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Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： di jin Xiao-Qi Kong Ya-Juan Zhu Zong-Xin chen Xi-Ming Wang Cai-Hua Xu jin-Xian Pu jian-Quan Hou Yu-Hua Huang Fu-Hai ji chen Huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

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Botulinum toxin type A-targeted SPP1 contributes to neuropathic pain by the activation of microglia pyroptosis

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World Journal of Psychiatry 2024年第8期14卷 1254-1266页

作者： Li-Ping chen Xiao-die Gui Wen-di Tian Hou-Ming Kan jin-Zhao Huang Fu-Hai ji Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Pain Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Neuropathic pain(NP)is the primary symptom of various neurological *** with NP often experience mood disorders,particularly depression and anxiety,that can severely affect their normal *** cells are as-sociated with *** inflammatory responses,especially the secretion of large amounts of pro-inflammatory cytokines,ultimately lead to *** pyroptosis is a newly discovered form of inflammatory cell death associated with immune responses and inflammation-related diseases of the central nervous *** Two models,an in vitro lipopolysaccharide(LPS)-stimulated microglial cell model and a selective nerve injury model using BTX-A and SPP1 knockdown treatments,were *** proteins in the pyroptosis signaling pathway,NLRP3-GSDMD,were assessed using western blotting,real-time quantitative polymerase chain reaction,and *** factors[interleukin(IL)-6,IL-1β,and tumor necrosis factor(TNF)-α]were assessed using enzyme-linked immuno-sorbent *** also evaluated microglial cell proliferation and ***,we measured pain sensation by assessing the delayed hind paw withdrawal latency using thermal *** The expression levels of ACS and GSDMD-N and the mRNA expression of TNF-α,IL-6,and IL-1βwere enhanced in LPS-treated ***,SPP1 expression was also induced in LPS-treated ***,BTX-A inhibited SPP1 mRNA and protein expression in the LPS-treated ***,depletion of SPP1 or BTX-A inhibited cell viability and induced apoptosis in LPS-treated microglia,whereas co-treatment with BTX-A enhanced the effect of SPP1 short hairpin(sh)RNA in LPS-treated ***,SPP1 depletion or BTX-A treatment reduced the levels of GSDMD-N,NLPRP3,and ASC and suppressed the production of inflammatory *** Notably,BTX-A therapy and SPP1 shRNA enhance microglial proliferation and apoptosis and inhibit microglia

关键词： Botulinum toxin A SPP1 Microglia Pyroptosis Neuropathic pain

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A Shared Natural Neighbors Based-Hierarchical Clustering Algorithm for discovering Arbitrary-Shaped Clusters

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Computers, Materials & Continua 2024年第8期80卷 2031-2048页

作者： Zhongshang chen ji Feng Fapeng Cai Degang Yang College of Computer and Information Science Chongqing Normal UniversityChongqing400030China

In clustering algorithms,the selection of neighbors significantly affects the quality of the final clustering *** various neighbor relationships exist,such as K-nearest neighbors,natural neighbors,and shared neighbors,most neighbor relationships can only handle single structural relationships,and the identification accuracy is low for datasets with multiple *** life,people’s first instinct for complex things is to divide them into multiple parts to *** the dataset into more sub-graphs is a good idea approach to identifying complex *** inspiration from this,we propose a novel neighbor method:Shared Natural Neighbors(SNaN).To demonstrate the superiority of this neighbor method,we propose a shared natural neighbors-based hierarchical clustering algorithm for discovering arbitrary-shaped clusters(HC-SNaN).Our algorithm excels in identifying both spherical clusters and manifold *** on synthetic datasets and real-world datasets,HC-SNaN demonstrates significant advantages over existing clustering algorithms,particularly when dealing with datasets containing arbitrary shapes.

关键词： Cluster analysis shared natural neighbor hierarchical clustering

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Shaking table test study on performance and functionality of a typical telecommunication room after earthquakes

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 455-474页

作者： Li Bo Guo Endong Sun Guoliang ji Shuqiang Mao chenxi Wang Tao Han di Li Xiaofei Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake disaster Mitigation Ministry of Emergency ManagementHarbin 150080China China Academy of Information and Communications Technology Beijing 100191China School of Architecture Engineering Binzhou UniversityBinzhou 256600China

Large numbers of basic transceiver stations,where the telecommunication room is one of the main components,comprise an important part of the telecommunication *** earthquakes,considerable economic loss from telecommunication systems is often associated with seismic damage and functional loss of the telecommunication ***,research related to this has been *** this study,shaking table tests were conducted for a full-scale typical telecommunication room,including a light-steel house and the necessary communication and power supply *** tests not only focused on the seismic damage to all the structures but also considered the functions of the communication and power supply of the *** interactions between these facilities and their effects on communication function were also *** with the damage to structures,the interruption of the power supply due to earthquakes is a weak ***,the damage indexes,together with their threshold values of different damage states for the communication and power supply equipment,were derived from the test *** results of this research can contribute to the literature gaps regarding seismic performance studies of telecommunication rooms,and can serve as a valuable reference for future research on its seismic fragility and economic losses evaluation.

关键词： telecommunication light-steel house communication equipment power supply equipment seismic performance functionality

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Metal-to-insulator transition in platinum group compounds

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Rare Metals 2024年第8期43卷 3460-3474页

作者： Yu-Xuan Xia jian-Gang He Nuo-Fu chen ji-Kun chen School of New Energy North China Electric Power UniversityBeijing102206China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for PostMoore Chips(Ministry of Education) School of Materials Science and EngineeringJniversity of Science and Technology BeijingBeijing 100083China

The metal-to-insulator transition(MIT) as usually achieved in 3d-orbital transitional metal(TM) compounds opens up a new paradigm in correlated electronics via triggering abrupt variations in their transportation *** to such 3d-orbital TM compounds,the MIT within the platinum group(Pg) element compounds based on the 4d-and 5d-orbital configurations is more complicated,owing to their elevation in the spinorbit coupling and meanwhile weakened intra-atomic Coulomb *** brings in a new freedom to regulate the balance in their metallic or semiconductive orbital configurations,while their MIT properties can be potentially combined with their spintronic properties to enable new electronic ***,we review the electronic transport and MIT behaviors within the existing family of Pg-containing compounds,particularly those showing first-order MIT behaviors that can be useful in correlated *** is also hoped that summarizing the presently reported Pg-containing MIT compounds will lead to the discovery of more new material families and/or new mechanisms associated with the Pg-containing compounds showing MIT properties.

关键词： Metal-to-insulator transition Platinum group compounds Electron correlation Spin-orbital coupling

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A novel domain decomposition-based model for efficient dynamic predictions of large composite machine tools

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Science China(Technological Sciences) 2024年第6期67卷 1765-1782页

作者： YU YangBo ji Yu Lei chen YanRen XU Kun BI QingZhen State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

We propose a large combined moving component composed of carbon fiber reinforced polymer(CFRP)laminates for making lightweight machine tools with high dynamic *** accurate dynamic prediction of composite machine tools is essential for the new generation machine *** paper aims to address two challenges in numerical dynamic modeling and the design of composite machine tools to enhance development efficiency.(1)Anisotropic composite laminates,which form the composite machine tool,exhibit coupling in various *** propose the generalized continuity condition of the boundary to tackle this dynamic modeling challenge.(2)Composite machine tools feature numerous composite-metal coupled *** mechanical model correction of isotropic metals is performed to address their *** take the example of a five-axis gantry machine tool with composite moving parts,establish a dynamic model for efficient prediction,and verify it through simulation and *** proposed method yields remarkable results,with an average relative error of only 3.85%in modal frequency prediction and a staggering 99.7%reduction in solution time compared to finite element *** further discuss the dynamic performance of the machine tool under varied stacking angles and layer numbers of the composite machine *** propose general design criteria for composite machine tools to consider the modal frequency and manufacturing cost of machine tools.

关键词： machine tool dynamics carbon fiber reinforced polymer composite laminates

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Intermetallic Compounds Formation in dissimilar Friction Stir Welding of Mg/Cu Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1523-1532页

作者： Xue Li Qingzhen Zhao Hao Su ji chen Chuansong Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan250061China

Joining dissimilar Mg/Cu alloys was still an intractable problem because of the excessive intermetallic compounds(IMCs)and poor mechanical properties using conventional welding *** the present study,friction stir welding was employed for the butt joining of dissimilar AZ31B Mg-alloy and T2 pure Cu ***-free Mg/Cu joints were obtained with Mg-RS and Cu-AS configuration,at a welding speed of 50 mm/min and tool rotating speeds of 325 r/min,625 r/min and 925 r/*** the joining interface,both Mg_(2)Cu and MgCu_(2) IMC phases were observed,with a clear,uniform and continuous IMCs layer composed of two sub-layers,layer-A of Mg+Mg_(2)Cu and layer-B of Mg_(2)Cu+MgCu_(2).The maximum ultimate tensile strength of the Mg/Cu friction stir welding joint reached 130 MPa at 925 r/min due to enhanced mechanical interlocking between Mg and Cu,as well as sufficient metallurgical bonding at the joining interface with an IMCs layer thickness in the range of 1.0-2.0μm.

关键词： Friction stir welding Magnesium Copper Intermetallic compounds Mechanical properties

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Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt_(1)/Ni and Pt_(1)/Co single-atom alloy catalysts

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Rare Metals 2024年第6期43卷 2859-2868页

作者： Huan-Shi Lan Yi-Da Yang Qing-di Sun Hao Zhang Ying Zhang Qian He Ran chen Guo-Yi Bai Xiao-Hui He Hong-Bing ji School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education Fine Chemical Industry Research InstituteSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou510275China UBFC CNRSENSMMFEMTO-ST Institute25030 Besancon CEDEXFrance College of Chemistry and Materials Science Hebei UniversityBaoding 071002China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Selective hydrogenation of C=C and C=O bonds in cinnamaldehyde(CAL)to produce desired products is a challenging task due to the complex conjugate system of the two unsaturated functional *** this study,a simple ball milling method is presented for synthesizing Pt-based single-atom alloy catalysts(SAAs)that can function as a control switch for the selective hydrogenation of CAL into highly valuable products.

关键词： alloy hydrogenation conjugate

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Mass transfer enhancement and hydrodynamic performance with wire mesh coupling solid particles in bubble column reactor

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Chinese Journal of Chemical Engineering 2024年第3期67卷 195-205页

作者： Chuanjun di jipeng Dong Fei Gao Guanghui chen Pan Zhang jianlong Li Key Laboratory of Multiphase Flow Reaction and Separation Engineering of Shandong Province College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266043China

It is of vital significance to investigate mass transfer enhancements for chemical engineering *** work focuses on investigating the coupling influence of embedding wire mesh and adding solid particles on bubble motion and gas-liquid mass transfer process in a bubble *** image velocimetry(PIV)technology was employed to analyze the flow field and bubble motion behavior,and dynamic oxygen absorption technology was used to measure the gas-liquid volumetric mass transfer coefficient(kLa).The effect of embedding wire mesh,adding solid particles,and wire mesh coupling solid particles on the flow characteristic and kLa were analyzed and *** results show that the gas-liquid interface area increases by 33%-72%when using the wire mesh coupling solid particles strategy compared to the gas-liquid two-phase flow,which is superior to the other two strengthening *** with the system without reinforcement,kLa in the bubble column increased by 0.5-1.8 times with wire mesh coupling solid particles method,which is higher than the sum of kLa increases with inserting wire mesh and adding particles,and the coupling reinforcement mechanism for affecting gas-liquid mass transfer process was discussed to provide a new idea for enhancing gas-liquid mass transfer.

关键词： Fluid mechanics Bubble Mass transfer Wire mesh coupling solid particles Particle image velocimetry Hydrodynamics

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A Temporary Frequency Response Strategy Using a Voltage Source-Based PermanentMagnet Synchronous Generator and Energy Storage Systems

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Energy Engineering 2024年第2期121卷 541-555页

作者： Baogang chen Fenglin Miao jing Yang chen Qi Wenyan ji CSIC HaiZhuangWindpower Co. Ltd.Chongqing400000China State Key Laboratory of Operation and Control of Renewable Energy&Storage Systems China Electric Power Research InstituteBeijing100000China

Energy storage systems(ESS)and permanent magnet synchronous generators(PMSG)are speculated to be able to exhibit frequency regulation capabilities by adding differential and proportional control loops with different control *** available PMSG kinetic energy and charging/discharging capacities of the ESS were *** improve the inertia response and frequency control capability,we propose a short-term frequency support strategy for the ESS and *** this end,the weights were embedded in the control loops to adjust the participation of the differential and proportional controls based on the system frequency *** effectiveness of the proposed control strategy was verified using PSCAD/*** simulations revealed that the proposed strategy could improve the maximum rate of change of the frequency nadir and maximum frequency ***,it provides a promising solution of ancillary services for frequency regulation of PMSG and ESS.

关键词： Inertial control PMSG ESS wind power generation frequency support

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