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Selenium speciation determines the angiogenesis effect through regulating selenoproteins to trigger ROS-mediated cell apoptosis and cell cycle arrest

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Chinese chemical Letters 2023年第11期34卷 184-190页

作者： Bin Feng Yan Zhang ting Liu Leung chan Tianfeng chen Jianfu Zhao Department of Oncology Research Center of Cancer Diagnosis and Therapythe First Affiliated HospitalJinan UniversityGuangzhou 510632China

Tumor angiogenesis is closely related to tumor development,immune escape,and drug ***,the development of effective anti-tumor angiogenesis drugs is of great research *** the current clinical angiogenesis inhibitors have achieved certain efficacy,they also pose the problems of limited and short duration of efficacy,drug resistance,and intrinsic ***-tumor angiogenesis strategies targeting endothelial cells(ECs)have attracted widespread attention in the development of highly effective and low toxicity anti-angiogenesis *** have verified that the trace element selenium(Se)can inhibit tumor growth by inhibiting tumor angiogenesis through different ***,it is unclear whether Se speciation has different effects on anti-tumor ***,we found that Se exhibited effective anti-angiogenic activity,and its mechanisms of activity were determined by its chemical *** Se can significantly inhibit tumor angiogenesis by targeting thioredoxin reductase(TrxR)to trigger cell apoptosis and cell cycle arrest and by increasing reactive oxygen species(ROS)production in *** Se can induce cell cycle arrest and increase ROS production in ECs,showing promising anti-angiogenic *** nanoparticles(SeNPs)slightly inhibit tumor angiogenesis by inducing apoptosis and cell cycle arrest and by increasing the production of *** summary,this study elucidates the anti-angiogenic activity of Se speciation control with a view to providing a scientific reference for the design and development of novel Se-based highly effective and low toxicity angiogenesis inhibitors.

关键词： Se speciation Angiogenesis Apoptosis Reactive oxygen species TXNRD selenium

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Ethyl Acetate Fraction of Dicliptera chinensis(L.)*** Liver Fibrosis by Inducing Autophagy via PI3K/AKT/m TOR/p70S6K Signaling Pathways

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Chinese Journal of Integrative Medicine 2022年第1期28卷 60-68页

作者： LIU Yuan BI Yan-meng PAN ting ZENG ting MO chan SUN Bing GAO Lei LYU Zhi-ping College of Integrated Traditional Chinese and Western Medicine Jining Medical UniversityJiningShandong Province(272000)China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Traditional Chinese Medicine Affiliated Hospital of Jining Medical UniversityJiningShandong Province(272000)China

Objective:To investigate the molecular mechanism underlying the anti-hepatic fibrosis activity of ethyl acetate fraction Dicliptera chinensis(L.)Juss.(EDC)in human hepatic stellate cells(HSCs)in vitro and in a carbon tetrachloride(CCl4)-induced hepatic fibrosis mouse model in ***:For in vitro study,HSCs were pre-treated with platelet-derived growth factor(10 ng/mL)for 2 h to ensure activation and treated with EDC for 24 h and 48 h,*** effect of EDC on HSCs was assessed using cell counting kit-8 assay,EdU staining,transmission electron microscopy,immunofluorescence staining,and Western blot,*** in vivo experiments,mice were intraperitoneally injected with CCl4(2μL/g,adjusted to a 25%concentration in olive oil),3 times per week for 6 weeks,to develop a hepatic fibrosis *** 8-week-old male C57 BL/6 mice were divided into 4 groups using a random number table(n=10),including control,model,positive control and EDC treatment *** in the EDC and colchicine groups were intragastrically administered EDC(0.5 g/kg)or colchicine(0.2 mg/kg)once per day for 6 *** in the control and model groups received an equal volume of *** assays and histological examinations were used to assess liver *** expression levels ofα-smooth muscle actin(α-SMA)and microtubule-associated protein light chain 3 B(LC3 B)were measured by Western ***:EDC reduced pathological damage associated with liver fibrosis,downregulated the expression ofα-SMA and upregulated the expression of LC3 B(P<0.05),both in HSCs and the CCl4-induced liver fibrosis mouse *** intervention of bafilomycin A1 and rapamycin in HSCs strongly supported the notion that inhibition of autophagy enhancedα-SMA protein expression levels(P<0.01).The results also found that the levels of phosphoinositide(PI3 K),p-PI3 K,AKT,p-AKT,mammalian target of rapamycin(mTOR),p-mTOR,and p-p70 S6 K all decreased after EDC treatment(P<0.05).Conclusion:EDC has an

关键词： Dicliptera chinensis(L.)Juss. autophagy liver fibrosis hepatic stellate cells Chinese medicine

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Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 92-96页

作者： Dan-Yang che Zhu-Lin chan Ji-Bo Zhou Dong-Qing Zhu Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Health Science and Technology Shanghai Jiao Tong University School of MedicineShanghai 200011China The PLA Navy Anqing Hospital Anqing 246004Anhui ProvinceChina

AIM:To evaluate the efficacy and safety of silicone oil(SO)as a corneal lubricant to improve visualization during ***:Patients who underwent vitreoretinal surgery were divided into two *** 1 was operated on with initial SO(Oxane 5700)as a corneal *** 2 was operated on with initial lactated ringer’s solution(LRS)and then replaced with SO as *** clarity was scored during the *** staining was performed to determine the damage to corneal ***:Totally 114 eyes of 114 patients were *** SO use maintained a clear cornea and provided excellent visualization of surgical *** group 1,the fundus clarity was grade 3 in 41/45 eyes and grade 2 in 4/45 *** group 2,corneal edema frequently occurred after initial LRS *** fundus clarity was grade 3 in 19/69 eyes,2 in 37/69 eyes and 1 in 13/69 eyes(P0.05).CONCLUSION:The use of SO as a corneal lubricant is effective and safe for preserving and improving corneal clarity and providing clear surgical field during vitrectomy.

关键词： silicone oil corneal lubricant corneal edema vitrectomy

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OSDA-free synthesis of FeZSM-22 zeolite from natural minerals for n-octane hydroisomerization

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Chinese Journal of chemical Engineering 2024年第2期66卷 51-59页

作者： Tiesen Li ting chen Yinghui Ye Peng Dong tinghaiWang Qingyan Cui chan Wang Yuanyuan Yue National Engineering Research Center of chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China

A seed-directed approach to synthesizing Fe ZSM-22 zeolite without organic structure directing agent(OSDA)was developed by using Fe-rich diatomite as all aluminum and iron *** Fe ZSM-22zeolite with optimal crystallinity and purity can be obtained by systematically adjusting feed composition and synthesis *** show that Fe ZSM-22 zeolite synthesized with OSDA-free owns high crystallinity,obvious thin needle-shaped morphology and high Bronsted/Lewis acid ***,when used for n-octane hydroisomerization reaction,its derived catalyst exhibits the best catalytic performance reflected by the highest selectivity to C_(8)isomers compared to the two reference catalysts prepared based on a Fe-containing and a Fe-free ZSM-22 synthesized through an OSDA-directed route from natural diatomite and conventional chemicals,*** work provides an alternative route to sustainably synthesizing heteroatomic zeolites with high performance.

关键词： FeZSM-22 zeolite OSDA-free synthesis Natural minerals n-octane hydroisomerization

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Dietary analysis of the House Swift(Apus nipalensis)in Hong Kong using prey DNA in faecal samples

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Avian Research 2021年第1期12卷 86-101页

作者： Chun ting Chung Hok Sze Wong Man Long Kwok Qi Meng King Ming chan School of Life Sciences The Chinese University of Hong KongSha Tin 999077N.TChina Swift and Swallow Research Group The Hong Kong Bird Watching Society7CV Ga Building532 Castle Peak RoadLai Chi KokKowloonHong Kong 999077China

Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these techniques are often invasive,require expertise in identification,and often cannot produce accurate identifications at the species ***:DNA barcoding was used to analyse the dietary composition of House Swifts(Apus nipalensis)in Hong Kong,*** samples from five different colonial nest sites were collected between 2019 and *** used universal primers to amplify a region of the cytochrome C oxidase gene from prey DNA in the faecal samples for identification ***:Ten different orders and 44 families from three different classes of Arthropoda were identified in the collected faecal ***,Hemiptera and Diptera were the most prevalent groups of prey found in the *** in the dietary composition of House Swifts during the breeding(April to September)and nonbreeding(October to March)season were also ***,particularly ants(Formicidae),were predominant in the diet during the breeding season,whereas Diptera and Hemiptera were predominant during the non-breeding ***:The prey groups identified in this study were similar to those identified in a previous study of the diet of House Swift,which also suggests a possible role of House Swifts in reducing the numbers of local insect *** study demonstrates the usefulness of applying molecular tools for the dietary analysis of aerial *** local forested areas may be crucial for the maintenance of House Swift population.

关键词： Diet DNA barcoding House swift Urbanisation threat

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Effects of salt-alkali stress on active oxygen metabolism in roots of Spiraea × bumalda 'Gold Mound' and Spiraea × bumalda 'Gold Flame'

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Journal of Forestry Research 2011年第1期22卷 59-64页

作者： YAN Yong-qing che Dai-di SHI Xi-chan LIU Xing-liang College of Horticulture Northeast Agricultural University Harbin 150030 P. R. China.

Under artificially-simulated complex salt-alkali stress, the levels of active oxygen metabolism in roots were studied using three-year-old cutting seedlings of Spiraea × bumalda ‘Gold Mound＇ and Spiraea × bumalda ‘Gold Flame＇. The present study aimed at exploring the antioxidant capacity in roots of spiraeas and revealing their adaptability to salt-alkali stress. Results indicate that the oxygen free radicals contents, electrolyte leakage rates and MDA contents in roots of Spiraea × bumalda ＇Gold Mound＇ and Spiraea × bumalda ＇Gold Flame＇ show an increasing tendency with the increases of the salinity and pH value, whereas the activities of superoxide dismutase （SOD）, peroxidase （POD） and catalase （CAT） all increased firstly and then decreased. With the increase in intensity of salt-alkali stress, the CAT activity in roots of Spiraea × bumalda ‘Gold Flame＇ is higher and the increasing extents in the oxygen free radicals contents, electrolyte leakage rates as well as MDA contents are lower compared with Spiraea × bumalda ‘Gold Mound＇, indicating that Spiraea × bumalda ‘Gold Flame＇ has a stronger antioxidant capacity.

关键词： active oxygen metabolism roots salt-alkali stress Spiraea× bumalda ‘Gold Mound' Spiraea × bumalda ‘Gold Flame'

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Ultra-small Pd clusters supported by chitin nanowires as highly efficient catalysts

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Nano Research 2018年第6期11卷 3145-3153页

作者： Xianglin Pei Yi Deng Bo Duan ting-Shan chan Jyh-Fu Lee Aiwen Lei Lina Zhang College of chemistry and Molecular Sciences Wuhan University Wuhan 430072 China "National Synchrotron Radiation Research Center' Hsinchu 30076 Taiwan China

For the first time, chitin microspheres woven from nanowires with multi-scale porous structures were used as an excellent support for a catalyst of ultra-small Pd clusters. The Pd species anchored on the precursor Pre-Pd@chitin were 0.6 nm in average size, while the reduced catalyst Red-Pd@chitin featured ultra-small particles of 1.3 nm in average size. X-ray absorption spectroscopy （XAS） and transmission electron microscopy （TEM） demonstrated that the Pd catalyst in both oxidative and reductive states retained good dispersity and ultra-small clusters. The catalyst was tested for the hydrogenation of p-nitroanisole, exhibiting an excellent initial rate （13× that of commercial Pd/C） and excellent turnover frequency reaching 52,000 h^-1. Furthermore, the catalyst could be recycled and used more than 10 times with no decay of the catalytic activity, suggesting potential industrial applications.

关键词： Pd clusters chitin nanowires supported catalyst hydrogenation

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A multi-objective pigeon inspired optimization algorithm for fuzzy production scheduling problem considering mould maintenance

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Science China(Information Sciences) 2019年第7期62卷 15-32页

作者： Xiaoyue FU Felix T.S.chan Ben NIU Nick S.H.CHUNG ting QU Department of Industrial and Systems Engineering The Hong Kong Polytechnic University College of Management Shenzhen University School of Electrical and Information Engineering Jinan University

The fuzzy production scheduling problem considering mould maintenance(FPSP-MM) is studied. The processing time and the maintenance time are represented by triangular fuzzy numbers. When tasks are executed based on the sequence provided by the fuzzy schedule, the real duration of each task needs to be known so the posteriori solution with deterministic processing times can be obtained. Therefore, the concept of the schedule robustness needs to be considered for the fuzzy problem. The robustness is considered as the optimization objective except for the fuzzy makespan in this research. To optimize these two objective functions, a multi-objective pigeon inspired optimization(MOPIO) algorithm is developed. To extend the pigeon inspired optimization(PIO) algorithm from the single-objective case to the multi-objective case, nondominated solutions are used as candidates for the leader pigeon designation and a special crowding distance is used to ensure a good distribution of solutions in both the objective space and the corresponding decision space. Furthermore, an index-based ring topology is used to manage the convergence speed. Numerical experiments on a variety of simulated scenarios show the excellent efficiency and effectiveness of the proposed MOPIO algorithm by comparing it with other algorithms.

关键词： fuzzy production scheduling mould maintenance pigeon inspired optimization multi-objective

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A network condition classification scheme for supporting video delivery over wireless Internet*

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 794-800页

作者： chan Siu-ping SUN Ming-ting Department of Electrical Engineering University of Washington Seattle 98195 USA Department of Electrical Engineering University of Washington Seattle 98195 USA

Real-time video transport over wireless Internet faces many challenges due to the heterogeneous environment including wireline and wireless networks. A robust network condition classification algorithm using multiple end-to-end metrics and Support Vector Machine (SVM) is proposed to classify different network events and model the transition pattern of network conditions. End-to-end Quality-of-Service (QoS) mechanisms like congestion control, error control, and power control can benefit from the network condition information and react to different network situations appropriately. The proposed network condition classifica- tion algorithm uses SVM as a classifier to cluster different end-to-end metrics such as end-to-end delay, delay jitter, throughput and packet loss-rate for the UDP traffic with TCP-friendly Rate Control (TFRC), which is used for video transport. The algorithm is also flexible for classifying different numbers of states representing different levels of network events such as wireline congestion and wireless channel loss. Simulation results using network simulator 2 (ns2) showed the effectiveness of the proposed scheme.

关键词： Video transport, End-to-end QoS, Wireless Internet, Network condition classification, Support Vector Machine(SVM)

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CCRK-a hub for liver metastasis and cancer

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Cellular & Molecular Immunology 2021年第5期18卷 1341-1342页

作者： Jie-ting Low Guan-Ling Lin Michael W.Y.chan Department of Biomedical Sciences National Chung Cheng UniversityMin-HsiungChia-YiTaiwanChina Epigenomics and Human Disease Research Center National Chung Cheng UniversityMin-HsiungChia-YiTaiwanChina Center for Innovative Research on Aging Society(CIRAS) National Chung Cheng UniversityMin-HsiungChia-YiTaiwanChina

The liver is one of the most common sites for cancer metastasis,which leads to secondary hepatic *** all solid tumors,such as melanoma,breast cancer,gastric cancer,colorectal cancer,and lung cancer,metastasize to the liver.1,2 Overall,20–25%of colorectal cancer patients may eventually develop liver metastases(also known as CRC liver metastases).3 In addition to some common occurrence of liver metastasis in colorectal cancer,the liver is also one of the predominant metastatic sites for melanoma,including cutaneous and ocular melanoma.2 Thus,an understanding of the mechanism of liver metastasis is urgently needed for the development of novel strategies to prolong overall survival for patients with liver metastases.

关键词： metastasis cancer colorectal

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