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Associations between CD24 gene polymorphisms and inflammatory bowel disease:A meta-analysis

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World Journal of Gastroenterology 2015年第19期21卷 6052-6059页

作者： Xiao-Li huang Dong-hua Xu Guo-Pin Wang Shu Zhang Cheng-Gong Yu Department of Gastroenterology Gulou School of Clinical Medicine Nanjing Medical University Department of Gastroenterology Nanjing Jiangbei People’s Hospital Affiliated to Southeast University Department of Rheumatology the First Affiliated Hospital of Nanjing Medical University Nanjing University Medical School Department of Gastroenterology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School

AIM: To evaluate the relationships between CD24 gene polymorphisms and the risk of inflammatory bowel disease(IBD), including ulcerative colitis(UC)and Crohn's disease(CD).METHODS: The PubMed, Web of Science and Cochrane Library databases were searched(up to May30, 2014). The search terms "CD24", "inflammatory bowel disease", "Crohn's disease", "Ulcerative colitis","IBD", "CD" or "UC"; and "polymorphism", "mutation"or "variant" were used. Association studies were limited to the English language, but no limitations in terms of race, ethnicity or geographic area were *** SE12 software was used to calculate the pooled odds ratios(ORs) with 95% confidence intervals(CIs).P 0.05). However, in a disease subgroup analysis, we found that the CD24 C170 T polymorphism was associated with an increased risk of UC in a dominant model(OR = 1.79, 95%CI: 1.15-2.77, P =0.009) and an additive model(OR = 1.87, 95%CI:1.19-2.93, P = 0.007), but this relationship was not present for CD. The CD24 TG1570 del polymorphism was significantly associated with CD in the additive model(OR = 1.24, 95%CI: 1.01-1.52, P = 0.037).CONCLUSION: Our findings provide evidence that the CD24 C170 T polymorphism might contribute to the susceptibility to UC, and the CD24 TG1527 del polymorphism might be associated with the risk of CD.

关键词： CD24 Polymorphism Inflammatory boweldisease rs8734 rs3838646 Meta-analysis

A Preliminary Study on Anti-Colorectal Cancer Effect and Molecular Mechanism of Aegiceras Corniculatum Extract

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World Journal of Traditional Chinese Medicine 2023年第4期9卷 404-414页

作者： De‑chao Tan Xiao‑Tao Hou hua Luo Yi‑Wei Chen Zheng‑Cai Du Jin‑Ling Xie Lin‑Yao Wei Chi-Teng Vong Xiao‑Yan Wen Er‑Wei Hao Jia‑Gang Deng Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese MedicineNanningChina Guangxi Collaborative Innovation Center of Research on Functional Ingredients of Agricultural Residues NanningChina Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoMacaoChina Sino‑Canada Joint Zebrafish Lab for Chinese Herbal Drug Screening Guangxi University of Chinese MedicineNanningChina Zebrafish Center for Advanced Drug Discovery Keenan Research Center for Biomedical ScienceLi Ka Shing Knowledge InstituteSt.Michael’s HospitalTorontoOntarioCanada

Objective:To study the inhibitory effects on colorectal cancer(CRC)and the underlying mechanism of the petroleum ether extract of Aegiceras corniculatum leaves(PACL).Materials and Methods:The effect of PACL on the proliferation of CRC cell lines DLD-1,HT-29,and SW480was measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay and colony-forming *** then,a wound-healing assay was used to measure the migration ability of three CRC *** cell cycle and apoptosis of three CRC cells were measured by PI/RNase staining and annexin V-FITC/double staining,respectively,and the intrinsic apoptosis pathway was studied by the Western *** anti-CRC effect of PACL in vivo was evaluated by HT-29 xenograft zebrafish ***:PACL inhibited cell viability and proliferation in DLD-1,HT-29,and SW480 cells in a dose-and time-dependent *** can inhibit cell migration in DLD-1and SW480 cells but not in the less mobile phenotype cell *** treatment resulted in cell cycle arrest of DLD-1 and HT-29 cells in the G2/M ***,PACL can induce apoptosis in all three CRC cells,which may be achieved by regulating the intrinsic apoptosis pathway mediated by mitochondria and the endoplasmic ***,the tumor sizes were decreased after treatment with PACL and PACL combined with fluorouracil in HT-29 xenograft zebrafish ***:These findings suggested that PACL may exert its anti-CRC effect by inducing apoptosis through the intrinsic apoptosis pathway and show a significant anti-CRC effect in vitro and in vivo,so it might be potentially developed as an anti-CRC agent.

关键词： Aegiceras corniculatum apoptosis cell cycle colorectal cancer zebrafish xenograft

用格子Boltzmann方法模拟MKDV方程

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物理学报 2001年第5期50卷 837-840页

作者：李华兵黄乒花刘慕仁孔令江桂林电子工业学院计算科学与应用物理系桂林541004 广西师范大学物理与电子科学系桂林541004

用精确到 0 (ε4)的 5速格子Boltzmann模型模拟MKDV方程 :ut+6u2 ux+uxxx=0 ,并与MKDV方程的孤子解比较 ,二者精确吻合 .

关键词：格子Boltzmann方法 MKDV方程孤子解数值模拟非线性偏微分方程非线性物理学

Self-expanding metal stent for relieving the stricture after endoscopic injection for esophageal varices

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World Journal of Clinical Cases 2024年第28期12卷 6180-6186页

作者： Fu-Long Zhang Jing Xu Yu-Hong Jiang Yuan-Dong Zhu Yan Shi Xiao Li Hai Wang chao-Jun huang Chun-hua Zhou Qun Zhu Jing-Wen Chen Department of Gastroenterology Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Esophageal stricture is one of the complications after esophageal varices sclero-therapy injection(ESI),and the incidence rate is between 2%-10%.AIM To explore the efficacy of self-expanding metal stent(SEMS)for the stricture after endoscopic injection with cyanoacrylate(CYA)and sclerotherapy for esophageal *** We retrospectively analyzed the efficacy of SEMS to improve the stricture after endoscopic injection with CYA and sclerotherapy for esophageal varices in 4 patients from February 2023 to June *** The strictures were improved in four patients after *** stent was removed after two weeks because of chest pain with embedding into esophageal mucosa in one *** stent was removed after one month,however,the stent was reinserted because of the strictures happening again in two *** stent was removed after three months,however,the stent was reinserted because of the strictures happening again in one *** stent embedded into esophageal mucosa in three *** were 3 patients suffered reflux esophagitis,and the acid reflux was relieved by taking *** was no other complication of esophageal perforation,bleeding from varices or *** SEMS may relieve the stricture which happened after endoscopic injection with CYA and sclerotherapy for esophageal ***,when we should remove the stent still needs to be explored.

关键词： Stent Stricture Endoscopic injection Esophageal varices cyanoacrylate Sclerotherapy

Effect of ultrasonic and mechanical vibration treatments on evolution of Mn-rich phases and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2393-2414页

作者： Bo LIN Xiang-xiang HE Song-chao XIA hua-qiang XIAO Yu-liang ZHAO Khashayar KHANLARI School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Centro Nacional de Investigaciones Metalúrgicas(CENIM) C.S.I.C.Avda.de Gregorio del Amo 8Madrid 28040Spain Department of Chemical&Biotechnological Engineering Universitéde SherbrookeQuébecQC J1K 2R1Canada

Effects of ultrasonic vibration(UV)and mechanical vibration(MV)on the Mn-rich phase modification and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys were *** results show that the UV and UV+MV treatments can significantly refine and fragmentize the *** addition,UV treatment can significantly passivate the primary Mn-rich Al15Mn3Si2 *** formation mechanisms of refinement and passivation of the grains and non-dendrite particles were *** with the gravity die-cast alloys,the UV and UV+MV treated alloys exhibit improved tensile and creep resistance at room and elevated *** results can be attributed to the refinement of theα(Al)grains and the secondary intermetallics,the increased proportion of refined heat-resistant precipitates,and the formation of nano-sized Si *** ultimate tensile strength of the UV treated alloys at 350℃ exceeds that of commercial piston *** indicates the high application potential of the developed piston alloys in density diesel engines.

关键词： Al−Si piston alloys Mn-rich phases mechanical properties ultrasonic vibration mechanical vibration

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基于努力程度的创业投资最优股权分配模型

系统工程 2005年第9期23卷 70-73页

作者：党兴华赵巧艳黄正超西安理工大学工商管理学院陕西西安710048

主要围绕与创业投资有关的股权分配及激励兼容问题,将创业资本家努力因素引入收益函数,建立了在创业资本家和创业企业家均衡努力情况下的最优股权分配模型。通过分析得出了创业资本家在创业企业中所占股权是随其努力重要程度λ的变化同... 详细信息

主要围绕与创业投资有关的股权分配及激励兼容问题,将创业资本家努力因素引入收益函数,建立了在创业资本家和创业企业家均衡努力情况下的最优股权分配模型。通过分析得出了创业资本家在创业企业中所占股权是随其努力重要程度λ的变化同向变化的,而不是绝对地按投资阶段递增或递减的结论。文章还讨论了创业企业潜力、股票市场等因素对最优股权分配的影响。

关键词：创业投资信息不对称股权分配

New timing of the Indosinian intracontinental deformation from the Triassic growth strata in the Kuqa Depression,Southern Tianshan,China

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China Geology 2022年第4期5卷 771-773页

作者： Xiang Qin Xuan-hua Chen Zhao-gang Shao Yi-ping Zhang Yong-chao Wang Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural ResourcesBeijing 100037China

*** In the Indosinian duration,series of Gondwana-related plates pieced together and formed the geological sketch of China for the first time,*** Yangtze,Sino Korean,Tarim plates,and other sub-plates that had been isolated for a long *** and collision among the Tarim,Qaidam,and Qiangtang blocks in Triassic,as well as the closure of the Paleo-Tethys Ocean,reactivated Late Paleozoic suture zones in the Tianshan orogen region(Hendrix MS et al.,1992).

关键词： Tianshan Triassic strata

AM-MA-AMPS三元共聚物的合成及溶液性能研究

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精细化工 2000年第11期17卷 679-681页

作者：金勇黄荣华中国科学院成都有机化学研究所四川成都610041 四川联合大学高分子材料研究所四川成都610065

以丙烯酰胺 (AM)、丙烯酸甲酯 (MA)和α 丙烯酰胺基 α 甲基丙磺酸 (AMPS)为原料 ,通过水溶液共聚 ,合成了一种新型三元共聚物 (AM -MA -AMPS) ,并对其进行了表征。DSC和TG测试表明该三元共聚物的玻璃化温度为 2 45℃ ,分解温度为 381 ... 详细信息

以丙烯酰胺 (AM)、丙烯酸甲酯 (MA)和α 丙烯酰胺基 α 甲基丙磺酸 (AMPS)为原料 ,通过水溶液共聚 ,合成了一种新型三元共聚物 (AM -MA -AMPS) ,并对其进行了表征。DSC和TG测试表明该三元共聚物的玻璃化温度为 2 45℃ ,分解温度为 381 8℃ ,均高于聚丙烯酰胺 (PAM)。实验表明 ,质量浓度为 2 0kg m3 的AM -MA -AMPS三元共聚物的水溶液黏度为 2 1 0 6mPa·s ,标准复合盐溶液黏度为 7 36mPa·s ,均较相应的PAM有提高。

关键词： AM-MA-AMPS 共聚物溶液性能合成丙烯酰胺

Climate Evolution Recorded by Organic Carbon Stable I sotope since 5 *** Poyang Lake Area, China

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Journal of China University of Geosciences 2003年第1期14卷 25-27页

作者： Peng Hongxia Li Chang’an Shi chaoyi Yang chao huang Changsheng Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 Faculty of Earth Sciences China University of GeosciencesWuhan 430074

Based on the data of organic carbon stable isotope ratios and magnet ic susceptibility, climate evolution in the past 5 kaB.P. in Poyang Lake plain (in Jiangxi Province) has been reconstructed. The results of the research indicate that the climate evolution can be divided into nine stages in the past 5 kaB.P.. Comparisons of different regional environmental records suggest that the intens ity and the temporal spatial changes of monsoon in China mainly controlled the climate evolution.

关键词： Poyang Lake area paleoclimate evolution organic carbon stable isoto pe ratios magnetic susceptibility.