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Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss

Current Medical Science 2023年第2期43卷 367-375页

作者： chao-ye duan Wan-lin FAN Fei CHEN Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologne50937Germany Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective To explore the role of extracellular vesicles(EVs)in the pathogenesis of glaucoma caused by E50K *** A photoreceptor cell line,RGC-5,was transfected with empty plasmids and plasmids expressing wild-type(WT)optineurin(OPTN)or E50K OPTN to investigate the effects of OPTN glaucoma as well as to identify the role of EVs in glaucoma *** RGC-5 cells were also stimulated with glutamate,and their viability was evaluated using flow cytometry or CCK-8 *** were extracted,labeled with PKH-26,and added into the medium for normal RGC-5 culture,and the status of the cells was observed *** WT OPTN overexpression,E50K OPTN,and glutamate stimulation induced apoptosis of RGC-5 ***,when glutamate stimulation was used as an add-on treatment,the degree of apoptosis in WT OPTN-overexpressing RGC-5 cells was significantly lower than that in E50K OPTN-expressing and normal RGC-5 *** viability of normal RGC-5 cells was reduced when co-cultured with WT OPTN-overexpressing RGC-5 or E50K OPTN-overexpressing *** released by the latter two transfected lines similarly reduced normal RGC-5 *** Our results indicate that WT OPTN overexpression may lead to photoreceptor ***,overexpression also confers a degree of protection against high concentrations of extracellular ***,EVs released by transfected RGC-5 cells may regulate the cell *** findings may improve our understanding of the mechanisms of cell-cell interactions in pathological conditions,providing a basis for the use of EVs as novel targets for early diagnosis and treatment of glaucoma.

关键词： E50K mutation extracellular vesicles glaucoma optineurin RGC-5 photoreceptor cell line

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei ye Cong duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Advances in genotypic antimicrobialresistance testing: a comprehensive review

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Science China Life Sciences 2025年第01期 130-143页

作者： Boheng duan Xianjun Zeng Junping Peng Huan Kui College of Nanchang University Department of Imaging The Second Affiliated Hospital of Nanchang University NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences & Peking Union Medical College Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences & Peking Union Medical College Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education) State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen BiologyChinese Academy of Medical Sciences & Peking Union Medical College

Antimicrobial resistance(AMR) represents a substantial threat to global public health, complicating the treatment of common infections and leading to prolonged illness and escalated healthcare expenses. To effectively combat AMR, timely and accurate detection is crucial for AMR surveillance and individual-based therapy. Phenotypic antibiotic resistance testing(AST) has long been considered the gold standard in clinical applications, serving as the foundation for clinical AMR diagnosis and optimized therapy. It has significantly contributed to ensuring patients′ health and the development of novel antimicrobials. Despite advancements in automated culture-based AST technologies,inherent limitations impede the widespread use of phenotypic AST in AMR surveillance. Genotypic AST technologies offer a promising alternative option, exhibiting advantages of rapidity, high sensitivity, and specificity. With the continuous advancement and expanding applications of genotypic AST technologies, such as microfluidics, mass spectrometry, and high-resolution melting curve analysis, new vigor has been injected into the development and clinical implementation of genotypic AST technologies. In this narrative review, we discuss the principles, applications, and advancements of emerging genotypic AST methods in clinical settings. The comprehensive review aims to highlight the significant scientific potential of emerging genotypic AST technologies in clinical AMR diagnosis, providing insights to enhance existing methods and explore novel approaches.

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Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen duan Lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Selective C-C bonds formation,N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

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Chinese Chemical Letters 2022年第1期33卷 266-270页

作者： Guanxin Zhu Zheng-chao duan Haiyan Zhu Dongdong ye Dawei Wang The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China School of Chemical and Environmental Engineering Hubei Minzu UniversityEnshi 445000China

Earth abundant metals are much less expensive,promising,valuable metals and could be served as catalysts for the borrowing hydrogen reaction,dehydrogenation and heterocycles synthesis,instead of noble *** uniformly dispersed zinc composites were designed,synthesized and carefully characterized by means of XPS,EDS,TEM and *** resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines,ketones with alcohols in water under base-free conditions,while unsaturated carbonyl compounds could also be synthesized by tuning the reaction ***,it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green ***,this zinc catalyst could be easily recovered and reused for at least five times.

关键词： Unsymmetrical Zinc Borrowing hydrogen Recyclability Selective

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Spin-modulated near-infrared-Ⅰ emission in a xanthene-decorated Fe(Ⅱ) spin-crossover complex

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Science China Chemistry 2025年

作者： Cheng Yi Duyong Chen Shihui Zhang Rui Cai Chunying duan Yinshan Meng Tao Liu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials and Chemical Engineering School of Chemical Engineering Dalian University of Technology Instrumental Analysis Center Dalian University of Technology School of Chemistry Dalian University of Technology Liaoning Binhai Laboratory

Molecular materials showing synergetic coupling of near-infrared （NIR） fluorescence and spin-crossover （SCO） are promisingly applicable in in-vivo bioimaging,temperature sensing,and spintronic *** the related study faces formidable *** this work we graft the NIR fluorophore xanthene onto the dipyridyl substituted triazole ligand and construct a new Febased SCO material,{FeⅡ（ddxc-abpt）2[N（CN）2]2}(1,ddxc-abpt:（E）-4-(((3,5-di（pyridin-2-yl）-4H-1,2,4-triazol-4-yl)imino)methyl)-N,N-diethyl-2,3-dihydro-1H-xanthen-6-amine).Magnetic studies indicate that compound 1 exhibits thermally induced SCO property in both the solid and solution ***-temperature fluorescence emission spectra reveal a remarkable 7-fold increase in photoluminescence intensity upon the transition from the low-spin state at 110 K to the high-spin state at 280 K,which is the record of all reported coupled fluorescence-SCO ***-temperature ultraviolet-visible （UV-Vis）absorption spectra show a significant change in absorption intensity within the fluorescence emission window,consistent with the F?rster resonance energy transfer （FRET） ***-dependent density functional theory （TD-DFT） calculations demonstrate that the strong coupling is attributed to disrupted energy transfer between the xanthene fluorophore and high-spin *** work provides a feasible approach for expanding the synergetic SCO-fluorescence materials to the NIR-Iwavelength region,and hopefully contributes to the applications of tunable NIR-SCO molecule-based sensors and devices.

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Mineral Deposit Model of Cu-Fe-Au Skarn System in the Edongnan Region, Eastern China

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Acta Geologica Sinica(English Edition) 2020年第6期94卷 1797-1807页

作者： XIE Guiqing MAO Jingwen ZHU Qiaoqiao HAN Yingxiao LI Wei duan chao ye Hui Institute of Earth Sciences China University of GeosciencesBeijing 100083China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China Faculty of Geosciences and Resources China University of GeosciencesBeijing 100083China Hubei Sanxin Gold Copper Limited Company DayeHubei 435102China

Cu and Fe skarns are the world's most abundant and largest skarn type deposits,especially in China,and Au-rich skarn deposits have received much attention in the past two decades and yet there are few papers focused on schematic mineral deposit models of Cu-Fe-Au skarn *** types of Au-rich deposits are recognized in the Edongnan region,Middle-Lower Yangtze River metallogenic belt:~140 Ma Cu-Au and Au-Cu skarn deposits and distal Au-Tl deposits.137-148 Ma Cu-Fe and 130-133 Ma Fe skarn deposits are recognized in the Edongnan *** Cu-Fe skarn deposits have a greater contribution of mantle components than the Fe skarn deposits,and the hydrothermal fluids responsible for formation of the Fe skarn deposits involved a greater contribution from evaporitic sedimentary rocks compared to Cu-Fe skarn *** carbonate-hosted Au-Tl deposits in the Edongnan region are interpreted as distal products of Cu-Au skarn mineralization.A new schematic mineral deposit model of the Cu-Fe-Au skarn system is proposed to illustrate the relationship between the Cu-Fe-Au skarn mineralization,the evaporitic sedimentary rocks,and distal Au-Tl *** model has important implications for the exploration for carbonate-hosted Au-Tl deposits in the more distal parts of Cu-Au skarn systems,and Fe skarn deposits with the occurrence of gypsum-bearing host sedimentary rocks in the MLYRB,and possibly elsewhere.

关键词： mineral deposit model exploration Cu-Fe-Au skarn system Middle-Lower Yangtze River metallogenic belt

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Formal management-specifying approach for model-based safety assessment

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Journal of Systems Engineering and Electronics 2023年第6期34卷 1589-1601页

作者： XU Changyi duan Yiman ZHANG chao School of Control Science and Engineering Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of EducationDalian University of TechnologyDalian 116024China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

In the field of model-based system assessment,mathematical models are used to interpret the system ***,the industrial systems in this intelligent era will be more *** management operations will be dynamically set,and the system will be no longer static as it is initially ***,the static model generated by the traditional model-based safety assessment(MBSA)approach cannot be used to accurately assess the *** mainly exists three ***:huge and complex behaviors make the modeling to be trivial manual;Dynamic:though there are thousands of states and transitions,the previous model must be resubmitted to assess whenever new management arrives;Unreusable:as for different systems,the model must be resubmitted by reconsidering both the management and the system itself at the same time though the management is the *** by solving the above problems,this research studies a formal management specifying approach with the advantages of agility modeling,dynamic modeling,and specification design that can be ***,three typical managements are specified in a series-parallel system as a demonstration to show the potential.

关键词： model-based safety assessment(MBSA) management availability reliability maintainability continuous time Markov chain.

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基于注意力循环神经网络的联合深度推荐模型

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现代电子技术 2025年第1期48卷 80-84页

作者：郭东坡何彬张明焱段超江汉大学湖北武汉430056 华中师范大学湖北武汉430079 浙江师范大学浙江省智能教育技术与应用重点实验室浙江金华321004

为了向用户推荐符合兴趣偏好的项目,设计一种基于注意力循环神经网络的联合深度推荐模型。将双层注意力机制设置于网络中,该模型由五个部分构成,在输入层中生成联合深度推荐模型的输入矩阵,通过序列编码层对项目评论文本语义展开正向和... 详细信息

为了向用户推荐符合兴趣偏好的项目,设计一种基于注意力循环神经网络的联合深度推荐模型。将双层注意力机制设置于网络中,该模型由五个部分构成,在输入层中生成联合深度推荐模型的输入矩阵,通过序列编码层对项目评论文本语义展开正向和反向编码,获得隐藏状态输出,并将其输入双层注意力机制中,提取项目特征,利用全连接层提取用户偏好特征。在预测层中建立项目与用户的交互模型,获得项目评分,为用户推荐高评分的项目。为了提高模型精度,加权融合MSE损失函数、CE损失函数和RK损失函数建立组合损失函数,对深度联合训练模型展开训练,提高模型的推荐性能。仿真结果表明,所提方法具有良好的推荐效果,能够适应不断变化的市场需求和用户行为。

关键词：双层注意力机制循环神经网络用户偏好组合损失函数交互模型联合深度推荐模型

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