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The Crop Journal 2018年第5期6卷 516-526页

作者： Jing Li yueyi Tang Alana L.Jacobson Phat M.Dang Xiao Li Ming Li Wang Austin Hagan charles y.chen Department of Crop Soil and Environmental SciencesAuburn UniversityAuburnAL 36849USA Shandong Peanut Research Institute Qingdao 266100China Department of Entomology and Plant Pathology Auburn UniversityAuburnAL 36849USA USDA-ARS National Peanut Research Laboratory DawsonGA 39842USA USDA-ARS Plant Genetic Resources Conservation Unit GriffinGA 30223USA

Tomato spotted wilt(TSW)is a serious virus disease of peanut in the United *** for TSWV resistance would be facilitated by the implementation of marker-assisted selection in breeding programs;however,genes associated with resistance have not been *** mapping is a type of genetic mapping that can exploit relationships between markers and traits in many *** objectives of this study were to examine genetic diversity and population structure in the *** mini-core collection using simple sequence repeat(SSR)markers,and to conduct association mapping between SSR markers and TSWV resistance in cultivated *** hundred and thirty-three SSR markers were used for genotyping 104 *** subpopulations,generally corresponding to botanical varieties,were classified by population structure *** mapping analysis indicated that five markers:pP GPseq5D5,GM1135,GM1991,TC23C08,and TC24C06,were consistently associated with TSW resistance by the Q,PCA,Q+K,and PCA+K *** markers together explained 36.4%of the phenotypic ***,pP GPseq5D5 and GM1991 were associated with both visual symptoms of TSWV and ELISA values with a high R^*** potential of these markers for use in a marker-assisted selection program to breed peanut for resistance to TSWV is discussed.

关键词： Association mapping SSR markers Tomato spotted wilt virus Peanuts

花生荚果与种子相关性状QTL定位及与环境互作分析

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美国花生微核心种质资源纯化系的引进与表型评价

作物学报 2021年第10期47卷 1874-1890页

作者：孟鑫浩张靖男崔顺立 charles y.chen 穆国俊侯名语杨鑫雷刘立峰华北作物改良与调控国家重点实验室 / 河北省种质资源重点实验室 / 河北农业大学河北保定 071001 奥本大学作物、土壤与环境科学系美国奥本 36849

花生荚果、种子性状与产量紧密相关,是重要的农艺性状.为挖掘与荚果、种子性状紧密连锁的分子标记,本研究以大果品种冀花5号和小果美国资源M130组配衍生的315个家系RIL8群体为材料,利用SSR、AhTE、SRAP和TRAP等标记构建了一张包含363个... 详细信息

花生荚果、种子性状与产量紧密相关,是重要的农艺性状.为挖掘与荚果、种子性状紧密连锁的分子标记,本研究以大果品种冀花5号和小果美国资源M130组配衍生的315个家系RIL8群体为材料,利用SSR、AhTE、SRAP和TRAP等标记构建了一张包含363个多态性位点的遗传连锁图谱.该图谱共包含21个连锁群,总长为1360.38 cM,标记间平均距离为3.75 cM.利用完备区间作图法对2017—2018年5个环境的荚果、种子相关性状进行数量性状基因座(quantitative trait locus,QTL)分析,共鉴定到97个与荚果、种子性状相关的QTL,可解释的表型变异为2.36％～12.15％,分布在A02、A05、A08、A09、B02、B03、B04、B08和B09等9条染色体上.其中,9个与荚果长相关,13个与荚果宽相关,14个与荚果厚相关,11个与种子长相关,14个与种子宽相关,13个与种子厚相关,13个与百果重相关,10个与百仁重相关;4个主效QTL分别为qPWA08.1、qPTA08.3、qPTA08.4和qSWB08.5,可解释的表型变异分别为10.02％、11.06％、12.15％和11.97％;45个稳定表达的QTL在3个以上环境可被重复检测;连锁群A02、A08、B02、B04和B08上存在QTL聚集区.另外,检测到15对上位性QTL,可解释的表型变异为10.23％～51.84％.研究结果将为花生荚果、种子性状的分子标记辅助育种提供重要的理论依据.

关键词：花生荚果种子 QTL QTL×E

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植物遗传资源学报 2017年第3期18卷 381-389页

作者：崔顺立孟硕何美敬杨鑫雷侯名语穆国俊 charles y.chen 刘立峰教育部华北作物种质资源实验室/河北省作物种质资源重点实验室/河北农业大学保定071001 Department of Crop Soil and Environmental SciencesAuburn University

花生种质资源是花生新品种选育和重要农艺性状遗传研究的基础材料。引进国外优异花生种质资源,并对其进行鉴定和评价对发掘优良花生种质、丰富我国花生资源遗传多样性以及合理利用种质资源进行遗传改良具有重要意义。本研究于2014-2015... 详细信息

花生种质资源是花生新品种选育和重要农艺性状遗传研究的基础材料。引进国外优异花生种质资源,并对其进行鉴定和评价对发掘优良花生种质、丰富我国花生资源遗传多样性以及合理利用种质资源进行遗传改良具有重要意义。本研究于2014-2015年连续2年在河北保定对104份引进的美国花生微核心种质资源纯化系进行了农艺性状考察和抗病性鉴定。鉴定结果表明,美国微核心种质纯化系多为匍匐型,主茎高变异范围为24.50~89.50 cm,侧枝长为39.37~99.23 cm,单株果数和单株果重分别为8.75~46.33个和8.49~29.54 g,百果重为80.76~216.72 g,单株粒数为18.25~58.00个,单株粒重为9.89~33.36 g,百仁重为25.52~74.18 g,出仁率为52.58%~76.08%。抗病性鉴定表明,部分美国微核心种质资源纯化系高抗褐斑病和网斑病,性状优良。该研究结果为花生新品种选育与遗传研究提供了优异材料和参考信息。

关键词：花生微核心种质农艺性状抗病性

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花生种质资源果腐病的抗性评价

植物遗传资源学报 2018年第4期19卷 780-789页

作者：何美敬刘阳杰崔顺立杨鑫雷穆国俊 charles y.chen 郭巍刘立峰河北农业大学保定071001 Auburn University AuburnAL 36849USA 北京农学院北京102206

花生果腐病是一种由真菌引起的世界性的严重病害,直接影响花生的产量及品质。通过田间自然发病对引进的77份美国资源和39份国内资源进行连续2年的鉴定,筛选抗果腐病的花生种质资源,为花生抗果腐病育种提供优异材料。结果表明:供试花生... 详细信息

花生果腐病是一种由真菌引起的世界性的严重病害,直接影响花生的产量及品质。通过田间自然发病对引进的77份美国资源和39份国内资源进行连续2年的鉴定,筛选抗果腐病的花生种质资源,为花生抗果腐病育种提供优异材料。结果表明:供试花生材料间的受害指数差异极显著(P<0.01),两年间的差异也达到显著水平(P<0.05)。根据受害指数的聚类分析将供试花生材料的果腐病抗性分为高抗、抗、中抗、感病和高感病5组,该结果作为花生果腐病抗性评价标准,能够明确评价供试花生材料对果腐病的抗性。综合两年抗性表现较一致的96份种质,筛选到高抗材料2份,平均受害指数分别为16.67和21.91;抗性材料6份,平均受害指数分布在26.33~42.41之间;中抗材料32份,平均受害指数在45.19~60之间;感病材料34份,平均受害指数在60.87~74.39之间;高感材料22份,平均受害指数在75.27~83.34之间。该结果为评价花生果腐病抗性和合理利用种质资源进行花生抗病品种遗传改良提供了参考和优异材料。

关键词：花生种质资源果腐病鉴定

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar Rana Hum Kala Rana Jacob BLandis Tianhui Kuang Juntong chen Hengchang Wang Tao Deng charles C.Davis Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest China comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

A machine learning-based calibration method for strength simulation of self-piercing riveted joints

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Advances in Manufacturing 2024年第3期12卷 465-483页

作者： yu-Xiang Ji Li Huang Qiu-Ren chen charles K.S.Moy Jing-yi Zhang Xiao-ya Hu Jian Wang Guo-Bi Tan Qing Liu Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Design School Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuPeople’s Republic of China Materials Bigdata and Applications Division Materials Academy JitriSuzhou215131JiangsuPeople’s Republic of China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

This paper presents a new machine learning-based calibration framework for strength simulation models of self-piercing riveted(SPR)*** simulations were conducted through the integrated modeling of SPR joints from process to performance,while physical quasi-static tensile tests were performed on combinations of DP600 high-strength steel and 5754 aluminum alloy sheets under lap-shear loading conditions.A sensitivity study of the critical simulation parameters(e.g.,friction coefficient and scaling factor)was conducted using the controlled variables method and Sobol sensitivity analysis for feature ***,machine-learning-based surrogate models were used to train and accurately represent the mapping between the detailed joint profile and its load-displacement *** of the simulation model is defined as a dual-objective optimization task to minimize errors in key load displacement features between simulations and experiments.A multi-objective genetic algorithm(MOGA)was chosen for *** three combinations of SPR joints illustrated the effectiveness of the proposed framework,and good agreement was achieved between the calibrated models and experiments.

关键词： Machine learning Self-piercing riveting(SPR) Sensitivity analysis Multi-objective optimization

Nanotechnology-based delivery systems to overcome drug resistance in cancer

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Medical Review 2024年第1期4卷 5-30页

作者： Harsh Patel Jiaxin Li Letao Bo Riddhi Mehta charles R.Ashby Shanzhi Wang Wei Cai Zhe-Sheng chen College of Pharmacy and Health Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineHuaihuaHunan ProvinceChina St.John’s College of Liberal Arts and Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineNo.492 Jinxi South RoadHuaihua41800Hunan ProvinceChina College of Pharmacy and Health Sciences St.John’s UniversityNo.8000 Utopia ParkwayQueensNew YorkNY 11439USA

Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional *** resistance(MDR)in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic *** have been successes in the development of cancer nanomedicine to overcome MDR;however,relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of *** is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer ***,we discuss the advances,types of nanomedicines,and the challenges regarding the translation of in vitro to in vivo results and their relevance to effective therapies.

关键词： nanotechnology multidrug resistance drug delivery systems nanoformulations enhanced permeability and retention effect

Impact of COVID-19 on Safety Performance for Motorcycles: Pre-and during-Pandemic Conditions

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Journal of Transportation Technologies 2024年第3期14卷 390-401页

作者： Hongyun chen Amelia Lawson charles Hurda Madalyn Smith Tate Grant Civil Engineering Department Embry-Riddle Aeronautical University Daytona Beach FL USA

Florida has the highest number of motorcycle fatalities in the United States and contains the second largest population of registered motorcycles. The COVID-19 pandemic influenced the roads, traffic, and driving behavior in the continental United States. Motorcycle crashes decreased during the COVID-19 years (2020 and 2021) while the fatality rates increased. The purpose of this study is to 1) investigate motorcycle crashes before and during the Pandemic period to understand the impacts on motorcycle safety and contributing factors to the crash severity levels;2) develop the crash predictive model for different degrees of severity in motorcycle crashes in Florida. Florida statewide crash data were collected. T tests have been conducted to compare the contributing factors between two periods. The injury severities are significantly different among all five levels between those during normal period and the Pandemic period. A crash predictive model has been developed to determine the facts to injury severity levels for motorcycle crashes. A total of eight variables are found to significantly increase the injury severity levels for motorcycle crashes during the Pandemic period.

关键词： Motorcycle Crash Pandemic Injury Severity Contributing Factors

Global research trends and prospects of cellular metabolism in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 527-542页

作者： yan-chen Liu Zhi-cheng Gong Chao-Qun Li Peng Teng yan-yan chen Zhao-Hui Huang Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through *** To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by *** Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer *** The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three ***,China and the United States were two of the most prominent contri-butors in these four *** addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-yuan Fang,Senji Hirasawa,Wei Jia,and charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in *** Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in *** metabolic vulnerability appears to be a promising direction in CRC therapy.

关键词： Cellular metabolism Colorectal cancer Glucose metabolism Amino acid metabolism Lipid metabolism Nucleotide metabolism

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy

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Protein & Cell 2011年第2期2卷 141-149页

作者： Kazuo Fushimi charles Long Neha Jayaram Xiaoping chen Liming Li Jane y.Wu Department of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Department of Molecular Pharmacology and Biological Chemistry Northwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in *** of either wild type or ALS-associated R524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased ***,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative ***,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated *** N-terminus of FUS,containing the QGSy and G rich regions,is sufficient for the formation of aggregates but not *** C-terminal domain,which contains a cluster of mutations,did not show aggregation or *** to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human *** the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast ***,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity.

关键词： FUS/TLS protein aggregation cytotoxicity