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Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin Chen En-Da yu chao-yu miao Department of Colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of Endocrinology and Metabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been *** the popularization of endoscopic technology,a number of early CRC has been ***,despite current treatment methods,some patients with early CRC still experience postoperative recurrence and *** To search for indicators associated with early CRC recurrence and metastasis to identify high-risk *** A total of 513 patients with pT2N0M0 or pT3N0M0 CRC were retrospectively enrolled in this *** of blood routine test,liver and kidney function tests and tumor markers were collected before *** were followed up through disease-specific database and telephone *** recurrence,metastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and *** We comprehensively compared the predictive value of preoperative blood routine,blood biochemistry and tumor markers for disease-free survival(DFS)and overall survival(OS)of *** multivariate analysis demonstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum carcinoembryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for *** cutoff value of serum CEA level for predicting OS was 2.74 ng/*** the OS of CRC patients with serum CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0M0 or T3N0M0 CRC,preoperative platelet count was a protective factor for DFS,while serum CEA level was an independent risk factor for *** that these measures are easier to detect and more acceptable to patients,they may have broader applications.

关键词： Colorectal cancer Platelet count Serum carcinoembryonic antigen Total cholesterol level Overall survival Disease-free survival

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Mitochondrial transplantation as a promising therapy for mitochondrial diseases

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1028-1035页

作者： Tian-guang Zhang chao-yu miao Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

Mitochondrial diseases are a group of inherited or acquired metabolic disorders caused by mitochondrial dysfunction which may affect almost all the organs in the body and present at any ***,no satisfactory therapeutic strategies have been available for mitochondrial diseases so *** transplantation is a burgeoning approach for treatment of mitochondrial diseases by recovery of dysfunctional mitochondria in defective cells using isolated functional *** models of mitochondrial transplantation in cells,animals,and patients have proved effective via various routes of mitochondrial *** review presents different techniques used in mitochondrial isolation and delivery,mechanisms of mitochondrial internalization and consequences of mitochondrial transplantation,along with challenges for clinical *** some unknowns and challenges,mitochondrial transplantation would provide an innovative approach for mitochondrial medicine.

关键词： Mitochondria Mitochondrial transplantation Mitochondrial disease Mitochondrial isolation Mitochondrial delivery Mitochondrial storage Mitochondrial transplantation rejection Ethical issue

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Targeting NAMPT as a therapeutic strategy against stroke

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Stroke & Vascular Neurology 2019年第2期4卷 83-89页

作者： Shu-Na Wang chao-yu miao Department of Pharmacology Second Military Medical UniversityShanghaiChina

Stroke is the second and the leading most common cause of death in the world and China,respectively,but with few effective *** phosphoribosyltransferase(NAMPT)is the rate-limiting enzyme for nicotinamide adenine dinucleotide(NAD)salvage synthesis in mammals,thereby influencing NAD-dependent enzymes and constituting a strong endogenous defence system against various *** in-vitro and in-vivo studies have demonstrated the neuroprotective effect of NAMPT in ***,we review the direct evidence of NAMPT as a promising target against stroke from five potential therapeutic strategies,including NAMPT overexpression,recombinant NAMPT,NAMPT activators,NAMPT enzymatic product nicotinamide mononucleotide(NMN),and NMN precursors nicotinamide riboside and nicotinamide,and describe the relevant mechanisms and limitations,providing a promising choice for developing novel and effective therapeutic interventions against ischaemic and haemorrhagic stroke.

关键词： NAMPT therapeutic protective

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The generation and properties of human cortical organoids as a disease model for malformations of cortical development

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Neural Regeneration Research 2023年第10期18卷 2119-2126页

作者： Xiu-Ping Zhang Xi-yuan Wang Shu-Na Wang chao-yu miao Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghaiChina

As three-dimensional“organ-like”aggregates,human cortical organoids have emerged as powerful models for studying human brain evolution and brain disorders with unique advantages of humanspecificity,fidelity and *** cortical organoids derived from human pluripotent stem cells can elaborately replicate many of the key properties of human cortical development at the molecular,cellular,structural,and functional levels,including the anatomy,functional neural network,and interaction among different brain regions,thus facilitating the discovery of brain development and *** addition to studying the neuro-electrophysiological features of brain cortex development,human cortical organoids have been widely used to mimic the pathophysiological features of cortical-related disease,especially in mimicking malformations of cortical development,thus revealing pathological mechanism and identifying effective *** this review,we provide an overview of the generation of human cortical organoids and the properties of recapitulated cortical development and further outline their applications in modeling malformations of cortical development including pathological phenotype,underlying mechanisms and rescue strategies.

关键词： cortical development disease models human cortical organoids human cortical spheroids human pluripotent stem cells malformations of cortical development telencephalon organoids whole brain organoids

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How can technology and efficiency alleviate the dilemma of economic growth and carbon emissions in China's industrial economy? A metafrontier decoupling decomposition analysis

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Petroleum Science 2024年第2期21卷 1415-1428页

作者： miao Wang chao Feng School of Business Zhengzhou UniversityZhengzhou450001HenanChina School of Economics and Business Administration Chongqing UniversityChongqing400030China

This paper attempts to explore the decoupling relationship and its drivers between industrial economic increase and energy-related CO_(2) emissions(ICE). Firstly, the decoupling relationship was evaluated by Tapio index. Then, based on the DEA meta-frontier theory framework which taking into account the regional and industrial heterogeneity and index decomposition method, the driving factors of decoupling process were explored mainly from the view of technology and efficiency. The results show that during2000-2019, weak decoupling was the primary state. Investment scale expansion was the largest reason hindering decoupling process of industrial increase from ICE. Both energy saving and production technology achieved significant progress, which facilitated the decoupling process. Simultaneously, the energy technology gap and production technology gap among regions have been narrowed, and played a role in promoting decoupling process. On the contrary, both scale economy efficiency and pure technical efficiency have inhibiting effects on decoupling process. The former indicates that the scale economy of China's industry was not conducive to improve energy efficiency and production efficiency, while the latter indicates that resource misallocation problem may exist in both energy market and product market.

关键词： China's industrial sector Decoupling process Meta-frontier DEA Index decomposition method Driving factors

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What factors control plant height?

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Journal of Integrative Agriculture 2024年第6期23卷 1803-1824页

作者： Li miao Xiangyu Wang chao yu Chengyang Ye Yanyan Yan Huasen Wang College of Horticulture Qingdao Agricultural UniversityQingdao 266109China Key Laboratory for Quality and Safety Control of Subtropical Fruits and Vegetables College of Horticulture ScienceZhejiang Agriculture and Forestry UniversityHangzhou 311300China

Plant height(PH)is one of the most important components of the plant ideotype,and it affects plant biomass,yield,lodging resistance,and the ability to use mechanized *** many complex pathways controlling plant growth and development remain poorly understood,we are still unable to obtain the most ideal plants solely through breeding *** can be influenced by genotype,plant hormonal regulation,environmental conditions,and interactions with other ***,we comprehensively review the factors influencing PH,including the regulation of PH-related developmental processes,the genetics and QTLs contributing to PH,and the hormone-regulated molecular mechanisms for ***,the symbiotic influence of grafting on PH is discussed,focusing on the molecular regulation of gene expression and ***,we propose strategies for applying recent findings to breeding for better PH,highlight some knowledge gaps,and suggest potential directions for future studies.

关键词： dwarfism plant hormones interaction grafting QTLs phenotyping

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Blood pressure variability and baroreflex sensitivity are not different in spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

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Acta Pharmacologica Sinica 2005年第8期26卷 959-962页

作者： Lin-shu ZHAN, yun-feng GUAN, Ding-feng SU, chao-yu miao~2 Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University Shanghai China

Aim: To demonstrate and compare hemodynamic phenotypes of blood pressure (BP), blood pressure variability (BPV) and baroreflex sensitivity (BRS) in genetic hypertensive rats. Methods: BP was recorded continuously in conscious, freely moving rats using a computerized technique. BPV was expressed as the standarddeviation of beat-to-beat BP values during a 1-h period. BRS was determined by measuring the heart period prolongation in response to the elevation in BP pro-duced by an intravenous injection of phenylephrine. Results: Body weight and heart period were not different between spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP) at the age of 15 weeks. The BP level was markedly higher in SHR-SP than SHR, whereas there were no significant differences in BPV and BRS. Quantitatively, systolic, diastolic and mean BP were significantly elevated by 36.9%, 42.9% and 39.5%, respectively, in SHR-SP compared with SHR (P0.05). Conclusion: BPV and BRS were not changed in parallel with the BP alterations in SHR and SHR-SP.

关键词： blood pressure variability baroreflex hypertension genetics

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Blood pressure,baroreflex sensitivity,and end organ damage in hybrid offspring of spontaneously hypertensive rats and Spraque-Dawlev rats

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Acta Pharmacologica Sinica 2005年第9期26卷 1049-1056页

作者： He-hui XIE~2 Fu-ming SHEN~2 chao-yu miao Ding-feng SU~3 Department of Pharmacology,Second Military Medical University,Shanghai 200433,China Department of Pharmacology Second Military Medical University Shanghai China

Aim:To investigate the blood pressure(BP),baroreflex sensitivity(BRS),andorgan damage in hybrids of spontaneously hypertensive rats and ***:Spontaneously hypertensive rats and Sprague-Dawley rats werecrossbred,and the F1hybrids were inbred randomly to produce an *** the age of 52 weeks,the F1and F2hybrids were tested to determine BP and BRSin a conscious *** examinations were carried out after BPrecording and BRS ***:BP and BRS were not different in F1and *** was inversely related to systolic BP(SBP)in male,female,or wholepopulations of ***,BRS values were one-third determined bySBP level(the determinant coefficient was 0.326).The indexes for left ventricularhypertrophy,aortic hypertrophy,and renal damage were all positively related toBP,and negatively related to *** multiple-regression analysis,left ventricularand aortic hypertrophy and glomerulosclerosis score were all most significantlyassociated with lower BRS and higher systolic *** contribution of BRS to leftventricular and aortic hypertrophy and glomerulosclerosis was greater than thatof ***:The present work with hybrid rats demonstrated quantita-tively that the BRS value was one-third determined by SBP *** BP leveland BRS value contributed greatly to the hypertensive organ ***,the contribution of BRS to the hypertensive organ damage was greater than thatof BP level in these rats.

关键词： baroreflex blood pressure end organ damage hypertension genetic hybridization

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Hypertonic and isotonic potassium solutions have different effects on vessel contractility resulting in differences in optimal resting tension in rat aorta

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Acta Pharmacologica Sinica 2007年第5期28卷 643-650页

作者： yun-feng GUAN Ruo-hua CHEN Pei WANG Ye QIN Ding-feng SU chao-yu miao Department of Pharmacology,Second Military Medical University,Shanghai 200433,China Department of Pharmacology Second Military Medical University Shanghai China

Aim:To compare high K~+-induced contraction and optimal resting tension mea-sured by two commonly used techniques of hypertonic and isotonic K~+ in aortaswith and without adventitial fat from various age ***:Three age groupsof rats (15,25,and 62 weeks) were used to prepare thoracic aortic rings in whichadventitial fat was either removed or left *** K~+ (30 mmol/L)-inducedcontractions were observed under increasing resting tensions of 1.0,1.5,2.0,2.5,3.0,and 3.5 *** resting tension was the resting tension at which the aortashowed a maximal ***:The contractions induced by 2 kinds ofhigh K~+ were significantly *** and isotonic K~+ induced a differ-ent style of contraction,and the pattern varied with different *** the age of15 weeks,isotonic K~+-induced contractions were greater than hypertonic K~+-in-duced ***,at the age of 62 weeks,isotonic K~+-induced con-tractions were smaller than hypertonic K~+-induced *** restingtensions measured by 2 kinds of high K~+ were *** restingtensions in different kinds of aortic preparations from various age rats were almosta constant of 2 g,determined by isotonic K~+,but a variable,determined by hyper-tonic K~+.The adventitial fat could delay the development of high K~+-inducedcontractions at different resting tensions,but had little effect on the ***:Hypertonic and isotonic K~+ may produce differentcontractions resulting in differences in optimal resting tension in rat aorta.

关键词： potassium osmolarity contraction aorta fat

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Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

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Zoological Research 2024年第4期45卷 924-936页

作者： Ruo-Wen Guo Wen-Jing Xie Biao yu chao Song Xin-miao Ji Xin-yu Wang Mei Zhang Xin Zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD *** diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic *** this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD *** indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in *** the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory *** examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse *** findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

关键词： lzheimer’s disease Rotating magnetic field Amyloid-β Cognitive function Alzheimer’s disease animal models

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