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Frost Resistance of Pervious Concrete Mixed with Waste Glass Powder

Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1325-1336页

作者： AN Baofeng LI Qiong QIAO Hongxia SU Rui wang Xi wang chaoqun JIAO Daowei School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu Advanced Civil Engineering Materials Engineering Research Center Lanzhou 730050China China Construction First Group The Fifth Construction Co.Ltd Beijing 100000China

The contents of waste glass powder(WGP)(0%,10%,15%,20%,25%)and water-binder ratio(W/C)(0.24,0.26,0.28)were used as influencing factors,and the quality loss rate(Δm)and compressive strength loss rate(Δfc)were used as characterization *** Ca/Si ratio and main element contents of C-S-H gels with different WGP content were investigated by energy dispersive spectrometry(EDS).The pore structure evolution characteristics of WGP composite cementing materials were investigated by low field nuclear magnetic resonance(NMR).UsingΔfc as the index of frost resistance degradation and Weibull function,the frost resistance degradation of glass doped pervious concrete(WGP-PC)was *** results show that,with WGP,for the same number of cycles,Δm andΔfc decrease and increase with the increase of *** the same WGP content,Δm andΔfc decrease first and then increase with the increase of W/*** 100 freeze-thaw cycles,the samples with WGP content of 20%and W/C of 0.26 have the best *** tests show that with the increase of WGP content,the Ca/Si ratio of C-S-H gel decreases at first and then increases with the increase of WGP *** extreme value of Ca/Si is 2.36 when WGP is added by 20%.The pore volume of hardened paste with 20%WGP content decreased by 18.6%compared with that of cement system without *** overall compactness of the specimen was *** the basis of the test data,a life prediction model was established according to Weibull *** experiment showed thatΔfc could be used as a durability degradation index,and the slope of the reliability curve became gentle after WGP was added,which reduced the damage degradation rate of PC.W/C was ***'s about 5000 hours.

关键词： pervious concrete glass powder frost resistance energy dispersive analysis test low field nuclear magnetic resonance instrument life prediction

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In situ autophagy regulation in synergy with phototherapy for breast cancer treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2317-2332页

作者： Huijuan Zhang Xiangyang Xuan Yaping wang Zijun Qi Kexuan Cao Yingmei Tian chaoqun wang Junbiao Chang Zhenzhong Zhang Lin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China School of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/*** project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor *** achieve this goal,we first synthesized TRANSFERRIN(Tf)biomimetic mineralized nano-tellurium(Tf-Te)as photosensitizer and then used disulfide bond reconstruction technology to induce Tf-Te *** autophagy inhibitor hydroxychloroquine(HCQ)and iron ions carried by Tf were simultaneously loaded to prepare a tumor-responsive drug reservoir Tf-Te/*** entering breast cancer cells through the“self-guidance system”,Tf-Te/HCQ can generate hyperpyrexia and ROS under NIR laser irradiation,to efficiently induce PTT/PDT ***,the disulfide bond broke down in response to GSH,and the nanoparticles disintegrated to release Fe2+and HCQ at fixed *** simultaneously induce lysosomal alkalinization and increased osmotic pressure,effectively inhibit autophagy,and synergistically enhance the therapeutic effect of *** vivo anti-tumor results have proved that the tumor inhibition rate of Tf-Te/HCQ can be as high as 88.6%on 4T1 tumor-bearing *** multifunctional drug delivery system might provide a new alternative for more precise and effective tumor phototherapy.

关键词： Autophagy Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium

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Seismogenic Structure of the 1605 Qiongshan M7½ Earthquake and Its Holocene Activity History in Northern Hainan Island, China: Evidence from Cross-Section Drilling and Shallow Seismic Profile

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Journal of Earth Science 2024年第3期35卷 905-917页

作者： chaoqun wang Liyun Jia Daogong Hu Shibiao Bai Zhengwang Hu Dongxia Sun Xiaoxiao Yang Lei Zhang Xiumin Ma Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China Key Laboratory of Geohazard Prevention of Hilly Mountains Ministry of Land and Resources(Fujian Key Laboratory of Geohazard Prevention)Fuzhou 350002China Observation and Research Station of Crustal Stress and Strain in Beijing Ministry of Natural ResourcesBeijing 100081China College of Marine Science and Engineering Nanjing Normal UniversityNanjing 210023China Hubei Subsurface Multi-Scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

The 1605 M7½ Earthquake is the only earthquake in the history of China that has caused large-scale land subsidence into the sea,with the total area of land subsidence exceeding 100 *** disaster has led to the sinking of 72 *** is still no clear understanding of the source seismogenic fault of this *** this work,we conducted a detailed study of the middle segment of the Maniao-Puqian fault(MPF),which is the epicenter area,through geomorphological survey,data collection,shallow seismic exploration,cross-section drilling,and chronological *** results showed that the middle segment of the MPF zone is composed of three nearly parallel normal faults with a dextral strike-slip:“Macun-Luodou fault(F2-1),Haixiu-Dongyuan fault(F2-2),and ChangliuZhuxihe fault(F2-3)”.And F2-2 is composed of two secondary faults,namely F2-2′and F2-2″,with a flower-shaped structure buried under the *** is distributed nearly east-west,dipping to the north and has experienced at least five stages of activities since the *** vertical activity rates of F2-2′and F2-2″are~2.32 and~2.5 mm/a,since the Holocene,*** were eight cycles of transgression and regression since the *** fault activity resulted in the thickening of the Holocene strata with a slight dip to the south,on the hanging wall,showing V-shaped *** MPF is likely the source seismogenic fault of the M7½ earthquake that hit Qiongshan in 1605.

关键词： seismogenic structure earthquakes Maniao-Puqian fault fault activity history geomorphology.

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Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan Jiayu Zhang Cheng Hu Gongwei wang Qianyao Ren chaoqun wang Jia Dan Zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying Liu Guangmei Yan Yuan Lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

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中国普惠性生育保障制度设计及其筹资需求

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社会保障评论 2024年第2期8卷 135-147页

作者：王超群华中师范大学公共管理学院

中国生育保障制度缺乏统一制度设计,覆盖范围窄,待遇水平低,难以适应当前人口发展状况。本文提出应建立普惠性生育保障制度,覆盖全体国民,由基本医疗保险支付生育相关医疗费用,设立面向所有分娩女性的生育津贴。本文测算了2021—2035年... 详细信息

中国生育保障制度缺乏统一制度设计,覆盖范围窄,待遇水平低,难以适应当前人口发展状况。本文提出应建立普惠性生育保障制度,覆盖全体国民,由基本医疗保险支付生育相关医疗费用,设立面向所有分娩女性的生育津贴。本文测算了2021—2035年,不同方案下普惠性生育保障制度的筹资需求及其财政负担。结果发现,不同方案的筹资需求差异较大。总筹资需求中,从儿童类型来看(一孩、二孩和三孩),一孩和二孩的筹资占比约90%;从保障内容来看(生育津贴、产检和分娩报销),生育津贴筹资占比约70%;从城乡来看,城市和镇筹资占比约85%。财政为城乡居民医疗保险参保人提供普惠性生育津贴所需的额外筹资占财政收入的0.31%-0.62%,可负担性较强。本文建议:建立普惠性生育保障制度;制定全国统一的、标准化的产检一揽子服务包,并将其纳入门诊特种病报销,实行按服务项目付费;提高生育相关医疗费用的报销比例;普惠性生育津贴可从低起点起步,保证财务可持续性。

关键词：普惠性生育保障制度设计精算分析普惠性生育津贴

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Quantitative analysis of laser-generated ultrasonic wave characteristics and their correlation with grain size in polycrystalline materials

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Chinese Physics B 2024年第8期33卷 526-543页

作者：徐兆文白雪马健万壮壮王超群 Laser Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250104China

Quantitative relationship between nanosecond pulsed laser parameters and the characteristics of laser-generated ultrasonic waves in polycrystalline materials was *** high energy of the pulsed laser with a large irradiation spot simultaneously generated ultrasonic longitudinal and shear waves at the epicenter under the slight ablation *** optimized denoising technique based on wavelet thresholding and variational mode decomposition was applied to reduce noise in shear waves with a low signal-to-noise *** approach for characterizing grain size was proposed using spectral central frequency ratio(SCFR)based on time-frequency *** results demonstrate that the generation regime of ultrasonic waves is not solely determined by the laser power density;even at high power densities,a high energy with a large spot can generate an ultrasonic waveform dominated by the thermoelastic *** is ascribed to the intensification of the thermoelastic effect with the proportional increase in laser irradiation spot area for a given laser power ***,both longitudinal and shear wave SCFRs are linearly related to grain size in polycrystalline materials;however,the shear wave SCFR is more sensitive to finer-grained *** study holds great significance for evaluating metal material properties using laser ultrasound.

关键词： laser-ultrasonics polycrystalline materials ultrasonic time-frequency characteristics grain size

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东昆仑志留纪火山岩锆石U-Pb年龄及其对陆-陆碰撞时限的制约

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地质学报 2024年第2期98卷 433-446页

作者：张耀玲戚帮申胡道功倪晋宇王超群中国地质科学院地质力学研究所北京100081 自然资源部活动构造与地质安全重点实验室北京100081 五矿勘查开发有限公司北京100089

东昆仑造山带早古生代经历了完整的洋壳形成、俯冲消减、陆-陆碰撞造山和造山后垮塌演变过程,目前对陆-陆初始碰撞时间及碰撞时限还存在较大争议。周缘前陆盆地启动引发的沉积环境突变或不整合形成时间是用来约束大陆初始碰撞时间最直... 详细信息

东昆仑造山带早古生代经历了完整的洋壳形成、俯冲消减、陆-陆碰撞造山和造山后垮塌演变过程,目前对陆-陆初始碰撞时间及碰撞时限还存在较大争议。周缘前陆盆地启动引发的沉积环境突变或不整合形成时间是用来约束大陆初始碰撞时间最直接和最有效的方法之一。本文以东昆仑水泥厂地区角度不整合覆盖于石灰厂组之上的志留纪周缘前陆盆地沉积哈拉巴依沟组为研究对象,开展火山岩夹层锆石U-Pb年代学研究,为约束早古生代陆-陆初始碰撞时间与碰撞造山时限提供沉积记录证据。结果表明,水泥厂东和雪水河东哈拉巴依沟组下部流纹质凝灰岩锆石U-Pb年龄分别为443.0±3.9 Ma和441.8±1.3 Ma,结合已报道的石灰厂组火山岩锆石U-Pb年龄(450.4±4.3 Ma),可以确定东昆仑陆-陆初始碰撞发生在450~443 Ma之间。综合区域上古生代岩浆活动、变质作用、构造变形与相关沉积记录证据,认为东昆仑地区至少从450 Ma左右开始进入陆壳深俯冲及陆-陆碰撞阶段,在425 Ma左右进入碰撞后伸展阶段,碰撞造山作用至少持续了25 Ma。

关键词：锆石U-Pb年龄哈拉巴依沟组初始碰撞时间陆-陆碰撞时限东昆仑

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不同前处理对水中多氯联苯含量的影响

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供水技术 2024年第2期18卷 51-55页

作者：王超群沈阳水务集团水质检验中心沈阳110005

应用固相萃取气相色谱法及液液萃取气相色谱法对水中18种多氯联苯进行分析比较,液液萃取的平均回收率为90.87%,固相萃取的平均回收率为63.64%,液液萃取效率优于固相萃取。经实验发现,水样经过充分活化、降低上样流速以及使用合适的洗脱... 详细信息

应用固相萃取气相色谱法及液液萃取气相色谱法对水中18种多氯联苯进行分析比较,液液萃取的平均回收率为90.87%,固相萃取的平均回收率为63.64%,液液萃取效率优于固相萃取。经实验发现,水样经过充分活化、降低上样流速以及使用合适的洗脱液均可以提高固相萃取的回收率,水中加入甲醇也可以起到一定的活化作用进而提高萃取效率。应用液液萃取气相色谱法对沈阳市9个水厂的20个出口水进行检测,均未检出指示性多氯联苯及二噁英类多氯联苯的存在。

关键词：多氯联苯气相色谱法固相萃取

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新型HDPE卷材组合防水体系在地铁车站防水工程中的应用

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中国建筑防水 2024年第9期 47-50页

作者：王超群北京东方雨虹防水技术股份有限公司北京101111

北京地铁某车站项目采用1.2 mm厚高透型HDPE高分子防水卷材+1.2 mm厚非砂面背粘型高分子自粘胶膜预铺防水卷材组合防水体系施工,并对桩头、格构柱、后浇带等细部节点进行了防水处理,解决了卷材层间窜水渗漏的问题,提高了施工效率,达到... 详细信息

北京地铁某车站项目采用1.2 mm厚高透型HDPE高分子防水卷材+1.2 mm厚非砂面背粘型高分子自粘胶膜预铺防水卷材组合防水体系施工,并对桩头、格构柱、后浇带等细部节点进行了防水处理,解决了卷材层间窜水渗漏的问题,提高了施工效率,达到了良好的防水效果。

关键词：地铁车站双道防水 HDPE防水卷材高透明度高分子自粘胶膜预铺防水卷材双面自粘

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以制度型开放助推新质生产力发展:理论机制与政策建议

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国际贸易 2024年第3期 5-14页

作者：李瑞琴王超群陈丽莉中央财经大学国际经济与贸易学院北京工商大学经济学院、数字商科与首都发展创新中心

发展新质生产力需要扩大高水平对外开放、全面深化改革,形成与之相适应的新型生产关系。通过制度型开放推动中国全面深化改革,构建高标准的市场体系,是形成与新质生产力发展相适应的生产关系的重要途径。文章首先介绍了新质生产力的内... 详细信息

发展新质生产力需要扩大高水平对外开放、全面深化改革,形成与之相适应的新型生产关系。通过制度型开放推动中国全面深化改革,构建高标准的市场体系,是形成与新质生产力发展相适应的生产关系的重要途径。文章首先介绍了新质生产力的内涵及其提出的历史逻辑,然后分析了当前制度型开放的具体表现和中国的实践成效。在此基础上,揭示了制度型开放主要通过吸引和聚集全球高端生产资源、畅通和强化技术创新激励机制、参与并引领数字经贸规则制定、发挥市场优化配置资源的作用,以及提升生产性服务业的竞争力等途径推动新质生产力的发展。最后,对如何加快推进制度型开放,促进新质生产力发展提出了有针对性的政策建议。

关键词：新质生产力制度型开放理论机制

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