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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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SDGSAT-1: Capabilities for Monitoring and Evaluating SDG Indicators

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空间科学学报 2024年第4期44卷 677-686页

作者： GUO Huadong DOU changyong LIANG Dong JIANG Nijun tang Yunwei MA Wenyong International Research Center for Big Data for Sustainable Development Beijing 100094 Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094 University of Chinese Academy of Sciences Beijing 100049

SDGSAT-1,the world's first science satellite dedicated to assisting the United Nations 2030 Sustainable Development Agenda,has been operational for over two and a half *** provides valuable data to aid in implementing the Sustainable Development Goals *** its Open Science Program,the satellite has maintained consistent operations and delivered free data to scientific and technological users from 88 *** program has produced a wealth of scientific output,with 72 papers,including 28 on data processing methods and 44 on applications for monitoring progress toward SDGs related to sustainable cities,clean energy,life underwater,climate action,and clean water and ***-1 is equipped with three key instruments:a multispectral imager,a thermal infrared spectrometer,and a glimmer imager,which have enabled ground-breaking research in a variety of domains such as water quality analysis,identification of industrial heat sources,assessment of environmental disaster impacts,and detection of forest *** precise measurements and ongoing monitoring made possible by this invaluable data significantly advance our understanding of various environmental *** are essential for making well-informed decisions on a local and global *** its application to academic research,SDGSAT-1 promotes global cooperation and strengthens developing countries'capacity to accomplish their sustainable development *** the satellite continues to gather and distribute data,it plays a pivotal role in developing strategies for environmental protection,disaster management and relief,and resource *** initiatives highlight the satellite's vital role in fostering international collaboration and technical innovation to advance scientific knowledge and promote a sustainable future.

关键词： SDGSAT-1 Earth observation Remote sensing SDGs

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Innovative discontinuous-SEI constructed in ether-based electrolyte to maximize the capacity of hard carbon anode

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Journal of Energy Chemistry 2023年第4期79卷 459-467页

作者： Fanghong Zeng Lidan Xing Wenguang Zhang Zhangyating Xie Mingzhu Liu Xiaoyan Lin Guangxia tang changyong Mo Weishan Li Engineering Research Center of MTEES(Ministry of Education) Research Center of BMET(Guangdong Province)Engineering Lab.of OFMHEB(Guangdong Province)Key Lab.of ETESPG(GHEI)and Innovative Platform for ITBMD(Guangzhou Municipality)School of ChemistrySouth China Normal UniversityGuangzhou 510006GuangdongChina

Compared with graphite,the lower sodiation potential and larger discharge capacity of hard carbon(HC)makes it the most promising anode material for sodium-ion *** ether-based electrolyte rather than conventional carbonate-based electrolyte,HC achieves superior electrochemical ***,the mechanism by which ether-based electrolyte improves the properties of HC is still controversial,primarily focusing on whether it forms solid electrolyte interphase(SEI)*** this work,according to the sodium storage mechanisms in HC at low voltage(<0.1 V),including Na^(+)-diglyme co-interaction into the carbon layer(SEI forbidden)and desolvated Na^(+)insertion in the irregular carbon holes(SEI required),the NaPF6concentration in ether-based electrolyte was regulated,so as to construct a discontinuous-SEI on the surface of the HC anode,which significantly enhances the electrochemical performances of ***,with 0.2 M NaPF6ether-based electrolyte,HC deliverers a discharge capacity of 459.7 mA h g^(-1)at 0.1 C and stays at 357.2 mA h g^(-1)after 500 cycles at 1 C,which is substantially higher than that of higher/lower salt concentration electrolytes.

关键词： Sodium ion battery Hard carbon Ether-based electrolyte SEI/SEI-free

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Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation

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Neuroscience Bulletin 2019年第5期35卷 826-840页

作者： Hongji Sun Xuan Ma Liya tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou changyong Wang School of Life Science and Technology Harbin Institute of Technology 92 West Dazhi Street Nan Gang District Harbin 150080 China Department of Neural Engineering and Biological Interdisciplinary Studies Institute of Military Cognition and Brain Sciences Academy of Military Medical Sciences 27 Taiping Rd Beijing 100850 China Department of Neurology Chinese PLA General Hospital Beijing 100853 China

Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) ***, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention.

关键词： Macaque Primary motor cortex Primary somatosensory cortex Posterior parietal cortex Temporal perception Local field potentials

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Stability of liquid crystal systems doped withγ-Fe_(2)O_(3)nanoparticles

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Chinese Physics B 2021年第9期30卷 364-370页

作者： Xu Zhang Ningning Liu Zongyuan tang Yingning Miao Xiangshen Meng Zhenghong He Jian Li Minglei Cai Tongzhou Zhao changyong Yang Hongyu Xing Wenjiang Ye School of Sciences Hebei University of TechnologyTianjin 300401China School of Physical Science and Technology Southwest UniversityChongqing 400715China Hebei Jiya Electronics Co.Ltd. Shijiazhuang 050071China Hebei Provincial Research Center of FPD Engineering Technology Shijiazhuang 050071China

In order to explore the stability of a liquid crystal(LC)system doped withγ-Fe_(2)O_(3)nanoparticles,the physical properties(clearing point,dielectric properties),electro-optical properties and residual direct-current voltage(RDCV)of the doped LC system were measured and evaluated at different ***,the temperature was controlled by precision hot stage,and the clearing point temperature of doped LC was observed and measured by a polarized optical *** a precision LCR meter,we measured the capacitance-voltage curves of the doped LC system at the temperature of 27℃.The dielectric constant of doped LC was calculated by the dualcell capacitance ***,the electro-optical properties of the doped LC system were ***,the RDCV of the doped LC system was measured and *** five months,the parameters of the doped LC system were re-measured and analyzed under the same conditions to evaluate its *** experimental results show that,within five months,the clearing point change rate of doped LC is in the range of 0.24%-1.37%,the change of dielectric anisotropy is in the range of 0.035-0.2,the curves of electro-optical properties are basically fitted,and the change rate of saturated RDCV is about 11.2%,which basically indicate that the LC system doped withγ-Fe_(2)O_(3)nanoparticles has good stability.

关键词： γ-Fe_(2)O_(3)nanoparticles stability of liquid crystal system clearing point dielectric properties electro-optical properties

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A Knowledge-based Infrared Search System In Complicate IR Background

A Knowledge-based Infrared Search System In Complicate IR Ba...

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1998 Fourth International Conference Signal Processing

作者： Zheng Wenlong tang Xinyi Zhang Yong Wu changyong Shanghai Institute of Technical Physics The Science Academy of China

＜正＞This paper describes a knowledge-based infrared（IR） search system for the detection and classification of the target formations in IR image sequences in complicate IR background. The system employs a fast fuzzy-based approach for detecting and recognizing targets,and utilizes some advanced technology of spatial digital filtering,target acquisition by frame to frame, knowledge-based synthetic decision,and also uses digital signal processors（DSPs） and field programmable gate arrays（FPGAs） to construct real-time parallel processing *** system is capable of automatic multi-target recognition in complicate IR *** system processing rate reaches 30 frame per second,system responding time is less than 1 second.

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Commelina communis L.: Copper Hyperaccumulator Found in Anhui Province of China

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Pedosphere 1997年第3期7卷 207-210页

作者： tang SHIRONG HUANG changyong and ZHU ZUXIANG (Department of Soil Science, College of Environmental Sciences and Natural Resources, Zhejiang Agricultural University, Hangzhou 310029 China) DepartmentofSoilScience CollegeofEnvironmentalSciencesandNaturalResourcesZhejangAgriculturalUniversi

Commelina communis L. growing over some new copper mining wastelands at Bijiashan, Tongling City of Anhui Province, China, was found to be a copper hyperaccumulator. Its copper concentrations were 2707-6159 (4439±2434) mg kg-1, 369-831 (731±142) mg kg-1, and 429-587 (547±57) mg kg-1, respectively, in the roots, stems, and leaves. The soils supporting the growth of the species had a copper concentration ranging from 4620 to 5020 mg kg-1 and averaging 4835±262 mg kg-1, suggesting that the species could not only grow on heavily copper-contaminated soils but also accumulate extraordinarily high concentration of copper. Thus, it shows great potential in the phytoremediation of copper-contaminated soils,the restoration of mined land, geochemical prospecting, and the study of environmental pollution changes.

关键词： Anhui Province Commelina communis L. copper hyperaccumulator

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红橘响应褐斑病菌侵染的转录组学分析

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中国农业科学 2020年第22期53卷 4584-4600页

作者：唐科志周常勇西南大学柑桔研究所

【目的】明确红橘(Citrus reticulata Blanco, cv. Hongjv)接种褐斑病致病菌——链格孢菌橘致病型(Alternaria alternata tangerine pathotype)后基因种类和表达量在转录水平的变化规律,确定红橘响应该致病型侵染的关键基因。【方法】... 详细信息

【目的】明确红橘(Citrus reticulata Blanco, cv. Hongjv)接种褐斑病致病菌——链格孢菌橘致病型(Alternaria alternata tangerine pathotype)后基因种类和表达量在转录水平的变化规律,确定红橘响应该致病型侵染的关键基因。【方法】采用链格孢菌橘致病型接种红橘离体叶片,28 h后选取感病叶片和未接种叶片提取RNA,进行转录组高通量测序,然后利用生物信息学分析,以甜橙基因组为参考,以|log2 fold change|≥1,q-value≤0.01为阈值选取感病和健康红橘叶片转录组的差异表达基因,应用GO数据库对差异表达基因(differentially expressed gene,DEG)进行功能分类,KEGG分析代谢途径,MapMan软件分析生物胁迫信号通路相关基因的表达变化。采用qRT-PCR方法对测序结果进行验证。【结果】红橘接种链格孢菌橘致病型28 h后产生大量与胁迫相关的差异表达基因,获得上调差异基因5 173个,下调差异基因6 555个。GO功能分类显示差异基因主要与蛋白结合、膜、氧化还原过程等相关。通过KEGG富集和MapMan软件分析发现,红橘在受链格孢菌橘致病型胁迫的过程中基础代谢被严重破坏。乙烯、水杨酸和生长素等寄主防御相关的植物激素信号转导途径多个基因表达出现差异,其中乙烯起主导作用,乙烯受体ETR 3个成员被不同程度激活,下游激酶和乙烯响应因子均上调,生长素大部分关键信号基因、绝大部分生长素响应因子ARF和水杨酸合成途径的基因均下调表达。同时,黄酮醇、花青素、萜类化合物和生物碱合成相关基因受该菌诱导显著变化,萜类合成中大部分基因下调,而黄酮类合成相关上调基因数量和表达趋势均强于表达下调基因,有抗虫和抑菌作用的硫代葡萄糖苷基因呈上调趋势。进一步研究发现,大量参与抗逆过程的转录因子如WRKY、bZIP、ERF、MYB、NAC被诱导激活,其中大部分WRKY和bZIP转录因子受该菌正向调控,超过50%的ERF家族基因表达上调;在转录因子调控下,PTI及ETI响应基因如受体激酶、R蛋白、NBS抗病蛋白等大量表达,多个PR家族抗菌蛋白基因上调表达,22个抗氧化保护酶系统POD成员基因受到活性氧信号激发大量表达。以上结果表明链格孢菌橘致病型侵染对寄主内部生理状态产生显著影响。选取了19个与植物抗病相关基因进行qRT-PCR分析,其基因表达趋势与测序数据一致。【结论】获得了红橘响应链格孢菌橘致病型侵染的差异表达基因及显著上调表达基因,其主要富集于代谢过程、应激反应及转录调控等条目中,这些基因的相互协同调控是红橘对该致病型产生防御反应的重要机制。

关键词：红橘链格孢菌橘致病型转录组差异表达基因

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数字接收机I/Q支路不平衡的时域补偿

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清华大学学报（自然科学版） 2007年第1期47卷 49-52页

作者：唐世刚龚克潘长勇杨知行清华大学电子工程系微波与数字通信技术国家重点实验室北京100084

为了消除数字接收机同相与正交(I/Q)支路幅度和相位不平衡对数字接收机接收性能的影响,根据时域数据I/Q支路的功率与正交关系,提出了一种I/Q支路不平衡参数估计和补偿方法。该方法的估计和补偿均在时域进行,可以在计算复杂度、估计时间... 详细信息

为了消除数字接收机同相与正交(I/Q)支路幅度和相位不平衡对数字接收机接收性能的影响,根据时域数据I/Q支路的功率与正交关系,提出了一种I/Q支路不平衡参数估计和补偿方法。该方法的估计和补偿均在时域进行,可以在计算复杂度、估计时间和补偿性能三者之间进行折衷;它无需导频或者训练序列,可应用于多种制式的单载波和多载波接收机中。仿真结果表明:利用该方法的64QAM-OFDM系统误码率在AWGN信道下可以达到理想性能,在多径信道下1×10-3误码率处的性能损失可以减小到0.1 dB左右。

关键词：数字接收机 I/Q支路不平衡时域补偿

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精神医学中的生物统计学(15) 对观察性数据和聚类数据应用生存分析评估个体和环境的自杀危险因素(英文)

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上海精神医学 2013年第3期25卷 183-194页

作者： Kerry Louise KNOX Alina BAJORSKA changyong FENG Wan tang Pan WU Xin Ming TU Department of Psychiatry University of Rochester Medical Center Rochester NY USA Veterans Integrated Service Network 2 Center of Excellence for Suicide Preventon Canandaigua VA Medical Center Canandaigua NY USA Department of Biostatstcs University of Rochester Medical Center Rochester NY US

*** Survival analysis concerns the time from a well-defined origin to some event of interest, such as the time from surgery to death of a cancer patient, the time from wedding to divorce, and the time between the first and second suicide *** originated in research on the active lifetime of light bulbs and other electric devices, modern applications of survival analysis include many non-survival ***, survival analysis may be more appropriately called the time-to-event analysis.

关键词：生存分析危险因素评估环境集群观测事件分析癌症患者

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