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Acute hospital-community hospital care bundle for elderly orthopedic surgery patients:A propensity score-matched economic analysis

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World Journal of Orthopedics 2023年第4期14卷 231-239页

作者： Ivan En-Howe Tan Aik Yong Chok Yun Zhao Yonghui Chen chee hoe koo Junjie Aw Mave Hean Teng Soh Chek Hun Foo Kwok Ann Ang Emile John Kwong Wei Tan Andrew Hwee Chye Tan Marianne Kit Har Au Group Finance Singapore Health ServicesSingapore 168582Singapore Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Post-Acute and Continuing Care Family MedicineOutram Community HospitalSingapore 168582Singapore Finance Singapore General HospitalSingapore 169608Singapore Department of Orthopedic Surgery Singapore General HospitalSingapore 169856Singapore Singhealth Community Hospital Singapore 168582Singapore

BACKGROUND While Singapore attains good health outcomes,Singapore’s healthcare system is confronted with bed shortages and prolonged stays for elderly people recovering from surgery in acute *** Acute Hospital-Community Hospital(AHCH)care bundle has been developed to assist patients in postoperative *** core concept is to transfer patients out of AHs when clinically recommended and into CHs,where they can receive more beneficial dedicated care to aid in their recovery,while freeing up bed capacities in *** To analyze the AH length of stay(LOS),costs,and savings associated with the AH-CH care bundle intervention initiated and implemented in elderly patients aged 75 years and above undergoing elective orthopedic *** A total of 8621:1 propensity score-matched patients aged 75 years and above who underwent elective orthopedic surgery in Singapore General Hospital(SGH)before(2017-2018)and after(2019-2021)the care bundle intervention period was *** measures were AH LOS,CH LOS,hospitalization metrics,postoperative 30-d mortality,and modified Barthel Index(MBI)*** costs of AH inpatient hospital stay in the matched cohorts were compared using cost data in Singapore *** Of the 862 matched elderly patients undergoing elective orthopedic surgery before and after the care bundle intervention,the age distribution,sex,American Society of Anesthesiologists classification,Charlson Comorbidity Index,and surgical approach were comparable between both *** transferred to CHs after the surgery had a shorter median AH LOS(7 d vs 9 d,P<0.001).The mean total AH inpatient cost per patient was 14.9%less for the elderly group transferred to CHs(S$24497.3 vs S$28772.8,P<0.001).The overall AH U-turn rates for elderly patients within the care bundle were low,with a 0%mortality rate following orthopedic *** elderly patients were discharged from CHs,their MBI scores increased significantly(50.9 vs 71.9,P<0.

关键词： Care bundle Community hospital Orthopedic surgery Cost-effectiveness Care transition Intervention

Assessment of Pb uptake,translocation and immobilization in kenaf (Hibiscus cannabinus L.) for phytoremediation of sand tailings

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Journal of Environmental Sciences 2008年第11期20卷 1341-1347页

作者： HO Wai Mun ANG Lai hoe LEE Don koo Forest Research Institute Malaysia 52109 KepongSelangorMalaysia Department of Forest Sciences Seoul National UniversitySeoul 151-921Korea

The potential of kenaf (Hibiscus cannabinus L.) for phytoremediation of lead (Pb) on sand tailings was investigated.A pot experiment employing factorial design with two main effects of fertilizer and lead was conducted in a nursery using sand tailings from an ex-tin mine as the growing *** showed that Pb was found in the root,stem,and seed capsule of kenaf but not in the *** of organic fertilizer promoted greater biomass yield as well as higher accumulation capacity of *** Pb-spike...

关键词： kenaf lead fertilizer bioaccumulation capacity phytoremediation

Clustering Indoor Location Data for Social Distancing and Human Mobility to Combat COVID-19

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Computers, Materials & Continua 2022年第4期71卷 907-924页

作者： Yuan Ai Ho chee Keong Tan Yin hoe Ng School of Information Technology Monash University MalaysiaJalan Lagoon SelatanBandar Sunway47500Selangor Darul EhsanMalaysia Faculty of Engineering Multimedia UniversityPersiaran MultimediaCyberjaya63100Selangor Darul EhsanMalaysia

The world is experiencing the unprecedented time of a pandemic caused by the coronavirus disease(i.e.,COVID-19).As a countermeasure,contact tracing and social distancing are essential to prevent the transmission of the virus,which can be achieved using indoor location *** on the indoor location analytics,the human mobility on a site can be monitored and planned to minimize human’s contact and enforce social distancing to contain the transmission of *** the indoor location data,the clustering can be applied to cluster spatial data,spatio-temporal data and movement behavior features for proximity detection or contact tracing *** specifically,we propose the Coherent Moving Cluster(CMC)algorithm for contact tracing,the density-based clustering(DBScan)algorithm for identification of hotspots and the trajectory clustering(TRACLUS)algorithm for clustering indoor *** feature extraction mechanism is then developed to extract useful and valuable features that can assist the proposed system to construct the network of users based on the similarity of the movement behaviors of the *** network of users is used to model an optimization problem to manage the human mobility on a *** objective function is formulated to minimize the probability of contact between the users and the optimization problem is solved using the proposed effective scheduling solution based on *** simulation results show that the proposed indoor location analytics system outperforms the existing clustering methods by about 30%in terms of accuracy of clustering *** adopting this system for human mobility management,the count of close contacts among the users within a confined area can be reduced by 80%in the scenario where all users are allowed to access the site.

关键词： Indoor location analytics COVID-19 contact tracing social distancing spatial-temporal dimensions human mobility

An Efficient Stacked-LSTM Based User Clustering for 5G NOMA Systems

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Computers, Materials & Continua 2022年第9期72卷 6119-6140页

作者： S.Prabha Kumaresan chee Keong Tan Yin hoe Ng Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia School of Information Technology Monash UniversitySubang Jaya47500Malaysia

Non-orthogonal multiple access(NOMA)has been a key enabling technology for the fifth generation(5G)cellular *** on the NOMA principle,a traditional neural network has been implemented for user clustering(UC)to maximize the NOMA system’s throughput performance by considering that each sample is independent of the prior and the subsequent ***,the prediction of UC for the future ones is based on the current clustering information,which is never used again due to the lack of memory of the ***,to relate the input features of NOMA users and capture the dependency in the clustering information,time-series methods can assist us in gaining a helpful insight into the *** its mathematical complexity,the essence of time series comes down to examining past behavior and extending that information into the ***,in this paper,we propose a novel and effective stacked long short term memory(S-LSTM)to predict the UC formation of NOMA users to enhance the throughput performance of the 5G-based NOMA *** the proposed strategy,the S-LSTM is modelled to handle the time-series input data to improve the predicting accuracy of UC of the NOMA users by implementing multiple LSTM layers with hidden *** implemented LSTM layers have feedback connections that help to capture the dependency in the clustering information as it propagates between the ***,we develop,train,validate and test the proposed model to predict the UC formation for the futures ones by capturing the dependency in the clustering information based on the time-series *** results demonstrate that the proposed scheme effectively predicts UC and thereby attaining near-optimal throughput performance of 98.94%compared to the exhaustive search method.

关键词： Non-orthogonal multiple access(NOMA) deep neural network(DNN) long short term memory(LSTM) temporal channel user clustering

Mitochondrial homeostasis in Parkinson＇s disease-a triumvirate rule？

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Neural Regeneration Research 2017年第8期12卷 1270-1272页

作者： chee-hoe Ng Liting Hang Kah-Leong Lim National Neuroscience Institute Singapore Neuroscience & Behavioral Disorders Program Duke-NUSMedical School Singapore Department of Physiology National University of SingaporeSingapore NUS Graduate School for Integrative Sciences and Engineering Singapore

Mitochondrial dysfunction in Parkinson＇s disease：Mitochondria are the primary energy generator of the cell and they are important for cell survival and *** mitochondrial homeostasis is frequently reported in human d... 详细信息

关键词： PPAR PD cell PGC AMPK Mitochondrial homeostasis in Parkinson’s disease-a triumvirate rule

New prognostic model for patients with advanced gastric cancer:Fluoropyrimidine/platinum doublet for first-line chemotherapy

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World Journal of Gastroenterology 2021年第48期27卷 8357-8369页

作者： Dong-hoe koo Min-Hee Ryu Mi-Yeon Lee Mee-Sun Moon Yoon-koo Kang Division of Hematology/Oncology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Biostatistics Department of R&D ManagementKangbuk Samsung HospitalSeoul 03181South Korea

BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic *** To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were *** A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk *** the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with *** new model is simpler than the old and more easily predicts OS.

关键词： Stomach neoplasms Chemotherapy Prognosis Validation Gastric cancer

High-Resolution Infrared-Vacuum Ultraviolet Photoion and Pulsed Field Ionization-Photoelectron Methods for Spectroscopic Studies of Neutrals and Cations

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Chinese Journal of Chemical Physics 2008年第3期21卷 193-201页

作者： Xi Xing Beth Reed Mi Kyung Bahng Peng Wang Hin koo Woo Sun Jong Baek chee Shing Lain Cheuk Yiu Ng Department of Chemistry University of California Davis Davis California 95616 USA

We show that by scanning the frequency of a single mode infrared （IR） optical parametric oscillator （IR- OPO） laser to excite the molecular species of interest and fixing the frequency of a vacuum ultraviolet （VUV） laser to photoionize the IR excited species, high-resolution IR spectra of polyatomic neutrals can be obtained with high sensitivity. The fact that this IR-VUV-photoion （IR-VUV-PI） method is based on VUV photoionization probe, and thus, allows the identification of the neutral IR absorber, makes it applicable for IR spectroscopy measurements of isotopemers, radicals, and clusters, which usually exist as impure samples. The highly resolved IR-VUV-PI measurements achieved using the single mode IR-OPO laser have made possible the selection of single rovibrational states of CH3X （X=Br and I）, C2H4, and C3H4 for VUV-pulsed field ionization-photoelectron （VUV-PFI-PE） measurements, resulting in rovibrationally resolved photoelectron spectra for these polyatomic molecules. These experiments show that the signal- to-noise ratios of the IR-VUV-PI and IR-VUV-PFI-PE spectra obtained by employing the high-resolution IR-OPO laser are significantly higher than those observed in previous IR-VUV-PI and IR-VUV-PFI-PE studies using a low-resolution IR-OPO laser. Further improvement in sensitivity of IR-VUV-PI and IR- VUV-PFI-PE measurements by using the collinear arrangement of IR-VUV lasers and molecular beam is discussed.

关键词： Vacuum ultraviolet Infrared Pulse-field photoelectron High resolution

Restoration of an Inner-City Stream and Its Impact on Air Temperature and Humidity Based on Long-Term Monitoring Data

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Advances in Atmospheric Sciences 2009年第2期26卷 283-292页

作者： Kyu Rang KIM Tae Heon KWON Yeon-Hee KIM Hae-Jung koo Byoung-Cheol CHOI chee-Young CHOI Applied Meteorology Research Laboratory National Institute of Meteorological Research Korea Meteorological Administration Applied Meteorology Research Laboratory National Institute of Meteorological ResearchKorea Meteorological Administration

Spatiotemporal changes in air temperature and humidity associated with the restoration of an innercity stream in Seoul, Korea, are investigated based on long-term monitoring data. The Cheonggye stream, covered under a concrete structure for 46 years, was restored in 2005 and runs 5.8 km eastward through a central region of Seoul. Long-term monitoring of the air temperature and relative humidity was made along the stream throughout the restoration and across the stream after the restoration. The area along the stream had a higher air temperature than the entire metropolitan area. The temperature anomaly between the monitoring area and the surrounding metropolitan area was 0.13℃ lower on average at the center of the stream after the restoration. The stream＇s effect on the air temperature was also evident in the temperature distribution along a street traversing the stream. The relative and specific humidities were increased due to the restoration. The restored stream modified the nearby urban climate in the opposite direction compared to urbanization. The results could be used as a model case in mitigating urban climate by a stream in future urban planning practices.

关键词： urban heat island stream restoration land-use vegetation Cheonggye stream

Targeted Blue Nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation

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Nano Research 2011年第11期4卷 1163-1173页

作者： Aniruddha Ray Xueding Wang Yong-Eun koo Lee hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman Biophysics University of Michigan Ann Arbor MI 48109 USA Department of Radiology University of Michigan Ann Arbor MI 48109 USA Department of Chemistry University of Michigan Ann Arbor MI 48109 USA Department of Neurosurgery University of Michigan Ann Arbor MI 48109 USA Institute of Acoustics Naniing University Nanjing 210093 China

Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water （equivalent to 0.84 μmol/L Coomassie Blue dye）. The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.

关键词： Brain tumor surgery targeted nanoparticles F3 peptide Coomassie Blue dye photoacoustic imaging