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氨甲酰基硅烷与硝酮的反应及产物的互变异构

化学学报 2009年第14期67卷 1709-1711页

作者：陈建新温雪山山西师范大学化学与材料科学学院临汾041004

氨甲酰基硅烷可以与硝酮反应,合成α-(N′-甲基-N′-三甲基硅氧基)氨基-N,N-二甲基苯乙酰胺(5).经研究发现,该产物具有互变异构现象,提出了这一互变异构体的结构,并通过1HNMR谱在不同温度(55～-30℃)下的数据,证实了指定结构的存在:在5... 详细信息

氨甲酰基硅烷可以与硝酮反应,合成α-(N′-甲基-N′-三甲基硅氧基)氨基-N,N-二甲基苯乙酰胺(5).经研究发现,该产物具有互变异构现象,提出了这一互变异构体的结构,并通过1HNMR谱在不同温度(55～-30℃)下的数据,证实了指定结构的存在:在55℃时,呈现结构(5)的形式;而在-30℃时,呈现结构(8)的形式,它们互变的中间体结构则在55～-30℃之间随温度的变化而变化.

关键词：氨甲酰基硅烷硝酮互变异构

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

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Acta Pharmaceutica Sinica B 2023年第8期13卷 1164-1179页

作者： Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu jianxin chen Ying Xie Elaine Lai-Han Leung Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyTaipaMacao 999078China Beijing University of Chinese Medicine Beijing 100029China Cancer Center Faculty of Health Science、MOE Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120China

Sepsis-induced liver injury(SILI)is an important cause of septicemia ***(BWBDS)was extracted from a formula of Panax ginseng ***,Lilium brownie *** ex Miellez *** Baker,Polygonatum sibiricum *** Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)***.,and Cortex ***,we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut *** protected mice against SILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal *** selectively promoted the growth of Lactobacillus johnsonii(***)in cecal ligation and puncture treated *** microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis ***,*** significantly reduced SILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal ***,heat inactivation ***(***)treatment promoted macrophage anti-inflammatory activity and alleviated *** findings revealed BWBDS and gut microbiota *** as novel prebiotic and probiotic that may be used to treat *** potential underlying mechanism was at least in part,via ***-dependent immune regulation and interleukin-10+M2 macrophage production.

关键词： BaWeiBaiDuSan Sepsis-induced liver injury Network pharmacology 16S PacBio SMRT sequencing Lactobacillus johnsonii Macrophages Interleukin-10

Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China(Life Sciences) 2024年第8期67卷 1666-1675页

作者： Zhennan Lin jianxin Li Fangchao Liu Jie Cao Shufeng chen Jichun chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular DiseasesBeijing 100037China Medical School Southern University of Science and TechnologyShenzhen 518055China

Individuals with a high degree of salt sensitivity(SS)have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains *** study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the MetaSalt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt *** untargeted metabolomics,lipidomics,and BP measurements were scheduled at each *** were grouped into extreme SS,moderate SS,and salt-resistant(SR)individuals according to their BP responses to *** mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial *** randomization(MR)analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and *** the 713 metabolites,467 were significantly changed after the high-salt *** them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS *** the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to *** 41 metabolites explained 23%of the variance in ***,SS and its metabolomics signature were positively correlated with arterial *** analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the *** study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster *** study provides insight into understanding the biolog

关键词： salt sensitivity dietary salt intake metabolomics Mendelian randomization cardiovascular disease

Optical second-harmonic generation imaging for identifying gastrointestinal stromal tumors

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 139-146页

作者： Shichao Zhang Xingxin Huang Deyong Kang Jikui Miao Zhenlin Zhan Guoxian Guan jianxin chen Yongjian Zhou Lianhuang Li Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University Fuzhou 350007P.R.China Department of Pathology Fujian Medical University Union Hospital Fuzhou 350001 P.R.China Department of Colorectal Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou 350001 P.R.China Department of Gastric Surgery Fujian Medical University Union Hospital Fuzhou 350001 P.R.China

Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors arising in the digest *** brings a challenge to diagnosis because it is asymptomatic *** is well known that tumor development is often accompanied by the changes in the morphology of collagen ***,an emerging optical imaging technique,second-harmonic generation(SHG),can directly identify collagen fibers without staining due to its noncentrosymmetric ***,in this study,we attempt to assess the feasibility of SHG imaging for detecting GISTs by monitoring the morphological changes of collagen fibers in tumor *** found that collagen alterations occurred obviously in the GISTs by comparing with normal tissues,and furthermore,two morphological features from SHG images were extracted to quantitatively assess the morphological difference of collagen fibers between normal muscular layer and GISTs by means of automated image *** analyses show a significant difference in the two collagen *** study demonstrates the potential of SHG imaging as an adjunctive diagnostic tool for label-free identification of GISTs.

关键词： Multiphoton imaging two-photon excited fluorescence second-harmonic generation gastrointestinal stromal tumors.

Electrochemical CO_(2)reduction to C_(2+)products over Cu/Zn intermetallic catalysts synthesized by electrodeposition

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Frontiers in Energy 2024年第1期18卷 80-88页

作者： Ting DENG Shuaiqiang JIA Shitao HAN jianxin ZHAI Jiapeng JIAO Xiao chen cheng XUE Xueqing XING Wei XIA Haihong WU Mingyuan HE Buxing HAN School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China Institute of Eco-Chongming Shanghai 202162China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Electrocatalytic CO_(2)reduction(ECR)offers an attractive approach to realizing carbon neutrality and producing valuable chemicals and fuels using CO_(2)as the ***,the lack of cost-effective electrocatalysts with better performances has seriously hindered its ***,a one-step co-electrodeposition method was used to introduce Zn,a metal with weak^(*)CO binding energy,into Cu to form Cu/Zn intermetallic catalysts(Cu/Zn IMCs).It was shown that,using an H-cell,the high Faradaic efficiency of C_(2+)hydrocarbons/alcohols()could be achieved in ECR by adjusting the surface metal components and the applied *** suitable conditions,FEC_(2+)and current density could be as high as 75%and 40 mA/cm^(2),*** with the Cu catalyst,the Cu/Zn IMCs have a lower interfacial charge transfer resistance and a larger electrochemically active surface area(ECSA),which accelerate the ***,the^(*)CO formed on Zn sites can move to Cu sites due to its weak binding with*CO,and thus enhance the C–C coupling on the Cu surface to form C_(2+)products.

关键词： carbon dioxide electroreduction electrochemistry co-electrodeposition intermetallic catalysts value-added chemicals

2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway

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Food Science and Human Wellness 2024年第5期13卷 2543-2561页

作者： Shikai Yan Leilei Yu Fengwei Tian jianxin Zhao Wei chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Immune checkpoint blockade(ICB)therapeutics are highly effective in cancer immunotherapy,but gastrointestinal toxicity limited the *** microbiota plays a crucial role in ICB-associated colitis.2’-Fucosyllactose(2’FL)is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory *** study aimed to determine the effects of 2’FL on ICB-associated colitis and to uncover the mediating ***-associated colitis was induced by the ipilimumab and dextran sulfate *** administration of 2’FL(0.6 g/(kg∙day))ameliorated ICB-induced colitis by enhancing regulatory T cells(Treg)and the M2/M1 ratio of macrophages in colon.2’FL treatment also increased the expression of tight junction proteins(zonula occludens-1(ZO-1)and mucin 2(MUC2))and antioxidant stress indicators(superoxide dismutase(SOD)and catalase(CAT)).In addition,administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus,and elevated the levels of microbial metabolites,such as indole-3-lactic acid(ILA),which activated the aryl hydrocarbon receptor ligands(AHR)*** protective effect of 2’FL was abolished upon depletion of gut microbiota,and ILA treatment partially simulated the protective effect of 2’***,2’FL did not exhibit inhibition of antitumor *** findings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.

关键词： 2’-Fucosyllactose Immune checkpoint blockade-associated colitis Gut microbiota Metabolomics Regulatory T cells(Treg)

How neonatal diet affects the long-term development of rumination behavior,rumen fermentation and feed digestion in dairy calves fed a high milk level?

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Animal Nutrition 2024年第1期16卷 326-337页

作者： jianxin Xiao Tianyu chen Rong Peng Gibson M.Alugongo Hui Yang Shuai Liu Yulin Ma Jingjun Wang Shengli Li Zhijun Cao State Key Laboratory of Animal Nutrition and Feeding International Calf and Heifer OrganizationCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of Low Carbon Culture and Safety Production in Cattle in Sichuan Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China

This study was to investigate growth performance,rumination development,rumen fermentation and feed digestion in young calves provided high volumes(about 20%of calf birth weight)of milk with or without forage inclusion and how these parameters correlate with each *** after birth,160 newborn Holstein female calves(41.6±4.2 kg of initial BW)were randomly divided into 2 treatments:1)starter(CON,only starter)and 2)starter and hay(HAY,both starter and hay).The calves were fed their respective experimental diets from d 4 to 84,after which they were all introduced to similar diets until the end of the experiment on d *** had no effect on growth and structural measurements throughout the experimental ***,treatment had an effect on the other parameters,mainly during the post-weaning *** supplementation tended to reduce starter dry matter intake(P=0.05),while increasing the forage intake(P<0.01)and the feed-to-gain ratio(P<0.01).HAY calves had increased neutral detergent fiber(NDF)and physically effective NDF(peNDF)intakes(P<0.05)and tended to lower(P<0.01)starch intake compared to CON *** HAY calves had a higher rumination time(P<0.01),ruminal pH(P<0.01),and acetate-to-propionate ratio(P=0.05)compared to the CON *** correlation analysis showed that rumination time was positively related to the ruminal p H at d 84(P=0.01)and 196(P=0.02).The HAY calves had similar apparent total-tract digestibility of dry matter(DM),NDF and ether extract(EE),but lower digestibility of organic matter(OM,P=0.03),crude protein(CP,P<0.01)and starch(P<0.01)compared to those of the CON calves at week ***,there were no positive relationships between rumination time and nutrient digestibility or between rumination time per kilogram DM and nutrient *** conclusion,feeding hay to calves fed a high milk level improved rumination during the post-weaning period only,without a concomitant effect on growth performance thro

关键词： Neonatal calf Early forage feeding Rumination Rumen fermentation Nutrient digestibility

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Demonstration of LDPC-coded PS-64QAM OFDM employing novel bit-class distribution matching in a W-band RoF system

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Chinese Optics Letters 2024年第8期22卷 35-40页

作者： Haitao Zhao Bangning Xu Wei Xun jianxin Ren Shuaidong chen Long Zhang Li Zhao Bo Liu School of Communication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China Institute of Optics and Electronics Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory for Information Science of Electromagnetic Waves Fudan UniversityShanghai 200433China

In this work,we proposed and experimentally demonstrated a novel probabilistic shaping(PS)64-ary quadrature amplitude modulation(QAM)orthogonal frequency division multiplexing(OFDM)with low-density parity-check(LDPC)-coded modulation in a W-band radio-over-fiber(RoF)system using envelope *** proposed PS scheme has the advantages of no complex multiplication and division operations and low hardware implementation *** our experiments,the two-stage bit weight distribution matching-based PS-64QAM OFDM signals with a rate of 28.13 Gb/s transmission over 4 m wireless+45-km standard single-mode fiber transmission can be *** system performance is investigated under one LDPC code rate(3/4)and two PS parameter values(k=3 and 9).The experimental results show that the receiver power sensitivity and the system fiber nonlinear effect tolerance can be significantly improved compared with uniformly distributed OFDM signals.

关键词： probabilistic shaping two-stage bit weight distribution matching orthogonal frequency division multiplexing W-band radio-over-fiber system

Large-area superconducting nanowires fabricated based on laser exposure on photoresist

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Nano Research 2024年第9期17卷 8220-8225页

作者： Han Zhou Shangqing Li Yicong Huang Wenqian Liu Haohui Zhang Yao Wu Wenzhi Zhang Enhua chen Chaoyun Zhang Xiaoliang Wang Daqian Liu jianxin Lin Qingdao Innovation and Development Center of Harbin Engineering University Qingdao 266000China College of Intelligent systems and Engineering Harbin Engineering UniversityHarbin 150000China

To realize large-scale micro/nanofabrication process in superconducting devices,the nano laser direct writing(NLDW)as a potential tool was *** this paper,thermal effect induced laser-matter(superconducting film)interaction based on laser direct writing on Nb films and laser exposure on photoresist were investigated by simulation and *** avoid nanoscale thermal effect on superconducting films,large-scale superconducting nanoarrays with the area up to 100μm×100μm based on laser exposure on photoresist were *** with laser direct writing on superconducting films,which lead to the degradation of superconducting performance such as critical current,transition temperature,the superconducting nanoarrays based on laser exposure on photoresist maintain excellent superconducting performance without *** that,by further optimizing the process parameters and the thickness of photoresist,the nanowires with the width down to nanometers are *** with the traditional electron beam and ion beam process,to some extent,the nanowires fabrication process based on NLDW provides a more efficient and cost-effective path for the fabrication of large-area superconducting devices/circuits.

关键词： nano laser direct writing(NLDW) superconducting nanowire arrays superconducting devices light-matter interaction