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多孔材料与声腔、钣金耦合的研究及建模方法标定

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汽车工程学报 2024年第1期14卷 144-153页

作者：张荣荣 charles zhang 洪卫芳李永超比亚迪汽车工业有限公司广东深圳518000

为突破汽车NVH仿真中NTF仿真精度难题,设计制作了“刚性壁乘员舱”,把“声腔模态”与“容器”的耦合效应降到可以忽略。基于此刚性壁乘员舱,分析了子声腔对整体声腔模态的影响,讨论了多孔材料的建模方法,建立了座椅和地毯等多孔材料模型... 详细信息

为突破汽车NVH仿真中NTF仿真精度难题,设计制作了“刚性壁乘员舱”,把“声腔模态”与“容器”的耦合效应降到可以忽略。基于此刚性壁乘员舱,分析了子声腔对整体声腔模态的影响,讨论了多孔材料的建模方法,建立了座椅和地毯等多孔材料模型,量化分析了前围隔声材料对钣金振动与声腔模态耦合的影响。仿真和试验对标的结果表明,空腔模态、空气传递声传递函数、结构传递振动传递函数和声传递函数均获得较好的仿真精度,为整车低频路噪和发动机噪声控制提供了参考。

关键词：声腔模态多孔吸声材料空气传递噪声结构传递噪声有限元建模试验仿真对标

Debugging Concurrent Software： Advances and Challenges

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Journal of Computer Science & Technology 2016年第5期31卷 861-868页

作者： Jeff Huang charles zhang Department of Computer Science and Engineering Texas A&M University College Station TX 77843 U.S.A. Department of Computer Science and Engineering Hong Kong University of Science and Technology Hong Kong China

Concurrency debugging is an extremely important yet challenging problem that has been hampering developer productivity and software reliability in the multicore era. We have worked on this problem in the past eight years and have developed several effective methods and automated tools for helping developers debugging shared memory concurrent programs. This article discusses challenges in concurrency debugging and summarizes our research contributions in four important directions： concurrency bug reproduction, detection, understanding, and fixing. It also discusses other recent advances in tackling these challenges.

关键词： debugging concurrency record and replay

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基于某纯电动车的低频制动噪声优化研究

汽车工程 2021年第9期43卷 1411-1417页

作者：祝丹晖杨乐 charles zhang 比亚迪汽车工业有限公司深圳518118

由于纯电动车加速快、质量大、制动力要求高和制动散热量需求大等特征的综合作用,使常用的通风盘式制动系统产生一种从高速到低速均能被清晰感知的低频噪声,显著影响车内乘客舒适度。本文中针对这类制动噪声进行了整车和系统级分析,提... 详细信息

由于纯电动车加速快、质量大、制动力要求高和制动散热量需求大等特征的综合作用,使常用的通风盘式制动系统产生一种从高速到低速均能被清晰感知的低频噪声,显著影响车内乘客舒适度。本文中针对这类制动噪声进行了整车和系统级分析,提出了通风盘位移波动量是引起通风盘表面振动并导致车内噪声的机理假设,利用数值模拟方法验证了假设的正确性;并对影响通风盘位移波动量的关键参数进行了研究,结果显示散热筋跨距是其核心优化参数,文中还给出了位移波动量的经验值;据此提出了综合优化方案,将方案进行了仿真、整车样件试验和主观评价三重验证。结果表明,优化样件可完全解决此类制动噪声问题,同时也论证了关键设计参数的有效性,为各类型电动车的通风盘设计及其多参数优化奠定了基础。

关键词：电动汽车 NVH 制动噪声盘式制动器通风盘

Three-dimensional numerical analysis of plant-soil hydraulic interactions on pore water pressure of vegetated slope under different rainfall patterns

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3696-3706页

作者： Haowen Guo charles Wang Wai Ng Qi zhang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall ***,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further *** address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding *** series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall *** rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the *** computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return *** extreme rainfalls with advanced(PA),bimodal(PB)and uniform(PU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(PD)and uniform(PU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).For the long duration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and slope stability may not be sufficient.

关键词： Root-soil interactions Rainfall patterns Slope stability Three-dimensional(3D)

Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine

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Chinese Chemical Letters 2024年第10期35卷 165-172页

作者： Jing zhang charles Wang Yaoyao zhang Haining Xia Yujuan Wang Kun Ma Junfeng Wang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefei Institutes of Physical Science Chinese Academy of Sciences University of Science and Technology of China University of California San Diego International Magnetobiology Frontier Research Center

For a significant duration, enhancing the efficacy of cancer therapy has remained a critical concern. Magnetotactic bacteria(MTB), often likened to micro-robots, hold substantial promise as a drug delivery system. MTB, classified as anaerobic, aquatic, and gram-negative microorganisms, exhibit remarkable motility and precise control over their internal biomineralization processes. This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion, enclosed within a membrane. These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments. By harnessing these biochemical attributes, MTB could potentially offer substantial advantages in the realm of cancer therapy. This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties. The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.

关键词： Bioconjugation Drug delivery Engineering microrobot Magnetotactic bacteria Tumor treatment

Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy

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Acta Pharmaceutica Sinica B 2019年第2期9卷 381-396页

作者： Xiuxiu Jiao Yuan Yu Jianxia Meng Mei He charles Jian zhang Wenqian Geng Baoyue Ding Zhuo Wang Xueying Ding Department of Pharmaceutics Shanghai General Hospital Shanghai Jiao Tong University of Medicine Department of Pharmaceutical Sciences School of Pharmacy Second Military Medical University Department of Pharmacy Changhai Hospital Second Military Medical University Department of Pharmaceutical Sciences College of Pharmacy Western University of Health Sciences Department of Pharmaceutics College of Medicine Jiaxing University

Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy(RT). However, there is no effective drug delivery system to effectively overcome the blood–brain barrier(BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles(ch-Kn(s-s)R8-An) to deliver Dbait into glioma for RT. Angiopep-2 can target the low-density lipoprotein receptor-related protein-1(LRP1) that is overexpressed on brain capillary endothelial cells(BCECs) and glioma cells. In particular, due to upregulated matrix metalloproteinase 2(MMP-2) in the tumor microenvironment, we utilized MMP-2-responsive peptides as the enzymatically degradable linkers to conjugate angiopep-2. The results showed that ch-Kn(s-s)R8-An micelles maintained a reasonable size(80–160 nm) with a moderate distribution and a decreased mean diameter from the cross-linking as well as exhibited low critical micelle concentration(CMC) with positive surface charge, ranging from 15 to40 mV. The ch-K5(s-s)R8-An/pEGFP showed high gene transfection efficiency in vitro, improved uptake in glioma cells and good biocompatibility in vitro and in vivo. In addition, the combination of ch-K5(s-s)R8-An/Dbait with RT significantly inhibited the growth of U251 cells in vitro. Thus, ch-K5(s-s)R8-An/Dbait may prove to be a promising gene delivery system to target glioma and enhance the efficacy of RT on U251 cells.

关键词： Glioma-targeting Cell-penetrating peptides Microenvironment-responsive micelles Gene delivery Radiosensitizer

Modelling the water diversion of a sustainable cover system under humid climates

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2429-2440页

作者： Haowen Guo charles Wang Wai Ng Qi zhang Chuanxiang Qu Liwen Hu Shenzhen Research Institute of Hong Kong University of Science and Technology Shenzhen518057China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong SAR999077China CCCC Fourth Harbor Engineering Institute Co. LtdGuangzhou510230China

Extreme rainfall significantly threatens the safety of the landfill cover system,especially under humid *** study aims to provide design recommendations for a sustainable landfill cover system consisting of a low-permeability soil layer underlying a two-layer capillary barrier for humid ***,the numerical back-analysis was conducted for verification against a series of flume model ***,a parametric study was performed to investigate the effects of inclination angle,particle size and layer thickness on the lateral diversion length(DL)of the three-layer cover system under the 100-year return period rainfall of humid *** results show that the water lateral DL of the cover system can be greatly enhanced by increasing the inclination angle from 3°to 18°.Moreover,the bottom layer of the cover system with a coarser d10 was more susceptible to the impact of the heavy rainfall,while this can be alleviated by increasing the thickness of the bottom layer.A dimensionless number,defined as the ratio of thickness and d_(10) of the bottom layer,is proposed for designing lateral diversion of the three-layer cover system under humid *** preserve the maximum DL,it is suggested that the proposed dimensionless number should be larger than 95 and 110 for the design of rainfall events with 50-year and 100-year return periods for humid climates,respectively.

关键词： Unsaturated soil Recycling Construction waste Three-layer landfill cover Water infiltration

Three-year field study on grass growth and soil hydrological properties in biochar-amended soil

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2764-2774页

作者： Haowen Guo charles Wang Wai Ng Junjun Ni Qi zhang Yuchen Wang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina School of Transportation Southeast UniversityNanjingChina

Field monitoring was conducted to investigate and quantify the long-term effects of peanut shell biochar on soil-grass interaction over three *** 10 m5 m grassed plots were constructed in completely decomposed granitic *** of them were amended,respectively,with 5%and 10%biochar contents(m^(3)/m^(3))for grass growth,while the third was without biochar *** the threeyear monitoring,plant characteristics,saturated water permeability(k_(s))of grassed soil and soil suction were *** monitored results show that the grass leaf area index(LAI)and root length density(RLD)with biochar amendment were improved by 38%and 200%,*** the grassed plot without biochar,a threshold RLD existed with a value of 1.7 cm/cm^(3),beyond which k_(s) raised *** threshold RLD increased by 52%when biochar content increased from 0%to 10%.This implies that biochar may restrict the increase in k_(s) of grassed soil due to the rise in the threshold *** presence of biochar and grass can retain over 100%higher suction after heavy rainfalls,while 54%lower peak suction under evapotranspiration(ET)compared with the non-amended *** can alleviate the negative effects on hydraulic properties caused by plant growth and reduce ET-induced excessive water loss.A 5%peanut shell biochar content is recommended for the long-term management of vegetated earthen infrastructures.

关键词： Soil-grass interaction Biochar Long-term Water infiltration Soil drying

The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite

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Advances in Atmospheric Sciences 2024年第3期41卷 379-390页

作者： Minqiang ZHOU Zhili DENG charles ROBERT Xingying zhang Lu zhang Yapeng WANG Chengli QI Pucai WANG Martine De MAZIÈRE Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Royal Belgian Institute for Space Aeronomy(BIRA-IASB) Brussels 1180Belgium National Satellite Meteorology Center China Meteorological AdministrationBeijing 100081China Department of Science&Technology and Climate Change China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed.

关键词： ammonia HIRAS/FY-3D satellite thermal-infrared observation remote sensing optimal estimation method