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Prevalence of HFE mutations and relation to serum (?)ron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan

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World Journal of Gastroenterology 2005年第25期11卷 3905-3908页

作者： Tsung-Jung Lin Chih-Lin Lin chaur-shine wang Division of Gastroenterology

AIM: To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD ***: We examined C282Y and H63D mutations of HFE gene in 125 healthy subjects, 29 patients with CHC,and 33 patients with NAFLD. The serum iron markers,including ferritin, iron, and total iron binding capacity (TIBC),were assessed in all ***: All of the healthy subjects and patients were free from C282Y mutation. The prevalence of H63D heterozygosity was 4/125 (3.20%) in healthy subjects, 2/29(6.90%) in CHC group, and 1/33 (3.03%) in NAFLD *** healthy subjects showed no significant difference in the prevalence of H63D mutation as compared with the CHC or NAFLD group. Increased serum iron store was found in 34.48% of CHC patients and 36.36% of NAFLD *** three patients of H63D heterozygosity, only one CHC patient had increased serum iron store. There was no significant difference in the prevalence of HFE mutations between patients with increased serum iron store and those without in CHC or NAFLD ***: The HFE mutations may not contribute to iron accumulation in the CHC or NAFLD group even when serum iron overload is observed in more than one-third of these patients in Taiwan.

关键词： Hereditary hemochromatosis HFE gene Serum iron Chronic hepatitis C Nonalcoholic fatty liver disease

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Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第39期11卷 6115-6119页

作者： chaur-shine wang Chin-Lin Lin Hsi-Chang Lee Kuan-Yang Chen Ming-Feng Chiang Hung-Sheng Chen Tsung-Jung Lin Department of Gastroenterology Ren-Ai Branch Taipei City HospitalTaipeiTaiwanChina

AIM： To evaluate whether DCP is better than AFP for differentiating HCC from nonmalignant liver disease and further evaluate the usefulness of DCP in early diagnosis of small HCC. METHODS： Serum DCP and AFP levels were determined in 127 patients. Among these patients, 32 were with noncirrhotic chronic hepatitis, 34 were with compensated cirrhosis, and 61 were with HCC. The cut-off value for the DCP and AFP were set as 40 mAU/mL and 20 ng/mL, respectively. To compare the diagnostic value of DCP and AFP in distinguishing HCC from nonmalignant chronic liver disease, receiver operating characteristic （ROC） curves were constructed for each assay. RESULTS： The accuracy, sensitivity, and specifidty of DCP were higher than AFP in detecting HCC （81.9%, 77%, and 86.4% vs 68.5%, 59%, and 77.3%, respectively）. The area under the ROC （AUROC） curves revealed that DCP had a better accuracy than AFP in diagnosis of HCC （0.85 [95%CI, 0.78-0.91] vs 0.73 [95%CI, 0.65-0.81], P= 0.013）. In 39 patients with solitary HCC, the positive rates of DCP were 100% in patients with tumor size larger than 3 cm, 66.7% in patients with tumor size 2-3 cm and 50% in patients with tumor size less than 2 cm. The positive rates of AFP in patients with tumor size larger than 3 cm, 2-3 crn and less than 2 cm were 55.6%, 50%, and 33.3%, respectively. The median level of DCP in HCC patients with tumor size larger than 3 cm was significantly higher than those with tumor size 2-3 cm and those with the size of less than 2 cm. CONCLUSION： Our study indicates that DCP has a better diagnostic value than AFP in differentiating HCC from nonmalignant chronic liver disease. DCP has not only a stronger correlation with HCC than AFP in tumor size but also more effectiveness than AFP in detecting small size of HCC.

关键词： Des-γ-carboxy prothrombin α-Fetoprotein Hepatocellular carcinoma

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2205双相不锈钢沉积氯化钠之高温腐蚀

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电化学 2005年第4期11卷 369-376页

作者：彭富福王朝正林裕章台湾科技大学机械工程研究所

本文研究表面沉积2 mg/cm2氯化钠的2205双相不锈钢(2205 DSS)在500 vppm NaCl(8)流动气氛加热炉内550～850℃下之高温腐蚀.结果显示,2205 DSS之高温腐蚀动力学遵守抛物线定律,腐蚀反应速率随温度的上升而加速.高温腐蚀后生成的腐蚀皮膜... 详细信息

本文研究表面沉积2 mg/cm2氯化钠的2205双相不锈钢(2205 DSS)在500 vppm NaCl(8)流动气氛加热炉内550～850℃下之高温腐蚀.结果显示,2205 DSS之高温腐蚀动力学遵守抛物线定律,腐蚀反应速率随温度的上升而加速.高温腐蚀后生成的腐蚀皮膜结构由外而内依次为Fe2O3、Fe3O4、Cr2O3及FeCr2O4,不同温度下腐蚀生成的皮膜结构并无明显相异,唯850℃之试片于氧化皮膜脱落后,从其表层较容易检测到SiO2及NiO.在双相结构腐蚀顺序实验中,对表面沉积2 mg/em2氯化钠的试片,其腐蚀顺序与α、γ相无关,为全面性的腐蚀.但于500 vppm NaCl(8)的流动气氛下,虽无法分辨α、γ相的腐蚀顺序,但可发现γ相较α相有较快速腐蚀的现象.

关键词：双相不锈钢 2205 高温腐蚀

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430不锈钢热浸镀铝(硅)之铝化层成长研究

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电化学 2005年第3期11卷 271-276页

作者：陈鹏交王朝正林裕章金萱台湾科技大学机械工程研究所东南技术学院机械工程系

使用430不锈钢于680至800℃下作熔融铝硅合金热浸处理,研究热浸温度及热浸时间对铝硅合金化层成长的影响及铝化层之成长动力学.结果表明,430不锈钢在680～800℃经热浸16～289 s后,表面镀层与铝化层之生成厚度随热浸时间及热浸温度而增加... 详细信息

使用430不锈钢于680至800℃下作熔融铝硅合金热浸处理,研究热浸温度及热浸时间对铝硅合金化层成长的影响及铝化层之成长动力学.结果表明,430不锈钢在680～800℃经热浸16～289 s后,表面镀层与铝化层之生成厚度随热浸时间及热浸温度而增加,铝化层之成长动力学符合拋物线定律,并因相互扩散而形成FeAl3及Fe2Al5相,金相截面观察显示,680℃热浸处理的合金化层界面平坦,而在800℃下的即趋于不规则.

关键词：热浸镀铝硅热浸镀铝 430不锈钢合金化层

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