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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai wang Yanbo Liang chao wang Yunhong Zhang Hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan Guo-Da Zhang chao wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

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米糠蛋白提取、改性及在食品加工中的应用

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食品与发酵工业 2025年第1期51卷 363-372页

作者：刘芳韩伟郭超张颖张维清刘玉春王超上海理工大学健康科学与工程学院上海200093 国家粮食和物资储备局科学研究院北京100037

米糠是稻谷加工过程中的主要副产物之一,产量大、营养价值丰富,蛋白质含量高出普通精米的一倍,是一种极具开发潜力的高附加值资源。从中提取的蛋白质含氨基酸种类齐全、过敏性低、生物效价高且具有多种生理活性,是优质的植物性蛋白,可... 详细信息

米糠是稻谷加工过程中的主要副产物之一,产量大、营养价值丰富,蛋白质含量高出普通精米的一倍,是一种极具开发潜力的高附加值资源。从中提取的蛋白质含氨基酸种类齐全、过敏性低、生物效价高且具有多种生理活性,是优质的植物性蛋白,可用来弥补蛋白质资源的缺乏。但目前米糠蛋白的提取效率低、成本高,导致加工利用水平不高。该文综述了米糠蛋白的提取和改性技术,比较了不同提取方法对米糠蛋白含量和提取率的影响以及不同改性方法对米糠蛋白乳化性、起泡性、溶解性等功能特性的影响,简述了米糠蛋白在食品加工行业的应用情况,展望了生物发酵法、组合法高效提取并改性米糠蛋白的研究前景以及米糠蛋白在食品、药品领域的应用前景,旨在提高米糠的综合利用率,为米糠蛋白的生产、加工提供一些思路和参考。

关键词：米糠蛋白发酵改性应用食品加工

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核糖体蛋白RpsL调控须糖多孢菌中丁烯基多杀菌素的合成

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农业生物技术学报 2025年第1期33卷 179-189页

作者：苏畅王靖楠郭超徐周钦李春张根林王超国家粮食和物资储备局科学研究院石河子大学化学化工学院北京理工大学化学与化工学院清华大学化学工程系

须糖多孢菌（Saccharopolyspora pogona）发酵产生的次级代谢物丁烯基多杀菌素（butenyl-spinosyn）是一种绿色生物杀虫剂。但由于发酵产量低不能满足工业生产需求，选育高生产性能的菌株是实现工业化生产的关键。本研究以须糖多孢菌为... 详细信息

须糖多孢菌（Saccharopolyspora pogona）发酵产生的次级代谢物丁烯基多杀菌素（butenyl-spinosyn）是一种绿色生物杀虫剂。但由于发酵产量低不能满足工业生产需求，选育高生产性能的菌株是实现工业化生产的关键。本研究以须糖多孢菌为底盘细胞分别构建了核糖体蛋白S12（ribosomal protein S12,RpsL）及RpsL突变体的基因过表达工程菌株Q8（rpsl）、W43(rpslK88R)、W44(rpslR86P)、W45(rpslK88E)和W46(rpslK43N)，通过摇瓶发酵验证及RpsL蛋白结构比对，分析RpsL对丁烯基多杀菌素合成的影响。结果表明，工程菌株Q8、W43、W44、W45和W46分别使丁烯基多杀菌素的产量提高至275%、146%、111%、122%和降低至75%。进一步研究表明，rpsl和rpslK88R基因的过表达提高了合成途径基因的转录水平，从而使丁烯基多杀菌素的产量显著提高。对二者进行同源建模发现，RpsLK88R突变体结构与RpsL相比，其侧链发生较大的偏转，影响了与m RNA的结合作用进而降低了核糖体翻译效率，因此其提产效果略低于RpsL。本研究为蛋白质工程改造RpsL提高丁烯基多杀菌素的产量提供参考。

关键词：丁烯基多杀菌素核糖体蛋白须糖多孢菌基因突变

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Mean-Square Stabilization of Networked Sampled-Data Systems with Packet Losses:Critical Sampling Intervals

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Journal of Systems Science & Complexity 2022年第4期35卷 1278-1292页

作者： wang chao wang Bingchang School of Control Science and Engineering Shandong UniversityJinan250061China

This paper studies the stabilizing problem of networked sampled-data linear systems with independent and identically distribution(i.i.d.) packet dropouts. First of all, for the sampled-data system without packet losses, the necessary and sufficient conditions for the critical sampling intervals are given to ensure the mean square stability where zero order holder and generalized holder are adopted, respectively. Secondly, for the sampled-data system with i.i.d. packet losses, necessary and sufficient conditions for the critical sampling intervals are given to ensure the mean square stability where the zero order holder control is adopted. The random sampling framework is used to examine the case that the value of the control signal is not zero when the packet loss occurs, but the value of the previous control signal when the data packet is not lost. For the sampled-data system with *** losses, the range of the sampling interval is given to ensure the mean square stability where the generalized holder control is adopted. Some numerical simulations are provided to validate the theoretical results.

关键词： Generalized hold i.i.d.packet dropout sampled-data linear system zero-order hold

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Development of acoustic computer simulation for performance spaces: A systematic review and meta-analysis

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Building Simulation 2022年第10期15卷 1729-1745页

作者： chao wang Jian Kang School of Architecture Tianjin UniversityTianjin 300072China UCL Institute for Environmental Design and Engineering The BartlettUniversity College London(UCL)Central House14 Upper Woburn PlaceLondon WC1H0NNUK

This article aims to review the development of acoustic computer simulation for performance spaces. The databases of Web of Science and Scopus were searched for peer-reviewed journal articles published in English between 1960 and 2021, using the keywords for “simulation”, “acoustic”, “performance space”, “measure”, and their synonyms. The inclusion criteria were as follows: (1) the searched article should be focused on the field of room acoustics (reviews were excluded);(2) a computer simulation algorithm should be used;(3) it should be clearly stated that the simulated object is a performance space;and (4) acoustic measurements should be used for comparison with the simulation. Finally, twenty studies were included. A standardised data extraction form was used to collect the modelling information, software/algorithm, indicators for comparison, and other information. The results revealed that the most used acoustic indicators were early decay time (EDT), reverberation time (T30), strength (G), and definition (D50). The accuracy of these indicators differed greatly. For non-iterative simulation, the simulation accuracies of most indicators were outside their respective just noticeable differences. Although a larger sample size was required for further validation, simulations of T30, EDT, and D50 all showed an increase in accuracy with increasing time from 1979 to 2020, except for G. In terms of frequency, the simulation was generally less accurate at lower frequencies, which occurred at T30, G, D50 and T20. However, EDT accuracy did not exhibit significant frequency sensitivity. The prediction accuracy of inter-aural cross-correlation coefficients (IACC) was even higher at low frequencies than it was at high frequencies. The average value of most indicators showed a clear systematic deviation from zero, providing hints for future algorithm improvements. Limitations and the risks of bias in this review were discussed. Finally, various types of benchmark tests were sug

关键词： acoustic simulation accuracy systematic review performance space iterative simulation

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A Machine Learning Method for Differentiating and Predicting Human-Infective Coronavirus Based on Physicochemical Features and Composition of the Spike Protein

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Chinese Journal of Electronics 2021年第5期30卷 815-823页

作者： wang chao ZOU Quan Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Hainan Key Laboratory for Computational Science and Application Hainan Normal University

Several Coronaviruses(CoVs) are epidemic pathogens that cause severe respiratory syndrome and are associated with significant morbidity and mortality. In this paper, a machine learning method was developed for predicting the risk of human infection posed by CoVs as an early warning system. The proposed Spike-SVM(Support vector machine) model achieved an accuracy of 97.36% for Human-infective CoV(HCoV) and Nonhuman-infective CoV(Non-HCoV) classification. The top informative features that discriminate HCoVs and Non-HCoVs were identified. Spike-SVM is anticipated to be a useful bioinformatics tool for predicting the infection risk posed by CoVs to humans.

关键词： Spike protein NonHCoVs genetics microorganisms Support vector machine mortality Spike-SVM model Human-infective CoV severe respiratory syndrome machine learning method biology computing predicting Human-infective coronavirus diseases proteins HCoV human infection differentiating Nonhuman-infective CoV infection risk CoVs discriminate HCoVs learning (artificial intelligence) bioinformatics support vector machines informative features significant morbidity molecular biophysics early warning system epidemic pathogens Coronaviruses

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Optimization of Quantum Computing Models Inspired by D-Wave Quantum Annealing

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Tsinghua Science and Technology 2020年第4期25卷 508-515页

作者： Baonan wang Feng Hu chao wang Key laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai 200444China the State Key Laboratory of Cryptology Beijing 100878China the Center for Quantum Computing Peng Cheng LaboratoryShenzhen 518000China

With the slow progress of universal quantum computers,studies on the feasibility of optimization by a dedicated and quantum-annealing-based annealer are *** quantum principle is expected to utilize the quantum tunneling effects to find the optimal solutions for the exponential-level problems while classical annealing may be affected by the *** study constructs a new Quantum-Inspired Annealing(QIA)framework to explore the potentials of quantum annealing for solving Ising model with comparisons to the classical *** various configurations of the 1 D Ising model,the new framework can achieve ground state,corresponding to the optimum of classical problems,with higher probability up to 28%versus classical counterpart(22%in case).This condition not only reveals the potential of quantum annealing for solving the Ising-like Hamiltonian,but also contributes to an improved understanding and use of the quantum annealer for various applications in the future.

关键词： Quantum Annealing(QA) annealing schedule quantum tunneling optimization problem

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Active control for performance enhancement of electrically controlled rotor

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Chinese Journal of Aeronautics 2015年第5期28卷 1494-1502页

作者： Lu Yang wang chao National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics and Astronautics

Electrically controlled rotor （ECR） system has the potential to enhance the rotor perfor- mance by applying higher harmonic flap inputs. In order to explore the feasibility and effectiveness for ECR performance enhancement using closed-loop control method, firstly, an ECR rotor performance analysis model based on helicopter flight dynamic model is established, which can reflect the performance characteristics of ECR helicopter at high advance ratio. Based on the simulation platform, an active control method named adaptive T-matrix algorithm is adopted to explore the feasibility and effectiveness for ECR performance enhancement. The simulation results verify the effectiveness of this closed-loop control method. For the sample ECR helicopter, about 3% rotor power reduction is obtained with the optimum 2/rev flap inputs at the advance ratio of 0.34. And through analyzing the distributions of attack of angle and drag in rotor disk, the underlying physical essence of ECR power reduction is cleared. Furthermore, the influence of the key control parameters, including convergence factor and weighting matrix, on the effectiveness of closed-loop control for ECR performance enhancement is explored. Some useful results are summarized, which can be used to direct the future active control law design of ECR performance enhancement.

关键词： Electrically controlled rotor(ECR) Helicopter Higher harmonic control Performance enhancement Swashplateless

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Overview of composition and technique process study on 2:17-type Sm-Co high-temperature permanent magnet

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Rare Metals 2021年第4期40卷 790-798页

作者： chao wang Ming-Gang Zhu Division of Functional Materials Central Iron and Steel Research InstituteBeijing 100081China

Sm-Co permanent magnets are widely used in aerospace equipments,tubes,sensors and hybrid electric vehicles due to their excellent magnetic properties at both room and high *** to that of Nd-Fe-B magnets,the capability of reliably operating at temperatures up to 500℃ is the biggest preponderance of Sm-Co permanent ***,the reliable high-temperature magnetic properties are susceptible to composition and technique ***,appropriate composition and matched technique processes are prerequisites for good high-temperature magnetic *** review mainly emphasizes the influences of Sm,Fe,Cu and Zr contents and technique processes on development of high-temperature performance and discusses the controversial hightemperature coercivity mechanism of 2:17-type high-temperature Sm-Co magnets.

关键词： 2-type Sm-Co magnet High temperature Coercivity temperature coefficient Coercivity mechanism

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