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Combination of Astragalus membranaceus and Euonymus alatus (THUNB.) SIEB. for treatment of diabetes: A network-based pharmacology research

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Journal of Traditional Chinese Medical Sciences 2016年第3期3卷 184-191页

作者： Kun chen Dong Deng Youliang Huang Xiaoyun Ma Xueli Li Wenting Zhang Zhiyong Li Yang Liu Wei Wang jianxin chen HuiHui Zhao Beijing University of Chinese Medicine Beijing 100029China Minzu University of China Beijing 100081China

Objective:To find the target genes in combination of astragalus root(Astragalus membranaceus)and spindle tree wings(Euonymus alatus(THUNB.)SIEB.)(Qijian Heji)with the function of regulating blood glucose levels in kk mice by real-time fluorescence quantitative PCR(RT-PCR).To achieve the primary exploration on the material basis for Qijian Heji to improve the blood glucose levels of type 2 diabetic kk ***:We applied RT-PCR to detecting the expression of gene targets in kidney tissues of type 2 diabetes model kk *** detected gene targets were predicted by the network pharmacology method in the early stage of the *** the observation of the hypoglycemic effect of different ratios of Qijian Heji,the optimal proportion was determined and then used to conduct research of material ***:Continuous administration of Qijian Heji(astragalus root:spindle tree wings Z 3:1)for six weeks resulted in significantly lowering blood glucose levels in mice in the fourth week,dropping from 33.3 to 21.9 mmol/L;this lower level was maintained in the fifth to sixth *** glucose values in the positive drug group decreased from 33.3 to 21.85 mmol/L in the fourth week and maintained steady decreasing in the fifth and sixth ***:Qijian Heji,with proportion of 3:1,could significantly reduce the blood glucose values in kk mice,animal experiment results verified the accurate prediction of network pharmacology,and at the same time,it is verified there was a certain therapeutic effect about the combination of the two herbs on reducing the glucose *** experiments and RT-PCR results showed that Qijian Heji conducted a hypoglycemic effect by modulating estrogen receptor(ESR1)and renin(REN)expression.

关键词： Astragalus Euonymus alatus Diabetes ESR1 REN

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Bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin chen Renqiang Yu R.Paul Ross Catherine Stanton Shilong Jiang jianxin Zhao Wei chen State Key Laboratory of Food Science and Resources， Jiangnan University Teagasc Food Research Centre Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. Department of Neonatology， Wuxi Maternity and Child Health Care Hospital， Affiliated Women's Hospital of Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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多光子显微技术在医学诊断中的应用

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中国激光 2018年第2期45卷 180-190页

作者：林宏心左宁卓双木陈建新福建师范大学医学光电科学与技术教育部重点实验室福建省光子技术重点实验室福建福州350007

多光子显微(MPM)技术通过探测由飞秒激光与生物组织内在成分相互作用而产生的双光子激发荧光和二次谐波等光信号,可实现对组织的无损、非标记成像。MPM具有对组织微结构灵敏度度和可实现高空间分辨成像、对生物组织杀伤性低和成像深度... 详细信息

多光子显微(MPM)技术通过探测由飞秒激光与生物组织内在成分相互作用而产生的双光子激发荧光和二次谐波等光信号,可实现对组织的无损、非标记成像。MPM具有对组织微结构灵敏度度和可实现高空间分辨成像、对生物组织杀伤性低和成像深度深、能够获取组织的生化信息等优点,在疾病诊断中具有很大的应用潜力。简要介绍MPM的基本原理,总结其在消化道肿瘤、皮肤疾病,以及角膜疾病诊断中的应用,并对MPM的发展前景进行展望。

关键词：医用光学生物光学多光子显微技术疾病诊断

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氨甲酰基硅烷作为氨酰基源合成α-磺酰氨基酰胺衍生物

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有机化学 2018年第8期38卷 1993-2001页

作者：韩宇玲仝文婷刘慧陈建新山西师范大学化学与材料科学学院临汾041004

氨甲酰基硅烷与N-磺酰亚胺在无催化剂苯作溶剂的条件下反应,直接合成了磺酰基保护的α-氨基酰胺衍生物,收率为71%~89%.该方法不仅可合成α-氨基叔酰胺,还可合成α-氨基仲酰胺.通过研究反应的影响因素发现,N-磺酰亚胺双键相连基团旳电子... 详细信息

氨甲酰基硅烷与N-磺酰亚胺在无催化剂苯作溶剂的条件下反应,直接合成了磺酰基保护的α-氨基酰胺衍生物,收率为71%~89%.该方法不仅可合成α-氨基叔酰胺,还可合成α-氨基仲酰胺.通过研究反应的影响因素发现,N-磺酰亚胺双键相连基团旳电子效应是影响反应的重要因素,它既影响反应完成的时间,又影响产物的产率.该反应具有条件温和、副产物少、产率高和后处理简单等优点,是有效合成α-氨基酰胺的新方法.

关键词：氨甲酰基硅烷 α-氨基酰胺 N-磺酰亚胺亲核加成合成方法

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异构蜂窝网络中分层任务卸载:建模与优化

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通信学报 2020年第4期41卷 34-44页

作者：赵临东庄文芹陈建新周亮南京邮电大学通信与网络技术国家工程研究中心江苏南京210003 南京邮电大学宽带无线通信与传感网技术教育部重点实验室江苏南京210003

为提高计算任务卸载的效率,提出了一种基于D2D通信、移动边缘计算和云计算的分层任务卸载框架,并引入D2D协作中继技术辅助用户接入远端计算资源。针对所提任务卸载框架在多用户场景中可能存在上行通信拥塞、边缘计算资源受限、D2D复用... 详细信息

为提高计算任务卸载的效率,提出了一种基于D2D通信、移动边缘计算和云计算的分层任务卸载框架,并引入D2D协作中继技术辅助用户接入远端计算资源。针对所提任务卸载框架在多用户场景中可能存在上行通信拥塞、边缘计算资源受限、D2D复用干扰和云计算回程时延等问题,设计了一种基于博弈论的卸载调度和负载均衡方案,充分利用了所提任务卸载框架中各层计算和通信资源。仿真结果表明,所提方案能够有效降低端到端时延和卸载能耗,并在资源受限的条件下具有良好的稳定性。

关键词：分层任务卸载移动边缘计算 D2D通信云计算博弈论

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Strain-specific effect of Streptococcus thermophilus consumption on host physiology

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Food Science and Human Wellness 2024年第5期13卷 2876-2888页

作者： Peng Yu Yang Jiang Yuqi Pan Min Guo Bo Yang Xiaoming Liu jianxin Zhao Hao Zhang Wei chen State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Pharmabiotics&Antibiotic Resistance Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China National Engineering Research Centre for Functional Food Wuxi 214122China

Streptococcus thermophilus is one of the most prevalent species in stool samples of westernized populations due to continuous exposure to fermented dairy ***,few studies have explored the effect on host physiology by multiple *** strains and considered the inter-strain differences in regulating *** the present study,we investigated how four *** strains influenced the gut microbiota,mucin changes,and host metabolism after 28 days of intervention in conventional *** results indicated that the consumption of *** affected the host with strain *** four *** strains,DYNDL13-4 and DQHXNQ38M61,especially DQHXNQ38M61,had more effect on host physiology by modulating gut microbiota and host metabolism than LMD9 and *** of strains DYNDL13-4 and DQHXNQ38M61 resulted in more remarkable changes in amino acid metabolism and lipid metabolism than that of strains LMD9 and 4M6,which may be related to the elevation of intestinal Bifidobacterium by DYNDL13-4 and *** enriched Coriobacteriaceae UCG-002,Rikenellaceae RC9 gut group,and Lactobacillus only in the DQHXNQ38M61 group,had a close relationship with the prominent effect of DQHXNQ38M61 on regulating amino acid and lipid *** addition,DQHXNQ38M61 had a strong influence on degrading colonic mucin fucose by decreasedα-fucosidase activity in feces,and improving mucin sulfation by upregulated Gal3ST2 *** genomic analysis revealed that the four *** strains belonged to different branches in the phylogenetic tree,and DYNDL13-4 and DQHXNQ38M61 had more genes involved in carbohydrate metabolism,amino acid metabolism,membrane transport,and signal transduction,which may confer the capacity of nutrient utilization and gastrointestinal adaptation of the strains and be associated with their strong regulation in *** study provides valuable information for understanding the regulation of host metabolism aft

关键词： Streptococcus thermophilus Intestinal microbiota Metabolome Comparative genomics

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氨甲酰基硅烷作氨酰基源与邻位二酮选择性氨酰化反应合成α-羟基-β-羰基仲(伯)酰胺衍生物

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有机化学 2020年第6期40卷 1737-1744页

作者：张鹏鹏韩生华陈建新山西师范大学化学与材料科学学院临汾041004 山西大同大学化学与工程学院大同037009

几种氨甲酰基硅烷与邻位二酮在无催化剂和氧化剂的温和条件下直接发生选择性氨酰化反应,制备了α-硅氧基-β-羰基仲(伯)酰胺衍生物,收率为62%~90%.氨甲酰基硅烷和邻位二酮的结构的空间位阻都影响在两个羰基上的反应选择性.氨基保护基甲... 详细信息

几种氨甲酰基硅烷与邻位二酮在无催化剂和氧化剂的温和条件下直接发生选择性氨酰化反应,制备了α-硅氧基-β-羰基仲(伯)酰胺衍生物,收率为62%~90%.氨甲酰基硅烷和邻位二酮的结构的空间位阻都影响在两个羰基上的反应选择性.氨基保护基甲氧甲基和苄基容易脱保护基转化成氢原子,得到α-羟基-β-羰基仲(伯)酰胺衍生物.通过选择不同氨甲酰基硅烷进行反应发现,此方法是选择性合成α-羟基-β-羰基叔酰胺、仲酰胺和伯酰胺衍生物的简易方法.该反应具有条件温和、副产物少、选择性強、产物得率高和后处理简单等优点,是有效合成α-羟基-β-羰基酰胺衍生物的新方法.

关键词：氨甲酰基硅烷 β-羰基-α-羟基酰胺氨酰化亲核加成邻位二酮

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Rational protein engineering of thermostable heparinase I from Bacteroides thetaiotaomicron for highly efficient heparin degradation

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Food Science and Human Wellness 2024年

作者： Chuan Zhang Ruohan Zhao Leilei Yu Qixiao Zhai jianxin Zhao Hao Zhang Xuegang Luo Fengwei Tian Wei chen State Key Laboratory of Food Science and Technology， Jiangnan University School of Food Science and Technology， Jiangnan University Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education & Tianjin Key Lab of Industrial Microbiology， College of Biotechnology， Tianjin University of Science and Technology National Engineering Research Center for Functional Food， Jiangnan University

Heparin， a glycosaminoglycan， is a stable source of carbon that supports the growth of microorganisms in the human intestine. It is also a commonly used anticoagulant drug in clinical practice， with significant therapeutic effects. Low molecular weight heparin （LMWH） is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin. LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients. Simultaneously， as a potential prebiotic， because of its low molecular weight， LMWH can be well degraded by the gut microbiota to maintain intestinal balance. Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation; however， only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years. The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes. Herein， we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening. Several Bt-HepI mutants were obtained and screened for high thermal stability. We obtained the Bt-HepID204C/K208C/H189W/Q198Rvariant， which features a stabilized protein surface structure， with a 1.3-fold increase in kcat/Km， a 2.44-fold increase in thermal stability at 50℃， and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃ compared with that seen with Bt-HepIWT. Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.

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CHARACTERS OF HYDROCORTISONE CRYSTALLIZED FROM METHANOL SOLVENT

CHARACTERS OF HYDROCORTISONE CRYSTALLIZED FROM METHANOL SOLV...

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第一届全国化学工程与生物化工年会

作者： chen jianxin WANG Jiangkang (School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China)

＜正＞ Hydrocortisone（HC）,an important grucocorticoid,it is not only one of the mosteffective antiphlogistic and immune-suppressive substance with instant effect,but it alsoshows with low-dosage long-term treatment,clear antiproliferative effects on the cartilage andbone destroying pannus in rheumatoid *** was crystallized from methanol solventand the single crystal of parallelepiped morphology was *** properties including

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Bifidobacterium adolescentis CCFM8630 Exerts Anti-Obesity Effects by Modulating Gut Microbiota-Related Tryptophan Metabolism

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Food Science and Human Wellness 2024年

作者： Bo Zhang Linlin Wang Peijun Tian Xing Jin Ming Liang Zehua chen jianxin Zhao Hao Zhang Gang Wang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University Infinitus (China) Company Ltd. Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch

Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases， such as cancer and cardiovascular diseases. Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota. In this study， we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat-diet (HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress. Furthermore， B. adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria， and thereby decreased the production of lipopolysaccharide (LPS) and the occurrence of LPS-related diseases. A high fiber intake increased the abundance of Lactobacillus and the concentrations of short-chain fatty acids in obese mice， but these changes were reversed by B. adolescentis CCFM8630 treatment. In addition， targeted metabolomic analysis and microbiota relationship analysis revealed that B. adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan (Trp) to xanthurenic acid， kynurenic acid， tryptamine， indole-3-acetic acid， and indole-3-carboxaldehyde; facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon; and upregulated the expression of tight junction proteins， thereby strengthening intestinal barriers. In summary， our findings suggest that the intake of B. adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.

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