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面向家禽兽医的研究生教育和培训——过去、现在和未来

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中国家禽 2007年第18期29卷 27-30页

作者： charles l.Hofacre Trevor J.Bagust 丁加波美国乔治亚大学兽医学院澳大利亚墨尔本大学临床兽医中心　

　　1 家禽兽医研究生教育的过去和现在　　美国乔治亚大学开设的禽类医学硕士学位课程以及墨尔本大学开设的禽类健康学硕士学位课程都采用全日制授课方式,学期一般为12～18个月,毕业无需提交论文.……

关键词：家禽兽医硕士学位课程研究生教育墨尔本大学授课方式禽类全日制乔治亚健康学医学美国论文毕业

"Reactance inversion" at low frequencies in a child undergoing treatment of a cystic fibrosis exacerbation

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Pediatric Investigation 2019年第4期3卷 257-260页

作者： Julian lewis Allen Clement l.Ren Joseph McDonough charles C.Clem Division of Pulmonary Medicine The Children's Hospital of PhiladelphiaPhiladelphiaPAUSA Riley Hospital for Children Indiana University School of MedicineIndianapolisIndianaUSA

Introduction:Impulse oscillometry(IOS)employs high frequency sinusoidal or impulse pressure and flow waveforms to interrogate the mechanical properties of the respiratory *** has special applications to preschool and younger children who may have difficulty performing the repetitive forced expiratory maneuvers required for *** presentation:We present a case illustrating improvements of respiratory system mechanics measured by IOS in a 6-year-old child with cystic fibrosis(CF)who demonstrated clinical and radiological improvement after a course of therapy with hospitalization and intravenous antibiotics,and initiation of a cystic fibrosis transmembrane regulator(CFTR)protein corrector/potentiator *** also report a new finding:observed lower than expected reactance at low compared to high frequencies("reactance inversion").Conclusion:Reactance inversion may reflect parallel pathway inhomogeneities in resistance and elastance or intrabreath airway inertance changes in young children with *** study is needed in children with airway obstruction due to asthma,cystic fibrosis,and chronic lung disease of infancy to demonstrate the prevalence of this finding and whether it is specific to a measurement device.

关键词： Cystic fibrosis Exacerbation Impulse oscillometry Reactance Reactance inversion

Phenol Biodegradation by <i>Corynebacterium glutamicum</i>Encapsulated in Electrospun Fibers

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Journal of Environmental Protection 2012年第2期3卷 164-168页

作者： Alon Nardi Ron Avrahami Eyal Zussman J. Stefan Rokem charles l. Greenblatt The Department of Microbiology and Molecular Genetics (IMRIC) Hebrew University of Jerusalem Jerusalem Israel

In Northern Israel, olive mills discharge liquid waste causing contamination of subterranean aquifers with phenol, rendering them albeit temporarily, unfit for both drinking and irrigation. The impact of groundwater pollution due to phenol spillage can be extensive. We developed a model system for the biodegradation of phenol-contaminated wastewater by the bacterium Corynebacterium glutamicum. Experiments consisting of suspended cultures demonstrated the native ability of this organism to utilize phenol for its metabolic pathways enabling degradation, at levels of nearly 100 ppm within 24 hours. With the use of bioinformatic data, a complete degradation pathway was constructed. Quantitative Real Time PCR analysis of the first two enzymes in this pathway revealed very distinct expression patterns and two different regulation mechanisms were postulated. Additionally, an electrospinning core-shell system was used to assemble electrospun microtubes containing bacteria on porous metallic carriers. We used these carriers as a new immobilization technique and demonstrated their significant phenol degrading capacity in a batch bioreactor configuration. This system demonstrates the feasibility of constructing a water treatment system for the management of phenol-contaminated water.

关键词： Phenol Biodegradation Encapsulated Bacteria Electrospinning Microtubes Phenol 2-Monooxygenase Catechol 1 2-Dioxygenase Olive Mill Waste Treatment Olive Mill Waste OMW

改进的HPlC测定生物样品中环丙沙星浓度的微量分析法(英文)

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中国药理学报 1994年第3期15卷 197-201页

作者：裴元英孟旭 charles H NIGHTINGAlE Visiting scholar from Department of Pharmaceutics Shanghai Medical U niversity Shanghai 200032 China. School of Pharmacy University of Conaecticut Storrs CT 06268 and Hartford Hosp ital Hartford CT 06115 USA

介绍一种测定生物样品中环丙沙星(Cip)的HPlC方法及其应用实例。采用Nucleosil C_(18)为固定相,18:82乙腈一磷酸缓冲液10mmol·l^(-1)(含硫酸四丁基铵5mmol·l^(-1),pH 2.7)为流动相,荧光检测。本法对血清和脑脊液中Cip的最低检测浓度... 详细信息

介绍一种测定生物样品中环丙沙星(Cip)的HPlC方法及其应用实例。采用Nucleosil C_(18)为固定相,18:82乙腈一磷酸缓冲液10mmol·l^(-1)(含硫酸四丁基铵5mmol·l^(-1),pH 2.7)为流动相,荧光检测。本法对血清和脑脊液中Cip的最低检测浓度分别为3 ng·ml^(-1)和5 ng·ml^(-1),具有简便、灵敏、准确且样品需量少(0.1 ml)等优点。

关键词：环丙沙星色谱法药代动力学

From Farming to Engineering： The Microbiota and Allergic Diseases

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Engineering 2017年第1期3卷 98-109页

作者： Dominique Angèle Vuitton Jean-charles Dalphin University Bourgogne Franche-Comte Besancon 25030 France Anergology Network of Franche-Comte Besancon 25030 France

The steady increase of lgE-dependent allergic diseases after the Second World War is a unique phenomenon in the history of humankind. Numerous cross-sectional studies, comprehensive longitudinal cohort studies of children living in various types of environment, and mechanistic experimental studies have pointed to the disappearance of ＂protective factors＂ related to major changes in lifestyle and environment. A common unifying concept is that of the immunoregulatory role of the gut microbiota. This review focuses on the protection against allergic disorders that is provided by the farming environment and by exposure to microbial diversity. It also questions whether and how microbial bioengineering will be able in the future to restore an interplay that was beneficial to the proper immunological development of children in the past and that was irreversibly disrupted by changes in lifestyle. The protective ＂farming environment＂ includes independent and additional influences： contact with animals, stay in barns/stables, and consumption of unprocessed milk and milk products, by mothers during pregnancy and by children in early life. More than the overall quanti- ty of microbes, the biodiversity of the farm microbial environment appears to be crucial for this protection, as does the biodiversity of the gut microbiota that it may provide. Use of conventional probiotics, especially various species or strains of lactobacillus and Bifidobacterium, has not fulfilled the expectations of allergists and pediatricians to prevent allergy. Among the specific organisms present in cowsheds that could be used for prevention, Acinetobacter （A.） lwoffii F78, lactococcus （ l.） lactis G121, and Staphylococcus （S.） sciuri W620 seem to be the most promising, based on experimental studies in mouse models of allergic respiratory diseases. However, the development of a new generation of probiotics based on very productive research on the farming environment faces several obstacles that cannot b

关键词： Allergy Farming Microbial biodiversity Immune regulation Microbiota Translational research

Customized Online Aggregation &Summarization Tool for Environmental Rasters (COASTER)

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Journal of Geographic Information System 2012年第6期4卷 530-541页

作者： Daniel J. Weiss Katie Gibson charles Sojka Jennifer W. Sheldon Robert l. Crabtree Yellowstone Ecological Research Center Bozeman USA

The Customized Online Aggregation & Summarization Tool for Environmental Rasters (COASTER) system (***) was developed by Yellowstone Ecological Research Center (YERC) (***) in response to the information needs of end-user communities interested in decision-support for natural resource management. The purpose of COASTER is to greatly simplify the process of creating predictor datasets for research exploring environmental impacts driven by climate change, land-use activities, disturbance, and invasive spread. COASTER achieves this goal by providing users with a web-based system for processing environmental (gridded, raster) datasets, using a set of standardized functions, to create output customized to meet their analytical needs. In doing so, COASTER effectively translates large and cumbersome datasets into user-specified information useful for parameterizing statistical models and for visualizing spatial and temporal patterns within environmental datasets. The COASTER system currently contains over 10 terabytes of climate data from several sources. These datasets have daily temporal resolutions, spatial resolutions ranging from 1km to 330km, and temporal extents ranging from 30 to 64 years (1948-2011). COASTER datasets are primarily limited to North America, but gridded datasets from other regions can easily be added to the system. Variables within the climatic datasets available on COASTER include metrics quantifying temperature, precipitation, shortwave radiation, vapor pressure deficit, humidity, and wind conditions. Notable features of COASTER include a conceptually simple yet flexible set of functions capable of producing a wide range of outputs, a design applicable to many types of raster datasets, and results formatted for seamless integration within most GIS and remote sensing software packages.

关键词： Geographic Information Retrieval Online Application Remote Geographic Data Processing

Ion mobility spectrometry-mass spectrometry : theory and applications

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Ion mobility spectrometry-mass spectrometry : theory and app...

From azoospermia to macrozoospermia,a phenotypic continuum due to mutations in the ZMYND15 gene

1000年

作者： edited by charles l. Wilkins Sarah Trimpin.

来源：畅想之星图书光盘版（南... 评论

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Asian Journal of Andrology 2022年第3期24卷 243-247页

作者： Zine-Eddine Kherraf Caroline Cazin Florence lestrade Jana Muronova charles Coutton Christophe Arnoult Nicolas Thierry-Mieg Pierre F Ray Univ.Grenoble Alpes INSERM U1209CNRS UMR 5309Institute for Advanced BiosciencesTeam Genetics Epigenetics and Therapies of InfertilityGrenoble 38000France CHU Grenoble Alpes UM GI-DPIGrenoble 38000France CHR Metz Thionville Hospital 1 allée ChâteauMETZ 57000France CHU Grenoble Alpes UM of Chromosomic GeneticsGrenoble 38000France Univ.Grenoble Alpes CNRSTIMC-IMAGGrenoble F-38000France

Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing(WES),many genes have now been linked to severe sperm defects.A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C(AURKC)***,we studied a subject with a severe oligozoospermia and a phenotypic diagnosis of *** analysis did not reveal any deleterious *** was then initiated which permitted to identify a homozygous loss of function variant in the zinc finger MYND-type containing 15(ZMYND15)***15 has been described to serve as a switch for haploid gene expression,and mice devoid of ZMYND15 were shown to be sterile due to nonobstructive azoospermia(NOA).In man,ZMYND15 has been associated with NOA and severe *** confirm here that the presence of a bi-allelic ZMYND15 variant induces a severe *** addition,we show that severe oligozoospermia can be associated macrozoospermia,and that a phenotypic misdiagnosis is possible,potentially delaying the genetic *** conclusion,genetic defects in ZMYND15 can induce complete NOA or severe oligozoospermia associated with a very severe *** our experience,severe oligozoospermia is often associated with severe teratozoospermia and can sometimes be misinterpreted as macrozoospermia or *** these instances,specific AURKC or dpy-19 like 2(DPY19l2)diagnosis is usually negative and we recommend the direct use of a pan-genomic techniques such as WES.

关键词： azoospermia gene defect macrozoospermia male infertility

Image Analysis of the Sugar-reduced Muffin Formulated with Stevianna or Inulin as a Sugar Replacer

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Grain & Oil Science and Technology 2018年第2期1卷 63-71页

作者： GAO Jingrong HAN Fezhong GUO Xinbo ZENG Xi'an MASON Susan l BRENNAN Margaret A BRENNAN charles S Department of Wine Food and Molecular Biosciences Lincoln University Riddet Institute College of light Industry and Food Science South China University of Technology

Sugar replacement, and/or reduction, in cereal products is important in relation to consumer appeal for nutritionally balanced, calorie reduced, products. However, when using sugar replacers, product structure can be negatively altered. The effect on air cell development and microstructure with the use of Stevianna, or inulin, as sugar replacer was evaluated using muffins as a model food. The total replacement of sugar using Stevianna or inulin resulted in the development of non-uniform air cells leading to poor muffin microstructure. However, formulations involving partial sugar replacers gave similar air cell characteristics and hence microstructural characteristics, to that of the control sample. The results indicated that sugar is an important factor for the development of muffin microstructure and is difficult to replace completely.

关键词： Stevianna Inulin Muffin microstructure Air cell Scanning electron microscopy