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Theoretical Studies of Photodynamic Therapy Properties of Azopyridine δ-OsCl2(Azpy)2Complex as a Photosensitizer by a TDDFT Method

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Computational Chemistry 2021年第1期9卷 64-84页

作者： Wawohinlin Patrice Ouattara Kafoumba Bamba Affi Sopi Thomas Fatogoma Diarrassouba Lamoussa Ouattara Massapihanhoro Pierre Ouattara Kouakou Nobel N'guessan Mamadou Guy Richard Kone charles guillaume kodjo Nahossé Ziao Laboratoire de Thermodynamique et de PHysico-Chimie du Milieu UFR-SFA Université NanguiAbrogoua Abidjan C&#244te d’Ivoire

Photochemical reactions have an important place in photodynamic treatments. A good use of this therapeutic method requires a good mastery of the mechanisms of the reactions involved. Therefore, we have explored in this work the photosensitization mechanism of an organometallic complex of azopyridine δ-OsCl2(Azpy)2 through a calculation with the method of Time Dependent Density Functional Theory TDDFT. First, we evaluated the effect of polar and non-polar solvents on the triplet and singlet excited states of this complex. Then secondly, we highlighted the photosensitization mechanism to understand how the complex acts over the diseased cells. These investigations have shown that the δ-OsCl2(Azpy)2 complex is likely to develop photodynamic activity according to two mechanisms: on one hand, it can generate damage to DNA bases or target tissues indirectly through the production of singlet oxygen in water and in DMSO. On the second hand, through the production of the anionic superoxide radical in water can act directly or indirectly on these substrates. In addition, polar solvents are assumed to better carry out the photochemical reactions of this azopyridine complex of osmium.

关键词： Time Dependent-Density Functional Theory Azopyridine Excited States Photosensitization Photodynamic Therapy Osmium

Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene

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Journal of Biophysical Chemistry 2021年第1期12卷 1-9页

作者： Tuo Nanou Tiéba Kangah Niameke Jean Baptiste Ballo Daouda Kablan Ahmont Landry Claude kodjo charles guillaume Yapo Ossey Bernard Ziao Nahossé Laboratoire de Thermodynamique et de Physico-Chimie du Milieu UFR SFA Université NanguiAbrogoua Abidjan C&#244 te d’Ivoire Laboratoire de Chimie Organique Heterocyclique URAC 21 P&#244 le de Compétence Pharmacochimie Faculté des Sciences Université’ Mohammed V Rabat Moroc Laboratoire de Constitution et Réaction de la Matière (LCRM) UFR Sciences des Structures de la Matière et Technologie Université Félix Houphou&#235 t-Boigny Abidjan C&#244 te d’Ivoire UFR Des Sciences Biologiques Université Péléforo Gon Coulibaly de Korhogo Korhogo C&#244 te d’Ivoire Laboratoire Centrale de l’Environnement (LCE) Centre Ivoirien Antipollution (CIAPOL) Abidjan C&#244 te d’Ivoire Laboratoire des Sciences de l’Environnement (LSE) UFR SGE Université Nangui Abrogoua Abidjan C&#244 te d’Ivoire

From (2,3-dihydro-1H-perimidin-2-yl)-phenyl, the substitution of OH group in ortho or para position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in para position has the lowest activity in both cases. Therefore the para position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.

关键词： Perimidine Spectrometry Antioxidant Activity 2 2-Diphenyl-1-Picrylhydrazyl Method and Ferric Reducing Antioxidant Power Method

The sperm-interacting proteome in the bovine isthmus and ampulla during the periovulatory period

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Journal of Animal Science and Biotechnology 2023年第3期14卷 980-1000页

作者： Coline Mahe Regis Lavigne Emmanuelle Com charles Pineau Aleksandra Maria Zlotkowska guillaume Tsikis Pascal Mermillod Jennifer Schoen Marie Saint-Dizier CNRS IFCEINRAEUniversite de ToursPRC37380 NouzillyFrance Univ Rennes InsermEHESPIrset(Institut de Recherche en SanteEnvironnement Et Travail)-UMR-S 1085F‑35000 RennesFrance Univ Rennes CNRSInsermBiosit UAR 3480 US_S 018Protim Core Facility35000 RennesFrance Institute of Reproductive Biology Leibniz Institute for Farm Animal BiologyFBNDummerstorfGermany Present Address:Department of Reproduction Biology Leibniz Institute for Zoo and Wildlife Research(IZW)BerlinGermany

Background Spermatozoa interact with oviduct secretions before fertilization in vivo but the molecular players of this dialog and underlying dynamics remain largely *** objectives were to identify an exhaustive list of sperm-interacting proteins(SIPs)in the bovine oviduct fluid and to evaluate the impact of the oviduct anatomical region(isthmus ***)and time relative to ovulation(pre-ovulatory ***-ovulatory)on SIPs number and *** Pools of oviduct fluid(OF)from the pre-ovulatory ampulla,pre-ovulatory isthmus,post-ovulatory ampulla,and post-ovulatory isthmus in the side of ovulation were collected from the ***-thawed bull sperm were incubated with OF or phosphate-buffered saline(control)for 60 min at 38.5℃.After protein extraction and digestion,sperm and OF samples were analyzed by nanoLC-MS/MS and label-free protein *** A quantitative comparison between proteins identified in sperm and OF samples(2333 and 2471 proteins,respectively)allowed for the identification of 245 *** highest number(187)were found in the pre-ovulatory isthmus,i.e.,time and place of the sperm *** total,41 SIPs(17%)were differentially abundant between stages in a given region or between regions at a given stage and 76 SIPs(31%)were identified in only one region×stage *** analysis of SIPs predicted roles in cell response to stress,regulation of cell motility,fertilization,and early embryo *** This study provides a comprehensive list of SIPs in the bovine oviduct and evidences dynamic spatiotemporal changes in sperm-oviduct interactions around ovulation ***,these data provide protein candidates to improve sperm conservation and in vitro fertilization media.

关键词： Ampulla Fallopian tube Interactome Isthmus Oviduct Ovulation Post-ovulatory Pre-ovulatory Proteomics Spermatozoa

French Spine Surgery Society guidelines for management of spinal surgeries during COVID-19 pandemic

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World Journal of Clinical Cases 2020年第10期8卷 1756-1762页

作者： Solène Prost Yann Philippe charles Jérome Allain Jean-Luc Barat Henri d'Astorg Manuel Delhaye Chistophe Eap Fahed Zairi Pierre Guigui Brice Ilharreborde Jean Meyblum Jean-charles Le Huec Nicolas Lonjon guillaume Lot Olivier Hamel guillaume Riouallon Stéphane Litrico Patrick Tropiano Benjamin Blondel Aix-Marseille Université APHMCNRSISMCHU TimoneUnitéde Chirurgie RachidienneMarseille 13005France Service de Chirurgie du Rachis Hopitaux Universitaires de StrasbourgStrasbourg 67200France Institut Parisien du dos Paris 75005France Service de Neurochirurgie Hopital privéClairval-Ramsay santéMarseille 13009France Unitéde Chirurgie du Rachis Centre Orthopédique SantyLyon 69008France Centre Francilien du dos Versailles 78000France CHU Reims Hopital Maison BlancheNeurochirurgieReims 51100France Hopital PrivéLe Bois Ramsay Santé Lille 59000France Hopital Européen Georges-Pompidou HEGP Paris 75015France Service de Chirurgie Orthopédique Pédiatrique CHU Robert DebréAPHPUniversitéde ParisParis 75019France Service de Chirurgie Orthopédique Groupe Hospitalier Paris Saint-JosephParis 75014France Polyclinique Bordeaux Nord Aquitaine Bordeaux 33300France Service de Neurochirurgie Hopital Gui de ChauliacMontpellier 34090France Hopital-Fondation Rothschild Service de NeurochirurgieParis 75019France Clinique Des Cèdres Service de Neurochirurgie Chateau D’AlliezCornebarrieu 31700France Hopital Paris Saint-Joseph Paris 75014France Unitéde Chirurgie Rachidienne Hopital Pasteur 2CHU de NiceNice 06001France

Since the outbreak of coronavirus disease 2019(COVID-19)in December 2019 in China,various measures have been adopted in order to attenuate the impact of the virus on the *** regard to spine surgery,French physicians are devoted to take place in the national plan against COVID-19,the French Spine Surgery Society therefore decided to elaborate specific guidelines for management of spinal disorders during COVID-19 pandemic in order to prioritize management of patients.A three levels stratification was elaborated with Level I:Urgent surgical indications,Level II:Surgical indications associated to a potential loss of chance for the patient and Level III:Non-urgent surgical *** also report French experience in a COVID-19 cluster region illustrated by two clinical *** hope that the guidelines formulated by the French Spine Surgery Society and the experience of spine surgeons from a cluster region will be helpful in order optimizing the management of patients with urgent spinal conditions during the pandemic.

关键词： COVID-19 Spine Surgery Guidelines Organization Cluster region

Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men

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Asian Journal of Andrology 2015年第1期17卷 68-73,I0008页

作者： Leyla Ounis Abdelali Zoghmar charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray Laboratoire de Biologie Moleculaire et Cellulaire Faculte des Sciences de la Nature et de la Vie Universite Constantine I Algerie Clinique Ibn Rochd Centre de Medecine de la Reproduction Constantine Algerie Universite Grenoble Alpes Grenoble France Equipe Genetique Epigenetique et Therapies de I'lnfertilitE CNRS AGIM Grenoble France Laboratoire de GEnetique Chromosomique CHU Grenoble Grenoble France Laboratoire de Biochimie et Genetique Moleculaire CHU Grenoble Grenoble France Equipe Muscle et Pathologies INSERM U836 Grenoble Institut des Neurosciences Grenoble France.

Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C （AURKCj and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. We carried out genetic analyses on Algerian patients, to evaluate the prevalence of these syndromes in this population and to compare it with the expected frequency of Klinefelter syndrome and Y-microdeletions. We carried out a retrospective study on 599 consecutive patients consulting for couple infertility at the assisted reproduction unit of the Ibn Rochd Clinique, Constantine, Algeria. Abnormal sperm parameters were observed in 404 men. Fourteen and seven men had typical macrozoospermia and globozoospermia profiles, respectively. Molecular diagnosis was carried out for these patients, for the AURKC and DPY19L2 genes. Eleven men with macrozoospermia had a homozygous AURKC mutation （79%）, corresponding to 2.7% of all patients with abnormal spermograms. All the men with globozoospermia studied （n = 5）, corresponding to 1.2% of all infertile men, presented a homozygous DPY19L2deletion. By comparison, we would expect 1.6% of the patients in this cohort to have Klinefelter syndrome and 0.23% to have Y-microdeletion. Our findings thus indicate that AURKCmutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. Furthermore, we estimate that AURKCand DPY19L2 molecular defects are 10 and 5 times more frequent, respectively, than Y-microdeletions.

关键词： aurora kinase C DPY19L2 globozoospermia intracytoplasmic sperm injection infertility macrozoospermia

Inflammatory bowel disease registries for collection of patient iron parameters in Europe

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World Journal of Gastroenterology 2018年第10期24卷 1063-1071页

作者： Jonas Halfvarson Fraser Cummings Olof Grip guillaume Savoye Department of Gastroenterology Faculty of Medicine and HealthOebro UniversityObro SE 70182Sweden Department of Gastroenterology Southampton University Hospital NHS Foundation TrustSouthamptonHampshire SO16 6YDUnited Kingdom Department of Gastroenterology Skae University HospitalMalmo-20502Sweden Service d'heato-gastroenteologie CHU de Rouen-Hoital Charles NicolleRouen 76031France

Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are gaps in our understanding about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical registries have a key role in collecting data on the disease's natural history, the safety and effectiveness of drugs in routine clinical practice, and the quality of care delivered by healthcare services. Even though iron deficiency impacts inflammatory bowel disease patients and healthcare systems substantially, none of the established European inflammatory bowel disease registries systematically collects information on iron parameters and related outcomes. Collection of robust iron parameter data from patient registries is one way to heighten awareness about the importance of iron deficiency in this disease and to generate data to improve the quality of patient care, patient outcomes, and thus quality of life. This objective could be achieved through collection of specific laboratory, clinical, and patientreported measurements that could be incorporated into existing registries. This review describes the status of current European inflammatory bowel disease registries and the data they generate, in order to highlight their potential role in collecting iron data, to discuss how such information gathering could contribute to our understanding of iron deficiency anemia, and to provide practical information in regard to the incorporation of accumulated iron parameter data into registries.

关键词： Anemia Iron deficiency Registries Inflammatory bowel disease Patient care

Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui Lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen Wen Luo Lars Allmendinger Andreas Tittl Leonardo de Souza Menezes guillaume Maurin Shihe Yang and Stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil School of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia Department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect

Crohn’s disease: Why the ileum?

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World Journal of Gastroenterology 2023年第21期29卷 3222-3240页

作者： Nicolas Richard guillaume Savoye Mathilde Leboutte Asma Amamou Subrata Ghosh Rachel Marion-Letellier University of Rouen Normandie INSERMADEN UMR 1073NutritionInflammation and Microbiota-Gut-Brain AxisRouen F-76000France CHU Rouen Department of GastroenterologyRouen University Hospital-Charles NicolleRouen F-76000France Institute for Research and Innovation in Biomedicine University of Rouen NormandieRouen F-76000France APC Microbiome Ireland Biosciences BuildingUniversity College CorkCork T12 YT20Ireland

Crohn’s disease(CD)is an inflammatory bowel disease characterized by immunemediated flares affecting any region of the intestine alternating with remission *** CD,the ileum is frequently affected and about one third of patients presents with a pure ileal ***,the ileal type of CD presents epidemiological specificities like a younger age at onset and often a strong link with smoking and genetic susceptibility *** of these genes are associated with Paneth cell dysfunction,a cell type found in the intestinal crypts of the ***,a Western-type diet is associated in epidemiological studies with CD onset and increasing evidence shows that diet can modulate the composition of bile acids and gut microbiota,which in turn modulates the susceptibility of the ileum to ***,the interplay between environmental factors and the histological and anatomical features of the ileum is thought to explain the specific transcriptome profile observed in CD ***,both immune response and cellular healing processes harbour differences between ileal and non-ileal *** together,these findings advocate for a dedicated therapeutic approach to managing ileal ***,interventional pharmacological studies have failed to clearly demonstrate distinct response profiles according to disease ***,the high rate of stricturing disease in ileal CD requires the identification of new therapeutic targets to significantly change the natural history of this debilitating disease.

关键词： Ileum Crohn’s disease Bile acids Paneth cells Diet Genetics Strictures

Acidic open-cage solution containing basic cage-confined nanospaces for multipurpose catalysis

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National Science Review 2022年第5期9卷 99-107页

作者： Kang Li Kai Wu Yan-Zhong Fan Jing Guo Yu-Lin Lu Yuan-Fan Wang guillaume Maurin Cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen University School of Chemistry South China Normal University Institute charles Gerhardt Montpellier Centre National de la Recherche Scientifiqueécole Nationale Supérieure de Chimie de MontpellierUniversité de Montpellier

The nanoscale chemical spaces inherent in porous organic/coordination cages or solid/liquid materials have been continuously explored for their nanoconfinement effect on selective adsorption and reaction of small gas or organic ***,we aim to rationalize the unconventional chemical reactivities motivated by the cage-confined nanospaces in aqueous solutions,where the robust yet permeable nanospaces defined by the open cages facilitate dynamic guest exchange and unusual chemical *** high positive charges on [(Pd/Pt)6(RuL3)8]28+nanocages drive imidazole-proton equilibrium to display a significantly perturbed pKashift,creating cage-defined nanospaces in solution with distinct intrinsic basicity and extrinsic *** supramolecular cage effect plays pivotal roles in elaborating robust solution nanospaces,controlling ingress-and-egress molecular processes through open-cage portals and endowing nanocages with transition-state stabilization,amphoteric reactivities and the phase transfer of insoluble molecules,thus promoting chemical transformations in unconventional ***,a wide range of application of cage-confined catalysis with anomalous reactivities maybe expected based on this kind of open-cage solution medium,which combines cage nanocavity,solution heterogeneity and liquid-phase fluidity to benefit various potential mass transfer and molecular process options.

关键词： open-cage solution supramolecular cage effect supramolecular catalysis cage-confined catalysis cage-confined nanospaces in solution