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A novel model for predicting fatty liver disease by means of an artificial neural network

Gastroenterology Report 2021年第1期9卷 31-37,I0001,I0002页

作者： Yi-Shu Chen Dan Chen chao Shen Ming Chen chao-hui Jin Cheng-Fu Xu chao-hui yu You-Ming Li Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Health Management Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Hithink Royal Flush Information Network Co. LtdHangzhouZhejiangP.R.China

Background:The artificial neural network(ANN)emerged recently as a potent diagnostic tool,especially for complicated systemic *** study aimed to establish a diagnostic model for the recognition of fatty liver disease(FLD)by virtue of the ***:A total of 7,396 pairs of gender-and age-matched subjects who underwent health check-ups at the First Affiliated Hospital,College of Medicine,Zhejiang University(Hangzhou,China)were enrolled to establish the ANN *** available in health check-up reports were utilized as potential input *** performance of our model was evaluated through a receiver-operating characteristic(ROC)curve *** outcome measures included diagnostic accuracy,sensitivity,specificity,Cohen’s k coefficient,Brier score,and Hosmer-Lemeshow *** Fatty Liver Index(FLI)and the Hepatic Steatosis Index(HSI),retrained using our training-group data with its original designated input variables,were used as comparisons in the capability of FLD ***:Eight variables(age,gender,body mass index,alanine aminotransferase,aspartate aminotransferase,uric acid,total triglyceride,and fasting plasma glucose)were eventually adopted as input nodes of the ANN *** applying a cut-off point of 0.51,the area under ROC curves of our ANN model in predicting FLD in the testing group was 0.908[95%confidence interval(CI),0.901-0.915]—significantly higher(P<0.05)than that of the FLI model(0.881,95%CI,0.872-0.891)and that of the HSI model(0.885;95%CI,0.877-0.893).Our ANN model exhibited higher diagnostic accuracy,better concordance with ultrasonography results,and superior capability of calibration than the FLI model and the HSI ***:Our ANN system showed good capability in the diagnosis of *** is anticipated that our ANN model will be of both clinical and epidemiological use in the future.

关键词： artificial neural network diagnostic model fatty liver disease Fatty Liver Index Hepatic Steatosis Index uric acid

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Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-analysis

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World Journal of Gastroenterology 2014年第2期20卷 569-577页

作者： Juan Du Yan-Yan Ma chao-hui yu You-Ming Li Department of Gastroenterology The First Affiliated HospitalMedical SchoolZhejiang University

AIM: To evaluate the effects of pentoxifylline therapy in patients with nonalcoholic fatty liver disease (NAFLD).

关键词： Pentoxifylline Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Meta-analysis

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Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第7期20卷 1768-1776页

作者： Xue-Qun Zhang Cheng-Fu Xu chao-hui yu Wei-Xing Chen You-Ming Li Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang University

Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent ***,the underlying mechanisms leading to the development of NAFLD are not fully *** endoplasmic reticulum(ER)stress response has recently been proposed to play a crucial role in both the development of steatosis and progression to nonalcoholic *** stress is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed due to the accumulation of unfolded or misfolded ***,delayed or insufficient responses to ER stress may turn physiological mechanisms into pathological consequences,including fat accumulation,insulin resistance,inflammation,and apoptosis,all of which play important roles in the pathogenesis of ***,understanding the role of ER stress in the pathogenesis of NAFLD has become a topic of intense *** review highlights the recent findings linking ER stress signaling pathways to the pathogenesis of NAFLD.

关键词： Endoplasmic reticulum stress Unfolded protein response Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

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Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study

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World Journal of Gastroenterology 2014年第33期20卷 11865-11870页

作者： Ping Xu Cheng-fu Xu Xing-yong Wan chao-hui yu chao Shen Peng Chen Gen-yun Xu You-ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University International Health Care Center the First Affiliated Hospital College of Medicine Zhejiang University Department of Laboratory Medicine the First Affiliated Hospital College of Medicine Zhejiang University

AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population.

关键词： Fatty liver Alpha-fetoprotein Association Obesity Risk factor

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Prevalence of fatty liver disease and the economy in China: A systematic review

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World Journal of Gastroenterology 2015年第18期21卷 5695-5706页

作者： Jin-Zhou Zhu Qin-Yi Zhou yu-Ming Wang Yi-Ning Dai Jiang Zhu chao-hui yu You-Ming Li Department of Gastroenterology The First Affiliated Hospital College of Medicine Zhejiang University Department of Statistics Columbian College of Arts and Science The George Washington University Bureau of Statistics Municipal GovernmentSuqian

AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in China's Mainland. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to crosssectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product(GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models. RESULTS: There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73%(95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country(adjusted R2 = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas(R2 = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28%(95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1%(95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82(95%CI: 17.94%-25.71%) vs 17.01%(95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year. CONCLUSION: This study reveals a correlation between the economy and the prevalence of FLD in China's Mainland.

关键词： Fatty liver disease Epidemiology Gross domestic product per capita Prevalence Economy

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Effects of probiotics on nonalcoholic fatty liver disease:A meta-analysis

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World Journal of Gastroenterology 2013年第40期19卷 6911-6918页

作者： Yan-Yan Ma Lin Li chao-hui yu Zhe Shen Li-Hua Chen You-Ming Li Department of Gastroenterology the First Affiliated HospitalZhejiang University School of Medicine

AIM:To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease(NAFLD),we performed a meta-analysis to evaluate the effects of probiotic therapy in ***:We searched PubMed,Medline,Embase,Web of Science,the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/nonalcoholic steatohepatitis(NASH).A statistical analysis was performed using RevMan 5.0 ***:Four randomized trials involving 134 NAFLD/NASH patients were *** results showed that probiotic therapy signifcantly decreased alanine aminotransferase(ALT),aspartate transaminase(AST),total-cholesterol(T-chol),high density lipoprotein(HDL),tumor necrosis factor(TNF)-αand homeostasis model assessment of insulin resistance(HOMAIR)[ALT:weighted mean difference(WMD)-23.71,95%CI:-33.46--13.95,P<0.00001;AST:WMD-19.77,95%CI:-32.55--7.00,P=0.002;T-chol:WMD-0.28,95%CI:-0.55--0.01,P=0.04;HDL:WMD-0.09,95%CI:-0.16-0.01,P=0.03;TNF-α:WMD-0.32,95%CI:-0.48--0.17,P<0.0001;HOMA-IR:WMD-0.46,95%CI:-0.73--0.19,P=0.0008].However,the use of probiotics was not associated with changes in body mass index(BMI),glucose(GLU)and low density lipoprotein(LDL)(BMI:WMD 0.05,95%CI:-0.18-0.29,P=0.64;GLU:WMD 0.05,95%CI:-0.25-0.35,P=0.76;LDL:WMD-0.38,95%CI:-0.78-0.02,P=0.06).CONCLUSION:Probiotic therapies can reduce liver aminotransferases,total-cholesterol,TNF-αand improve insulin resistance in NAFLD *** of the gut microbiota represents a new treatment for NAFLD.

关键词： Probiotics Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Liver function Insulin resistance Meta-analysis

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LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

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World Journal of Gastroenterology 2019年第45期25卷 6607-6618页

作者： Xue-Yang Chen Chang-Zhou Cai Meng-Li yu Ze-Min Feng yu-Wei Zhang Pei-Hao Liu Hang Zeng chao-hui yu Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Clinical Research Center for Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina

BACKGROUND It is well known that nonalcoholic fatty liver disease(NAFLD)is associated with insulin resistance(IR).LB100,a serine/threonine protein phosphatase 2A(PP2A)inhibitor,is closely related to ***,there is little data regarding its direct influence on *** To elucidate the effect and underlying mechanism of LB100 in *** After 10 wk of high fat diet(HFD)feeding,male C57BL/6 mice were injected intraperitoneally with vehicle or LB100 for an additional 6 wk(three times a week).The L02 cell line was treated with LB100 and free fatty acids(FFAs)for 24 *** and eosin and oil red O staining were performed for histological *** blot analysis was used to detect the protein expression of Sirtuin 1(Sirt1),total and phosphorylated AMP-activated protein kinaseα(AMPKα),and the proteins involved in lipogenesis and fatty acid *** mRNA levels were determined by *** inhibition of AMPK was performed to further examine the exact mechanism of LB100 in *** LB100 significantly ameliorated HFD-induced obesity,hepatic lipid accumulation and hepatic injury in *** addition,LB100 significantly downregulated the protein levels of acetyl-CoA carboxylase,sterol regulatory element-binding protein 1 and its lipogenesis target genes,including stearoyl-CoA desaturase-1 and fatty acid synthase,and upregulated the levels of proteins involved in fatty acidβ-oxidation,such as peroxisome proliferator-activated receptorα(PPARα),peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α),carnitine palmitoyltransferase 1α,acyl-CoA oxidase 1 and uncoupling protein 2,as well as the upstream mediators Sirt1 and AMPKαin the livers of HFD-fed *** vitro,LB100 alleviated FFA-induced lipid accumulation in L02 cells through the AMPK/Sirt1 signaling *** studies showed that the curative effect of LB100 on lipid accumulation was abolished by inhibiting AMPKαin L02 *** PP2A inhibition by LB

关键词： LB100 Nonalcoholic fatty liver disease Serine/threonine-protein phosphatase 2A Lipid metabolism AMP-activated protein kinaseα Sirtuin 1

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Upregulation of caveolin-1 and SR-B1 in mice with non-alcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 630-636页

作者： Yan Qiu Shan Liu Hong-Tan Chen chao-hui yu Xiao-Dong Teng Hong-Tian Yao Guo-Qiang Department of Gastroenterology First Affiliated HospitalZhejiang University School of Medicine

BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)is one of the most frequent causes of liver diseases,with markedly increased ***,its mechanisms are not *** present study was undertaken to illustrate the role of caveolin-1(cav1)and the scavenger receptor class B type 1(SR-B1)in ***:Adult male C57BL/6 mice were fed with a normal diet or high fat and cholesterol(HFC)diet for 14 *** mice were sacrificed to collect plasma and harvest the liver;their plasma lipid concentration was *** cav1and SR-B1 mRNA and protein expression were determined by real-time quantitative polymerase chain reaction(qPCR)and Western blotting,*** order to study cav1 and SR-B1distribution and change in hepatocytes,immunohistochemical analysis was ***:HFC diet increased plasma lipids,induced NAFLD and increased the liver/body weight *** to the control mice(n=6),the mRNA and protein levels of cav1 and SR-B1 in liver tissue of the NAFLD mice(n=12)increased significantly(cav1 mRNA:1.536±0.226 vs 0.980±0.272,P<0.05;protein:0.643±0.240 vs 0.100±0.130,P<0.01;SR-B1 mRNA:1.377±0.125 vs 0.956±0.151,P<0.01;protein:2.156±0.507vs 0.211±0.211,P<0.01).Furthermore,both cav1 and SR-B1immunoreactivity increased and their distribution was also changed,mainly in the plasma membrane of hepatocytes,cytoplasm and membrane of lipid droplets and ***:NAFLD is associated with increased concentration of plasma lipids and upregulation of hepatic cav1 and SR-B1 gene and protein expressions,which indicate that cav1 and SR-B1 might play crucial roles in the pathogenesis of NAFLD.

关键词： non-alcoholic fatty liver disease caveolin-1 scavenger receptor class B type 1 pathogenesis high fat and cholesterol diet

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Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice

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World Journal of Gastroenterology 2014年第28期20卷 9513-9518页

作者： Guo-Qiang Xu Cheng-Fu Xu Hong-Tan Chen Shan Liu Xiao-Dong Teng Gen-yun Xu chao-hui yu Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Laboratory Medicine the First Affiliated HospitalCollege of MedicineZhejiang University

AIM: To investigate the role of caveolin-3 (CAV3) and cholecystokinin A receptor (CCKAR) in cholesterol gallstone disease (CGD).

关键词： Cholesterol gallstone disease Caveolin-3 Cholecystokinin A receptor Lithogenic diet Mechanism

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Effects of tea polyphenols on hepatic fibrosis in rats with alcoholic liver disease

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 577-579页

作者： You-Ming Li Xing-Guo Zhang Hua-Li Zhou Shao-Hua Chen yu Zhang chao-hui yu Digestive Department First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. liyouming@***

BACKGROUND: As an anti-oxidation agent, tea polyphenols may have the effect of anti-fibrosis. This study was designed to observe the effect of tea polyphenols on hepatic fibrosis in rats with alcoholic liver disease and to explore the related mechanisms.METHODS: Sixty healthy Sprague-Dawley rats were divided randomly into normal control group, single alcohol group, and three alcohol groups given different doses of tea polyphenols. Alcohol or isovolumic normal saline and corresponding doses of tea polyphenols were given daily to the rats separately. The rats were sacrificed at the end of the 24th week. Masson staining was performed to observe liver fibrosis, serum endotoxin, and oxidant and anti-oxidant activity.RESULTS: Hepatic fibrosis was less severe in the rats of the alcohol groups given tea polyphenols than in the single alcohol group. Tea polyphenols increased the serum anti-oxidant capacity and decreased the endotoxin level.CONCLUSION: Tea polyphenols show anti-fibrosis effect in rats with alcoholic liver disease, and the mechanism may be related to the clearance of overall oxidant and decrease of the endotoxin level.

关键词： hepatic fibrosis tea polyphenols rat

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