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From azoospermia to macrozoospermia,a phenotypic continuum due to mutations in the ZMYND15 gene

Asian Journal of Andrology 2022年第3期24卷 243-247页

作者： Zine-Eddine Kherraf Caroline Cazin Florence Lestrade Jana Muronova charles coutton Christophe Arnoult Nicolas Thierry-Mieg Pierre F Ray Univ.Grenoble Alpes INSERM U1209CNRS UMR 5309Institute for Advanced BiosciencesTeam Genetics Epigenetics and Therapies of InfertilityGrenoble 38000France CHU Grenoble Alpes UM GI-DPIGrenoble 38000France CHR Metz Thionville Hospital 1 allée ChâteauMETZ 57000France CHU Grenoble Alpes UM of Chromosomic GeneticsGrenoble 38000France Univ.Grenoble Alpes CNRSTIMC-IMAGGrenoble F-38000France

Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing(WES),many genes have now been linked to severe sperm defects.A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C(AURKC)***,we studied a subject with a severe oligozoospermia and a phenotypic diagnosis of *** analysis did not reveal any deleterious *** was then initiated which permitted to identify a homozygous loss of function variant in the zinc finger MYND-type containing 15(ZMYND15)***15 has been described to serve as a switch for haploid gene expression,and mice devoid of ZMYND15 were shown to be sterile due to nonobstructive azoospermia(NOA).In man,ZMYND15 has been associated with NOA and severe *** confirm here that the presence of a bi-allelic ZMYND15 variant induces a severe *** addition,we show that severe oligozoospermia can be associated macrozoospermia,and that a phenotypic misdiagnosis is possible,potentially delaying the genetic *** conclusion,genetic defects in ZMYND15 can induce complete NOA or severe oligozoospermia associated with a very severe *** our experience,severe oligozoospermia is often associated with severe teratozoospermia and can sometimes be misinterpreted as macrozoospermia or *** these instances,specific AURKC or dpy-19 like 2(DPY19L2)diagnosis is usually negative and we recommend the direct use of a pan-genomic techniques such as WES.

关键词： azoospermia gene defect macrozoospermia male infertility

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Commentary on ＂morphological characteristics and initial genetic study of multiple morphological anomalies of the flagella in China＂

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Asian Journal of Andrology 2016年第5期18卷 812-812页

作者： charles coutton Christophe Arnoult Pierre F Ray Universite Grenoble Alpes Grenoble F-38000 France Equipe 'Genetics Epigenetics and Therapies of Infertility' Institut Albert Bonniot INSERM U823 La Tronche F-38706 France Departement de Genetique et Procreation Hopital Couple Enfant CHU Grenoble Grenoble F-38000 France Laboratoire de Biochimie Genetique et Moleculaire CHU Grenoble Grenoble F-38000 France.

Dear Editor, We have read with a great interest, the excellent article by Yang et al.1 which, for the first time, fully describes the structural and ultrastructural defects of spermatozoa with multiple morphological anomalies of the flagella （MMAF） in Chinese patients. This study revealed in these patient＇s spermatozoa, a completely disorganized axoneme and, in particular, the displacement or absence of the central pair （CP） in most of the cross sections were analyzed.

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Recent development and challenges in enhancing fire performance on wood and wood-based composites:A 10-year review from 2012 to 2021

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Journal of Bioresources and Bioproducts 2024年第1期9卷 27-42页

作者： charles Michael Albert Kang Chiang Liew Faculty of Tropical Forestry Universiti Malaysia SabahKota Kinabalu 88400Kota KinabaluSabah 88400Malaysia

Due to their durability,versatility,and aesthetic value,wood and wood-based composites are widely used as building *** fact that these materials are flammable,however,raises a major worry since they might cause fire hazards and significant loss of life and *** article investigates the variables that affect fire performance as well as the various fire-retardant treatments and their *** current developments and challenges in improving the fire performance of wood and wood-based composites treated with fire-retardant materials are summarized in this ***,organic chemicals,and densification are some recent developments in fire-retardant treatments that are also *** points from the review are summarized,along with potential areas for further research and development.

关键词： Fire performance Fire-retardant materials Wood Wood-based composite Nanoparticles coating Surface charring Bio-based fire retardant Densification

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Historic,pre-stock enhancement,demographic conditions of exploited populations of dusky flathead,Platycephalus fuscus,in eastern Australia

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Aquaculture and Fisheries 2024年第2期9卷 314-323页

作者： charles A.Gray WildFish Research Grays PointSydney2232Australia

Responsible stock enhancement initiatives require baseline data of wild population demographic conditions that can be used in testing management *** study provides the first fishery-independent assessment of length-and age-based biological characteristics of exploited populations of Platycephalus fuscus in eastern Australia prior to stock *** was conducted over seven estuaries spanning seven degrees of latitude and the geographical range of proposed stock *** in all estuaries showed evidence of length and age truncation,especially those subject to commercial fisheries where young individuals of both sexes dominated *** longevities were 12 and 11 years for females and males respectively,but few females>5 years and males>3 years were generally *** dominated populations,and on average,the mean lengths and ages of females were greater than males within each estuary and across all age *** dimorphic variation in growth was evident across all estuaries,with females attaining greater maximum lengths than ***-specific differences in individual growth were not *** average,over 50%of females sampled in each estuary were>the minimum legal length(MLL),but the opposite was evident for *** contrast,over 25%of males in each estuary were>the mean length at maturity(L50),whereas in all but one estuarythe *** male and female *** should recruit to the fishery in 2 and 3 years,and contribute to the spawning stock in 1.5 and 4.5 years,*** study provides important historical baseline data that can contribute to testing stock enhancement outcomes on populations.

关键词： Baseline data Fishery enhancement Management evaluation Platycephalidae Recreational fishing Restocking Stock assessment

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： charles H.Nelson Udai B.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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NRF2 signaling cascade in amyotrophic lateral sclerosis:bridging the gap between promise and reality

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Neural Regeneration Research 2024年第5期19卷 1006-1012页

作者： Pauline Tarot Christelle Lasbleiz Jean-charles Liévens MMDN Univ MontpellierEPHEINSERMMontpellierFrance CNRS ParisFranceEPHEINSERMMontpellierFrance

Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor *** include muscle weakness and atrophy,spasticity,and progressive ***,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral *** only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial *** difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis *** mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious *** the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and *** here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis C9orf72 NRF2 oxidative defense oxidative stress sulforaphane superoxide dismutase 1 TDP43

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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika Fujii charles F.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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Metabolic reprogramming of the inflammatory response in the nervous system:the crossover between inflammation and metabolism

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Neural Regeneration Research 2024年第10期19卷 2189-2201页

作者： Jesus Amo-Aparicio charles A.Dinarello Ruben Lopez-Vales Department of Medicine University of ColoradoAuroraCOUSA Institute of Neurosciences and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud Carlos ⅢSpain

Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism) or used to build macromolecules(anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions. Metabolic processes such as glycolysis, oxidative phosphorylation, and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response, facilitating the energetic and biosynthetic demands. This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation, with a special focus on central nervous system disorders. Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.

关键词： central nervous system fatty acid oxidation glycolysis inflammation macrophage metabolism microglia neurodegeneration oxidative phosphorylation

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New evidence for the epigenetic regulation of skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao charles K.F.Chan Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

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光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素

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Asian Journal of Andrology 2015年第1期17卷 68-73,I0008页

作者： Leyla Ounis Abdelali Zoghmar charles coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray Laboratoire de Biologie Moleculaire et Cellulaire Faculte des Sciences de la Nature et de la Vie Universite Constantine I Algerie Clinique Ibn Rochd Centre de Medecine de la Reproduction Constantine Algerie Universite Grenoble Alpes Grenoble France Equipe Genetique Epigenetique et Therapies de I'lnfertilitE CNRS AGIM Grenoble France Laboratoire de GEnetique Chromosomique CHU Grenoble Grenoble France Laboratoire de Biochimie et Genetique Moleculaire CHU Grenoble Grenoble France Equipe Muscle et Pathologies INSERM U836 Grenoble Institut des Neurosciences Grenoble France.

Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C （AURKCj and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. We carried out genetic analyses on Algerian patients, to evaluate the prevalence of these syndromes in this population and to compare it with the expected frequency of Klinefelter syndrome and Y-microdeletions. We carried out a retrospective study on 599 consecutive patients consulting for couple infertility at the assisted reproduction unit of the Ibn Rochd Clinique, Constantine, Algeria. Abnormal sperm parameters were observed in 404 men. Fourteen and seven men had typical macrozoospermia and globozoospermia profiles, respectively. Molecular diagnosis was carried out for these patients, for the AURKC and DPY19L2 genes. Eleven men with macrozoospermia had a homozygous AURKC mutation （79%）, corresponding to 2.7% of all patients with abnormal spermograms. All the men with globozoospermia studied （n = 5）, corresponding to 1.2% of all infertile men, presented a homozygous DPY19L2deletion. By comparison, we would expect 1.6% of the patients in this cohort to have Klinefelter syndrome and 0.23% to have Y-microdeletion. Our findings thus indicate that AURKCmutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. Furthermore, we estimate that AURKCand DPY19L2 molecular defects are 10 and 5 times more frequent, respectively, than Y-microdeletions.

关键词： aurora kinase C DPY19L2 globozoospermia intracytoplasmic sperm injection infertility macrozoospermia

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