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Chinese Medicine and Culture 2019年第4期2卷 184-188页

作者： chee hoong lim Seng Keat lim Guo Lin Wong Linchao Qian Yun Jin Kim School of Traditional Chinese Medicine Xiamen University Malaysia

Taoism refers to an indigenous Chinese philosophical and religious tradition. For more than two and a half millennia, it has had a profound social and intellectual influence on Eastern Asia and since the 19 th century has deeply influenced Western countries. Dao De Jing(《道德经》Tao Te Jing) is still considered to be the primary text of Taoism. The Tao Te Jing is attributed to Laozi, the classical Chinese Philosopher, and describes the major doctrines of Taoism. It is most relevant to Traditional Chinese Medicine(TCM). This article offers a brief introduction to the Taoism within TCM – the relation between Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic) and Dao De Jing(《道德经》Tao Te Jing).

关键词： Dao De Jing (《》 Tao Te Jing) Huang Di Nei Jing (《》 The Yellow Emperorss Inner Classic) Taoism Philosophy

Safety and efficacy of Kaffes intraductal self-expanding metal stents in the management of post-liver transplant anastomotic strictures

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World Journal of Transplantation 2024年第2期14卷 88-98页

作者： chee lim Jonathan Ng Babak Sarraf Rhys Vaughan Marios Efthymiou Leonardo Zorron Cheng Tao Pu Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthMelbourne HeidelbergVIC 3084Australia Melbourne Medical School The University of MelbourneMelbourne ParkvilleVIC 3052Australia

BACKGROUND Endoscopic management is the first-line therapy for post-liver-transplant anas-tomotic *** the optimal duration of treatment with plastic stents has been reported to be 8-12 months,data on safety and duration for metal stents in this setting is *** to limited access to endoscopic retrograde cholan-giopancreatography(ERCP)during the coronavirus disease 2019 pandemic in our centre,there was a change in practice towards increased usage and length-of-stay of the Kaffes biliary intraductal self-expanding stent in patients with suitable *** was mainly due to the theoretical benefit of Kaffes stents allowing for longer indwelling periods compared to the traditional plastic *** Adult liver transplant recipients aged 18 years and above who underwent ERCP were retrospectively identified during a 10-year period through a database *** admissions post-Kaffes stent insertion were identified manually through electronic and scanned medical *** main outcome was the incidence of complications when stents were left indwelling for 3 months vs 6 *** efficacy was calculated via rates of stricture recurrence between patients that had stenting courses for≤120 d or>120 *** During the study period,a total of 66 ERCPs with Kaffes insertion were performed in 54 patients throughout their stenting *** 33 ERCPs,the stent was removed or exchanged on a 3-month *** pancreatitis,perfor-ations or deaths *** post-ERCP complications were similar between the 3-month(abdominal pain and intraductal migration)and 6-month(abdominal pain,septic shower and embedded stent)groups-6.1%vs 9.1%respectively,P=*** strictures resolved at the end of the stenting course,but the stenting course was variable from 3 to 22 *** recurrence rate for stenting courses lasting for up to 120 d was 71.4%and 21.4%for stenting courses of 121 d or over(P=0.03).There were 28 patients that were treated with a sin

关键词： Liver transplantation Cholangiopancreatography Endoscopic retrograde Constriction Pathologic Self expandable metallic stents Bile duct diseases Cholestasis

Performance of pulsed plasma thruster at low discharge energy

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Plasma Science and Technology 2024年第4期26卷 122-132页

作者：李鸿俊林泽豪胡浩俊吴文东陈爱虹杜德扬 Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Faculty of Engineering The University of Nottingham Malaysia CampusSemenyih 43500Malaysia Faculty of Engineering Multimedia UniversityCyberjaya 63100Malaysia

As the size of satellites scales down, low-power and compact propulsion systems such as the pulsed plasma thruster(PPT) are needed for stabilizing these miniature satellites in orbit. Most PPT systems are operated at 2 J or more of discharge energy. In this work, the performance of a PPT with a side-fed, tongue-flared electrode configuration operated within a lower discharge energy range of 0.5-2.5 J has been investigated. Ablation and charring of the polytetrafluoroethylene propellant surface were analyzed through field-effect scanning electron microscopy imaging and energy-dispersive X-ray spectroscopy. When the discharge energy fell below 2 J, inconsistencies occurred in the specific impulse and the thrust efficiency due to the measurement of the low mass bit. At energy ≥2 J, the performance parameters are compared with other PPT systems of similar configuration and discussed in depth.

关键词： pulsed plasma thruster low discharge energy performance parameters

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全球日晒行为调查研究

中华皮肤科杂志 2024年第7期57卷 672-673页

作者： Thierry Passeron Henry W. lim chee Leok Goh Hee Young Kang Fatimata Ly Akimichi Morita Jorge Ocampo-Candiani Susana Puig Sergio Schalka Wei Liu Anne-Laure Demessant-Flavigny Caroline Le Floc’h Delphine Kerob Brigitte Dreno Jean Krutmann Department of Dermatology Côte d'Azur University Nice University Hospital Center Nice France INSERM U1065 C3M Côte d'Azur University Nice France Department of Dermatology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Department of Dermatology Ajou University School of Medicine Suwon South Korea Department of Dermatology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonoma de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Dermatology Department Hospital Clinic de Barcelona Barcelona University Barcelona Spain Medcin Skin Research Center and Biochemistry Department Chemistry Institute of Sao Paulo University Sao Paulo Brazil Department of Dermatology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environmental Medicine Duesseldorf Germany Medical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm)和红外线(700nm~1mm)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

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儒家智德思想赋能智能时代大学生道德教育

教育文化论坛 2024年第2期16卷 77-86页

作者：孙雷林志敏拉曼大学中华研究院马来西亚吉隆坡43200 海口经济学院网络学院海南海口571100

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育... 详细信息

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育承担着人才培养、文化传承与社会服务等历史使命,德育是教育的重中之重。通过分析智能时代大学生的道德教育面临新的挑战,提出以儒家“智德”思想赋能“智能”时代大学生道德教育,从儒家“智德”思想中总结出五重价值:明辨是非,知耻明辱;仁者爱人,以智辅仁;学而知之,崇智明德;仁智并重,从善利他;敬德修业,知行并进。

关键词：智能时代儒家智德大学生道德教育

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Freehand transperineal prostate biopsy with a coaxial needle under local anesthesia:Experience from a single institution in Malaysia

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Cancer Pathogenesis and Therapy 2023年第1期1卷 33-39页

作者： Ing Soon Ngu Ming Soen Ngooi Han Kun Ng Kenny Tang Long Tee chee hoong Loo Meng Shi lim Department of Urology Sarawak General Hospital93586KuchingSarawakMalaysia Department of Urology Sarawak Heart Centre94300Kota SamarahanSarawakMalaysia

Background Freehand transperineal prostate biopsy(TPPBx)using a coaxial needle technique offers an alternative to probe-mounted freehand or template-guided techniques in the diagnosis of prostate cancer(PCa).It only requires the same equipment used for transrectal ultrasound-guided(TRUS)*** study is the first in Malaysia to report this experience and its *** aim to determine PCa detection rate and pain tolerability of freehand TPPBx utilizing a coaxial needle under local anesthesia(LA).Methods Institutional review board approval was obtained from National Medical Research Register(NMRR ID-21-02052-VIL).We retrospectively reviewed the medical records of patients who underwent TPPBx between August 2020 and April *** were reviewed for patients’characteristics,prostate volume,prostate-specific antigen(PSA)results,biopsy results and pain *** was analyzed to determine PCa and clinically significant prostate cancer(csPCa)detection *** was achieved using perineal skin infiltration and a periprostatic nerve *** commonly used standard side-firing transrectal ultrasound with its Prostate Biplane Transducer was used as an imaging *** principles of the Ginsburg protocol were *** tolerability was assessed using a visual analog *** A total of 55 patients with elevated PSA levels underwent freehand TPPBx under *** mean age was 67.3 years,the median PSA was 14.2 ng/mL,and the median PSA density(PSAD)was 0.33 ng/mL/*** optimal PSAD cutoff for predicting csPCa was 0.35 ng/mL/cc(area under the curve[AUC],0.792;sensitivity,87.5%;specificity,69.2%).PCa was detected in 24 patients(43.6%),of whom 16(29.1%)had *** median pain scores during LA infiltration and biopsy were four and two,respectively,which were significant different(P<0.05).TPPBx exhibited an infection rate of *** The PCa detection rate and patient tolerability of freehand TPPBx using a coaxial needle are similar to those of a cont

关键词： Prostate cancer Freehand Transperineal biopsy of prostate Coaxial needle TRUS biopsy PSA density Pain tolerability

Relevant Visual Semantic Context-Aware Attention-Based Dialog

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Computers, Materials & Continua 2023年第8期76卷 2337-2354页

作者： Eugene Tan Boon Hong Yung-Wey Chong Tat-chee Wan Kok-lim Alvin Yau National Advanced IPv6 Centre Universiti Sains MalaysiaPenangMalaysia Lee Kong Chian Faculty of Engineering and Science(LKCFES) Universiti Tunku Abdul RahmanSungai LongSelangorMalaysia

The existing dataset for visual dialog comprises multiple rounds of questions and a diverse range of image ***,it faces challenges in overcoming visual semantic limitations,particularly in obtaining sufficient context from visual and textual aspects of *** paper proposes a new visual dialog dataset called Diverse History-Dialog(DS-Dialog)to address the visual semantic limitations faced by the existing ***-Dialog groups relevant histories based on their respective Microsoft Common Objects in Context(MSCOCO)image categories and consolidates them for each ***,each MSCOCO image category consists of top relevant histories extracted based on their semantic relationships between the original image caption and historical *** relevant histories are consolidated for each image,and DS-Dialog enhances the current dataset by adding new context-aware relevant history to provide more visual semantic context for each *** new dataset is generated through several stages,including image semantic feature extraction,keyphrase extraction,relevant question extraction,and relevant history dialog *** DS-Dialog dataset contains about 2.6 million question-answer pairs,where 1.3 million pairs correspond to existing VisDial’s question-answer pairs,and the remaining 1.3 million pairs include a maximum of 5 image features for each VisDial image,with each image comprising 10-round relevant question-answer ***,a novel adaptive relevant history selection is proposed to resolve missing visual semantic information for each ***-Dialog is used to benchmark the performance of previous visual dialog models and achieves better performance than previous ***,the proposed DSDialog model achieves an 8% higher mean reciprocal rank(MRR),11% higher R@1%,6% higher R@5%,5% higher R@10%,and 8% higher normalized discounted cumulative gain(NDCG)compared to ***-Dialog also achieves approximately 1 point improvement o

关键词： Visual dialog context-aware relevant history computer vision natural language processing

Measurement of sub-fm/Hz^(1/2) displacement spectral densities in ultrahigh-Q single-crystal microcavities with hertz-level lasers

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Photonics Research 2022年第5期10卷 1202-1209页

作者： YOON-SOO JANG JINKANG lim WENTING WANG SEUNG-WOO KIM ANATOLIY SAVCHENKOV ANDREY BMATSKO chee WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Division of Physical Metrology Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea CACI-LGS Labs Florham ParkNew Jersey 07932USA Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea OEwaves Inc. PasadenaCalifornia 91107USA Jet Propulsion Laboratory California Institute of TechnologyPasadenaCalifornia 91109USA

Tracing a resonance frequency of a high quality factor(Q)optical cavity facilitates subpicometer displacement measurements of the optical cavity via Pound-Drever-Hall(PDH)locking scheme,tightly synchronizing a laser frequency to the optical *** we present observations of subfemtometer displacements on a ultrahigh-Q single-crystal MgF_(2)whispering-gallery-mode microcavity by frequency synchronization between a 1 Hz cavity-stabilized laser and a resonance of the MgF_(2) cavity using PDH laser-cavity *** characterize not only the displacement spectral density of the microcavity with a sensitivity of 1.5×10^(-16) m/Hz^(1/2) over the Fourier offset frequency ranging from 15 mHz to 100 kHz but also a 1.77 nm displacement fluctuation of the microcavity over 4500 *** measurement capability not only supports the analysis of integrated thermodynamical and technical cavity noise but allows for minute displacement measurements using laser-cavity locking for ultraprecise positioning,metrology,and sensing.

关键词： synchronization displacement cavity

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Hybrid SDS and WPT-IBBO-DNM Based Model for Ultra-short Term Photovoltaic Prediction

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 66-76页

作者： Hui Hwang Goh Qinwen Luo Dongdong Zhang Hui Liu Wei Dai chee Shen lim Tonni Agustiono Kurniawan Kai Chen Goh School of Electrical Engineering Guangxi UniversityNanningGuangxi 530004China University of Southampton Malaysia Iskandar Puteri 79200Malaysia College of the Environment and Ecology Xiamen UniversityFujian 361102China Department of Technology Management Faculty of Construction Management and BusinessUniversity Tun Hussein Onn Malaysia86400 Parit RajaJohorMalaysia

Accurate photovoltaic(PV)power prediction has been a subject of ongoing study in order to address grid stability concerns caused by PV output unpredictability and *** paper proposes an ultra-short-term hybrid photovoltaic power forecasting method based on a dendritic neural model(DNM)in this *** model is trained using improved biogeography-based optimization(IBBO),a technique that incorporates a domestication operation to increase the performance of classical biogeography-based optimization(BBO).To be more precise,a similar day selection(SDS)technique is presented for selecting the training set,and wavelet packet transform(WPT)is used to divide the input data into many *** is then used to train DNM weights and thresholds for each component ***,each component’s prediction results are stacked and *** suggested hybrid model is used to forecast PV power under various weather conditions using data from the Desert Knowledge Australia Solar Centre(DKASC)in Alice *** results indicate the proposed hybrid SDS and WPT-IBBO-DNM model has the lowest error of any of the benchmark models and hence has the potential to considerably enhance the accuracy of solar power forecasting(PVPF).

关键词： Dendritic neural model improved biogeography-based optimization photovoltaic power forecasting similar day selection wavelet packet transform

Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases

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World Journal of Gastroenterology 2022年第18期28卷 1934-1945页

作者： Wynne Sim Wei-Meng lim Ling-Wei Hii chee-Onn Leong Chun-Wai Mai School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia School of Pharmacy International Medical UniversityKuala Lumpur 57000Malaysia Center for Cancer and Stem Cell Research Institute for ResearchDevelopmentand InnovationInternational Medical UniversityKuala Lumpur 57000Malaysia AGTC Genomics Kuala Lumpur 57000Malaysia State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical Chemistry Faculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor ***,it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses,thus allowing continuous tumor growth and *** evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic *** with other cancers,pancreatic cancer has a tumor microenvironment that can resist most treatment modalities,including emerging ***,the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients,suggesting that pancreatic cancer has successfully evaded *** this review,we summarize the impact of genetic alteration and epigenetic modification(especially histone deacetylases,HDAC)on immune evasion in pancreatic *** overexpression significantly suppresses tumor suppressor genes,contributing to tumor growth and *** review the evidence on HDAC inhibitors in tumor eradication,improving T cells activation,restoring tumor immunogenicity,and modulating programmed death 1 *** provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.

关键词： Histone acetylation Histone deacetylases inhibitors Immune evasion Pancreatic cancers Pancreatic ductal adenocarcinoma