检索结果-南通市图书馆

连接蛋白30在运动型星形胶质细胞中局部调控肌动蛋白细胞骨架和机械重构

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2024年第10期19卷 F0003-F0003页

作者：唐颖馨(编译) Center for Interdisciplinary Research in Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Doctoral School N° 158 Sorbonne UniversitéParisFrance Center for Interdisciplinary Research in Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUK Center for Interdisciplinary Research in Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Doctoral School N°562 Université Paris CitéParisFrance Institut Pasteur Université de ParisCNRSCell PolarityMigration and Cancer UnitParisFrance Université de Lille CNRSInsermCHU LilleInstitut Pasteur de LilleCIIL-Center for Infection and Immunity of LilleLilleFrance Université Paris-Saclay CEACNRSMIRCenLaboratoire des Maladies NeurodégénérativesFontenay-aux-RosesFrance Center for Interdisciplinary Research in Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUK

在大脑成熟过程中,星形胶质细胞形成了复杂的形态结构,展现出强烈的结构可塑性。连接蛋白30(Cx30),是一种在出生后表达的缝隙连接通道形成蛋白,在发育过程中通过控制细枝状突起的分支和延伸来动态调节星形胶质细胞的形态特性。然而,其... 详细信息

在大脑成熟过程中,星形胶质细胞形成了复杂的形态结构,展现出强烈的结构可塑性。连接蛋白30(Cx30),是一种在出生后表达的缝隙连接通道形成蛋白,在发育过程中通过控制细枝状突起的分支和延伸来动态调节星形胶质细胞的形态特性。然而,其背后的机制尚未被探索。我们在体外发现Cx30在星形胶质细胞中与肌动蛋白细胞骨架相互作用,并在细胞迁移期间抑制其结构重组和动态变化。

关键词：星形胶质细胞连接蛋白细胞迁移肌动蛋白细胞骨架结构可塑性缝隙连接通道形态特性动态调节

染色体12q15-q23中间缺失和周边角膜异常患者的临床和分子特征

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 12-12页

作者： Tocyap m. L. Azar N. Chen T. Wiggs J. 安胜(译) 不详 Department of Ophthalmology Harvard Medical School Massachusetts Eye and Ear Infirmary 243 Charles Street Boston MA 02114 United States

PURPOSE: To describe the ocular features of a patient with an interstitial deletion of chromosome 12 and to determine the molecular boundaries of the deletion. DESIGN: Observational case report and laboratory investigation. mETHODS: A patient with an interstitial deletion of chromosome 12 was clinically examined for ocular abnormalities. DNA samples were used for molecular studies to define the deletion boundaries. RESULTS: Ocular examination showed abnormalities of the anterior segment consistent with a diagnosis of cornea plana. molecular analyses showed the deletion included the KERA gene,the SLRP (small leucine repeat protein) gene cluster,the genetic loci for autosomal-dominant (CNA1) and autosomalrecessive (CNA2) cornea plana,and a portion of the mapped locus for high myopia (mYP3). CONCLUSIONS: These results,combined with previous genetic linkage studies,identifies a 3-cm region located between microsatellite markers D12S82 and D12S351 that is likely to contain a gene responsible for CNA1.

关键词：常染色体隐性遗传分子特征临床检查膜异常患者常染色体显性遗传 ERA基因周边失和中间缺失

在线全文

学校读者我要写书评

暂无评论

肛门生殖器部乳腺样腺的罕见增生

世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 47-页

作者： Kazakov D.V. Hügel H. Vanecek T. michal m. 李晓莉 Sikl's Department of Pathology Charles University Medical Faculty Hospital Alej Svobody 80 30460 Pilsen Czech Republic Dr.

Anogenital mammary-like glands, although known to exist (as ectopic breast tissue) as early as 1872, have only recently been thoroughly studied and suggested to be the possible origin for various neoplastic (benign and malignant) and reactive conditions that show a striking homology with lesions in the breast. Reported herein is an unusual benign lesion involving anogenital mammary-like glands in the perineal area of a 41-year-old woman. The lesion is unique in that it does not fully fit into any of the previously recognized conditions affecting anogenital mammary-like glands nor has it an apparent well-defined mammary counterpart. microscopically, at first glance the lesion appeared as a cluster of extended anogenital mammary-like glands of variable complexity and a lobular architecture, which probably resulted from a compact proliferation of closely situated ducts with small, round lumens (when cut transversally).When cut longitudinally, some of these tiny ducts appeared to bud from larger ductal structures, resembling so-called satellitosis in the breast and this gave a fibroadenomatous appearance to the areas. In addition, there were adenosis-like areas. This lesion extends the spectrum of changes seen in anogenital mammary-like glands.

关键词：生殖器泌尿生殖系统乳腺乳房肛门魄门

血小板-单核细胞聚集可预测经皮冠状动脉介入后肌钙蛋白增高,且可被阿昔单抗抑制

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 53-53页

作者： Ray m. J. Walters D. L. Bett J. N. H. 刘健 Cardiology Department Prince Charles Hospital Chermside QLD 4032 Australia

Platelet-monocyte aggregates and other markers of platelet activation were investigated before and after percutaneous coronary intervention(PCI) with abciximab therapy. The study sought to assess the relationship between the level of platelet-monocyte aggregation and increases in cardiac troponin I post coronary intervention. methods: Blood samples were collected from 40 patients before PCI and 10 min after abciximab administration. These were tested for platelet activation markers by flow cytometry. Cardiac troponin I levels were assayed at baseline and at 24 h post PCI. Results: Compared to healthy controls, patients with coronary artery disease had elevated markers of platelet activation including platelet-monocyte aggregates, P-selectin and PAC- 1(a marker specific for activated glycoprotein IIb/IIIa) prior to PCI. Increased levels of platelet-monocyte aggregates before PCI were associated with increased expression of P-selectin on the platelet surface. Abciximab therapy reduced platelet-monocyte aggregate levels but had no effect on P-selectin expression. The high levels of expression of activated glycoprotein IIb/IIIa(PAC-1) on platelets prior to PCI was reduced with abciximab therapy. Patients with higher levels of platelet-monocyte aggregates prior to PCI were more likely to develop an elevation of cardiac troponin I during the 24 h after PCI. Conclusions: Increased levels of platelet-monocyte aggregates may predict patients at risk for troponin elevation following PCI and identify those most likely to benefit from abciximab.

关键词：阿昔单抗肌钙蛋白选择素血小板激活前血小板血液样本流式细胞仪测量样本

糖尿病相关的足病的定义和标准(2023年更新版)

在线全文

学校读者我要写书评

暂无评论

感染、炎症、修复 2024年第1期25卷 80-85页

作者： Jaap J.van Netten Sicco A.Bus Jan Apelqvist Pam Chen Vivienne Chuter Robert Fitridge Frances Game Robert J.Hinchliffe Peter A.Lazzarini Joseph mills matilde monteiro-Soares Edgar J.G.Peters Katherine m.Raspovic Eric Senneville Dane K.Wukich Nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) Department of Rehabilitation medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam movement Sciences Program RehabilitationAmsterdamthe Netherlands Department of Endocrinology University Hospital of MalmöMalmöSweden Joondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia michael E.DeBakey Department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal mEDCIDS–Departamento de medicina da Comunidade Informação e Decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal Department of Internal medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

维普期刊数据库博看期刊

外伤性脉络膜破裂视力预后和脉络膜新生血管膜形成的预测因素

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2006年第12期 13-13页

作者： Ament C.S. Zacks D.N. Lane A.m. J. W. miller 王静波 Retina Service Massachusetts Eye and Ear Infirmary 243 Charles St Boston MA 02114 United StatesDr.

Objective: To determine predictors of choroidal neovascularization (CNV) and visual outcome after traumatic choroidal rupture. methods: A retrospective review of patients with traumatic choroidal rupture diagnosed in the Retina Service, massachusetts Eye and Ear Infirmary, Boston, between January 1993 and August 2001 was performed. Parametric and nonparametric statistical methods were used to evaluate visual prognosis, CNV, and retinal detachment after traumatic choroidal rupture. Results: One hundred eleven cases were identified and reviewed. Visual acuity (VA) changes were recorded in all of the cases. Thirty-eight (34%) of the 111 patients recovered driving vision (VA ≥20/40). Rupture location was recorded in 107 cases. Recovery of driving vision was seen in 20 (59%) of 34 eyes with peripheral choroidal ruptures, 17 (22%) of 73 eyes with macular choroidal ruptures, 38 (38%) of 99 eyes without CNV, 1 (8%) of 12 eyes with CNV, 38 (40%) of 96 eyes without retinal detachment, and 1 (7%) of 15 eyes with retinal detachment. Older age and location of rupture within the arcades were positively associated with CNV formation (P=.04 and .03, respectively). Foveal location of rupture, multiple ruptures, and poor baseline VA were associated with failure to recover driving vision in univariate regression analyses. In multivariate analysis, rupture location and baseline VA were independently associated with visual outcome. Of 12 patients diagnosed with CNV, 5 were not treated, 4 were treated with argon laser photocoagulation, 1 was treated with surgery, 1 was treated with argon laser photocoagulation followed by surgery, and 1 was treated with verteporfin photodynamic therapy. Conclusions: most patients with traumatic choroidal rupture do not achieve final VA of 20/40 or better. Poor visual outcome was most highly associated with a macular rupture and baseline VA of less than 20/40. The formation of CNV was most strongly associated with older age and macular choroidal rupture.

关键词：脉络膜破裂脉络膜撕裂视力预后 CNV 外伤性预测因素

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.maharachchikumbura Walter Rossi marco Leonardi Hyang Burm Lee Hye Yeon mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun m.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene mayrada Silva Soares Helio Longoni Plautz Jr Helen maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina mariade Souza-motta Oliane maria Correia magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-mei Tian Armin mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage ming Zeng Thilini Chethana Deping Wei martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul m Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,micarea squamulosa,muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用磁化转移率评价克罗恩病病人肛瘘的活动性

国际医学放射学杂志 2017年第2期 228-228页

作者： C.Pinson m.Dolores Y.Cruypeninck E.Koning J.N.Dacher G.Savoye 刘炜 Department of Radiology Rouen University Hospital -Charles Nicolle

摘要目的肛瘘的评价对于指导克罗恩病(CD)的治疗有重要意义。本研究旨在分析磁化传递(mT)成像评估肛瘘的可行性,并评价其对于评估疾病活动性的价值。方法 15

关键词：活动性克罗恩病局限性回肠炎肠炎肛瘘肛门疾病转移率病人

5%米喹莫特霜剂治疗12例未分化外阴上皮内肿瘤的前瞻性研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 9-9页

作者： Wendling J. Saiag P. Berville-Levy S. m.moyal-Barracco 罗素菊冯义国 Serv. Dermatol. Gen. et Oncologique H.opital Ambroise-Par'e 9 Avenue Charles-de-Gaulle 92104 Boulogne Cedex France Dr.

Objective: To assess the efficacy of 5%imiquimod cream on undifferentiated vulvar intraepithelial neoplasia (VIN), a disease caused by high-risk human papillomavirus. Design: Prospective, uncontrolled study. Setting: University hospital vulvar clinic. Patients: Twelve consecutive patients treated with 5%imiquimod cream for undifferentiated VIN between march 1, 1999, and may 31, 2001. Intervention: Self-application of 5%imiquimod cream, initially 3 times a week, then adjusted according to tolerance, for up to 7 months according to clinical response. main Outcome measures: Therapeutic response, clinically assessed by successive photographs and histologically confirmed for complete responders, was scored as complete, partial (≥50%decrease in lesion size), or failure. Tolerance was evaluated at each visit. Results: A total of 3, 4, and 5 patients achieved complete response, partial response (≥75%reduction in lesion size for all such cases), and failure, respectively. mean duration of treatment was 3.6 months (37.3 applications), 5.0 months (50.7 applications), and 3.4 months (25.2 applications) for complete responders, partial responders, and failures, respectively. Follow-up after treatment was 5 to 18, 14 to 32, and 2 to 28 months, respectively, with 1 partial responder lost to long-term follow-up. No patient developed invasive carcinoma. All but 2 patients experienced vulvar discomfort, resulting in treatment withdrawal for 3. Two patients had flulike symptoms. Conclusions: Imiquimod cream could be a therapeutic option for undifferentiated VIN. Although poorly tolerated, this self-applied treatment could spare patients, either totally or partially, the classic painful and sometimesmutilating treatments of VIN. Controlled, randomized studies are needed to evaluate its efficacy and tolerance.

关键词：外阴上皮内肿瘤莫特霜剂人类乳头瘤病毒组织学检查临床反应用药次数侵袭性癌流感样症状大学医院