and disseminated intravascular coagulation （DIC）. The CDV neucleocapsid protein positive reaction, metabolic disorder and apoptosis of oligodendrocytes were observed in demyelinating areas. Lots of astrocytes displayed CDV antigen-positive, especially in their process. Some of them became apoptotic cell confirmed by TUNEL staining. Fibrous astrocytes showed more intense GFAP-positive in mild and moderate demyelinating area. Some of nervous cells located in pyramidal cell layers and nucleus nervi were in degeneration, necrosis. Satellitosis, neuronophagia and apoptotic neurons were examined by hematoxylin and eosin （HE） and TUNEL staining. The results suggested that the demyelinating changes in brain tissues infected with CDV mainly related to the metabolic disorder and apoptosis of ogliodendrocytes and astrocytes; also involved with the local disturbance of blood circulation and some neuron lost.

关键词： acute canine distemper demyelinating encephalopathy oligodendrocyte astrocyte apoptosis

Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

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Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： Xinming GAO Binbin FENG chen DU Congcong HOU shan jin Daojun TANG Junquan ZHU Key Laboratory of Applied Marine Biotechnology by the Ministry of Education and Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some *** mechanism and role of mitochondrial morphology regulation,however,remain somewhat *** this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta *** full-length cDNA of the *** opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino *** Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting *** and protein expression was higher in the coelomic fluid(a site of spermatid development)of male *** and increased first and then decreased from March to ***,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in *** *** Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic ***,Pe-OPA1 was mainly detected in the spermatid *** experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in *** *** results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

A whole-net cooperative positioning method based on CDGNSS and inter-vehicle ranging

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Chinese Journal of Aeronautics 2024年第2期37卷 401-416页

作者： shan HU Hongbo ZHAO chen ZHUANG School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Relative positioning is recognized as an important issue for vehicles in urban ***-vehicle Cooperative Positioning(CP)techniques which fuse the Global Navigation Satellite System(GNSS)and inter-vehicle ranging have attracted attention in improving the performance of baseline estimation between ***,current CP methods estimate the baselines separately and ignore the interactions among the positioning information of different *** interactions are called’information coupling’.In this work,we propose a new multivehicle precise CP framework using the coupled information in the network based on the Carrier Differential GNSS(CDGNSS)and inter-vehicle *** demonstrate the benefit of the coupled information by deriving the Cramer-Rao Lower Bound(CRLB)of the float estimation in *** fully use this coupled information,we propose a Whole-Net CP(WN-CP)method which consists of the Whole-Net Extended Kalman Filter(WN-EKF)as the float estimation filter,and the Partial Baseline Fixing(PBF)as the ambiguity resolution *** WN-EKF fuses the measurements of all baselines simultaneously to improve the performance of float estimation,and the PBF strategy fixes the ambiguities of the one baseline to be estimated,instead of full ambiguity resolution,to reduce the computation load of ambiguity *** tests involving four vehicles were conducted in urban *** results show that the proposed WN-CP method can achieve better performance and meanwhile maintain a low computation load compared to the existing methods.

关键词： GNSS Cooperative positioning Baseline Ambiguity resolution Information coupling

Recent advances in quantifying the inactive lithium and failure mechanism of Li anodes in rechargeable lithium metal batteries

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Journal of Energy Chemistry 2024年第9期96卷 226-248页

作者： Mingming Tao Junning chen Hongxin Lin Yingao Zhou Danhui Zhao Peizhao shan Yanting jin Yong Yang State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Department of ChemistryCollege of Chemistry and Chemical EngineeringTan Kah Kee Innovation Laboratory(IKKEM)Xiamen UniversityXiamen 361005FujianChina School of Engineering Westlake UniversityHangzhou 310024ZhejiangChina School of Energy Research Xiamen UniversityXiamen 361005FujianChina

Lithium metal is considered as the ultimate anode material for the next generation of high-energy density ***,non-uniform lithium dendrite growth,serious electrolyte consumption,and significant volume changes during lithium deposition/stripping processes lead to sustained accumulation of inactive lithium and poor cycling *** the formation and evolution of inactive lithium under different conditions and fully evaluating the complex failure modes are the key issues in this challenging *** article comprehensively reviews recent research progress on the quantification of formation and evolution of inactive lithium detected by different quantitative techniques in rechargeable lithium metal *** key research challenges such as failure mechanism,modification strategies and operando characterization of lithium metal anodes are systematically summarized and *** review provides a new angle of view to understand failure mechanism of lithium metal anodes and inspiration and guidance for the future development of rechargeable lithium metal batteries.

关键词： Lithium metal anodes Inactive lithium Quantitative technique Failure mechanism

Quantum advantages for image filtering on images with efficient encoding and lower-bounded signal-to-noise ratio

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 2-12页

作者： Zidong Cui shan jin Akira Sone Xiaoting Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610051China Key Laboratory of Quantum Physics and Photonic Quantum Information Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Physics University of MassachusettsBoston 02125USA

Quantum image processing has long been a fascinating field,but establishing the existence of quantum speedup for all images remains *** this study,we aim to identify a subset of images for which a quantum algorithm can be developed with a guaranteed ***,we present a quantum image filtering algorithm that exhibits an exponential speedup for efficiently encoded images with a lower-bounded signal-to-noise *** approach relies on a fixed-point Grover's search to emulate the effect of Hadamard multiplication with the filtering *** demonstrate its effectiveness,we apply our method to three typical filtering ***,we emphasize the significance of the efficient-encoding assumption by illustrating that the quantum speedup may diminish for images lacking efficient *** work underscores the importance of exploring image types and features to realize potential quantum advantages in image processing.

关键词： quantum computing quantum image filtering quantum speedup

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu shan jin Yi chen CAI Chang TANG Hou Lin QIN Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

Concurrent hetero-/homo-geneous electrocatalysts to bi-phasically mediate sulfur species for lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第6期93卷 663-668,I0016页

作者： Rui-Bo LingHu jin-Xiu chen jin-Hao Zhang Bo-Quan Li Qing-shan Fu Gulnur Kalimuldina Geng-Zhi Sun Yunhu Han Long Kong Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816JiangsuChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Department of Mechanical and Aerospace Engineering School of Engineering and Digital SciencesNazarbayev UniversityKabanbay Batyr Ave.53Astana 010000Kazakhstan

Expediting redox kinetics of sulfur species on conductive scaffolds with limited charge accessible surface is considered as an imperative approach to realize energy-dense and power-intensive lithium-sulfur(Li-S)*** this work,the concept of concurrent hetero-/homo-geneous electrocatalysts is proposed to simultaneously mediate liquid-solid conversion of lithium polysulfides(LiPSs)and solid lithium disulfide/sulfide(Li_(2)S_(2)/Li_(2)S)propagation,the latter of which suffers from sluggish reduction kinetics due to buried conductive scaffold surface by extensive deposition of Li_(2)S_(2)/Li_(2)*** selected model material to verify this concept is a two-in-one catalyst:carbon nanotube(CNT)scaffold supported iron-cobalt(Fe-Co)alloy nanoparticles and partially carbonized selenium(C-Se)*** Fe-Co alloy serves as a heterogeneous electrocatalyst to seed Li_(2)S_(2)/Li_(2)S through sulphifilic active sites,while the C-Se sustainably releases soluble lithium polyselenides and functions as a homogeneous electrocatalyst to propagate Li_(2)S_(2)/Li_(2)S via solution *** bi-phasic mediation of the sulfur species benefits reduction kinetics of LiPS conversion,especially for the massive Li_(2)S_(2)/Li_(2)S growth scenario by affording an additional solution directed route in case of conductive surface being largely *** strategy endows the Li-S batteries with improved cycling stability(836 mA h g^(-1)after 180 cycles),rate capability(547 mA h g^(-1)at 4 C)and high sulfur loading superiority(2.96 mA h cm^(-2)at 2.4 mg cm^(-2)).This work hopes to enlighten the employment of bi-phasic electrocatalysts to dictate liquid-solid transformation of intermediates for conversion chemistry batteries.

关键词： Lithium-sulfur batteries Electrocatalysis Lithium polysulfides Sulfur cathode Energy density

Hepatic recompensation according to the Baveno VII criteria via a transjugular intrahepatic portosystemic shunt: Is this true?

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2742-2744页

作者： jin-shan Zhang Department of General Surgery Capital Institute of PediatricsBeijing 100020China

Hepatic recompensation is firstly described in the Baveno VII criteria,which requires the fulfillment of strict ***,a primary cause of cirrhosis must be addressed,suppressed,or ***,complications of liver cirrhosis,inclu-ding ascites,encephalopathy,and variceal hemorrhage,must disappear without any ***,liver function indicators must be ***,without addressing/suppressing/curing cirrhosis and improvement in liver syn-thetic function,complications,including ascites and variceal hemorrhage can be improved by a transjugular intrahepatic portosystemic shunt(TIPS),which is not evidence of hepatic ***,on the basis of the definition of hepatic recompensation,TIPS does not achieve hepatic recompensation.

关键词： Hepatic recompensation Transjugular intrahepatic portosystemic shunt Liver function Cirrhosis

The role of m^(6)A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

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Genes & Diseases 2024年第1期11卷 252-267页

作者： Yunan shan Wei chen Yanbin Li The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong 250013China Department of Neurology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qjanfoshan HospitalShandong Institute of NeuroimmunologyShandong Key Laboratory of Rheumatic Disease and Translational MedicineJinanShandong 250013China Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

N6-methyladenosine m^(6)A modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent *** m^(6)A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and *** advances have highlighted that m^(6)A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune *** this re-view,we summarized the regulatory mechanisms of m^(6)A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m^(6)A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immunediseases.

关键词： Adaptive immunity Autoimmune diseases Innate immunity Immune response m^(6)A RNA methylation