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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-zhou Huang wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu chao-wen zhou Man-Fei Deng wen-Tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A case report

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World Journal of Clinical Cases 2021年第11期9卷 2627-2633页

作者： Xu-Yan Hu Yu-Cheng Fei wen-chao zhou Jin-Miao Zhu Dong-Lai Lv Department of Clinical Medicine Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Clinical Oncology 901 Hospital of Joint Logistics Support Force of People Liberation ArmyHefei 230031Anhui ProvinceChina Intelligent Pathology Institute The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Pharmaceutical Engineering Hefei Normal UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(EGFR)mutation positive advanced or metastatic non-small cell lung cancer(NSCLC).However,primary or acquired resistance to EGFR-tyrosine kinase inhibitors(EGFR-TKIs)seems inevitable,and when drug-resistance occurs during treatment with osimertinib,the standard of care is to discontinue the *** SUMMARY A 57-year-old female patient with lung adenocarcinoma presented with an irritating cough accompanied by chest distress of one month *** enhanced head magnetic resonance imaging scan showed brain *** EGFR mutation(exon 21 L858R)was detected in pleural *** patient was treated with oral osimertinib(80 mg once daily)from January 2018 but developed progressive disease on December *** was then successfully treated with rechallenge and tri-challenge with osimertinib(80 mg once daily)by resensitization chemotherapy twice after the occurrence of drug-resistance to osimertinib,and to date has survived for 31 *** This case may provide some selective therapeutic options for NSCLC patients with acquired drug-resistance who were previously controlled on osimertinib treatment.

关键词： Osimertinib Retreatment Epidermal growth factor receptor Tyrosine kinase inhibitor Non-small cell lung cancer Case report

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Polyoxometalates-derived nanostructures for electrocatalysis application

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Rare Metals 2024年第5期43卷 1845-1866页

作者： chao-Yue Sun wen Li Kai Wang Wei-Jia zhou Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China Shandong Electrical Engineering and Equipment Group Intelligent Electric Co. Ltd.Jinan 250022China

The conversion of intermittent renewable electrical energy to chemical energy is of great importance which can not only mitigate current energy and environmental crisis but also contribute to the ongoing carbon neutrality national *** is serving as a low-carbon conversion technology that enables green and efficient energy conversion mainly through hydrogen evolution reaction(HER),carbon dioxide reduction reaction(CO_(2)RR),and nitrogen reduction reaction(NRR).The core of electrocatalysis is the design and construction of low-cost high-activity and high-stability electrocatalyst to drive reaction thermodynamics and *** employment of polyoxometalates(POMs)as platforms or precursors to construct different types of electrocatalysts has been widely ***,we systematically summarized the recent advances in POM-derived nanostructures for electrocatalysis *** strategies for precursor design and electrocatalyst synthesis were briefly *** morphology control,phase control,composite modulation,and heterostructure engineering in POM-derived nanostructures were presented in *** structure–activity relationship of POM-derived nanostructures is fully discussed for HER CO_(2)RR,and NRR ***,the current challenges and future outlooks of POM-derived nanostructures are summarized to provide insights toward high-efficiency electrocatalysts for energy conversion technologies.

关键词： Microforming Cylindrical compression Size effects Grain orientation Inhomogeneous deformation

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Sensing properties and mechanisms of LaF_(3)-Co_(3)O_(4) nanorods for low-concentration methanol detection

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Rare Metals 2024年第5期43卷 2193-2204页

作者： Xiao-Xi He Hong-Feng Chai Yi-wen zhou Ke-Wei Liu Ze-Xin Yu chao Zhang College of Mechanical Engineering Yangzhou UniversityYangzhou225127China Institutefor Manufacturing Technologies of Ceramic Components and Composites(IMTCCC) University of Stuttgart70569 StuttgartGermany

Methanol is one of the characteristic gases that distinguish between healthy individuals and lung cancer(LC)lesions in exhaled human *** concentration in exhaled breath is generally below one part per million(1×10^(-6)).The second-phase composite is widely regarded as one of the methods to improve the gas-sensing perfor-mance of metal oxide semiconductor(MOS)*** this study,LaF_(3)-Co_(3)O_(4) was synthesized by a simple hydrothermal method to enhance its low-concentration methanol gas-sensing performance.5 at%LaF_(3)-Co_(3)O_(4) nanorods exhibited excellent methanol detection performance,including a wider linear detection concentration range(0.2×10^(-6)~5×10^(-6)),a response value exceeding 4.0 for 1×10^(-6)methanol at 275°C and 75%relative humidity(RH),long-term stability(maximum deviation within 15%over 2 weeks),and excellent *** mechanism of performance enhancement was studied using various techniques,and density functional *** special spinel structure of Co_(3)O_(4),the high ionic migration of F-in LaF_(3),the larger specific surface area of 5 at%LaF_(3)-Co_(3)O_(4) nanorods,and the generated crystal defects all explain the excellentmethanol gas-sensing *** work provides a novel route to prepare MOS composite materials for low-concentration methanol gas detection.

关键词： Gas sensor LaF_(3) Co_(3)O_(4) Methanol Lung cancer

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Intelligent feedforward gust alleviation based on neural network

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Chinese Journal of Aeronautics 2024年第3期37卷 116-132页

作者： Yitao zhou Zhigang WU chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

This paper proposes a neural network-based intelligent feedforward gust alleviation framework,which includes a neural network identification model and a neural network controller.A neural network training dataset is formed by collecting flight data and the gust data encountered during the aircraft flight.A neural network identification model is first trained to accurately predict the aircraft’s ***,based on the output of the identification model and the collected flight data,the parameters of the time-delay neural network controller are obtained through a learning *** simulation results show that the designed intelligent controller has good gust alleviation effects for both continuous turbulence excitation and discrete gust *** example,when the aircraft is 40000 kg and the flight speed is 0.81Ma,the controller achieves a 67.82%reduction in wingtip acceleration and a 35.90%reduction in center of mass acceleration under continuous turbulence *** considering the measurement uncertainties,such as noise existing in the collected data,the trained controller can still achieve an acceptable gust alleviation ***,considering a flight in which the aircraft mass is constantly changing,the intelligent controller,which continuously learns from new flight data,maintains a good gust alleviation effect throughout the flight.

关键词： Gust alleviation Intelligent control Feedforward control Neural networks Time-varying aircraft

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Aerodynamic characteristics of a pitching airfoil with leading-edge morphing

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Chinese Journal of Aeronautics 2024年第7期37卷 81-92页

作者： chaoyuan wen Yuting DAI Yuntao XU chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Tianmushan Laboratory Hangzhou 311115China

This paper focuses on the effect of the phase offset of Leading-Edge(LE)morphing on the aerodynamic characteristics of a pitching NACA0012 *** an unstretched camber and using polynomial interpolation,an explicit expression for LE nonlinear morphing is proposed and implemented for the large pitching motion of the *** field results and aerodynamic forces are obtained by solving the unsteady Reynolds-averaged Navier-Stokes equations for both the airfoil’s pitching motion and LE ***,the index of instantaneous aerodynamic power is used to quantify the work done by the airflow in a dynamic *** to the instantaneous aerodynamic power and energy map,which denotes the energy transfer between the airfoil’s oscillation and flow field,the airfoil is subject to stall *** results show that LE morphing with an optimal phase offset of 315°reduces the energy extraction from the flow field,suppressing the stall flutter *** optimal phase offset is effective at different pitching axis positions of the *** results signify that LE morphing can suppress stall flutter by advancing the occurrence of the first LE vortex and increasing the nose-down moment during the upstroke period.

关键词： Aerodynamics Computational fluid dynamics Leading-edge morphing OpenFOAM Dynamic stall Dynamic mesh

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26-electrons redox-active polyoxovanadate clusters for aqueous zincion batteries

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Nano Research 2024年第5期17卷 4047-4054页

作者： Yimin Xing wen Yan Haiyang Wu Peng Huang chao Wang chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116China

Aqueous zinc-ion batteries(ZIBs)are attaining increasing attention for their high safety and low *** significant progresses in realizing high-performance cathode material for ZIBs,simultaneously endowing them with high capacity and fast-charging capability,the long-term cycling stability remains a major unsolved *** this work,a polyoxovanadate cluster of(NH_(4))_(8)[V_(19)O_(41)(OH)_(9)]·11H_(2)O(NOV)is defined as a cathode material for ZIBs that contains mixed-valence vanadium sites(V^(4+)and V^(5+)).A maximum of 26 electrons can be accommodated in one[V_(19)O_(41)(OH)_(9)]^(8-){V_(19)O_(50)}cluster,contributing to the high theoretical specific capacity of 328 mA·h·g^(-1).The Ti_(3)C_(2)T_(x) MXene nanosheets are incorporated into NOV with the help of ionic liquid(IL)linkers to restrain the dissolution of vanadium species and facilitate electron transport across the *** interfacial bonding,anion exchange,and electrostatic interactions among NOV and MXene are provided by IL *** nanohybrid of NOV-IL-MXene endows excellent contact between MXene and NOV,thereby enhanced charge transfer is observed at ***,the as-synthesized NOV-IL-MXene cathodes exhibit high discharge capacity of 413 mA·h·g^(-1) at 0.2 A·g^(-1) even at high mass loading of 5.2 mg·cm^(-2),remarkable rate performance of 182 mA·h·g^(-1) at 10 A·g^(-1),and impressive cycling stability of 94%capacity retention after 2000 *** work opens up new opportunities to develop advanced polyoxovanadate hybrid cathodes for low-cost and high-performance aqueous ZIBs.

关键词： polyoxovanadate MXene composite materials cathodes zinc-ion batteries

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Mechanism and control of nonuniform phase transformation of microalloyed dual-phase steel during cooling process after hot rolling

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Journal of Iron and Steel Research International 2024年第2期31卷 428-441页

作者： wen-quan Sun Sheng-yi Yong Tie-heng Yuan chao Liu San-bao zhou Rui-chun Guo Meng-xia Tang National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Strip Production Plant Xichang Steel and Vanadium Corporation of Pangang GroupXichang615000SichuanChina

After cooling in the hot rolling process,the metallographic structure of microalloyed dual-phase steel is nonuniform along the rolling direction,while the thickness fluctuation of microalloyed dual-phase steel with a nonuniform metallographic structure will occur during cold *** mechanism of nonuniform phase transformation of microalloyed dual-phase steels was studied during the cooling process after hot rolling,and the nonuniform phase transformation of microalloyed dual-phase steel was regulated during the cooling process after hot rolling through process ***,the empirical equation of phase transformation temperature was measured by a dilatometer considering thermal ***,the phase field and temperature field of laminar cooling process were calculated to provide initial boundary conditions for the finite element *** that,the coupling finite element model of the temperature phase transformation of the strip steel in coiling transportation process was *** simulation results show that the different thermal contact conditions of the microalloyed dual-phase steel during coil transportation lead to uneven cooling of the coil,which leads to nonuniform transformation of the coil along the rolling *** addition,by prolonging the time interval from coiling to unloading,the phenomenon of nonuniform phase transformation of microalloyed dual-phase steel can be effectively *** simulation results are applied to industrial *** application results show that prolonging the time interval from coiling to unloading can effectively improve the nonuniform phase transformation of microalloyed dual-phase steel in the cooling process after hot rolling.

关键词： Microalloyed dual-phase steel Thickness fluctuation Cooling Heat conduction Nonuniform phase transition Finite element method

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Prospect of ultrahigh-resolution fast neutron absorption spectroscopy based on a laser plasma electron accelerator

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High Power Laser Science and Engineering 2024年第1期12卷 108-115页

作者： wen-Zhao Wang Jie Feng Xiao-Peng Zhang Yao-Jun Li Wei-Jun zhou wen-chao Yan Guo-Qiang Zhang Chang-Bo Fu Li-Ming Chen Key Laboratory of Laser Plasma(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghaiChina Institute of High Energy Physics Chinese Academy of SciencesBeijingChina Shanghai Advanced Research Institute Chinese Academy of SciencesShanghaiChina Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghaiChina

Fast neutron absorption spectroscopy is widely used in the study of nuclear structure and element analysis. However,due to the traditional neutron source pulse duration being of the order of nanoseconds, it is difficult to obtain a high-resolution absorption spectrum. Thus, we present a method of ultrahigh energy-resolution absorption spectroscopy via a high repetition rate, picosecond duration pulsed neutron source driven by a terawatt laser. The technology of single neutron count is used, which results in easily distinguishing the width of approximately 20 keV at 2 MeV and an asymmetric shape of the neutron absorption peak. The absorption spectroscopy based on a laser neutron source has one order of magnitude higher energy-resolution power than the state-of-the-art traditional neutron sources, which could be of benefit for precisely measuring nuclear structure data.

关键词： fast neutron absorption spectroscopy laser plasma accelerator photo-nuclear neutrons single neutron count

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： chao-Yue Sun wen Li Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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