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Cocrystallization-like strategy for the codelivery of hydrophobic and hydrophilic drugs in a single carrier material formulation

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Chinese Chemical Letters 2021年第10期32卷 3071-3075页

作者： Yi Li chao teng Helena S.Azevedo Lifang Yin Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 210009China School of Engineering and Materials Science Institute of BioengineeringQueen Mary University of LondonLondon E14NSUnited Kingdom

Codelivery of drugs by drug carriers is a promising strategy against several diseases such as infections and ***,traditional drug carriers are typically characterized by low drug payload,limiting their treatment *** nanocrystals of insoluble drug as carriers,a carrier free platform was developed previously to deliver a second insoluble drug for *** extend the concept,we hypothesized,herein,that the platform allows for codelivery of hydrophobic and hydrophilic drugs using a cocrystalization-like *** obtain proof-of-concept,paclitaxel(PTX),an insoluble chemotherapeutic agent,and dichloroacetic acid(DCA),a water-soluble inhibitor of pyruvate dehydrogenase kinase,were utilized as model ***-DCA hybrid nanocrystals(PTX-DCA NCs)were prepared by antisolvent precipitation and *** in vitro antitumor activity against cancer cells was ***-DCA NCs prepared from the optimized formulation had a diameter of 160 nm and a rodshape morphology and possessed encapsulated efficacy of approximately 30%for *** use of the hybrid crystals enabled synergy to kill cancer cells,in particular in PTX-resistant cells in a dosedependent *** conclusion,by using a cocrystalization-like strategy,a hydrophilic drug can be formulated into a drug’s nanocrystal for codelivery.

关键词： Hybrid nanocrystal Codelivery Multidrug resistance Paclitaxel Dichloroacetic acid Cocrystallization

Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4509-4525页

作者： Jiahui Zou Xuyang Xing chao teng Qingling Zhao Wei He Xuri Wu Yuanzheng Xia School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Multidrug resistance(MDR),the major mechanism by which various cancers develop specific resistance to therapeutic agents,has set up enormous obstacles to many forms of tumor *** cocktail therapy administration,based on the combination of multiple drugs for anti-MDR chemotherapy,often suffers from inconsistent in vivo pharmacokinetic behaviors that cannot act synchronously on the lesions,leading to limited pharmacodynamic *** the emergence of nanomedicines,which has improved chemotherapeutic drugs’bioavailability and therapeutic effect on clinical application,these monotherapy-based nano-formulations still show poor progression in overcoming ***,a“one stone and three birds”nanococktail integrated by a cocrystal@protein-anchoring strategy was purposed for triple-payload delivery,which paclitaxel-disulfiram cocrystal-like nanorods(NRs)were anchored with the basic protein drug Cytochrome c(Cyt C),followed by hyaluronic-acid *** particular,NRs were utilized as carrier-like particles to synchronously deliver biomacromolecule Cyt C into tumor cells and then promote cell *** note,on A549/Taxol drug-resistant tumor-bearing mice,the system with extraordinarily high encapsulation efficiency demonstrated prolonged in vivo circulation and increased tumor-targeting accumulation,significantly reversing tumor drug resistance and improving therapeutic *** mechanistic study indicated that the system induced the apoptosis of Taxol-resistant tumor cells through the signal axis P-glycoprotein/Cyt C/caspase ***,this nanococktail strategy offers a promising approach to improve the sensitivity of tumor cells to chemotherapeutic drugs and strengthen intractable drug-resistant oncotherapy.

关键词： Cocktail Multidrug-resistant Co-delivery combined therapy Cytochrome C Nanocrystals

The correlation between thermally induced precipitateto-coacervate transition and glass transition in a polyelectrolyte-bolaamphiphile complex

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Aggregate

Aggregate 2023年第5期4卷 189-198页

作者： Xiaoqing Liu Zhihui Shi Feng Yu chao teng Chen Zhang Zhong-Ren Chen Institute of Critical Materials for Integrated Circuits Shenzhen PolytechnicShenzhenChina Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhenChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhenChina

The precipitate and the coacervate are two aggregated states in the polyelectrolyte complexes(PECs).The precipitate-to-coacervate transition and glass transition in PECs have been widely reported in the *** many cases,the two phenomena are studied independently,although both of them are apparently affected by water and small ***,utilizing a PEC system consisting of poly(acrylic acid)(PAA)and a cationic bolaamphiphile(DBON),we explore the states of PECs as a function of salt,temperature,and the molecular weight of *** a combination of microscopic observation,time-resolved fluorescence measurements,and differential scanning calorimetry,we identify salt/temperature driven precipitate-to-coacervate transitions of the *** thermally induced morphology transformation from the precipitate to coacervate occurs around the glass transition temperature,indicating a strong correlation between the two *** the molecular weight of the PAA increases,the thermal transition temperature becomes *** finding offers new insights on the mechanistic interactions that dictate the aggregated states of *** on the photothermal effect of DBON,we also develop a UV light-induced strategy to mediate the precipitate-to-coacervate transition,providing a fantastic platform to create functional PEC materials.

关键词： aggregation-induced emission coacervate glass transition polyelectrolyte complex precipitate

Collective motion of polar active particles on a sphere

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Chinese Physics B 2021年第10期30卷 239-244页

作者： Yi Chen Jun Huang Fan-Hua Meng teng-chao Li Bao-Quan Ai Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal UniversityGuangzhou 510006China

Collective motion of active particles with polar alignment is investigated on a *** discussed the factors that affect particle swarm motion and define an order parameter that can show the degree of particle swarm *** the model,we added a polar alignment strength,along with Gaussian curvature,affecting particles swarm *** find that when the force exceeds a certain limit,the order parameter will decrease with the increase of the *** with our definition of order parameter and observation of the model,the reason is that particles begin to move side by side under the influence of polar *** addition,the effects of velocity,rotational diffusion coefficient,and packing fraction on particle swarm motion are *** is found that the rotational diffusion coefficient and the packing fraction have a great influence on the clustering motion of particles,while the velocity has little influence on the clustering motion of particles.

关键词： clustering motion of Brownian particles polar active particles sphere

Geochronology and Geochemistry of Early Cretaceous A-type Granites in Central-Eastern Inner Mongolia,China:Implications for Late Mesozoic Tectonic Evolution of the Southern Great Xing'an Range

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Acta Geologica Sinica(English Edition) 2023年第4期97卷 1094-1111页

作者： ZHANG Yanwen ZHANG Xiaofei CHEN Lixin PANG Zhenshan CHEN Hui XUE Jianling ZHOU Yi teng chao CHEN Guochao School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Cores and Samples Center of Natural Resources China Geological SurveyYanjiaoHebei 065201China Development and Research Centre China Geological SurveyBeijing 100037China Mineral Exploration Technical Guidance Center Ministry of Natural ResourcesBeijing 100037China Chinese Academy of Natural Resources Economics Beijing 100035China Nanyang Institutte of Technolog NanyangHenan 473000China Hubei Key Laboratory of Resources and Eco-Environment Geology(Hubei Geological Bureau) Wuhan 430034China

The southern Great Xing'an Range is the most critical Sn-polymetallic metallogenic belt in northeast ***,the tectonic setting of the Early Cretaceous magmatic-metallogenic”flare-up“event remains *** paper presents an integrated study on the occurrence,petrology,zircon U-Pb ages,whole-rock geochemistry,and in situ zircon Hf isotopes for Wenduerchagan granites of Xi Ujimqin Banner,central-eastern Inner *** granites consist primarily of granite porphyry(with ages of 137±1 Ma and 138±1 Ma)and(porphyritic)alkali feldspar granite(with an age of 141±2 Ma),corresponding to the early Early *** are A-type granites characterized by high silicon,alkali,and TFeO/MgO contents while being depleted of Ba,Nb,Ta,Sr,P,and *** show right-dipping trend rare-earth element distribution characteristics with negative Eu anomalies(Eu/Eu^(*)=0.01-0.20)and weak heavy rare-earth element fractionation((Gd/Yb)_(N)=0.77-2.30).They demonstrate homogeneous zircon Hf isotopic compositions(positiveε_(Hf)(t)values from+5.3 to+7.1 and young two-stage Hf model ages of 851-742 Ma)and high zircon saturation temperatures(av.810℃).These geochemical characteristics indicate that Wenduerchagan granites originated from the partial melting of juvenile crust under high-temperature and low-pressure *** granites most likely formed in a post-collisional compression-extension transition regime caused by the closure of the Mongol-Okhotsk Ocean,when combined with regional *** a transition regime can probably be attributed to the upwelling of the asthenospheric mantle caused by the break-off of a subducted Mongol-Okhotsk oceanic *** asthenospheric mantle provided sufficient energy and favorable tectonic conditions for magmatism and mineralization of the Early Cretaceous.

关键词： magmatism and mineralization A-type granite post-collisional environment Early Cretaceous southern Great Xing'an Range Mongol-Okhotsk Ocean

Reservoir heterogeneity controls of CO_(2)-EOR and storage potentials in residual oil zones:Insights from numerical simulations

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Petroleum Science 2023年第5期20卷 2879-2891页

作者： Yan-Yong Wang Xiao-Guang Wang Ren-Cheng Dong Wen-chao teng Shi-Yuan Zhan Guang-Yong Zeng Cun-Qi Jia College of Energy Chengdu University of TechnologyChengdu610059SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina Engineering Research Center of Geothermal Resources Development Technology and Equipment Ministry of EducationJilin UniversityChangchun130026JilinChina The University of Texas at Austin AustinTX78712USA Department of Energy Resources Engineering Stanford UniversityStanfordCA94305USA State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059SichuanChina

Residual oil zones(ROZs)have large potential for CO_(2)enhanced oil recovery(EOR)and geologic *** CO_(2)injection,the migration of CO_(2)in ROZs controls the performance of both EOR and ***,it has not been clearly visualized and understood that how geological heterogeneity factors control the transport of CO_(2)in *** this study,the oil recovery performance and geologic storage potential during continuous CO_(2)injection in a representative ROZ are studied based on geostatistical modelling and high-fidelity three-phase flow *** examined the influence of autocorrelation length of permeability,global heterogeneity(DykstraeParsons coefficient),and permeability anisotropy on cumulative oil recovery and CO_(2)retention *** results indicate that,as the permeability autocorrelation length increases,the cumulative oil recovery and CO_(2)storage efficiency *** results from the accelerated migration of CO_(2)along high permeability zones(i.e.,gas channeling).The increase in global heterogeneity and permeability anisotropies can lead to low oil recovery and poor CO_(2)sequestration performance,depending on the degree of CO_(2)*** net utilization ratio of CO_(2)(CO_(2)retained/oil produced)unfavorably increases with both autocorrelation length and Dykstra eParsons coefficient,but decreases with the increase in kv/*** a decrease is attributed to enlarged swept volume induced by gravity *** study provides important implications for fieldscale CO_(2)EOR and storage applications in ROZs.

关键词： Residual oil zones CO_(2)injection Enhanced oil recovery Geologic sequestration

Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2369-2382页

作者： Bingbing Li chao teng Huiling Yu Xiaohong Jiang Xuyang Xing Qi Jiang Chenshi Lin Zongmin Zhao Ruifeng Zhang Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Anesthesiology Affiliated Drum Tower of Nanjing UniversityNanjing 210008China Department of Pharmaceutical Sciences College of PharmacyUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Respiratory Medicine Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Anesthesiology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjing 210004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Pulmonary hypertension(PH)is an insidious pulmonary vasculopathy with high mortality and morbidity and its underlying pathogenesis is still poorly *** hyperproliferation and apoptosis resistance of pulmonary artery smooth muscle cells(PASMCs)contributes to pulmonary vascular remodeling in pulmonary hypertension,which is closely linked to the downregulation of forkhead box transcriptional factor O1(FoxO1)and apoptotic protein caspase 3(Cas-3).Here,PA-targeted co-delivery of a FoxO1 stimulus(paclitaxel,PTX)and Cas-3 was exploited to alleviate monocrotaline-induced pulmonary *** co-delivery system is prepared by loading the active protein on paclitaxel-crystal nanoparticles,followed by a glucuronic acid coating to target the glucose transporter-1 on the *** co-loaded system(170 nm)circulates in the blood over time,accumulates in the lung,effectively targets the PAs,and profoundly regresses the remodeling of pulmonary arteries and improves hemodynamics,leading to a decrease in pulmonary arterial pressure and Fulton's *** mechanistic studies suggest that the targeted co-delivery system alleviates experimental pulmonary hypertension primarily via the regression of PASMC proliferation by inhibiting cell cycle progression and promoting *** together,this targeted co-delivery approach offers a promising avenue to target PAs and cure the intractable vasculopathy in pulmonary hypertension.

关键词： Pulmonary hypertension Pulmonary artery smooth muscle cells Fork-head box transcriptional factor O1 Caspase 3 Co-delivery

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高分子链的去拥挤转变及低温流动

高分子学报 2011年第9期21卷 1001-1006页

作者：滕超薛奇南京大学化学化工学院高分子科学与工程系南京微结构国家实验室(筹) 南京210093

简述了拥挤理论的基本原理,运用拥挤理论来说明高分子链间弱相互作用对高分子链所处的状态的影响,特别是对高分子玻璃化转变的影响.在实验中,采用固体核磁共振方法探测高分子的链间邻近度,并比较了不同链间邻近度的高分子样品在玻璃化... 详细信息

简述了拥挤理论的基本原理,运用拥挤理论来说明高分子链间弱相互作用对高分子链所处的状态的影响,特别是对高分子玻璃化转变的影响.在实验中,采用固体核磁共振方法探测高分子的链间邻近度,并比较了不同链间邻近度的高分子样品在玻璃化转变温度以下的压力诱导流行行为,发现即使测试温度比高分子玻璃化转变温度低132℃,高分子链在压力下依然可以进行局部流动,即高分子链的低温流动行为.拥挤理论为高分子链的低温流动行为提供了依据,并为玻璃化转变的机理提供了新的解释.与此同时,高分子链的低温流动也为高分子加工提供了新的思路和方法.

关键词：高分子链低温流动去拥挤转变高分子加工玻璃化转变

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1521-1533页

作者： chao teng Chenshi Lin Feifei Huang Xuyang Xing Shenyu Chen Ling Ye Helena S.Azevedo Chenjie Xu Zhengfeng Wu Zhongjian Chen Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China School of Engineering and Materials Science Institute of BioengineeringUniversity of LondonLondon E14NSUK Department of Biomedical Engineering City University of Hong KongKowloonHong KongChina Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy(drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals,named as baicalein nanorods(BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo. In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.

关键词： miR155 inflammatory sustained