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Gastric peritoneal carcinomatosis-a retrospective review

World Journal of Gastrointestinal Oncology 2017年第3期9卷 121-128页

作者： Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng tai Clarinda Wei Ling Chua Matthew chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo Division of Surgical Oncology National Cancer Centre Singapore Dvision of Medical Oncology National Cancer Centre Singapore

AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of *** We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral *** We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their

关键词： Peritoneal carcinomatosis Gastric cancer

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界面约束法在曲流河储层构型建模中的应用

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中国石油大学学报（自然科学版） 2011年第3期35卷 26-30,35页

作者：刘太勋陶自强中国石油大学地球科学与技术学院山东青岛266555 中国石油大港油田勘探开发研究院天津300280

根据多级界面联合约束的确定性建模方法,应用钻井、地质、测井及生产动态数据,对大港油田某断块曲流河储层进行构型建模研究。首先在沉积微相模型的基础上利用点坝内部构型解剖结果,采用多级界面联合约束、界面间设定构型单元的方法建... 详细信息

根据多级界面联合约束的确定性建模方法,应用钻井、地质、测井及生产动态数据,对大港油田某断块曲流河储层进行构型建模研究。首先在沉积微相模型的基础上利用点坝内部构型解剖结果,采用多级界面联合约束、界面间设定构型单元的方法建立储层结构模型,然后结合井点数据分析建立构型约束下的储层参数模型。结果表明:侧积层的间隔、倾角、倾向在其规模范围内有一定变化,在建模过程中需要利用井点数据计算修正;界面约束的建模方法能够很好地体现河道内部侧积夹层分布;储层构型约束下的属性建模是确定和随机相结合的建模方法,建立的模型能合理地反映油藏的实际情况。

关键词：界面约束储层构型建模属性建模河流相

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Study on the nitridation of β-Ga2O3 films

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Chinese Physics B 2019年第8期28卷 382-386页

作者： Fei Cheng Yue-Wen Li Hong Zhao Xiang-Qian Xiu Zhi-tai Jia Duo Liu Xue-Mei Hua Zi-Li Xie tao tao Peng Chen Bin Liu Rong Zhang You-Dou Zheng Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China

Single-crystal GaN layers have been obtained by nitridingβ-Ga2O3 films in NH3 *** effect of the temperature and time on the nitridation and conversion of Ga2O3 films have been *** nitridation process results in lots of holes in the surface of *** higher nitridation temperature and longer time can promote the nitridation and improve the crystal quality of GaN *** converted Ga N porous films show the single-crystal structures and lowstress,which can be used as templates for the epitaxial growth of high-quality GaN.

关键词： β-Ga2O3 nitridation GaN single-crystal

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Response to the Lomagundi-Jatuli Event in the southwestern margin of the Yangtze Plate:Evidence from the carbon and oxygen isotopes of the Paleoproterozoic Yongjingshao Formation

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China Geology 2023年第1期6卷 50-60页

作者： Jun-ping Liu Wei Yin Shi-pan Yang Jiang-tai Zhao Wen-tao Zeng Feng Tang Shi-jun He Wei-ke Li School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Yunnan Institute of Geological Survey Kunming 650216China Key Laboratory of Sanjiang Metallogeny and Resources Exploration and Utilization MNRKunming 650051China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China The Second Geological Institute of China Metallurgical Geology Bureau Fuzhou 350108China

The Lomagundi-Jatuli Event(LJE)refers to the significant positive carbon isotope excursion in seawater constituents that occurred immediately after the increase in atmospheric oxygen content during the Paleoproterozoic(2.22-2.06 Ga).Theδ^(13)C values of 46 dolostone samples collected from the Paleoproterozoic Yongjingshao Formation varied in the range of 0.05‰-4.95‰(V-PDB;maximum:4.95‰)in this study,which may be related to the multicellular eukaryotes in the Liangshan Formation in the Yimen *** are much higher than theδ^(13)C values of marine carbonates(-1.16‰on average).Theδ^(13)C values of other formations in the Paleoproterozoic Yimen Group are *** notable positive carbon isotope anomalies of the Yongjingshao Formation indicate the response to the LJE at the southwestern margin of the Yangtze Block,which is reported for the first ***,they are comparable to theδ^(13)C values of carbonates in the Dashiling Formation of the Hutuo Group in the Wutaishan area in the North China Craton,the Wuzhiling Formation of the Songshan Group in the Xiong'er area,Henan Province,and the Dashiqiao Formation of the Liaohe Group in the Guanmenshan area,Liaoning ***,it can be further concluded that the LJE is a global *** study reveals that LJE occurred in Central Yunnan at 2.15-2.10 Ga,lasting for about 50 *** macro-columnar,bean-shaped,and microfilament fossils and reticular ultramicrofossils of multicellular eukaryotes in this period were discovered in the Liangshan Formation of the Yimen *** are the direct cause for the LJE and are also the oldest paleontological fossils ever *** major events successively occurring in the early stage of the Earth include the Great Oxygenation Event(first occurrence),the global Superiortype banded iron formations(BIFs),the Huronian glaciation,the Great Oxygenation Event(second occurrence),the explosion of multicellular eukaryotes,the positive carbon isotope excursion,and the global a

关键词： Lomagundi-Jatuli Event Eucaryon Paleoproterozoic Bean-shaped fossil Micro-filament fossil Micro-columnar fossil Carbon and oxygen isotopes Yangtze Plate Geological survey engineering China

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Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

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World Journal of Gastroenterology 2010年第34期16卷 4281-4290页

作者： Zhang, Jun-Qiang Li, Yu-Min Liu, tao He, Wen-Ting Chen, Ying-tai Chen, Xiao-Hui Li, Xun Zhou, Wen-Ce Yi, Jian-Feng Ren, Zhi-Jian Lanzhou Univ Hosp 2 Lanzhou 730030 Gansu Province Peoples R China Gansu Prov Key Lab Digest Syst Tumors Lanzhou 730030 Gansu Province Peoples R China Lanzhou Univ Hosp 1 Dept Gen Surg Lanzhou 730000 Gansu Province Peoples R China Lanzhou Univ Clin Med Sch 1 Lanzhou 730000 Gansu Province Peoples R China

AIM: To study the antitumor effect of matrine in human hepatoma G2 (HepG2) cells and its molecular mechanism involved in antineoplastic activities. METHODS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect viability of HepG2 cells. The effect of matrine on cell cycle was detected by flow cytometry. Annexin-V-FITC/PI double staining assay was used to detect cellular apoptosis. Cellular morphological changes were observed under an inverted phase contrast microscope. Transmission electron microscopy was performed to further examine ultrastructural structure of the cells treatedwith matrine. Monodansylcadaverine (MDC) staining was used to detect autophagy. Whether autophagy is blocked by 3-methyladenine (3-MA), an autophagy inhibitor, was evaluated. Expression levels of Bax and Beclin 1 in HepG2 cells were measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR).RESULTS: Matrine signif icantly inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner, and induced G1-phase cell cycle arrest and apoptosis of HepG2 cells in a dose-dependent manner. The total apoptosis rate was 0.14% for HepG2 cells not treated with matrine. In contrast, the apoptosis rate was 28.91%, 34.36% and 38.80%, respectively, for HepG2 cells treated with matrine at the concentration of 0.5, 1.0 and 2.0 mg/mL. The remarkable morphological changes were observed under an inverted phase contrast microscope. Abundant cytoplasmic vacuoles with varying sizes were observed in HepG2 cells treated with matrine. Furthermore, vacuolization in cytoplasm progressively became larger and denser when the concentration of matrine was increased. Electron microscopy demonstrated formation of abundant autophagic vacuoles in HepG2 cells after matrine treatment. When the specif ic autophagic inhibitor, 3-MA, was applied, the number of autophagic vacuoles greatly decreased. MDC staining showed that the fluorescent density wa

关键词： Matrine Autophagy Apoptosis Bax Beclin 1 Hepatocellular carcinoma

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Impact of body mass index on complications following pancreatectomy:Ten-year experience at National Cancer Center in China

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World Journal of Gastroenterology 2015年第23期21卷 7218-7224页

作者： Ying-tai Chen Qian Deng Xu Che Jian-Wei Zhang Yu-Heng Chen Dong-Bin Zhao Yan-tao Tian Ya-Wei Zhang Cheng-Feng Wang Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical CollegeChina National Cancer Center National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Yale University School of Public Health

AIM: To examine the impact of body mass index(BMI)on outcomes following pancreatic resection in the Chinese ***: A retrospective cohort study using prospectively collected data was conducted at the Cancer Hospital of the Chinese Academy of Medical Sciences, China National Cancer Center. Individuals who underwent pancreatic resection between January2004 and December 2013 were identified and included in the study. Persons were classified as having a normal weight if their BMI was < 24 kg/m2 and overweight/obese if their BMI was ≥ 24 kg/m2 as defined by the International Life Sciences Institute Focal Point in China. A χ 2 test(for categorical variables) or a t test(for continuous variables) was used to examine the differences in patients' characteristics between normal weight and overweight/obese groups. Multiple logistic regression models were used to assess the associationsof postoperative complications, operative difficulty,length of hospital stay, and cost with BMI, adjusting for age, sex, and type of surgery ***: A total of 362 consecutive patients with data available for BMI calculation underwent pancreatic resection for benign or malignant disease from January1, 2004 to December 31, 2013. Of the 362 patients,156 were overweight or obese and 206 were of normal weight. One or more postoperative complications occurred in 35.4% of the patients following pancreatic resection. Among patients who were overweight or obese, 42.9% experienced one or more complications,significantly higher than normal weight(29.6%)individuals(P = 0.0086). Compared with individuals who had normal weight, those with a BMI ≥ 24.0kg/m2 had higher delayed gastric emptying(19.9% vs5.8%, P < 0.0001) and bile leak(7.7% vs 1.9%, P =0.0068). There were no significant differences seen in pancreatic fistula, gastrointestinal hemorrhage, reoperation,readmission, or other complications. BMI did not show a significant association with intraoperative blood loss, operative tim

关键词： Body mass index China Pancreatectomy Pancreatic cancer Postoperative complications

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Malignant extra-gastrointestinal stromal tumor of the pancreas:Report of two cases and review of the literature

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World Journal of Gastroenterology 2014年第3期20卷 863-868页

作者： Yan-tao Tian Hao Liu Su-Sheng Shi Yi-Bin Xie Quan Xu Jian-Wei Zhang Dong-Bing Zhao Cheng-Feng Wang Ying-tai Chen Department of Abdominal Surgery Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College Department of Pathology Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that arise from the gastrointestinal *** rare cases,these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract,such as the mesentery,omentum and ***,pancreatic extra-gastrointestinal stromal tumors are extremely rare,with only 14 previous cases reported.A 61-year-old man with no clinical symptoms had a routine check-up,during which an abdominal mass located in the pancreas tail was *** surgery was performed with resection of the pancreas tail and the spleen,and he was diagnosed with lowrisk *** 60-year-old man with no clinical symptoms underwent Computed tomography which revealed a well-demarcated tumor,6 cm in diameter,in the head of the *** was diagnosed with pancreatic ***,we describe two rare cases of pancreatic GISTs and review the cases previously reported in the literature.

关键词： Gastrointestinal Stromal tumors Extra-gastrointestinal Stromal Tumors Pancreatic gastrointestinal stromal tumors

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The Influence of Graded AlGaN Buffer Thickness for Crack-Free GaN on Si(111)Substrates by using MOCVD

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Chinese Physics Letters 2013年第2期30卷 221-224页

作者： XU Pei-Qiang JIANG Yang MA Zi-Guang DENG Zhen LU tai-Ping DU Chun-Hua FANG Yu-tao ZUO Peng CHEN Hong Key Laboratory for Renewable Energy Institute of PhysicsChinese Academy of SciencesBeijing 100190

GaN films with different thicknesses of Al composition graded AlGaN buffer are grown on substrates of Si(111)by metal-organic chemical vapor deposition(MOCVD).The thicknesses of graded AlGaN buffer are fixed at 200 nm,300 nm,and 450 nm,*** microscopy,atomic force microscopy,x-ray diffraction,and Raman spectroscopy are employed to characterize these *** find that the thickness of the graded AlGaN buffer layer plays a key role on the following growth of GaN *** optimized thickness of the graded AlGaN buffer layer is 300 *** such conditions,the GaN epitaxial film is crack-free,and its dislocation density is the lowest.

关键词： Si(111) AlGaN MOCVD

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CMOS Compatible Nonvolatile Memory Devices Based on SiO_(2)/Cu/SiO_(2) Multilayer Films

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Chinese Physics Letters 2011年第7期28卷 262-264页

作者： WANG Yan LIU Qi LV Hang-Bing LONG Shi-Bing ZHANG Sen LI Ying-tao LIAN Wen-tai YANG Jian-Hong LIU Ming College of Physical Science and Technology Lanzhou UniversityLanzhou 730000 Laboratory of Nano-Fabrication and Novel Devices Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029

We systematically investigate the resistive switching characteristics of SiO_(2) films with a Cu/SiO_(2)/Cu/SiO_(2)/Pt multilayer *** device exhibits good resistive switching performances,including a high ON/OFF resistance ratio(>103),good retention characteristic(>10^(4)s),satisfactory switching endurance(>200 cycles),a fast programming speed(<100 ns)and a high device yield(∼100%).Considering these results,SiO_(2)-based memories have highly promising applications for nonvolatile memory devices.

关键词： Films multilayer programming

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Microbial Presence on Kitchen Dishcloths in Chinese Housholds

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Biomedical and Environmental Sciences 2014年第12期27卷 978-981页

作者： SHEN Jin ZHAO Bin Xiu LI tao BAN Hai Qun TIAN Liang GE Yi Lin CHEN tai Yao LI Shi Yue ZHANG Liu Bo School of Public Health Wuhan University Institute of Environment Health and Related Product Safety Center for Disease Control and Prevention of China Center for Disease Control and Prevention of Shanghai

To study the microbiological contamination of kitchen dishcloths in Chinese housholds, 1010 ＇in-use＇ kitchen dishcloths were collected from residential premises in Beijing and Shanghai, and they were sent to the lab... 详细信息

关键词： Microbial Presence on Kitchen Dishcloths in Chinese Housholds

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