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A novel color image encryption algorithm based on a fractional-order discrete chaotic neural network and DNA sequence operations

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Frontiers of Information Technology & Electronic Engineering 2020年第6期21卷 866-879页

作者： Li-ping CHEN Hao YIN Li-guo YUAN António M.LOPES J.A.Tenreiro MACHADO ran-chao WU School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou 510642China UISPA–LAETA/INEGI Faculty of EngineeringUniversity of PortoRua Dr.Roberto FriasPorto 4200-465Portugal Department of Electrical Engineering Polytechnic Institute of PortoR.Dr.António Bernardino de Almeida431Porto 4249-015Portugal School of Mathematical Sciences Anhui UniversityHefei 230601China

A novel color image encryption algorithm based on dynamic deoxyribonucleic acid(DNA)encoding and chaos is presented.A three-neuron fractional-order discrete Hopfield neural network(FODHNN)is employed as a pseudo-random chaotic sequence *** initial value is obtained with the secret key generated by a fiveparameter external key and a hash code of the plain *** external key includes both the FODHNN discrete step size and *** hash is computed with the SHA-2 *** ensures a large secret key space and improves the algorithm sensitivity to the plain ***,a new three-dimensional projection confusion method is proposed to scramble the pixels among red,green,and blue color *** encoding and diffusion are used to diffuse the image ***-random sequences generated by FODHNN are employed to determine the encoding rules for each pixel and to ensure the diversity of the encoding ***,confusion II and XOR are used to ensure the security of the *** results and the security analysis show that the proposed algorithm has better performance than those reported in the literature and can resist typical attacks.

关键词： Fractional-order discrete systems Neural networks Deoxyribonucleic acid(DNA)encryption Color image encryption

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Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 650-659页

作者： chao-ran Li Lang Chen Long-Fei Wang Bin Yan You-Ling Liang Jing Luo Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina General Surgery Department the Third Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Cardiovascular Department Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of Pub Med and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis(Ps A)]. We used a random-effects model to calculate the pooled relative risks(RRs) adjusted for confounders, along with the 95% confidence intervals(CIs). RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis(RR=1.49;95%CI: 1.08-2.07), and Ps A(RR=3.16;95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis(RR=1.62;95%CI: 1.44-1.83), and Ps A(RR=4.44;95%CI: 3.52-5.60).CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease(psoriasis and Ps A), warranting increased awareness among clinicians involved in the management of these two ***, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis.

关键词： Meta-analysis psoriasis psoriatic arthritis risk uveitis

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Alerting effects of light in healthy individuals: a systematic review and meta-analysis

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Neural Regeneration Research 2022年第9期17卷 1929-1936页

作者： Yi-Man Mu Xiao-Dan Huang Sui Zhu Zheng-Fang Hu Kwok-Fai So chao-ran Ren Qian Tao Department of Public Health and Preventive Medicine School of Basic MedicineJinan UniversityGuangzhouGuangdong ProvinceChina Division of Medical Psychology and Behavior Science School of Basic MedicineJinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation ScienceQingdaoShandong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Light plays an essential role in psychobiological and psychophysiological processes,such as *** alerting effect is influenced by light characteristics and the timing of *** meta-analysis is the first to systematically review the effect of light intervention on alertness and to discuss the optimal protocol for light *** this meta-analysis,registered at PROSPERO(Registration ID:CRD42020181485),we conducted a systematic search of the Web of Science,PubMed,and PsycINFO databases for studies published in English prior to August *** outcomes included both subjective and objective *** analyses considered a variety of factors,such as wavelength,correlated color temperature(CCT),light illuminance,and timing of interventions(daytime,night-time,or all day).Twenty-seven crossover studies and two parallel-group studies were included in this meta-analysis,with a total of 1210 healthy participants(636(52%)male,mean age 25.62 years).The results revealed that light intervention had a positive effect on both subjective alertness(standardized mean difference(SMD)=-0.28,95%confidence interval(CI):-0.49 to-0.06,P=0.01)and objective alertness in healthy subjects(SMD=-0.34,95%CI:-0.68 to-0.01,P=0.04).The subgroup analysis revealed that cold light was better than warm light in improving subjective alertness(SMD=-0.37,95%CI:-0.65 to-0.10,P=0.007,I2=26%)and objective alertness(SMD=-0.36,95%CI:-0.66 to-0.07,P=0.02,I2=0).Both daytime(SMD=-0.22,95%CI:-0.37 to-0.07,P=0.005,I2=74%)and night-time(SMD=-0.32,95%CI:-0.61 to-0.02,P=0.04,I2=0)light exposure improved subjective *** results of this meta-analysis and systematic review indicate that light exposure is associated with significant improvement in subjective and objective *** addition,light exposure with a higher CCT was more effective in improving alertness than light exposure with a lower *** results also suggest that both daytime and night-time light exposure can

关键词： correlated color temperature illuminance light meta-analysis objective alertness subjective alertness time of light intervention wavelength

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Building biological foundries for next-generation synthetic biology

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Science China(Life Sciences) 2015年第10期58卷 658-665页

作者： chao ran YUAN YongBo ZHAO HuiMin Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign Institute for Genomic Biology University of Illinois at Urbana-Champaign Department of Bioengineering Department of Chemistry Center for Biophysics and Computational Biology University of Illinois at Urbana-Champaign

Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.

关键词： biofabrication automation metabolic engineering biosystems design DNA assembly DNA sequencing metaboliteanalysis

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Pollution-Free from Seed to Feed

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China Today 2006年第7期55卷 76-77页

作者： chao ran

FOUNDED in 1997, chaoda Modern Agriculture (Holdings) Ltd is an integrated modern agriculture enterprise engaged in the production and marketing of high quality organic vegetables and fruits. In August last year, chaoda was listed as one of the top 500 famous and valuable Chinese brands for 2005. In the same year, the company was also ranked 177th in terms of the overall strength of large Chinese enterprises.

关键词：中国农业企业农业产业化农业技术

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The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass(Micropterus salmoides)

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Animal Nutrition 2023年第3期14卷 32-42页

作者： Rui Xia Qingshuang Zhang Dongmei Xia Qiang Hao Qianwen Ding chao ran Yalin Yang Aizhi Cao Zhen Zhang Zhigang Zhou China-Norway Joint Lab on Fish Gut Microbiota Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Norway-China Joint Lab on Fish Gut Microbiota Institute of BiologyNorwegian University of Science and TechnologyTrondheimNorway Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Shandong Longchang Animal Health Care Co. Ltd.Jinan 251100China Institute of Animal Husbandry and Veterinary Jiangxi Academy of Agricultural ScienceJiangxi 330000China

Fish gut barrier damage under intensive culture model is a significant concern for aquaculture *** study aimed to investigate the effects of bile acids(BAs)on gut barriers in Micropterus salmoides.A germ-free(GF)zebrafish model was employed to elucidate the effects of the direct stimulation of BAs and the indirect regulations mediated by the gut microbiota on gut barrier *** diets were formulated with BAs supplemented at 0,150,300 and 450 mg/kg,and these 4 diets were defined as control,BA150,BA300 and BA450,*** 5 weeks of feeding experiment,the survival rate of fish fed with BA300 diet was increased(P0.05).The results of the gut microbiota transferring experiment demonstrated an upregulation of gut barrier-related genes,including immunoglobulin Z/T(Ig Z/T),IL-6,IL-1βand IL-10,by the gut microbiota transferred from the BA300 group compared with the control(P<0.05).Feeding the BA300 diet directly to GF zebrafish resulted in enhanced expression of Ig M,Ig Z/T,lysozyme

关键词： Bile acids Gut barrier Gut microbiota Largemouth bass Germ-free zebrafish

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A creep model for ultra-deep salt rock considering thermal-mechanical damage under triaxial stress conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 588-596页

作者： chao Liang Jianfeng Liu Jianxiong Yang Huining Xu Zhaowei Chen Lina ran College of Water Resource and Hydropower Sichuan UniversityChengdu610065China CNPC Key Laboratory of Oil and Gas Underground Storage Engineering Langfang065007China CNPC Engineering Technology R&D Company Limited Beijing102206China

To investigate the specific creep behavior of ultra-deep buried salt during oil and gas exploitation,a set of triaxial creep experiments was conducted at elevated temperatures with constant axial pressure and unloading confining pressure *** results show that the salt sample deforms more significantly with the increase of applied temperature and deviatoric *** accelerated creep phase is not occurring until the applied temperature reaches 130℃,and higher temperature is beneficial to the occurrence of accelerated *** describe the specific creep behavior,a novel three-dimensional(3D)creep constitutive model is developed that incorporates the thermal and mechanical variables into mechanical ***,the standard particle swarm optimization(SPSO)method is adopted to fit the experimental data,and the sensibility of key model parameters is analyzed to further illustrate the model *** a result,the model can accurately predict the creep behavior of salt under the coupled thermo-mechanical effect in deep-buried *** on the research results,the creep mechanical behavior of wellbore shrinkage is predicted in deep drilling projects crossing salt layer,which has practical implications for deep rock mechanics problems.

关键词： Creep experiments Creep model Thermal and mechanical damage Fractional derivative

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An UPLC-MS/MS method for simultaneous determination of multiple constituents in Guizhi Fuling capsule with ultrafast positive/negative ionization switching

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Chinese Journal of Natural Medicines 2018年第4期16卷 313-320页

作者： ZHANG Rong-Hua LI chao-ran YANG Hua LI Meng-Ning Karl W.K.Tsim LI Ping GAO Wen State Key Laboratory of Natural Medicines School of Traditional Chinese Pharmacy China Pharmaceutical University School of Traditional Chinese Medicine Guangdong Pharmaceutical University Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology

Guizhi Fuling capsule(GFC), a traditional Chinese medicine(TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various chemical structure types, quality control of GFC remains great challenge. In the present study, an ultra performance liquid chromatography hybrid triple-quadrupole mass spectrometry(UPLC-QQQ MS) method with ultrafast positive/negative ionization switching was developed for simultaneous determination of 18 bioactive components in GFC, including methyl gallate, ethyl gallate, oxypaeoniflorin, benzoic acid, albiflorin, paeonolide, paeoniflorin, 1, 2, 3, 4, 6-pentagalloylglucose, mudanpioside C, benzoyloxypaeoniflorin, benzoylpaeoniflorin, pachymic acid, amygdalin, cinnamaldehyde, paeonol, cinnamic acid, 4-hydroxybenzoic acid, and gallic acid. Separation was performed on an Agilent Zorbax Extend–C18 column(2.1 mm × 50 mm, 1.8 μm), using a gradient elution with acetonitrile and water containing 0.1% formic acid. Cholic acid was selected as the internal standard. This newly developed method was fully validated for linearity, precision, accuracy, and stability, and then applied to quality assessment of GFC. Finally, the batch-to-batch reproducibility of GFC samples was evaluated by the cosine ration and Euclidean distance method, which showed high quality consistency. The results demonstrated that the developed method provided a reasonable and powerful manner for quality control of GFC.

关键词： Guizhi Fuling capsule(GFC) UPLC-QQQ MS Ultrafast positive/negative ionization switching Quality control

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韩雪教授分症论治儿童抽动障碍经验

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世界中西医结合杂志 2024年第6期19卷 1126-1130,1144页

作者：赵闪闪韩雪四霄雪武超然邝殊静郑州大学附属儿童医院河南郑州450018 河南中医药大学儿科医学院河南郑州450000

总结韩雪教授治疗儿童抽动障碍(Tic disorder,TD)的临证经验。认为儿童TD以脏腑失和,肝失条达,内风妄动为总病机。TD临床病症多变,提出分症论治的观点,将TD常见的五类临床症状及共患病进行分类辨治,以小柴胡汤为基础方,并根据不同症状... 详细信息

总结韩雪教授治疗儿童抽动障碍(Tic disorder,TD)的临证经验。认为儿童TD以脏腑失和,肝失条达,内风妄动为总病机。TD临床病症多变,提出分症论治的观点,将TD常见的五类临床症状及共患病进行分类辨治,以小柴胡汤为基础方,并根据不同症状的病机特点与半夏厚朴汤、葛根汤、麻黄附子细辛汤、苓桂术甘汤、防己地黄汤、柴胡加龙骨牡蛎汤、四逆散合方组方施药。并附验案1则,以资佐证。

关键词：抽动障碍儿童共患病经方韩雪名医经验

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Zircon U-Pb age evidence of the Mesoarchean(2.9–3.2 Ga)crustal remnant in the Southern Dabie Orogen,South China

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China Geology 2023年第1期6卷 174-176页

作者： Da-liang Xu Lian-hong Peng Xin Deng chao-ran Liu Le Wan Xiao-ming Zhao Research Center for Petrogenesis and Mineralization of Granitoid Rocks China Geological SurveyWuhan 430205China Wuhan Center of China Geological Survey(China Central South China Innovation Center for Geosciences) Ministry of Natural ResourcesWuhan 430205China China University of Geosciences Beijing 100083China School of Earth Science China University of GeoscienceWuhan 430074China Institute of Karst Geology CAGSGuilin 541004China

*** Unlike the North China Plate where Archean and Paleoproterozoic crustal rocks are widely distributed,Early Precambrian basement rocks in the Yangtze Block of South China are locally exposed(Fig.1a),such as in the Kongling Complex,the Zhongxiang Complex,and the Douling Complex(Zhao GC and Cawood PA,2012).The Dabie Orogen is the eastward extension of the Qinling Orogen.

关键词： crustal Dabie South

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