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Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

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Chinese Chemical Letters 2024年第1期35卷 371-378页

作者： ran Tian Xinyu Qiu Wenyun Mu Bolei Cai Zhongning liu Shiyu liu Xin Chen School of Chemical Engineering and Technology Department of Chemical EngineeringShaanxi Key Laboratory of Energy Chemical Process IntensificationXi'an Jiao Tong UniversityXi'an 710049China School of Stomatology State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral DiseasesDepartment of Preventive DentistryThe Fourth Military Medical UniversityXi'an 710032China School of Stomatology State Key Laboratory of Military StomatologyDepartment of Oral and Maxillofacial SurgeryThe Fourth Military Medical UniversityXi'an 710032China Department of Prosthodontics Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China School of Stomatology State Key Laboratory of Military StomatologyNational Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringThe Fourth Military Medical UniversityXi'an 710032China

The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer ***,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection *** hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed *** bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose ***,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.

关键词： Smart hydrogel with self-adaptable size Breast cancer therapy Dual responsive cargoes release Selective tumor elimination On-demand adipose tissue regeneration Effective bacteria inhibition

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Crust and Upper Mantle Density Structures beneath the Eastern Tianshan Region and Its Tectonic Implications

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Journal of Earth Science 2024年第3期35卷 828-838页

作者： Yiming liu chao Chen Qing Liang Zhengwang Hu Hubei Subsurface Multi-Scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

The deformation mechanisms of the Tianshan orogenic belt(TOB)are one of the most important unresolved issues in the collision of the Indian and Eurasian *** better understand the lithospheric deformation of the eastern Tianshan orogenic belt,we combined the S-wave tomography and gravity data to develop a three-dimensional(3D)density model of the crust and upper mantle beneath the eastern Tianshan *** show that the crust of the eastern Tianshan is mainly characterized by positive density anomalies,revealing widespread subduction-related magmatism during the *** however have also observed extensive low-density anomalies beneath the eastern Tianshan at depths deeper than~100 km,which is likely linked to a relatively hot *** most fundamental differences of the lithosphere within the eastern Tianshan occur in the uppermost *** uppermost mantle layers in the Bogda Shan and Harlik Shan are relatively *** is likely associated with an eclogite body in the uppermost *** most significant negative anomaly of the uppermost mantle is however found in the Jueluotage tectonic belt and the central Tianshan Block and is possibly associated with depleted mantle *** suggest that these differences related to compositional changes may control the strength of the lithospheric mantle and have affected the uplift of the northern and southern segments of the eastern Tianshan after the Permian.

关键词： constrained inversion gravity anomaly three-dimensional lithospheric density structure eastern Tianshan geodynamics geophysics.

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Impact of Ni particle size on CO_(2)activation and CO formation during reforming process:A density functional theory study

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Frontiers in Energy 2024年第4期18卷 525-534页

作者： Juntian NIU Shengzhuo CHEN Xianrong ZHENG Haiyu liu Yan JIN Jingyu ran College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Ministry of Education) Chongqing UniversityChongqing 400044China

In recent years,the dry reforming of methane(DRM)reaction has gained widespread attention due to its effective utilization of two major greenhouse *** Ni-based catalysts for DRM exhibit a strong dependence on particle size,however,the reaction mechanisms involved remain *** this work,the effect of metal particle size on CO_(2)activation and CO formation was explored in the DRM reaction using the density functional ***/MgO(x=13,25,37)was constructed to investigate the CO_(2)activation and the formation of CO during the DRM *** is found that CO_(2)is more inclined to undergo chemisorption on Nix/MgO before *** the variation in particle size,the main activation pathway of CO_(2)on the catalyst *** the smallest Ni13/MgO,CO_(2)tends to directly dissociate,while on the larger Ni25/MgO and Ni37/MgO,the hydrogenation dissociation of CO_(2)is more kinetically *** to Ni13/MgO and Ni37/MgO,the oxidation of surface C atoms and the oxidation of CH occur more readily on Ni25/*** indicates that C atoms are less likely to form on Ni25 particle and are more easily to be *** some extent,the results suggest that Ni25/MgO exhibits superior resistance to carbon formation.

关键词： particle size Ni/MgO catalyst CO_(2)activation CO formation

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Preparing cyclic polymers at high concentrations via self-folding cyclization technique by adjusting the contents of hydrophilic units in linear precursors

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Chinese Chemical Letters 2024年第2期35卷 283-288页

作者： Hao Zha Zuowei Wang chao liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Cyclic polymers are a class of polymers that feature endless topology,and the synthesis of cyclic polymers has attracted the attention of many ***,cyclic polymers were efficiently constructed by self-folding cyclization technique at high *** poly((oligo(ethylene glycol)acrylate)-co-(dodecyl acrylate))(P(OEGA-co-DDA))precursors with different ratios of hydrophilic and hydrophobic moieties were synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization using a bifunctional chain transfer agent with two anthryl end *** amphiphilic linear precursors underwent the self-folding process to generate polymeric nanoparticles in *** irradiating the aqueous solution of the nanoparticles with 365 nm UV light,cyclic polymers were synthesized successfully via coupling of anthryl *** effects of the ratios of hydrophilic and hydrophobic moieties in linear P(OEGA-co-DDA)copolymers and polymer concentration on the purity of the obtained cyclic polymers were explored in detail via ^(1)H nuclear magnetic resonance(^(1)H NMR),dynamic light scattering(DLS),UV‒visible(vis)analysis,three-detection size exclusion chromatography(TD-SEC)and transmission electron microscopy(TEM).It was found that by adjusting the content of the hydrophilic segments in linear precursors,single chain polymeric nanoparticles(SCPNs)can be generated at high polymer ***,cyclic polymers with high purity can be constructed *** method overcomes the limitation of traditional ring-closure method,which is typically conducted in highly dilute conditions,providing an efficient method for the scalable preparation of cyclic polymers.

关键词： Cyclic polymers Self-folding cyclization technique Single chain polymeric nanoparticles RAFT polymerization Direct visualization

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Three-dimensional hydro-mechanical coupling numerical simulation of shield-driven cross-river twin tunnels:A case study

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Underground Space 2024年第3期16卷 106-125页

作者： Chengwen Wang Xiaoli liu Danqing Song Enzhi Wang Guohui Yan ran Zhou Department of Hydraulic Engineering State Key Laboratory of Hydroscience and EngineeringTsinghua UniversityBeijing 100084China YSD Rail Transit Construction Company Limited Guangzhou 510630China

With the rapid development of urban underground space,the construction of shield-driven cross-river twin tunnels is increasing,and the complex hydro-mechanical coupling effects and twin-tunnel interactions bring huge construction risks to such projects,which have attracted more and more *** study aims to understand the excavation effects induced by shield driving of cross-river twin tunnels through numerical simulation.A refined three-dimensional numerical model based on the fully coupled hydro-mechanical theory is *** model considers the main components of the slurry pressure balance shield(SPBS)machine,including support force,jacking thrust,grouting pressure,shield-rock interaction and lining-grouting interaction,as well as the detailed construction *** purpose is to examine the excavation effects during construction,including rock deformation around tunnels,the change in pore pressure,and the response of the *** results show the influence range of twin-tunnel excavation on rock deformation and pore pressure,as well as the modes of lining *** addition,this study also systematically investigates the effects of water level fluctuation and burial depth on twin-tunnel *** results indicate that the increase of water level or burial depth will enhance the excavation effects and strengthen the twin-tunnel *** results provide useful insights for estimating the construction impact range and degree of twin tunnels,and serve as basic references for the design of cross-river twin tunnels.

关键词： Numerical modeling Twin tunnels Crossing river Hydro-mechanical coupling Lining response

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Impact of mica on geotechnical behavior of weathered granitic soil using macro and micro investigations

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2250-2266页

作者： Xianwei Zhang Xinyu liu Haodong Gao Gang Wang ran An Zhu Liang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan430074China College of Urban Construction Wuhan University of Science and TechnologyWuhan430065China University of Chinese Academy of Sciences Beijing100049China Guangzhou Urban Planning&Design Survey Research Institute Guangzhou510000China Guangdong Enterprise Key Laboratory for Urban Sensing Monitoring and Early WarningGuangzhou510000China

The micaceous weathered granitic soil(WGS)is frequently encountered in civil engineering worldwide,unfortunately little information is available regarding how mica affects the physico-mechanical behaviors of *** study prepares reconstituted WGS with different mica contents by removing natural mica in theWGS,and then mixes it with commercial mica *** geotechnical behavior as well as the microstructures of the mixtures are *** addition of mica enables the physical indices of WGS to be specific combinations of coarser gradation and high permeability but high Atterberg ***,high mica content in WGS was found to be associated with undesirable mechanical properties,including increased compressibility,disintegration,and swelling potential,as well as poor compactability and low effective frictional *** analysis indicates that the influence of mica on the responses of mixtures originates from the intrinsic nature of mica as well as the particle packing being formed *** exists in the mixture as stacks of plates that form a spongy structure with high compressibility and swelling *** among the plates give the soil high water retention and high Atterberg *** pores are also generated by soil particles with bridging packing,which enhances the permeability and water-soil interactions upon *** study provides a microlevel understanding of how mica dominates the behavior of WGS and provides new insights into the effective stabilization and improvement of micaceous soils.

关键词： Weathered granitic soil(WGS) Mica Microstructure Physical properties Mechanical properties Mechanism

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Real-Time Energy Management for Net-Zero Power Systems Based on Shared Energy Storage

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 371-380页

作者： Pengbo Du Bonan Huang Ziming liu chao Yang Qiuye Sun School of Information Science and Engineering Northeastern UniversityShenyang 110004China Information and Communication Branch State Grid Liaoning Electric Power Company Ltd.Shenyang 110004China IEEE

Battery energy storage systems(BESSs)serve a crucial role in balancing energy fluctuations and reducing carbon emissions in net-zero power ***,the efficiency and cost performance have remained significant challenges,which hinders the widespread adoption and development of *** address these challenges,this paper proposes a real-time energy management scheme that considers the involvement of prosumers to support net-zero power *** scheme is based on two shared energy storage models,referred to as energy storage sale model and power line lease *** energy storage sale model balances real-time power deviations by energy interaction with the goal of minimizing system costs while generating revenue for shared energy storage providers(ESPs).Additionally,power line lease model supports peer-to-peer(P2P)power trading among prosumers through the power lines laid by ESPs to connect each *** model allows ESP to earn profits from the use of power lines while balancing power deviations and better consuming renewable *** results validate the effectiveness of the proposed scheme,ensuring stable power supply for net-zero power systems and providing benefits for both the ESP and prosumers.

关键词： Shared energy storage energy storage provider(ESP) energy management peer-to-peer(P2P)trading net-zero power system

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Starlet:Network defense resource allocation with multi-armed bandits for cloud-edge crowd sensing in IoT

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Digital Communications and Networks 2024年第3期10卷 586-596页

作者： Hui Xia Ning Huang Xuecai Feng Rui Zhang chao liu College of Computer Science and Technology Ocean University of ChinaQingdao266100China

The cloud platform has limited defense resources to fully protect the edge servers used to process crowd sensing data in Internet of *** guarantee the network's overall security,we present a network defense resource allocation with multi-armed bandits to maximize the network's overall ***,we propose the method for dynamic setting of node defense resource thresholds to obtain the defender(attacker)benefit function of edge servers(nodes)and ***,we design a defense resource sharing mechanism for neighboring nodes to obtain the defense capability of ***,we use the decomposability and Lipschitz conti-nuity of the defender's total expected utility to reduce the difference between the utility's discrete and continuous arms and analyze the difference ***,experimental results show that the method maximizes the defender's total expected utility and reduces the difference between the discrete and continuous arms of the utility.

关键词： Internet of things Defense resource sharing Multi-armed bandits Defense resource allocation

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Improve the industrial digital transformation through Industrial Internet platforms

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Frontiers of Engineering Management 2024年第1期11卷 167-174页

作者： ran liu Xiaolei XIE Department of Industrial Engineering&Management Shanghai Jiao Tong UniversityShanghai 200240China Department of Industrial Engineering Tsinghua UniversityBeijing 100084China

1 Introduction 1.1 Definition and stakeholders of the Industrial Internet The Industrial Internet is a novel network technology system that applies the Internet of Things(IoT)to the manufacturing and industrial *** facilitates the connection of various sensors,devices,systems,factories,and enterprises,enabling the sharing and exchange of data to improve production efficiency,reduce costs,enhance product quality,and enable smart *** Industrial Internet serves as a crucial cornerstone and essential support for the Fourth Industrial Revolution,offering specific approaches for industrial digital *** the comprehensive interconnection of people,machines,and things,the Industrial Internet analyzes various data from intelligent feedback,fostering the development of a new manufacturing and service system.

关键词： industrial digital transformation Industrial Internet platform manufacturing big data

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Wellbore-heat-transfer-model-based optimization and control for cooling downhole drilling fluid

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Petroleum Science 2024年第3期21卷 1955-1968页

作者： chao Wang He liu Guo-Wei Yu Chen Yu Xian-Ming liu Peng Huang Yangtze University Jingzhou434023HubeiChina State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China CNPC Bohai Drilling Engineering Co. LtdTianjin300280China Exploration Development and Construction Engineering Division of PetroChina Jidong Oilfield Company Tangshan63200HebeiChin Henan University of Urban Construction Pingdingshan467036HenanChina

To address the two critical issues of evaluating the necessity of implementing cooling techniques and achieving real-time temperature control of drilling fluids underground in the current drilling fluid cooling technology,we first established a temperature and pressure coupled downhole heat transfer model,which can be used in both water-based and oil-based drilling ***,fourteen factors,which could affect wellbore temperature,were *** on the standard deviation of the downhole temperature corresponding to each influencing factor,the influence of each factor was *** influencing factors that can be used to guide the drilling fluid's cooling technology were drilling fluid thermal conductivity,drilling fluid heat capacity,drilling fluid density,drill strings rotation speed,pump rate,viscosity,ROP,and injection *** nondominated sorting genetic algorithm was used to optimize these six parameters,but the optimization process took 182 *** these eight parameters'influence rules with the nondominated sorting genetic algorithm can reduce the optimization time to 108 ***,the downhole temperature has been demonstrated to increase with the inlet temperature increasing linearly under quasi-steady *** this law and PID,the downhole temperature can be controlled,which can reduce the energy for cooling the surface drilling fluid and can ensure the downhole temperature reaches the set value as soon as possible.

关键词： Drilling Cooling Influencing factors Analysis Optimization Control

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