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Regulations of m6A and other RNA modifications and their roles in cancer

FRONTIERS OF MEDICINE 2024年第4期18卷 622-648页

作者： chen, xin-hui Guo, Kun-Xiong Li, Jing Xu, Shu-hui Zhu, huifang Yan, Guang-Rong Guangzhou Med Univ Biomed Res Ctr Guangdong Prov Clin Res Ctr Obstet & Gynecol Guangdong Prov Key Lab Major Obstet DisState Key Guangzhou 510150 Peoples R China

RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA modifications have been identified to date; they include N-6-methyladenosine (m(6)A), N-1-methyladenosine (m(1)A), 5-methylcytosine (m(5)C), N-7-methylguanosine (m(7)G), N-6,2 '-O-dimethyladenosine (m(6)A(m)), N-4-acetylcytidine (ac(4)C), etc. RNA modifications, mediated by regulators including writers, erasers, and readers, are associated with carcinogenesis, tumor microenvironment, metabolic reprogramming, immunosuppression, immunotherapy, chemotherapy, etc. A novel perspective indicates that regulatory subunits and post-translational modifications (PTMs) are involved in the regulation of writer, eraser, and reader functions in mediating RNA modifications, tumorigenesis, and anticancer therapy. In this review, we summarize the advances made in the knowledge of different RNA modifications (especially m(6)A) and focus on RNA modification regulators with functions modulated by a series of factors in cancer, including regulatory subunits (proteins, noncoding RNA or peptides encoded by long noncoding RNA) and PTMs (acetylation, SUMOylation, lactylation, phosphorylation, etc.). We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer progression. Additionally, inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer MESSENGER-RNA RIBOSOMAL-RNA BINDING-PROTEIN NUCLEAR-RNA ONCOGENIC TRANSFORMATION THERAPEUTIC IMPLICATIONS FTO METHYLATION METHYLTRANSFERASE TRANSLATION

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水稻TFⅡB相关因子OsBRF1的功能探析

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农业生物技术学报 2024年第8期32卷 1729-1741页

作者：陈歆惠陈广娜宁鹤陈家洛王思怡朱诚杨素中国计量大学生命科学学院/浙江省特色农产品品质及危害物控制技术重点实验室

在大多数真核细胞中，TFⅡB (transcription factorⅡB)是DNA转录合成RNA过程中RNA聚合酶Ⅱ的通用转录因子。TFⅡB相关因子(TFⅡB-related factor 1, BRF1)是RNA聚合酶Ⅲ的通用转录因子，负责合成tRNA和5S rRNA。拟南芥(Arabidopsis thaliana)中AtBRF1和AtBRF2以功能冗余的方式参与生殖生长。作为重要粮食作物及单子叶模式植物，水稻(Oryza sativa)中BRF1基因的功能尚未见报道。本研究构建了OsBRF1基因启动子驱动的β-葡萄糖苷酸酶(β-glucuronidase, GUS)表达载体，GUS染色结果显示，OsBRF1在根、叶、叶鞘、柱头、成熟根、成熟叶、圆锥花序、花粉、胚乳和花药中均有较高表达，在颖壳中不表达。将OsBRF1与GFP的融合表达载体经根癌农杆菌(Agrobacterium tumefaciens)介导转入本氏烟草(Nicotiana benthamiana)叶片，发现OsBRF1蛋白主要定位于细胞核。利用CRISPR/Cas9基因编辑手段无法获得纯合移码突变植株，表明OsBRF1基因纯合致死；进一步利用RNAi植株进行表型观察，发现OsBRF1的RNAi植株花粉活性和结实率显著下降(P<0.05)，表明该基因可能通过调控花粉活性而影响水稻结实率。酵母双杂交和双分子荧光互补结果显示，OsBRF1与OsTBP1～3 (TBP:TATA结合蛋白,TATA-binding protein)存在蛋白互作，表明其可能仍然作为通用转录因子行使重要功能。本研究为深入探究OsBRF1基因功能及调控机制提供基础资料。

关键词：水稻 TFⅡB(transcription factorⅡB)家族表达分析功能分析蛋白互作

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基于ANSYS的储氢气瓶快充温升流热固耦合模拟研究

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真空 2024年第3期61卷 26-32页

作者：杨刚欧晨希陈新辉黄思广东省特种设备检测研究院广东佛山528000 华南理工大学机械与汽车工程学院广东广州510641

以某款车用碳纤维全缠绕储氢气瓶为研究对象,基于ANSYS Workbench平台,充分考虑气瓶不同结构层的差异性和温度载荷分布不均匀性,进行了流热固耦合模拟计算分析。首先对气瓶快速充装过程内部气体流场进行三维数值模拟研究其温升规律,然... 详细信息

以某款车用碳纤维全缠绕储氢气瓶为研究对象,基于ANSYS Workbench平台,充分考虑气瓶不同结构层的差异性和温度载荷分布不均匀性,进行了流热固耦合模拟计算分析。首先对气瓶快速充装过程内部气体流场进行三维数值模拟研究其温升规律,然后将流场计算结果加载到气瓶结构层进行稳态热分析,最后将流场及热分析结果均加载到气瓶结构层进行结构静力学分析。结果表明:当充装结束时,气瓶最高温度及碳纤维复合层受到的最大应力均出现在瓶尾封头和筒体的连接处;相较于内压引起的机械应力,温度载荷引起的热应力很小;机械应力与耦合应力数值相差不大,碳纤维复合层的机械应力略小于耦合应力,而铝合金内胆层由于膨胀系数大,温度载荷引起的压缩热应力抵消了一部分机械应力,使得耦合应力小于机械应力。

关键词：碳纤维全缠绕储氢气瓶快充温升流热固耦合

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山区“铁路工程-水土流失”系统关键要素识别

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长江科学院院报 2024年第8期41卷 38-46,72页

作者：鲍学英张程皓贺振霞李亚娟沈杜华陈慧鑫兰州交通大学土木工程学院兰州730070

建立了一种识别山区铁路工程水土流失关键要素的模型。首先确定易引发水土流失的铁路重点专业,分析“铁路工程-水土流失”的交互影响关系,识别“铁路工程-水土流失”要素,并构建其指标体系。然后基于复杂网络模型,结合熵权法、层次分析... 详细信息

建立了一种识别山区铁路工程水土流失关键要素的模型。首先确定易引发水土流失的铁路重点专业,分析“铁路工程-水土流失”的交互影响关系,识别“铁路工程-水土流失”要素,并构建其指标体系。然后基于复杂网络模型,结合熵权法、层次分析法(IGAHP)法、DWNodeRank算法构建一种多层网络关键要素识别模型。最后以山区某铁路工程为例,该山区铁路工程关键要素有弃渣处置、路基边坡防护、路基截排水沟布设等,水土保持性能关键要素有大型临时土地扰动、渣土弃置等,水土流失关键要素有水文、地表植被、流失物质。在山区铁路工程水土流失控制时需重点针对以上关键要素进行水土保持措施和工程结构的设计,以期有效地控制区域水土流失,改善和恢复破坏的生态环境。

关键词：铁路工程水土流失复杂网络关键要素指标体系

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压制压力对纳米Ti(C,N)基金属陶瓷微观组织和力学性能的影响研究

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稀有金属与硬质合金 2024年第1期52卷 51-56,62页

作者：贺逢源张文科熊萧陈鑫辉熊健松董定乾李辉四川轻化工大学机械工程学院四川自贡643000 自贡市希力数控工具有限公司四川自贡643011 中南大学粉末冶金国家重点实验室湖南长沙410083

采用不同的压制压力制备纳米Ti(C,N)基金属陶瓷生坯,研究低压烧结后金属陶瓷的微观组织、收缩性和力学性能。结果表明:当压制压力过低时,粉末排列不紧密,金属陶瓷组织不均匀;当压制压力过高时,金属陶瓷组织发生分层,孔隙度和缺陷增加。... 详细信息

采用不同的压制压力制备纳米Ti(C,N)基金属陶瓷生坯,研究低压烧结后金属陶瓷的微观组织、收缩性和力学性能。结果表明:当压制压力过低时,粉末排列不紧密,金属陶瓷组织不均匀;当压制压力过高时,金属陶瓷组织发生分层,孔隙度和缺陷增加。当压制压力为180 MPa时,得到的纳米Ti(C,N)基金属陶瓷最为致密,其相对密度为97.06%,收缩系数为1.23,孔隙率最低,为A02B00C00;同时,该金属陶瓷具有最优异的综合力学性能,其中维氏硬度为1680 HV_(30),抗弯强度为1650 MPa,断裂韧性为8.8 MPa·m^(1/2)。

关键词：纳米Ti(C,N)基金属陶瓷压制压力低压烧结微观组织收缩性力学性能

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Metal-organic-framework-derived copper-based catalyst for multicomponent C-S coupling reaction

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Chinese Journal of Chemical Engineering 2024年第6期70卷 1-8页

作者： Lixin chen hui Zhang Linxi Hou xin Ge Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Department of Materials-Oriented Chemical Engineering School of Chemical EngineeringFuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

Copper-based metal-organic frameworks(Cu-MOFs)are a promising multiphase catalyst for catalyzing C-S coupling reactions by virtue of their diverse structures and ***,the unpleasant odor and instability of the organosulfur,as well as the mass-transfer resistance that exists in multiphase catalysis,have often limited the catalytic application of Cu-MOFs in C-S coupling *** this paper,a Cu-MOFs catalyst modified by cetyltrimethylammonium bromide(CTAB)was designed to enhance mass transfer by increasing the adsorption of organic substrates using the long alkanes of ***,elemental sulfur was used to replace organosulfur to achieve a highly efficient and atom-economical multicomponent C-S coupling reaction.

关键词： Design Copper-based metal-organic frameworks (Cu-MOFs) Adsorption C-S coupling reaction Multiphase reaction

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Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He xin-hui chen hui Li Kai-hua Shi hui-wen Xiong xin Xiang Li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

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Revealing the Role of Defect in 3D Graphene-Based Photocatalytic Composite for Efficient Elimination of Antibiotic and Heavy Metal Combined Pollution

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Energy & Environmental Materials 2024年第3期7卷 168-178页

作者： xin Wang Jingzhe Zhang hui Wang Mengjun Liang Qiang Wang Fuming chen Research Institute of Frontier Science Southwest Jiaotong University Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Electronics and Information EngineeringSouth China Normal University School of Aeronautics Northwestern Polytechnical University Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology MOE Key Laboratory of Thermo-Fluid Science and Engineering School of Energy and Power EngineeringXi'an Jiaotong University

Defect engineering can give birth to novel properties for adsorption and photocatalysis in the control of antibiotics and heavy metal combined pollution with photocatalytic ***,the role of defects and the process mechanism are complicated and ***,TiO2/CN/3DC was fabricated and defects were introduced into the tripartite structure with separate O2plasma treatment for the single *** find that defect engineering can improve the photocatalytic activity,attributing to the increase of the contribution from h+and *** contrast to TiO2/CN/3DC with a photocatalytic tetracycline removal rate of 75.2%,the removal rate of TC with D-TiO2/CN/3DC has increased to 88.5%.Moreover,the reactive sites of tetracycline can be increased by adsorbing on the defective *** defect construction on TiO2shows the advantages in tetracycline degradation and Cu2+adsorption,but also suffers significant inhibition for the tetracycline degradation in a tetracycline/Cu2+combined *** contrast,the defect construction on graphene can achieve the cooperative removal of tetracycline and Cu2+.These findings can provide new insights into water treatment strategies with defect engineering.

关键词： 3D graphene Cu defect photocatalytic composite tetracycline

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Interfacial friction effects on sealing performances of elastomer packer

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Petroleum Science 2024年第3期21卷 2037-2047页

作者： Peng-cheng Wang Ming-hui chen Jim Jenkinson Yong-xin Song Li Sun Department of Mechanical Engineering University of HoustonHoustonTX77024USA Guren Nanomaterials Suzhou215127JiangsuChina Department of Marine Engineering Dalian Maritime UniversityDalian116026LiaoningChina

Elastomer sealing performance is of critical importance for downhole tools application including the use of fracturing(Frac)plugs during multi-stage hydraulic *** practice sealing performances of such plugs are normally evaluated through pressure tests,and in numerical simulation studies,maximum contact stress,average contact stress and contact length data are used to determine sealing quality between a packer and *** previous studies,the impact of friction forces on sealing performance is often *** work aims to fill this knowledge gap in determining the influence of friction forces on elastomer packer sealing *** first determined the most appropriate constitutive hyperelastic model for the elastomers used in frac *** we compared analytical calculation results with Finite Element Analysis simulation using a simplified tubular geometry and showed the significant influences on interfacial friction on elastomer packer stress distribution,deformation,and contact stress after *** the demonstration of validity of FEA method,we conducted systematic numerical simulation studies to show how the interfacial friction coefficients can affect the maximum contact stress,average contact stress,contact stress distribution,and maximum mises stress for an actual packer used in plug *** addition,we also demonstrated how the groove in a packer can affect packer deformation and evolvement during setting with the consideration of interfacial *** study underscores the critical role that friction forces play in Frac plug performance and provides a new dimension for optimizing packer design by controlling interfacial interactions at the packer contact surfaces.

关键词： Elastomer seal Friction Sealing performance Contact stress

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Theoretical understanding of correlation between magnetic phase transition and the superconducting dome in high-Tc cuprates

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 167-173页

作者： chen Zhang Cai-xin Zhang Su-Huai Wei Haiqing Lin hui-Xiong Deng State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Computational Science Research Center Beijing 100193China

Many issues concerning the origin of high-temperature superconductivity(HTS)are still under *** example,how the magnetic order varies with doping and its relationship with the superconducting temperature(Tc);and why Tcalways peaks near the quantum critical *** this paper,taking hole-doped La_(2)CuO_(4)as a classical example,we employ the first-principles band structure and total energy calculations with Monte Carlo simulations to explore how the symmetry-breaking magnetic ground state evolves with hole doping and the origin of a dome-shaped superconductivity region in the phase *** demonstrate that the local antiferromagnetic order and doping play key roles in determining the electron-phonon coupling,thus ***,the La_(2)CuO_(4)possesses a checkerboard local antiferromagnetic ground *** the hole doping increases,Tcincreases with the enhanced electron-phonon coupling *** as the doping increases further,the strength of the antiferromagnetic interaction weakens and spin fluctuation *** the critical doping level,a magnetic phase transition occurs that reduces the local antiferromagnetism-assisted electron-phonon coupling,thus diminishing the *** superconductivity disappears in the heavily overdoped region when the ferromagnetic order *** observations could account for why cuprates have a dome-shaped superconductivity region in the phase *** study,thus,contributes to a fundamental understanding of the correlation between doping,local magnetic order,and superconductivity of HTS.

关键词： high-temperature superconductivity antiferromagnetic order electron-phonon coupling doping effect cuprates

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