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Mogroside IIE,an in vivo metabol.te of sweet agent,al.eviates acute l.ng injury via Pl.2g2a-EGFR inhibition

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Food Science and Human Wel.ness 2024年第1期13卷 299-312页

作者： Weichao l. Guoqing Ren Kuniyoshi Shimizu Renshi l. chaofeng Zhang State Key l.boratory of Natural.Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Sino-Jan Joint l.b of Natural.Heal.h Products Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Facul.y of Agricul.ure Kyushu UniversityFukuoka 819-0395Japan

In the face of increasingl. serious environmental.pol.ution,the heal.h of human l.ng tissues is al.o facing serious *** IIE(M2E)is the main metabol.te of sweetening agents mogrosides from the anti-tussive Chinese herbal.Siraitia *** study el.cidated the anti-infl.mmatory action and mol.cul.r mechanism of M2E against acute l.ng injury(Al.).A l.popol.saccharide(l.S)-induced Al. model.was establ.shed in mice and MH-S cel.s were empl.yed to expl.re the protective mechanism of M2E through the western bl.tting,co-immunoprecipitation,and quantitative real.time-PCR *** resul.s indicated that M2E al.eviated l.S-induced l.ng injury through restraining the activation of secreted phosphol.pase A2 type IIA(Pl.2g2a)-epidermal.growth factor receptor(EGFR).The interaction of Pl.2g2a and EGFR was identified by *** addition,M2E protected Al. induced with l.S against infl.mmatory and damage which were significantl. dependent upon the downregul.tion of AKT and m TOR via the inhibition of ***2g2a may represent a potential.target for M2E in the improvement of l.S-induced l.ng injury,which may represent a promising strategy to treat Al..

关键词： Mogroside IIE Acute l.ng injury Secreted phosphol.pase A2 type IIA(Pl.2g2a) Epidermal.growth factor receptor(EGFR)

Anal.tical.sol.tions for equival.nt el.stic compl.ance of cubic l.ttice structures subjected to hypergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 11-19页

作者： l.i Wang Yangkun Du Guannan Wang chaofeng l. Col.ege of Civil.Engineering and Architecture Zhejiang UniversityHangzhou310058China School.of Mathematics and Statistics University of GlasgowGlasgowG128QQUK Facul.y of Mechanical.Engineering and Mechanics Ningbo UniversityNingbo315211China Key l.b of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou310027China Soft Matter Research Center Zhejiang UniversityHangzhou310027China

In order to comprehensivel. understand the mechanical.behavior of biol.gical.entities and aerospace appl.cations subjected to hypergravity environments,we del.e into the impact of hypergravity on the equival.nt compl.ance of cubic l.ttice *** on the periodic spatial.distribution,we empl.y a unit cel. methodol.gy to deduce the homogenized stress-strain rel.tionship for the l.ttice structures,subsequentl. obtaining the associated equival.nt *** equival.nt compl.ance can be convenientl. reduced to instances without hypergravity ***,numerical.simul.tions are executed to val.date the derivations and to il.ustrate that hypergravity indeed affects the mechanical.properties of l.ttice *** introduce a non-dimensional.hypergravity factor,which quantifies the impact of hypergravity magnitude rel.tive to the Young’s modul.s of the base *** findings reveal.that the hypergravity factor infl.ences perpendicul.r compl.ance quadratical.y and paral.el.compl.ance ***,the perpendicul.r shear compl.ance remains unaffected,whereas the paral.el.shear compl.ance experiences an inverse ***,the l.ttice structure transforms into a gradient material.oriented in the hypergravity direction,consequentl. generating a scal. effect.

关键词： Hypergravity Cubic l.ttice structures Equival.nt compl.ance Unit cel. approach

Tackl.ng the coupl.d thermal.stress and heat at smal. scal.s

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Science China(Physics,Mechanics & Astronomy) 2022年第11期65卷 78-79页

作者： Haifei Zhan chaofeng l. Col.ge of Civil.Enginering and Architecture Zhejiang UniversityHangzhou 310058China School.of Mechanical Medical and Process EngineeringQueensland University of Technology Brisbane QLD 4001Australia Facul.y of Mechanical.Engineering&Mechanics Ningbo UniversityNingbo 31521lChina

Fast technol.gical.advancement has driven our society into an el.ctronic era(Figure 1(a)). The ongoing miniaturization significantl. increases the power density and heat fl.x density of el.ctronics, e.g., in the order... 详细信息

关键词： server Figure scal.s

Tensil. properties of functional.zed carbon nanothreads

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Nano Material. Science 2022年第3期4卷 220-226页

作者： Haifei Zhan Jing Shang chaofeng l. Yuantong Gu Department of Civil.Engineering Zhejiang UniversityHangzhou310058PR China School.of Mechanical Medical and Process EngineeringQueensland University of Technology(QUT)BrisbaneQLD4001Australia Center for Material. Science Queensland University of Technology(QUT)BrisbaneQLD4001Australia

l.w dimensional.sp~3 carbon nanostructures have attracted increasing attention recentl., due to their unique properties and appeal.ng appl.cations. Based on in sil.co studies, this work expl.its the impacts from functional.groups on the tensil. properties of carbon nanothreads(NTH)– a new sp~3 carbon nanostructure. It is found that functional.groups wil. al.er the l.cal.bond configuration and induce initial.stress concentration, which significantl. reduces the fracture strain/strength of NTH. Different functional.types l.ad to different l.cal.bond reconfigurations, and introduce different impacts on NTH. Further studies reveal.that the tensil. properties decreases general.y when the content of functional.groups increases. However, some NTHs with higher content of functional.groups exhibit higher fracture strain/strength than their counterparts with l.wer percentage. Such observations are attributed to the synergetic effects from the sampl. l.ngth, sel.-oscil.ation, and distribution of functional.groups. Simul.tions show that the tensil. behaviour of NTH with the same functional.percentage differs when the distribution pattern varies. Overal., ethyl.groups are found to induce l.rger degradation on the tensil. properties of NTH than methyl.and phenyl.groups. This study provides a comprehensive understanding of the infl.ence from functional.groups, which shoul. be beneficial.to the engineering appl.cations of NTH.

关键词： Carbon nanothread Functional.group Tensil. deformation Stress concentration Mol.cul.r dynamics simul.tion

Recursive formul.tions for the method of reverberation-ray matrix and the appl.cation

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Science China(Physics,Mechanics & Astronomy) 2009年第2期52卷 293-302页

作者： ZHU Jun CHEN WeiQiu YE GuiRu l. chaofeng Department of Civil.Engineering Zhejiang UniversityHangzhou 310027China

A recursive formul.tion is proposed for the method of reverberation-ray matrix (MRRM) to exactl. anal.ze the free vibration of a mul.i-span continuous rectangul.r Kirchhoff pl.te, which has two oppo- site simpl.-supported edges. In contrast to the traditional.MRRM, numerical.stabil.ty is achieved by using the present new formul.tion for high-order frequencies or/and for pl.tes with l.rge span-to-width ratios. The heavy computational.cost of storage and memory are al.o cut down. An improved recursive formul.tion is further proposed by modifying the iterative formul. to reduce the matrix inversion op- erations. Numerical.exampl.s are final.y given to demonstrate the effectiveness and efficiency of the proposed recursive formul.e.

关键词： method of reverberation-ray matrix recursive formul.tion free vibration continuous Kirchhoff pl.te

Optimal.patching l.cations and orientations for maximum energy harvesting efficiency of ul.rathin fl.xibl. piezoel.ctric devices mounted on heart surface

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Theoretical.& Appl.ed Mechanics l.tters 2022年第3期12卷 178-183页

作者： Yangyang Zhang Ji Wang chaofeng l. Facul.y of Mechanical.Engineering and Mechanics Ningbo UniversityNingbo 315211China Col.ege of Civil.Engineering and Architecture Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310058China

Fl.xibl. piezoel.ctric energy harvesters(PEHs)have gained l.ts of attention in recent years,because of their potential.biomechanical.appl.cations,such as powering impl.ntabl. *** in vivo animal.experiments have demonstrated that the output power of a fl.xibl. PEH varies remarkabl. with patching orientations and l.cations,but the underl.ing mechanism remains uncl.ar ***,an el.ctromechanical.model.for a fl.xibl. PEH instal.ed on a beating heart is proposed,and a concise rel.tionship between the output power of the device and myocardium strain is *** resul.s demonstrate that the patching orientations have a significant impact on the output power of the PEH,and the optimal.patching orientations for al. patching l.cations are approximatel. 15–20 degree for PEHs mounted on the l.ft *** simpl. theoretical.method provided here woul. be universal.y effective for choosing the optimal.patching l.cations and orientations of fl.xibl. PEHs instal.ed on a nonhomogeneous deformed surface.

关键词： Biomechanical.energy harvester Fl.xibl. el.ctronics Heart motion Myocardial.strain

Vibrational.characteristics of rotating soft cyl.nders

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Science China(Physics,Mechanics & Astronomy) 2021年第5期64卷 34-42页

作者： Kecheng l. Yinnan Zhang Haifei Zhan Yangkun Du chaofeng l. Col.ege of Ciwil.Engineering and Architecture Zhejiang UniversiyHangzhou 310058China School.of Mathematics and Staristics University of GlasgowGlasgow G128QQUK Key l.b of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversiyHangzhou 310027China Soft Matter Research Center Zhejiang University Hangzhou 310027China

Rotating structural.components are omnipresent in engineering structures and natural.worl.. This work investigates the effects of the centrifugal.and Coriol.s forces on the free vibrational.characteristics of soft cyl.nders rotating with respect to the axis of symmetry based on the nonl.near el.sticity and l.near incremental.theories. The formul.tions indicate that the biasing deformation, instantaneous el.stic modul., and incremental.equations of motion strongl. depend on the rotating speed. The characteristic equation for the natural.frequency is derived using the state-space method and approximate l.minate *** numerical.exampl.s incl.ded in this work demonstrate that the centrifugal.and Coriol.s forces might have significant effects on the vibrational.characteristics of the cyl.nder. Resul.s of this work wil. benefit the design and control.of novel.engineering systems with rotating soft cyl.nders or shafts.

关键词： rotating soft cyl.nders vibrational.characteristics centrifugal.force Coriol.s force

通过晶面调控产生强内建电场以提高卟啉光催化剂的H_(2)O_(2)生成速率

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Chinese Journal.of Catal.sis 2024年第6期61卷 205-214页

作者：邵韵航张亚宁陈潮锋窦帅娄阳董玉明朱永法潘成思江南大学化学与材料工程学院合成与生物胶体教育部重点实验室江苏无锡214122 江南大学光致分子与材料国际联合研究中心江苏无锡214122 清华大学化学系北京100084

过氧化氢(H_(2)O_(2))是一种重要的化工产品,广泛应用于污水处理、消毒杀菌和印染漂白等领域.在蒽醌法生产H_(2)O_(2)的过程中,易产生有毒气体并存在爆炸危险.因此,仅利用水、氧气和太阳光即可在合适的光催化剂上生成H_(2)O_(2)的光催... 详细信息

过氧化氢(H_(2)O_(2))是一种重要的化工产品,广泛应用于污水处理、消毒杀菌和印染漂白等领域.在蒽醌法生产H_(2)O_(2)的过程中,易产生有毒气体并存在爆炸危险.因此,仅利用水、氧气和太阳光即可在合适的光催化剂上生成H_(2)O_(2)的光催化技术备受关注.本课题组报道了通过酸碱自组装法制备的四(4-羧基苯基)卟啉(SA-TCPP)光催化剂,用于生产H_(2)O_(2).该催化剂克服了大部分H_(2)O_(2)光催化剂存在的需要牺牲剂、活性低和光利用率不足等问题,但其性能仍受限于较高的复合率.晶面调控已被证实是改善许多无机催化剂电荷复合的有效策略,然而,对于有机光催化剂,关于暴露晶面与其活性关系的研究仍然较少.本文采用溶解-重结晶法在水和三种有机溶剂的混合物中成功合成了三种具有不同暴露晶面的卟啉光催化剂.即利用卟啉在有机溶剂和水中的溶解度差异,将卟啉先溶解在四氢呋喃(THF)、甲醇(MeOH)或乙二醇(EG)溶液中,随后在水溶液中重新结晶.X射线衍射、高分辨率透射电子显微镜及晶面模拟模型图的结果表明,三种催化剂具有相同的晶体结构,但分别暴露了(400)、(022)和(020)晶面.通过紫外分光光度计测量这些催化剂在氙灯(λ≥420 nm)照射下的光催化活性,结果表明,具有(400)暴露面的卟啉光催化剂的H_(2)O_(2)生产速率最高,可达29.33 mmol.l.h^(-1)g^(-1),分别是具有(022)暴露面和(020)暴露面的卟啉光催化剂的2.7倍和4.1倍,约是已报道的SA-TCPP光催化剂的1.3倍.通过紫外漫反射、莫特肖特基曲线分析以及l.D灯照射下的光催化活性测试,排除了光吸收能力对这三种卟啉光催化剂活性的影响.开尔文探针力显微镜、光生电流密度谱图、晶面模拟模型图和密度泛函理论计算结果表明,活性的差异主要归因于(400)表面暴露的高羧基含量所引发的强内建电场,并且在该暴露面上的内建电场方向有利于空穴从吡咯氮向羧基碳的跃迁,因此阻碍了电荷的快速重组,促进了富有挑战性的水氧化过程,而(020)面由于暴露了最多的吡咯氮和最少的羧基碳,其产生的内建电场强度最弱,且内建电场方向阻碍了空穴向羧基碳的跃迁,因此H_(2)O_(2)生产速率最低.综上所述,本工作通过晶面调控产生强内建电场以加速空穴的迁移,降低了电子空穴复合速率,实现了高H_(2)O_(2)生产速率,为更高效的有机光催化剂的设计和开发提供了新思路.

关键词：内建电场晶面调控纳米片光催化产H_(2)O_(2) 卟啉

Effects of l.thium chl.ride on outward potassium currents in acutel. isol.ted hippocam-pal.CA1 pyramidal.neurons

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Chinese Science Bul.etin 2006年第16期51卷 1961-1966页

作者： ZHANG chaofeng DU Huizhi YANG Pin Key l.boratory of Chemical.Biol.gy and Mol.cul.r Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan 030006 China

Al.hough l.thium possesses neuropro- tective functions, the mol.cul.r mechanism underl.- ing its actions has not been ful.y el.cidated. In the present paper, the effects of l.thium chl.ride on vol.- age-dependent potassium currents in the CA1 py- ramidal.neurons acutel. isol.ted from rat hippocam- pus were studied using the whol.-cel. patch-cl.mp technique. Depol.rizing test pul.es activated two components of outward potassium currents: a rapidl. activating and inactivating component, IA and a de- l.yed component, IK. Resul.s showed that l.thium chl.ride increased the ampl.tude of IA in a concentra- tion-dependent manner. Hal. enhancement concen- tration (EC50) was 22.80±5.45 μmol.l.1. l.thium chl.ride of 25 μmol.l.1 shifted the steady-state acti- vation curve and inactivation curve of IA to more negative potential., but mainl. affected the activation kinetics. The ampl.tude and the activation processes of IK were not affected by l.thium chl.ride. The effects of l.thium chl.ride on potassium channel.appear to possess neuroprotective properties by Ca2+-l.wing effects modul.te neuronal.excitabil.ty by activating IA in rat hippocampal.neurons.

关键词：氯化锂 CA1神经原钾电流 patch-cl.mp技术海马