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Effects of solid-state fermentation product of yeast supplementation on liver and intestinal health,and resistance of common carp(Cyprinus carpio)against spring viraemia carp virus

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Animal Nutrition 2024年第3期18卷 408-418页

作者： Mengxin Wang Dongmei Xia Lijuan Yu Qiang Hao Mingxu Xie Qingshuang Zhang Yajie Zhao Delong Meng Yalin Yang chao ran Tsegay Teame Zhen Zhang Zhigang Zhou China-Norway Joint Lab on Fish Gut Microbiota Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Hubei Key Laboratory of Animal Nutrition and Feed Science Wuhan Polytechnic UniversityWuhan 430000China Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Tigray Agricultural Research Institute Mekelle Agricultural Research CenterMekelleTigray 251Ethiopia

This study aimed to investigate the effects of solid-state fermentation products of yeast(SFPY)on liver and intestinal health and disease resistance of common carp(Cyprinus carpio).A total of 200 common carp with an initial average weight of 2.55±0.004 g were divided into 5 groups(4 replications per group and 10 fish per replication),and were fed with one of five diets,including a control diet and 4 diets supplemented with 2‰(Y2),3‰(Y3),4‰(Y4),or 5‰(Y5)SFPY,respectively,for 8 *** indicated that,the addition of SFPY to the diet of common carp did not affect the growth performance or survival rate of fish(P=0.253).Interestingly,with the addition of SFPY,the triacylglycerol(TAG)content of the liver presented a linear decreasing tendency(P=0.004),with significantly decreased in Y4 and Y5 groups(P=0.035)compared with *** lipopolysaccharide(LPS)content and diamine oxidase(DAO)activity presented a negative linear relationship with the addition of SFPY(P=0.015,P=0.030),while serum lipopolysaccharide binding protein(LBP)content first decreased and then increased(P<0.001).The total antioxidant capacity(T-AOC)in the intestine of fish increased continuously with increasing SFPY supplementation(P=0.026),reaching the highest level in Y5 *** villus height in all experimental groups were significantly higher than that in the control group(P<0.001).Furthermore,compared to the control,adding 3‰SFPY to the control diet of common carp significantly increased the relative abundance of Fusobacteria(P=0.018)and decreased that of Proteobacteria(P=0.039)at phylum level,and increased the relative abundance of Cetobacterium(P=0.018)and decreased that of Shewanella(P=0.013)at genus *** with the control,the relative mRNA expression level of spring viraemia of carp virus N protein(SVCV-n)in the kidney was lower than that of the control group without significance and bottomed out in Y4 group(P=0.138).In conclusion,dietary SFPY enhanced the SVCV resistance capa

关键词： Yeast Solid-state fermentation product Probiotic Immunity Gut microbiota Common carp

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Pichia pastoris composition expressed aerolysin mutant of Aeromonas veronii as an oral vaccine evaluated in zebrafish(Danio rerio)

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Marine Life Science & Technology 2024年第3期6卷 475-487页

作者： Yuan-Yuan Yao Qing-Shuang Zhang Shu-Bin Liu Hong-Wei Yang Xing-Yu Chen Ya-Lin Yang Chen-Chen Gao chao ran Tsegay Teame Zhen Zhang Zhi-Gang Zhou Key Laboratory for Feed Biotechnology of the Ministry of Agriculture Institute of Feed Research of Chinese Academy of Agricultural SciencesBeijing 100081China Sino-Norway Fish Gastrointestinal Microbiota Joint Lab Institute of Feed Research of Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Marine Sciences Shantou UniversityShantou 515063China Tigray Agricultural Research Institute(TARI)Mekelle Center Tigray 7101Ethiopia

Vaccines are one of the most practical means to stop the spreading of Aeromonas veronii in *** this study,virulence factor aerolysin mutant NTaer which has lost its hemolytic activity was used as a target *** pastoris constitutive secretory expression NTaer(GS115-NTaer)was used as a potential safe oral vaccine to evaluate its effectiveness on zebrafish *** result shows that vaccination of GS115-NTaer for four weeks did not affect the growth performance of the host,while eliciting an effective immune protective *** with the control group,the GS115-NTaer could significantly up-regulate the relative expression level of the intestinal tight junction protein 1α(TJP1α)gene,and significantly increased the contents of lysozyme(LYZ),complement C3 and C4 in the gut,indicating that the innate immune response of the fish was *** relative gene expression levels of macrophage-expressed gene 1(MPEG1)and T cell receptor(TCR-α)in the gut,and MPEG1,CD4,CD8,TCR-α,GATA3,and T-bet in the spleen were all increased significantly,indicating that the cellular immune response of the fish was ***,the contents of serum IgM and intestinal mucosa IgZ antibodies were significantly increased,which showed that humoral immunity was also ***,inoculation with GS115-NTaer significantly changed the structure of gut *** particular,the relative ratio of(Firmicutes+Fusobacteriota+Bacteroidota)/Proteobacteria was significantly higher than that of the control and GS115 ***,the vaccinated fish were challenged with ***,and the relative percent survival of GS115 and the GS115-NTear groups was 14.28%and 33.43%.This improvement of immunity was not only due to the specific immune response but also attributed to the improvement of innate immunity and the gut microbiota which was demonstrated by the germ-free zebrafish ***,this study provides information on the effectiveness of GS115-NTear

关键词： Aeromonas veronii Aerolysin mutant NTaer Oral vaccine Immune response Gut microbiota

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高层住宅施工用塔式起重机臂架腹杆布局优化设计

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工程技术研究 2024年第3期9卷 38-40页

作者：冉超中铁二十局集团第三工程有限公司重庆400060

文章针对现有高层住宅施工用塔式起重机起重力矩小、起重能力差的问题,结合塔式起重机最大力矩条件,设计臂架腹杆变截面;遵循周期性优化原则,从拉杆的选材、受力分析、对比及附着的水平角度,实现塔式起重机臂架腹杆布局优化。通过对比... 详细信息

文章针对现有高层住宅施工用塔式起重机起重力矩小、起重能力差的问题,结合塔式起重机最大力矩条件,设计臂架腹杆变截面;遵循周期性优化原则,从拉杆的选材、受力分析、对比及附着的水平角度,实现塔式起重机臂架腹杆布局优化。通过对比臂架腹杆布局优化前后的塔式起重机,证明新的优化设计方案可以有效加大塔式起重机的力矩,提升起重机整体起重能力。

关键词：高层住宅塔式起重机腹杆臂架

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A Survey of LLM Datasets:From Autoregressive Model to AI Chatbot

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Journal of Computer Science & Technology 2024年第3期39卷 542-566页

作者：杜非马新建杨婧如柳熠罗超然王学斌姜海鸥景翔 National Key Laboratory of Data Space Technology and System Beijing 100195China Advanced Institute of Big Data Beijing 100195China Fu Foundation School of Engineering and Applied Science Columbia UniversityNY 10027U.S.A. School of Software and Microelectronics Peking UniversityBeijing 100091China CCF IEEE

Since OpenAI opened access to ChatGPT,large language models(LLMs)become an increasingly popular topic attracting researchers’attention from abundant ***,public researchers meet some problems when developing LLMs given that most of the LLMs are produced by industries and the training details are typically *** datasets are an important setup of LLMs,this paper does a holistic survey on the training datasets used in both the pre-train and fine-tune *** paper first summarizes 16 pre-train datasets and 16 fine-tune datasets used in the state-of-the-art ***,based on the properties of the pre-train and fine-tune processes,it comments on pre-train datasets from quality,quantity,and relation with models,and comments on fine-tune datasets from quality,quantity,and *** study then critically figures out the problems and research trends that exist in current LLM *** study helps public researchers train and investigate LLMs by visual cases and provides useful comments to the research community regarding data *** the best of our knowledge,this paper is the first to summarize and discuss datasets used in both autoregressive and chat *** survey offers insights and suggestions to researchers and LLM developers as they build their models,and contributes to the LLM study by pointing out the existing problems of LLM studies from the perspective of data.

关键词： large language model(LLM) autoregressive model AI chatbot natural language processing(NLP)corpora OpenAI

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陕西省宁强县潘家坝地区金矿成矿地质条件分析

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世界有色金属 2024年第5期 100-102页

作者：党超冉中国冶金地质总局西北局六队陕西汉中723000

潘家坝地区位于可可西里-巴颜喀拉中生代造山带-摩天岭地块-碧口构造楔与龙门山-阳平关早古生代裂谷的交接部位,属摩天岭加里东褶皱带文县—勉县褶皱束西段,区内褶皱、断裂及节理十分发育,且工作区地层主要为碧口岩群二亚群中基性火山岩... 详细信息

潘家坝地区位于可可西里-巴颜喀拉中生代造山带-摩天岭地块-碧口构造楔与龙门山-阳平关早古生代裂谷的交接部位,属摩天岭加里东褶皱带文县—勉县褶皱束西段,区内褶皱、断裂及节理十分发育,且工作区地层主要为碧口岩群二亚群中基性火山岩组(Pt_(2-3)bk^(2)),该地层中Au等元素丰度高于地壳的1.3~3.2倍,同时岩体侵入活动,为成矿流体形成、迁移提供热源,故有良好的成矿条件。

关键词：潘家坝地区成矿条件

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Splicing factor proline and glutamine-rich is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in hepatocellular carcinoma

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Medical Data Mining 2024年第2期7卷 45-59页

作者： chao-ran Zhu Shi-Chen Zhu Clinical and Basic Medical Sciences College Shandong First Medical UniversityJinan 250021China Department of Surgery Jinan Changqing District Traditional Chinese Medicine HospitalJinan 250021China

Background:Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths *** factor proline and glutamine-rich(SFPQ)is a multifunctional protein that controls various biological *** a potential therapeutic target and a promising prognostic indicator,the potential effects and processes of SFPQ in HCC require further ***:The RNA sequencing data were obtained from the Gene Expression Omnibus,International Cancer Genome Consortium,and The Cancer Genome Atlas databases to analyze SFPQ expression and differentially expressed genes(DEGs).We utilized the LinkedOmics database to identify co-expressed genes.A Venn diagram was constructed to determine the overlapping genes between the DEGs and the co-expressed *** enrichment analysis was performed on the overlapping genes and ***,our study involved functional enrichment analysis,a protein-protein interaction network analysis,and an analysis of immune cell *** cBioPortal and Tumor Immune Single-cell Hub were utilized to investigate the genetic alterations of SFPQ and the single-cell transcriptome visualization of the tumor microenvironment.A ceRNA network was established with the assistance of the ENCORI ***,we elucidated the clinical significance of SFPQ in HCC by employing Kaplan-Meier survival analysis,univariate and multivariate Cox regression,and prognostic nomogram ***:The expression of SFPQ in HCC tissues was significantly elevated compared to normal *** results indicated that increased expression of SFPQ was associated with pathways related to *** ceRNA network,including SFPQ,hsa-miR-101-3p,AC023043.4,AC124798.1,AC145207.5,and GSEC,was constructed with the assistance of *** SFPQ expression was related to a poor prognosis in HCC and its *** and multivariate Cox regression analysis showed that elevated SFPQ expression is an independent predictive ***

关键词： biomarker splicing factor proline and glutamine-rich prognosis immune infiltration hepatic cell carcinoma

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基于硼酸酯标签制备具有精确侧基结构的可控聚合物

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高分子学报 2024年第7期55卷 881-890页

作者：云杰徐超然谢志康杜昱璇董进潘翔城聚合物分子工程国家重点实验室复旦大学高分子科学系上海200438

结构精确的聚合物在生物医药、信息储存、分级组装等领域具有重要作用,而其制备一直是高分子合成领域的挑战之一.本工作基于N-甲基亚氨二乙酸(MIDA)硼酸酯作为液相迭代合成中的标签,制备了4种不同结构的噻吩-苯基侧基的单体,对其经可控... 详细信息

结构精确的聚合物在生物医药、信息储存、分级组装等领域具有重要作用,而其制备一直是高分子合成领域的挑战之一.本工作基于N-甲基亚氨二乙酸(MIDA)硼酸酯作为液相迭代合成中的标签,制备了4种不同结构的噻吩-苯基侧基的单体,对其经可控自由基聚合制备得精确侧基结构的聚合物.聚合物的紫外可见光谱和荧光发射光谱显示了不同侧基结构聚合物具有不同的光学性质,而这些聚合物在热性质和结晶性质方面呈现相似性,这来源于其相同的主链结构和同种成分的侧基.建立了MIDA硼酸酯标签合成精确侧基单体的方法,为实现聚合物侧基的精准调控提供了思路和可行方法.

关键词：序列精准聚合物硼酸酯可控/活性聚合

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影响正畸患者口腔卫生的因素

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北京口腔医学 2024年第1期32卷 70-73页

作者：于超然张宁首都医科大学口腔医学院正畸科北京100050

正畸治疗过程中,如果患者的口腔卫生维护不善,极易引起正畸并发症。影响口腔健康的因素有很多,根据不同影响因素的来源,可以分为非治疗因素和正畸治疗相关因素。本文就影响正畸患者口腔卫生的因素进行综述,以期指导医生和患者,避免正畸... 详细信息

正畸治疗过程中,如果患者的口腔卫生维护不善,极易引起正畸并发症。影响口腔健康的因素有很多,根据不同影响因素的来源,可以分为非治疗因素和正畸治疗相关因素。本文就影响正畸患者口腔卫生的因素进行综述,以期指导医生和患者,避免正畸治疗对口腔健康造成不良后果。

关键词：正畸口腔卫生正畸并发症影响因素

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Modified Projective Synchronization of Fractional-order chaotic Systems with Different Dimensions

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 527-538页

作者： Xi ZHANG ran-chao WU School of Mathematics Anhui UniversityHefei 230601China Nanchang No.1 Secondary Vocational School Nanchang330013China

In this paper,the modified projective synchronization between two fractional-order chaotic systems with different dimensions is *** added-order scheme and the reduced-order scheme are proposed,*** on the Laplace transformation and feedback control theory,controllers are designed such that two chaotic systems with different dimensions could be synchronized asymptotically under the presented *** numerical simulations are given to show the effectiveness of the proposed schemes.

关键词： Modified projective synchronization Fractional-order chaotic systems Laplace transformation

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Role of lymphotoxin alpha as a new molecular biomarker in revolutionizing tear diagnostic testing for dry eye disease

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1883-1889页

作者： chao-ran Li Tianjin Medical University Eye Hospital Tianjin 310011China

Dry eye disease(DED),primarily classified as multifactorial ocular surface disorder,afflicts tens of millions of individuals worldwide,adversely impacting their quality of *** research has been conducted on tear film analysis over the past decades,offering a range of tests to evaluate its volume,health,and ***,early diagnosis and effective treatment for DED continue to pose significant challenges in clinical ***,by recognizing key phenomena in DED such as ocular surface inflammation,hyperosmolarity,and tear film instability,this article provides a comprehensive overview of both traditional and recently developed methods for diagnosing and monitoring *** information serves as a valuable resource not only for clinical diagnosis but also for further research into DED.

关键词： dry eye disease tear film biomarker matrix metalloproteinase 9 lymphotoxin alpha

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