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An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School-Guangzhou City,Guangdong Province,China,2023

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China CDC weekly 2024年第12期6卷 242-246,I0005页

作者： Xiang Zeng qing He Yilan Li Yong Zhou Xiaoping Shao Pei Hu Jian Liang Yudan Song chao Ma Lijie Zhang Limei Sun Lei luo Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina Zhuhai Center for Disease Control and Prevention Zhuhai CityGuangdong ProvinceChina Guangdong Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Guangzhou Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina Department of the National Immunization Programme Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows.Worldwide,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and W.What is added by this report?An outbreak of serogroup Y Neisseria meningitidis(Nm)in a secondary vocational school involved a single confirmed severe case and 24 individuals with laboratory-confirmed Nm carriage.Epidemiological investigation revealed that the outbreak was localized to the classroom of the confirmed case.Prolonged close contact within a confined space was identified as a significant risk factor for Nm transmission.The genotype sequence identified was type 1655(ST-1655),which is categorized under clonal complex 23(CC-23)and bears resemblance to 8 previously confirmed cases of serogroup Y meningococcal meningitis within Guangdong Province.This suggests that serogroup Y infections continue to sporadically emerge and have become prevalent strains.What are the implications for public health practice?This outbreak underscores the critical need to enhance surveillance of meningococcal serogroups and population carrier,and advocate for vaccination with MenY-containing vaccines.

关键词： break Secondary Guangdong

PARAMETER OPTIMIZATION AND VIBRATION REDUCTION ANALYSIS OF DOUBLE ELECTROMAGNETIC SHUNT TUNED MASS DAMPER

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High performance and stable pure-blue quasi-2D perovskite light-emitting diodes by multifunctional zwitterionic passivation engineering

Gongcheng Lixue/Engineering Mechanics 2024年第5期41卷 155-166页

作者： Sun, Hong-Xin Huang, chao-Yang luo, Yi-Fan Wang, Xiu-Yong Wen, qing School of Civil Engineering Hu’nan University of Science and Technology Hu’nan Provincial Key Laboratory of Intelligent Disaster Prevention-Mitigation and Ecological Restoration in Civil Engineering Hu’nan Xiangtan 411201 China

A novel electromagnetic shunt tuned mass damper (EMS-TMD) is proposed for structural vibration control. A new feature of the damper is the electromagnetic damping element that replaces the viscous damping of the traditional double tuned mass dampers. To further improve the damping performance and robustness of the damper, a double electromagnetic shunt tuned mass damper (DEMS-TMD) is designed. According to the Alembert’s theorem, the dynamic model of the coupled system DEMS-TMD and a single degree of freedom structure under seismic excitation is established. Based on the Monte Carlo pattern search method with the target of minimizing the value of the maximum dynamic amplification coefficient of the main structure displacement, the optimal parameters of DEMS-TMD, the structure frequency ratio, the electrical frequency ratio, the electromagnetic damping ratio and the electromechanical coupling coefficient are obtained, which provides the theoretical guidance for damping parameter design. The frequency and time domain simulations of the DEMS-TMD are conducted to analyze the performance of the vibration suppression of the DEMS-TMD. The results show that the reduction of the peak and RMS values of main structure displacement of the DEMS-TMD is superior to traditional parallel double tuned mass dampers (DTMD) in the frequency domain simulations. The reduction of the peak and RMS values of displacement and acceleration of the DEMS-TMD is superior to traditional DTMD in the time domain simulations, which shows the better damping effect of the DEMS-TMD on structures. © 2024 Tsinghua University. All rights reserved.

关键词： Acceleration

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Advanced Photonics 2024年第2期6卷 32-40页

作者： chao Shen Shuyan Fang Jibin Zhang Xiangfei Liang Chenhui Su Jian qing Wanzhu Cai Yunhan luo Renqiang Yang Lintao Hou Jinan University College of Physics and Optical EngineeringGuangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangzhou Key Laboratory of Vacuum Coating Technologies and New Energy MaterialsGuangzhouChina Jinan University College of Physics and Optical EngineeringGuangdong Provincial Key Laboratory of Optical Fiber Sensing and CommunicationsGuangzhouChina Zhengzhou University School of Physics and MicroelectronicsKey Laboratory of Materials Physics of Ministry of EducationZhengzhouChina Jinan University Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education InstitutesGuangzhouChina Jianghan University School of Optoelectronic Materials and TechnologyKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of EducationWuhanChina

Despite the rapid advances of red and green perovskite light-emitting diodes(Pe LEDs),achieving high brightness with high external quantum efficiency(EQE)remains a challenge for the pure-blue Pe LEDs,which greatly hinders their practical applications,such as white-light illumination and in optical communication as a high-speed and low-loss light source.Herein,we report a high-performance pure-blue Pe LED based on mixed-halide quasi-2D perovskites incorporated with a zwitterionic molecule of 3-(benzyldimethylammonio)propanesulfonate(3-BAS).Experimental and density functional theory analysis reveals that 3-BAS can simultaneously eliminate non-radiative recombination loss,suppress halide migration,and regulate phase distribution for smoothing energy transfer in the mixed-halide quasi-2D perovskites,leading to the final perovskites with high photoluminescence quantum yield and robust spectrum stability.Thus,the highperformance pure-blue Pe LED with a recorded brightness with 1806 cd m-2and a relative higher EQE of 9.25%is achieved,which is successfully demonstrated in a visible light communication system for voice signal transmission.We pave the way for achieving highly efficient pure-blue Pe LEDs with great application potential in future optical communication networks.

关键词： pure-blue PeLEDs quasi-2D perovskite zwitterionic additive visible light communication

Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： chao-Yue Sun Wen Li Hai-qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

Diagnostic value associated with the combination of saliva pepsin and microorganisms in functional heartburn and gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第19期30卷 2612-2614页

作者： Yu-Qi Huang chao Yang Wen luo Department of Stomatology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina School of Stomatology Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Research and Development Department Shenzhen Uni-medica Technology Co.LtdShenzhen 518051Guangdong ProvinceChina Department of Stomatology The People’s Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina

Heartburn is a common symptom shared by both gastroesophageal reflux disease(GERD)and functional heartburn(FHB),which can make it challenging to differentiate between the two conditions.However,examining oral manifestations of GERD can be a cost-effective and readily available method to aid in this differentiation process.It may serve as a valuable tool in distinguishing GERD from FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence Risk factors Dental erosion Periodontal diseases

Laser Powder Bed Fusion of Beta-Type Titanium Alloys for Biomedical Application:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 17-28页

作者： Xuan luo chao Yang Dongdong Li Lai-Chang Zhang State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic MaterialsSouth China University of TechnologyGuangzhou510640China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing ofβ-type titanium alloy is expected to replace Ti-6Al-4V alloy in the field of orthopedic implantation because of their low elastic modulus,excellent corrosion resistance,and biocompatibility.After briefly introducing the laser powder bed fusion(LPBF)process and physical phenomena,this paper reviews the recent progresses in LPBF-edβ-type Ti alloys.The strategies to strengthening and tougheningβ-type Ti alloys are critically reviewed.This is followed by the processing routes employed to achieve to low modulus for orthopedic applications,especially a new methodology for tailoring crystallographic orientation called multi-track coupled directional solidification.The effect of processing and compositions on performance metrics ofβ-type Ti alloys included corrosion behavior,and biocompatibility is reviewed.In the end,challenges in additive manufacturing ofβ-type Ti alloys in future are highlighted,with the aim to ensue clinical application of LPBF-edβ-type Ti alloys.

关键词： β-type Ti alloys Laser powder bed fusion Mechanical properties Elastic modulus Biocompatibility

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng Si Yue-Yue Wang chao-qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are scarce.In this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are realized.The generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three wavelengths.Positive and negative dispersion lead to different group velocities of solitons.The presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an explosion.With an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental results.This work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

Lipid metabolism analysis in esophageal cancer and associated drug discovery

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Journal of Pharmaceutical Analysis 2024年第1期14卷 1-15页

作者： Ruidi Jiao Wei Jiang Kunpeng Xu Qian luo Luhua Wang chao Zhao Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong518116China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China

Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tumors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

关键词： Lipid metabolism Esophageal cancer Progression Treatment resistance New therapeutic targets

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： Yulu Shi Quan Kang Hong Zhou Xiaohan Yue Yang Bi qing luo Stem Cell Biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few known differentia-tion inducers,and little research has been done on their targets.Cell differentiation is associated with an increase in mitochondrial content and activity.The metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as well as up-regulation of aerobic glycolysis and pentose phosphate pathways.Leucine-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated with tumorigenesis and progression,as well as cancer cell stemness.We found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and function.Knockdown of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathway,promoted oxidative phosphorylation,and led to osteogenic differentiation.It also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro model.When LETM1 was knocked down in vivo,there was reduced tumor formation and lung metastasis.These data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdown of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathway,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness