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World Journal of Orthopedics 2024年第8期15卷 754-763页

作者： Mahad M Hassan Aliya G Feroe Brenton W Douglass Andrew E Jimenez Benjamin Kuhns charles F Mitchell robert L Parisien Daniel A Maranho Eduardo N Novais Young-Jo Kim Ata M Kiapour Department of Orthopedic Surgery University of MinnesotaMinneapolisMN 55454United States Department of Orthopedic Surgery TRIA Orthopaedic CenterBloomingtonMN 55122United States Department of Orthopedic Surgery Boston Children’s HospitalBostonMA 02115United States Department of Orthopedic Surgery Mayo ClinicRochesterMN 55901United States Department of Orthopaedics and Rehabilitation Yale School of MedicineNew HavenCT 06510United States Department of Orthopedic Surgery American Hip Institute Research FoundationDes PlainesIL 60018United States Department of Orthopedic Surgery Mount SinaiNew YorkNY 10029United States Department of Biomechanics Medicineand Rehabilitation of the Locomotor SystemRibeirao Preto Medical SchoolUniversity of São PauloRibeirao Preto 14048-900São PauloBrazil

BACKGROUND The sphericity of the femoral head is a metric used to evaluate hip pathologies and is associated with the development of osteoarthritis and femoral-acetabular *** To analyze the three-dimensional asphericity of the femoral head of asymptomatic pediatric *** hypothesized that femoral head asphericity will vary significantly between male and female pediatric hips and increase with age in both *** Computed tomography scans were obtained on 158 children and adolescents from a single institution in the United States(8-18 years;50%male)without hip *** femoral measurements including the femoral head diameter,femoral head volume,residual volume,asphericity index,and local diameter difference were used to evaluate femoral head *** In both sexes,the residual volume increased by age(P13 years)in females,there were no sex-differences in residual volume and aspherity *** were no age-related changes in mean diameter difference in both sexes(P=0.07)with no significant sex-differences across different age groups(P=0.06).In contrast,there were significant increases in local aspherity(maximum diameter difference)across whole surface of the femoral head and all quadrants except the inferior regions in males(P=0.03).There were no sex-differences in maximum diameter difference at any regions and age group(P>0.05).Increased alpha angle was only correlated to increased mean diameter difference across overall surface of the femoral head(P=0.024).CONCLUSION There is a substantial localized asphericity in asymptomatic hips which increases with age *** 2D measured alpha angle can capture overall asphericity of the femoral head,it may not be sensitive enough to represent regional asphericity patterns.

关键词： Hip Femoral head Sphericity Skeletal growth Sex differences

Creation and validation of a novel low-cost dry lab for early resident training and assessment of robotic prostatectomy technical proficiency

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Current Urology 2024年第2期18卷 133-138页

作者： Kevin Kunitsky Abhishek Venkataramana Katherine E.Fero Jorge Ballon Jacob Komberg robert Reiter Wayne Brisbane Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFLUSA

Purpose:To evaluate the preliminary validity and acceptability of a low-cost low-fidelity robotic surgery dry lab for training and assessing residents’technical proficiency with key robotic radical prostatectomy *** and methods:Three standardized inanimate tasks were created to simulate the radical prostatectomy steps of posterior dissection,neurovascular bundle release,and urethrovesical *** trainees and faculty at a single institution completed and evaluated each dry lab *** validity was evaluated by comparing task completion times and Global Evaluative Assessment of Robotic Skills scores across four participant cohorts:medical students(n=5),junior residents(n=5),senior residents(n=5),and attending surgeons(n=7).Content validity,face validity,and acceptabilitywere evaluated through a posttask survey using a 5-point Likert ***:There was a significant difference in the individual and composite task completion times and Global Evaluative Assessment of Robotic Skills scores across all participant cohorts(all p<0.01).The model was rated favorably in terms of its content validity and acceptability for use in residency ***,model realism,compared with human tissue,was poorly *** dry lab production cost was less than US$***:This low-cost procedure-specific dry lab demonstrated evidence of content validity,construct validity,and acceptability for simulating key robotic prostatectomy technical steps and can be used to augment robot-assisted laparoscopic prostatectomy surgical training.

关键词： Robotic surgery education Radical prostatectomy Simulation Dry laboratory Validation

Treatment of gastric varices with partial splenic embolization in a patient with portal vein thrombosis and a myeloproliferative disorder

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World Journal of Gastroenterology 2014年第39期20卷 14495-14499页

作者： robert Gianotti Hearns charles Kenneth Hymes Hersh Chandarana Samuel Sigal Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 United States New York University School of Medicine New York NY 10022 United States

Therapeutic options for gastric variceal bleeding in the presence of extensive portal vein thrombosis associated with a myeloproliferative disorder are *** report a case of a young woman who presented with gastric variceal bleeding secondary to extensive splanchnic venous thrombosis due to a Janus kinase 2 mutation associated myeloproliferative disorder that was managed effectively with partial splenic embolization.

关键词： Gastric varices Partial splenic embolization Myeloproliferative disorder Janus kinase 2 Portal hypertension Portal vein thrombosis

Detection of respiratory viruses and bacteria in children using a twenty-two target reverse-transcription real-time PCR(RT-qPCR)panel

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世界儿科杂志:英文版 2016年第2期12卷 183-189页

作者： Chelsey Ellis Amita Misir charles Hui Mona Jabbour Nicholas Barrowman JonathanLangill Jennifer Bowes robert Slinger University of Ottawa Children's Hospital of Eastern OntarioChildren's Hospital of Eastern Ontario Research InstituteOttawaONCanada

Background:Rapid detection of the wide range of viruses and bacteria that cause respiratory infection in children is important for patient care and antibiotic *** therefore designed and evaluated a readyto-use 22 target respiratory infection reverse-transcription real-time polymerase chain reaction(RT-qPCR)panel to determine if this would improve detection of these agents at our pediatric ***:RT-qPCR assays for twenty-two target organisms were dried-down in individual wells of 96 well plates and saved at room *** included 18 respiratory viruses and 4 *** automated nucleic acid extraction of nasopharyngeal aspirate(NPA)samples,rapid qPCR was ***-qPCR results were compared with those obtained by the testing methods used at our hospital ***:One hundred fi fty-nine pediatric NPA samples were tested with the RT-qPCR *** or more respiratory pathogens were detected in 132/159(83%)*** was significantly higher than the detection rate of standard methods(94/159,59%)(P<0.001).This difference was mainly due to improved RT-qPCR detection of rhinoviruses,parainfl uenza viruses,bocavirus,and *** panel internal control assay performance remained stable at room temperature storage over a two-month testing ***:The RT-qPCR panel was able to identify pathogens in a high proportion of respiratory *** panel detected more positive specimens than the methods in use at our *** pre-made panel format was easy to use and rapid,with results available in approximately 90 *** now plan to determine if use of this panel improves patient care and antibiotic stewardship.

关键词： bacterial infections pediatric polymerase chain reaction respiratory infectious diseases viral infections

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Multidisciplinary management of Mirizzi syndrome with cholecystobiliary fistula: the value of minimally invasive endoscopic surgery

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 543-547页

作者： Fabien Le Roux charles Sabbagh Brice robert Thierry Yzet Laurent Dugue Jean-Paul Joly Jean-Marc Regimbeau Department of Digestive and Oncological Surgery Amiens University Hospital Jules Verne University of Picardie Department of Interventional and Diagnostic Imaging Amiens University Hospital Jules Verne University of Picardie Department of Digestive Surgery Saint-Camille Hospital Department of Hepatogastroenterology Amiens University Hospital Jules Verne University of Picardie

Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon＇s first task is to perform subtotal cholecystotomy（from the fundus of the gallbladder to the neck） without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place（in case a bile fistula forms）. This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and III is feasible and might help to decrease the postoperative complication rate.

关键词： jaundice Mirizzi syndrome cholecystobiliary fistula endoscopic treatment cholecystectomy T-tube drain

Effect of organic acid on Cd toxicityin tomato and bean growth

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Journal of Environmental Sciences 1995年第4期7卷 399-406页

作者： Xue Dongsen robert B. Harrison charles L. Henry(University of Washington , ARIO Seattle . WA 98195 , USA)

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关键词： admium pollution phytotoxicity oxalic acid tomato: bean.

An enhanced functional ability questionnaire(faVIQ) to measure the impact of rehabilitation services on the visually impaired

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 77-85页

作者： James Stuart Wolffsohn Jonathan Jackson Olivia Anne Hunt charles Cottriall Jennifer Lindsay Richard Gilmour Anne Sinclair robert Harper Aston University Life and Health SciencesOphthalmic Research Group Australian College of Optometry Royal Victoria Hospital Oxford Eye Hospital Royal Victoria Hospital Belfast Altnagelvin Area Hospital Low Vision Clinic Fife Low Vision Centre for the Blind Manchester Royal Eye Hospital and Manchester Academic and Health Science Centre Central Manchester University Hospitals NHS Foundation Trust

AIM: To develop a short,enhanced functional ability Quality of Vision(faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale,items and scoring of the visual related difficulties experienced by patients with visual impairment. · METHODS: Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. ·RESULTS: Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate(r =0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.·CONCLUSION: The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

关键词： quality of life visual impairment low vision functional ability sensitivity specificity

Mochi: Composing Data Services for High-Performance Computing Environments

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Journal of Computer Science & Technology 2020年第1期35卷 121-144页

作者： robert BRoss George Amvrosiadis Philip Carns charles DCranor Matthieu Dorier Kevin Harms Greg Ganger Garth Gibson Samuel KGutierrez robert Latham Bob Robey Dana Robinson Bradley Settlemyer Galen Shipman Shane Snyder Jerome Soumagne Qing Zheng Argonne National Laboratory LemontIL 60439U.S.A Parallel Data Laboratory Carnegie Mellon UniversityPittsburghPA 15213U.S.A Vector Institute for Artificial Intelligence TorontoOntarioCanada Los Alamos National Laboratory Los Alamos NMU.S.A The HDF Group Champaign ILU.S.A

Technology enhancements and the growing breadth of application workflows running on high-performance computing(HPC)platforms drive the development of new data services that provide high performance on these new platforms,provide capable and productive interfaces and abstractions for a variety of applications,and are readily adapted when new technologies are *** Mochi framework enables composition of specialized distributed data services from a collection of connectable modules and *** than forcing all applications to use a one-size-fits-all data staging and I/O software configuration,Mochi allows each application to use a data service specialized to its needs and access *** paper introduces the Mochi framework and *** Mochi core components and microservices are *** of the application of the Mochi methodology to the development of four specialized services are ***,a performance evaluation of a Mochi core component,a Mochi microservice,and a composed service providing an object model is *** paper concludes by positioning Mochi relative to related work in the HPC space and indicating directions for future work.

关键词： storage and I/O data-intensive computing distributed services high-performance computing