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Clinical longitudinal evaluation of COVID-19 patients and prediction of organ-specific recovery using artificial intelligence

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Precision Clinical Medicine 2021年第1期4卷 62-69页

作者： Winston T.Wang charlotte l.zhang Kang Wei Ye Sang Jun Shen Guangyu Wang Alexander X.lozano Department of Materials Science&Engineering Stanford UniversityStanfordCA 94305USA Mayo Clinic Alix school of Medicine ScottsdaleAZ 85259USA Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China The First College of Clinical Medical Science China Three Gorges UniversityYichang 443000China Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Within COVID-19 there is an urgent unmet need to predict at the time of hospital admission which COVID-19 patients will recover from the disease,and how fast they recover to deliver personalized treatments and to properly allocate hospital resources so that healthcare systems do not become *** this end,we have combined clinically salient CT imaging data synergistically with laboratory testing data in an integrative machine learning model to predict organ-specific recovery of patients from *** trained and validated our model in 285 patients on each separate major organ system impacted by COVID-19 including the renal,pulmonary,immune,cardiac,and hepatic *** greatly enhance the speed and utility of our model,we applied an artificial intelligence method to segment and classify regions on CT imaging,from which interpretable data could be directly fed into the predictive machine learning model for overall *** all organ systems we achieved validation set area under the receiver operator characteristic curve(AUC)values for organ-specific recovery ranging from 0.80 to 0.89,and significant overall recovery prediction in Kaplan-Meier *** demonstrates that the synergistic use of an artificial intelligence(AI)framework applied to CT lung imaging and a machine learning model that integrates laboratory test data with imaging data can accurately predict the overall recovery of COVID-19 patients from baseline characteristics.

关键词： artificial intelligence medical image COVID-19 longitudinal evaluation

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Mutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma

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Precision Clinical Medicine 2019年第4期2卷 213-220页

作者： Edward D.zhang Meixia zhang Gen li charlotte l.zhang Zhihuan li Guangxi Zang Zhiguang Su Ming zhang Daoman Xiang ling Zhao Jie Zhu Guangzhou Regenerative Medicine and Health Guangdong laboratory Guangzhou 510530China Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China Molecular Medicine Center West China HospitalSichuan UniversityChengdu 610041China State Key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China

Uveal melanoma is the most common intraocular cancer in the adult eye.R183 and Q209 were found to be mutational hotspots in exon 4 and exon 5 of GNAQ and GNA11 in ***,only a few studies have reported somaticmutations in GNAQ or GNA11 in uveal melanoma in *** extracted somatic DNA from paraffin-embedded biopsies of 63 Chinese uveal melanoma samples and sequenced the entire coding regions of exons 4 and 5 in GNAQ and *** results showed that 33%of Chinese uveal melanoma samples carried Q209 mutations while none had R183 mutation in GNAQ or *** addition,seven novel missense somatic mutations in GNAQ(Y192C,F194l,P170S,D236N,l232F,V230A,and M227I)and four novel missense somatic mutations in GNA11(R166C,I200T,S225F,and V206M)were found in our *** high mutation frequency of Q209 and the novel missense mutations detected in this study suggest that GNAQ and GNA11 are common targets for somatic mutations in Chinese uveal melanoma.

关键词： uveal melanoma GNAQ GNA11 somatic mutations Chinese

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Clinical applications of retinal gene therapies

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Precision Clinical Medicine 2018年第1期1卷 5-20页

作者： Xin Fu Viet Anh Nguyen Huu Yaou Duan Daniel S.Kermany Carolina C.S.Valentim Runze zhang Jie Zhu charlotte l.zhang Xiaodong Sun Kang zhang Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510005China Shiley Eye Institute Institute for Engineering in MedicineInstitute for Genomic MedicineUniversity of CaliforniaSan DiegoLa JollaCalifomia 92093USA Shanghai Key laboratory of Ocular Fundus Diseases Shanghai General HospitalShan ghai Jiaodong UniversityShanghai 200080China Molecular Medicine Research Center West China HospitalSichuan UniversityChengdu 610041China

Retinal degenerative diseases are a major cause of *** gene therapy is a trail-blazer in the human gene therapy field,leading to the frst FDA approved gene therapy product for a human genetic *** application of Clustered Regularly Interspaced Short Palindromic Repeat/Cas9(CRISPR/Cas9)-mediated gene editing technology is transforming the delivery of gene *** review the history,present,and future pro-spects of retinal gene therapy.

关键词： CRISPR/Cas9 therapy diseases

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Bilateral simultaneous primary acute angle-closure glaucoma

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Precision Clinical Medicine 2020年第4期3卷 297-300页

作者： charlotte l.zhang Wico llai Ian Ziyar laurance lai Yuen lau Jie Xu Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China University Hospital and Faculty of Medicine Macao University of Science and TechnologyMacaoChina

Dear Editor,Acute primary angle-closure glaucoma(PACG)is an important cause of blindness in East Asia.1 It is estimated that the overall prevalence of PACG will increase from 1.44%to 2.01%from 2020 to 2050.2 Acute PACG is typically related to increased high intraocular pressure(IOP),with symptoms including red eye,blurred vision,nausea,vomiting,and *** in timely IOPlowering treatment can result in permanent optic nerve damage and vision loss.

关键词： glaucoma acute primary angle closure

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EyeHealer:A large-scale anterior eye segment dataset with eye structure and lesion annotations

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Precision Clinical Medicine 2021年第2期4卷 85-92页

作者： Wenjia Cai Jie Xu Ke Wang Xiaohong liu Wenqin Xu Huimin Cai Yuanxu Gao Yuandong Su Meixia zhang Jie Zhu charlotte l.zhang Edward E.zhang Fangfei Wang Yun Yin Iat Fan lai Guangyu Wang Kang zhang Yingfeng Zheng State Key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Beijing Institute of Ophthalmology Capital Medical UniversityBeijing Tongren HospitalBeijing 100730China Department of Computer Science and Technology&BNRist Tsinghua UniversityBeijing 100084China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and Technology and University HospitalMacao 999078China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China Center for Translational Innovations West China Hospital and Sichuan UniversityChengdu 610041China Bioland laboratory Guangzhou 510005China School of Business Macao University of Science and TechnologyMacao 999078China Ophthalmic Center Kiang Wu HospitalMacaoChina School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Anterior segment eye diseases account for a significant proportion of presentations to eye clinics worldwide,including diseases associated with corneal pathologies,anterior chamber abnormalities(*** or inflammation),and lens *** construction of an automatic tool for segmentation of anterior segment eye lesions would greatly improve the efficiency of clinical *** research on artificial intelligence progressing in recent years,deep learning models have shown their superiority in image classification and *** training and evaluation of deep learning models should be based on a large amount of data annotated with expertise;however,such data are relatively scarce in the domain of ***,the authors developed a new medical image annotation system,called *** is a large-scale anterior eye segment dataset with both eye structures and lesions annotated at the pixel *** experiments were conducted to verify its performance in disease classification and eye lesion *** results showed that semantic segmentation models outperformed medical segmentation *** paper describes the establishment of the system for automated classification and segmentation *** dataset will be made publicly available to encourage future research in this area.

关键词： anterior segment eye diseases artificial intelligence annotation

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui zhang Jianshun zhang Roger Schmidt Jeremy l.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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Experimental clearance rate and intraguild predation of jellyfish Cyanea nozakii

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Journal of Oceanology and limnology 2024年第1期42卷 128-140页

作者： Pengpeng WANG Fang zhang Song SUN Shuguo lÜ CAS Key laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Ecology and Environmental Sciences Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Jiaozhou Bay Marine Ecosystem Research Station Chinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Institute of Marine Ecology and Environment Hainan Academy of Environmental SciencesHaikou 570100China

Cyanea nozakii,a common jellyfish distributed in offshore China,has a complex trophic relationship with other zooplankton ***,few studies have reported the predation rates and prey selection patterns of *** medusae on different prey *** is also lacking on the intraguild predation of Aurelia coerulea(another common bloom jellyfish in offshore China)by *** address the knowledge gaps,the clearance rates of *** for different prey items,including copepods(smalllarge>1000μm),fish larvae,and gelatinous prey(hydromedusae,*** ephyrae,and chaetognaths),were *** influence of predator size on the clearance rate was also ***,we examined the intraguild predation of *** on *** *** clearance rates of *** varied widely with prey organisms,being independent of prey *** organisms,except for chaetognaths,were captured with considerably high efficiency,followed by fish larvae and copepods,indicating the preferential prey selection of gelatinous organisms by *** clearance rate increased linearly with the cross-sectional area of *** size in medusae may,to some extents,underpin their capacity to capture more prey by increasing the encounter rate and capture success through *** preyed voraciously on *** in high feeding efficiency,but the clearance rate decreased with increasing ***(as prey)*** phenomenon of intraguild predation suggests a speculative hypothesis of potential population regulation of *** by *** information regarding the feeding ecology of *** reported in this study is important for understanding plankton dynamics in marine ecosystems with extensive occurrences of this jellyfish.

关键词： Scyphomedusae predation rate gelatinous organisms prey selection feeding mechanism

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The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?

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Engineering 2024年第6期37卷 18-21页

作者： John l.Provis Susan A.Bernal Zuhua zhang Department of Materials Science and Engineering University of SheffieldSheffield S13JDUK Paul Scherrer Institut Villigen PSI 5232Switzerland School of Civil Engineering University of LeedsLeeds LS29JTUK School of Materials Sciences and Engineering Tongji UniversityShanghai 201804China

*** and context Enormous emphasis is currently being paid to the decarbonization of the global built environment as a leading priority for the engineering community and related industrial sectors[1].One of the main contributors to the overall emissions footprint of the built environment-and thus a cornerstone of efforts to achieve decarbonization-is the emissions profile of construction materials during their production and *** cement and concrete sector is the largest-volume contributor to the emissions incurred in meeting the world’s construction material needs and is therefore targeted in the discussion of the deep,rapid decarbonization that must be achieved in order to minimize irreversible damage to the Earth and its ecosystems.

关键词： Alkali corners irreversible

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CRISPR/Cas9-mediated NlInR2 mutants:Analyses of residual mRNA and truncated proteins

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Journal of Integrative Agriculture 2024年第6期23卷 2006-2017页

作者： Jun lü Jingxiang Chen Yutao Hu lin Chen Shihui li Yibing zhang Wenqing zhang State Key laboratory of Biocontrol/School of life Sciences Sun Yat-sen UniversityGuangzhou 510275China Development of Food Science and Engineering Moutai InstituteRenhuai 564507China

CRISPR/Cas9 technology is a powerful genome manipulation tool in ***,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous *** study generated homozygous mutants of the insulin receptor gene 2(NlInR2)in the brown planthopper(Nilaparvata lugens)using CRISPR/Cas9 genome *** frameshift mutants,E5_D17 and E6_I7,differentiated towards long wings,but there were differences in wing morphology,with E5_D17 showing wing *** investigations revealed the presence of residual expression of NlInR2 mRNA in both mutants,as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_***,the E5_D17 exhibited the detection of N-terminally truncated NlInR2 *** interference experiments indicated that the knockdown of NlInR2 expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%,suggesting that the residual NlInR2 mRNA of the E5_D17 mutant might have retained some genetic *** results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation.

关键词： CRISPR/Cas9 Nilaparvata lugens residual mRNA skipping exon truncated protein

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High-efficiency Carbonation Modification Methods of Recycled Coarse Aggregates

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 386-398页

作者：张美香 YANG Xiaolin 丁亚红 SUN Bo zhang Xianggang lÜXiuwen Department of Civil Engineering Henan Polytechnic UniversityJiaozuo 454150China College of Architectural Engineering Xinyu UniversityXinyu 336500China

To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put *** carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were *** with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was *** experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are *** method of carbonation with nano-SiO_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 *** high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable CaCO_(3) and nano-scale silica gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized *** is concluded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.

关键词： recycled coarse aggregate pressurized carbonation high-efficiency carbonation nano-SiO2 strengthening mechanism

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