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Current and future molecular diagnostics in colorectal cancer and colorectal adenoma

World Journal of Gastroenterology 2014年第14期20卷 3847-3857页

作者： Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma charles ming-lok chan Nancy Bo-Yin Tsui Lawrence Wing-Chi chan Benjamin Yat-ming Yung Sze-Chuen Cesar Wong Department of Health Technology and Informatics Faculty of Health and Social SciencesHong Kong Polytechnic University Department of Surgery Prince of Wales Hospital State Key Laboratory in Oncology in South China Sir Y K Pao Centre for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong

Colorectal cancer(CRC)is one of the most prevalent cancers in developed *** the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or *** CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the *** occult blood test is a widely used non-invasive screening tool for *** fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the *** dysregulations have been found to play an important role in CRC *** better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for *** this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were *** review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma.

关键词： Colorectal cancer Colorectal adenoma Molecular diagnostics Fecal occult blood test Non-invasive

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New evidence for the epigenetic regulation of skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao charles K.F.chan Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

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Plant grafting:Molecular mechanisms and applications

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Molecular Plant 2024年第1期17卷 75-91页

作者： ming Feng Frauke Augstein Abdul Kareem charles W.Melnyk Department of Plant Biology Linnean Center for Plant BiologySwedish University of Agricultural SciencesAlmas allé575651 UppsalaSweden

People have grafted plants since antiquity for propagation,to increase yields,and to improve stress *** cutting and joining of tissues activates an incredible regenerative ability as different plants fuse and grow as *** over a hundred years,people have studied the scientific basis for how plants ***,new techniques and a deepening knowledge of the molecular basis for graft formation have allowed a range of previously ungraftable combinations to ***,we review recent developments in our understanding of graft formation,including the attachment and vascular formation *** analyze why plants graft and how biotic and abiotic factors influence successful *** also discuss the ability and inability of plants to graft,and how grafting has transformed both horticulture and fundamental plant *** our knowledge about plant grafting improves,new combinations and techniques will emerge to allow an expanded use of grafting for horticultural applications and to address fundamental research questions.

关键词： plant grafting regeneration mobile molecules tissue adhesion vascular differentiation stress tolerance

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Synchronization and firing mode transition of two neurons in a bilateral auditory system driven by a high–low frequency signal

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Chinese Physics B 2024年第5期33卷 722-735页

作者： charles Omotomide Apata 唐浥瑞周祎凡蒋龙裴启明 School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China

The FitzHugh–Nagumo neuron circuit integrates a piezoelectric ceramic to form a piezoelectric sensing neuron,which can capture external sound signals and simulate the auditory neuron *** piezoelectric sensing neurons are coupled by a parallel circuit consisting of a Josephson junction and a linear resistor,and a binaural auditory system is *** the non-singleness of external sound sources,the high–low frequency signal is used as the input signal to study the firing mode transition and synchronization of this *** is found that the angular frequency of the high–low frequency signal is a key factor in determining whether the dynamic behaviors of two coupled neurons are *** they are in synchronization at a specific angular frequency,the changes in physical parameters of the input signal and the coupling strength between them will not destroy their *** addition,the firing mode of two coupled auditory neurons in synchronization is affected by the characteristic parameters of the high–low frequency signal rather than the coupling *** asynchronous dynamic behavior and variations in firing modes will harm the auditory *** findings could help determine the causes of hearing loss and devise functional assistive devices for patients.

关键词： piezoelectric ceramic Josephson junction auditory neuron synchronization

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Recent development and challenges in enhancing fire performance on wood and wood-based composites:A 10-year review from 2012 to 2021

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Journal of Bioresources and Bioproducts 2024年第1期9卷 27-42页

作者： charles Michael Albert Kang Chiang Liew Faculty of Tropical Forestry Universiti Malaysia SabahKota Kinabalu 88400Kota KinabaluSabah 88400Malaysia

Due to their durability,versatility,and aesthetic value,wood and wood-based composites are widely used as building *** fact that these materials are flammable,however,raises a major worry since they might cause fire hazards and significant loss of life and *** article investigates the variables that affect fire performance as well as the various fire-retardant treatments and their *** current developments and challenges in improving the fire performance of wood and wood-based composites treated with fire-retardant materials are summarized in this ***,organic chemicals,and densification are some recent developments in fire-retardant treatments that are also *** points from the review are summarized,along with potential areas for further research and development.

关键词： Fire performance Fire-retardant materials Wood Wood-based composite Nanoparticles coating Surface charring Bio-based fire retardant Densification

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Historic,pre-stock enhancement,demographic conditions of exploited populations of dusky flathead,Platycephalus fuscus,in eastern Australia

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Aquaculture and Fisheries 2024年第2期9卷 314-323页

作者： charles A.Gray WildFish Research Grays PointSydney2232Australia

Responsible stock enhancement initiatives require baseline data of wild population demographic conditions that can be used in testing management *** study provides the first fishery-independent assessment of length-and age-based biological characteristics of exploited populations of Platycephalus fuscus in eastern Australia prior to stock *** was conducted over seven estuaries spanning seven degrees of latitude and the geographical range of proposed stock *** in all estuaries showed evidence of length and age truncation,especially those subject to commercial fisheries where young individuals of both sexes dominated *** longevities were 12 and 11 years for females and males respectively,but few females>5 years and males>3 years were generally *** dominated populations,and on average,the mean lengths and ages of females were greater than males within each estuary and across all age *** dimorphic variation in growth was evident across all estuaries,with females attaining greater maximum lengths than ***-specific differences in individual growth were not *** average,over 50%of females sampled in each estuary were>the minimum legal length(MLL),but the opposite was evident for *** contrast,over 25%of males in each estuary were>the mean length at maturity(L50),whereas in all but one estuarythe *** male and female *** should recruit to the fishery in 2 and 3 years,and contribute to the spawning stock in 1.5 and 4.5 years,*** study provides important historical baseline data that can contribute to testing stock enhancement outcomes on populations.

关键词： Baseline data Fishery enhancement Management evaluation Platycephalidae Recreational fishing Restocking Stock assessment

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： charles H.Nelson Udai B.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika Fujii charles F.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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NRF2 signaling cascade in amyotrophic lateral sclerosis:bridging the gap between promise and reality

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Neural Regeneration Research 2024年第5期19卷 1006-1012页

作者： Pauline Tarot Christelle Lasbleiz Jean-charles Liévens MMDN Univ MontpellierEPHEINSERMMontpellierFrance CNRS ParisFranceEPHEINSERMMontpellierFrance

Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor *** include muscle weakness and atrophy,spasticity,and progressive ***,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral *** only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial *** difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis *** mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious *** the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and *** here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis C9orf72 NRF2 oxidative defense oxidative stress sulforaphane superoxide dismutase 1 TDP43

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Evolution of the rare earth trade network:A perspective of dependency and competition

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Geoscience Frontiers 2024年第3期15卷 183-191页

作者： Jilan Xu Jiahao Li Vincent charles Xin Zhao School of Urban and Regional Science Shanghai University of Finance and EconomicsShanghai 200433China School of Business East China University of Science and TechnologyShanghai 200237China School of Management University of BradfordBradford BD71DPUnited Kingdom School of Statistics and Applied Mathematics Anhui University of Finance and EconomicsBengbu 233030China

As a global strategic reserve resource,rare earth has been widely used in important industries,such as military equipment and ***,existing analyses based solely on the total volume of rare earth trade fail to uncover the underlying competition and dependency *** address this gap,this paper employs the principles of trade preference and import similarity to construct dependency and competition *** network analysis is then employed to study the evolution of the global rare earth trade network from 2002 to *** main conclusions are as *** global rare earth trade follows the Pareto principle,and the trade network shows a scale-free *** has emerged as the world’s largest importer and exporter of rare earth since *** the dependency network,China has become the most dependent country since *** result of community division shows that China has separated from the American community and formed new communities with the Association of Southeast Asian Nations(ASEAN)*** United States of America has formed a super-strong community with European and Asian *** the competition network,the distribution of competition intensity follows a scale-free *** countries face low-intensity competition,but there are numerous competing *** competition related to China has increased ***,the competition source for the United States of America has shifted from Mexico to China,resulting in China,the USA,and Japan becoming the core participants in the competition network.

关键词： Rare earth Trade network Dependency Competition Complex network analysis

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