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Progress and perspective of organoid technology in breast cancer research

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中华医学杂志(英文版) 2024年第18期137卷 2024 Jan 8页

作者： huang changsheng Jin Hongyan Department of Obstetrics and Gynecology Peking University First Hospital Beijing China

Breast cancer, a malignant tumor with a high incidence in women, lacksin vitro research models that can represent the biological functions of breast tumorsin vivo. As a new biological tool, the organoid model has unique advantages over traditional methods, such as cell culture and patient-derived xenografts. Combining organoids with other emerging technologies, such as gene engineering and microfluidic chip technology, provides an effective method to compensate for the deficiencies in organoid models of breast cancerin vivo. The emergence of breast cancer organoids has provided new tools and research directions in precision medicine, and drug research. In this review, we summarized the merits and demerits of organoids compared to traditional biological models, explored the latest developments in the combination of new technologies and organoid models, and discussed the construction methods and application prospects of different breast cancer organoid models.

关键词： Organoids Breast cancer Preclinical model Bioengineering

Non-Newtonian Effect on Hemodynamic Characteristics of Blood Flow in Stented Cerebral Aneurysm

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Communications in Computational Physics 2013年第3期13卷 916-928页

作者： changsheng huang Zhenhua Chai Baochang Shi School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074P.R.China

Stent placement is considered as a promising and minimally invasive technique to prevent rupture of aneurysm and favor coagulation mechanism inside the *** scholars study the effect of the stent on blood flow in cerebral aneurysm by numerical simulations,and usually regard blood as the Newtonian fluid,blood,however,is a kind of non-Newtonian fluid in *** main purpose of the present paper is to investigate the effect of non-Newtonian behavior on the hemodynamic characteristics of blood flow in stented cerebral aneurysm with lattice Boltzmann *** Casson model is used to describe the blood non-Newtonian character,which is one of the most popular models in depicting blood *** particular,hemodynamic characteristics derived with Newtonian and non-Newtonian models are studied,and compared in *** results show that the non-Newtonian effect gives a great influence on hemodynamic characteristics of blood flow in stented cerebral aneurysm,especially in small necked ones.

关键词： Cerebral aneurysm lattice Boltzmann non-Newtonian fluid Casson model

Implementation of Multi-GPU Based Lattice Boltzmann Method for Flow Through Porous Media

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Advances in Applied Mathematics and Mechanics 2015年第1期7卷 1-12页

作者： changsheng huang Baochang Shi Nanzhong He Zhenhua Chai School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China

The lattice Boltzmann method(LBM)can gain a great amount of performance benefit by taking advantage of graphics processing unit(GPU)computing,and thus,the GPU,ormulti-GPU based LBMcan be considered as a promising and competent candidate in the study of large-scale fluid ***,the multi-GPU based lattice Boltzmann algorithm has not been studied extensively,especially for simulations of flow in complex *** this paper,through coupling with the message passing interface(MPI)technique,we present an implementation of multi-GPU based LBM for fluid flow through porous media as well as some optimization strategies based on the data structure and layout,which can apparently reduce memory access and completely hide the communication time *** the performance of the algorithm is tested on a one-node cluster equipped with four Tesla C1060 GPU cards where up to 1732 MFLUPS is achieved for the Poiseuille flow and a nearly linear speedup with the number of GPUs is also observed.

关键词： Lattice Boltzmann method GPU computing CUDA porous media MPI

Raising the Speed Limit of Axial Piston Pumps by Optimizing the Suction Duct

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 271-280页

作者： Yu Fang Junhui Zhang Bing Xu Zebing Mao Changming Li changsheng huang Fei Lyu Zhimin Guo State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310027China Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyoJapan Hangzhou Optimax Tech Co. LtdHangzhouChina Linde Hydraulics(China)Co. LtdWeifang261000China

The maximum delivery pressure and the maximum rotational speed determine the power density of axial piston ***,increasing the speed beyond the limit always accompanies cavitation,leading to the decrease of the volumetric *** pressure loss in the suction duct is considered a significant reason for the ***,this paper proposes a methodology to optimize the shape of the suction duct aiming at reducing the intensity of cavitation and increasing the speed *** first,a computational fluid dynamics(CFD)model based on the full cavitation model(FCM)is developed to simulate the fluid field of the axial piston pump and a test rig is set to validate the *** the topology optimization is conducted for obtaining the minimum pressure loss in the suc-tion *** the original suction duct with the optimized one in the simulation model,the pressure loss in the suction duct gets considerable reduction,which eases the cavitation intensity a *** simulation results prove that the speed limit can increase under several different inlet pressures.

关键词： Axial piston pump Speed limit Topology optimization Suction duct Cavitation

Advances in the formulation and defivery technology of paclitaxel for injection

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Journal of Chinese Pharmaceutical Sciences 2015年第8期24卷 487-500页

作者： Jing Sun Wenbing Dai Zhe Liang Zhaoyang wang changsheng huang Bing He Hua Zhang Xueqing Wang Qiang Zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191 China

Paclitaxel is a promising antineoplastic agent against a variety of human solid tumors, such as ovary, breast, lung, head and neck tumors, and melanoma. Owing to its poor solubility, the fast available formulation ofpaclitaxel （Taxol） exists as a non-aqueous concentrate composed of Cremophor EL （polyethoxylated castor oil） and ethanol. It must be diluted to a suitable aqueous solution prior to long time intravenous infusion. Based on the components and usage, Taxol has serious adverse effects and is inconvenient for clinical use. To address these problems, the development of a less-toxic, better-tolerated, Cremophor EL-free formulation of paclitaxel has been attempted. In recent years, new drug delivery systems （DDS） including albumin-based nanoparticles, micelles, liposomes, etc. have been investigated. In this review, we present the formulations and delivery technologies of paclitaxel for injection and focus on some of preclinical and clinical experience on the formulations which are already on the market or under clinical stages. Finally, possible nanotechnology advantages, existing challenges and future perspectives of paclitaxel delivery are highlighted.

关键词： Paclitaxel Taxol Preclinical and clinical studies New drug delivery system

A diffuse-interface lattice Boltzmann method for fluid-particle interaction problems

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A diffuse-interface lattice Boltzmann method for fluid-parti...

Climate Evolution Recorded by Organic Carbon Stable I sotope since 5 *** Poyang Lake Area, China

中国力学大会-2021+1

作者： Jiao Liu changsheng huang Zhenhua Chai Baochang Shi Huazhong University of Science and Technology

介绍/亮点Introduction/Highlight In this paper,a diffuse-interface lattice Boltzmann method (DI-LBM) is developed for fluid-particle interaction *** this method,the sharp interface between the fluid and solid is replaced by a thin but nonzero thickness transition region named diffuse interface,where the physical variables change *** order to describe the diffuse interface,

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Journal of China University of Geosciences 2003年第1期14卷 25-27页

作者： Peng Hongxia Li Chang’an Shi Chaoyi Yang Chao huang changsheng Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 Faculty of Earth Sciences China University of GeosciencesWuhan 430074

Based on the data of organic carbon stable isotope ratios and magnet ic susceptibility, climate evolution in the past 5 kaB.P. in Poyang Lake plain (in Jiangxi Province) has been reconstructed. The results of the research indicate that the climate evolution can be divided into nine stages in the past 5 kaB.P.. Comparisons of different regional environmental records suggest that the intens ity and the temporal spatial changes of monsoon in China mainly controlled the climate evolution.

关键词： Poyang Lake area paleoclimate evolution organic carbon stable isoto pe ratios magnetic susceptibility.

A novel thermo-sensitive gel intervening in tumor microenvironment for controlled local delivery of Trastuzumab

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A novel thermo-sensitive gel intervening in tumor microenvir...

2014年中国药学大会暨中国药师周

作者： Zhaoyang Wang changsheng huang Jing Sun Wenbing Dai Qiang Zhang Skate Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

With the development of phage display,antibody engineering,monoclonal antibody（Mab）has become mature and the efficaciously route to therapy cancer in recent years due to its specificity to the *** the Mab become the important way in cancer treatment,it still has the limitations such as the instability,immunogenicity,relatively short half-life due to the essence of protein drug,and the systematic toxicity by intravenous infusion（IV）.In practical,the local delivery system may be the potential way to avert the *** the local delivery,thermo-sensitive hydrogel is an ideal way for *** chose the PLGA-PEG-PLGA polymer as the hydrogel material as its admitted biocompatibility and biological *** 4°C,the polymer was in liquid *** 25°C,it occurred gelatinization and became the gelatin *** the comprehension of solid tumor structure,it is more and more clear that the tumor microenvironment（TME）particularly the collagen contributes to the drug resistance by preventing the penetration deep into the tumor,therefore,limiting the efficacy of therapeutic agents in conventional drug delivery system by *** in local delivery,the drug molecules also have difficulty in entering the interior due to the ***Ι-collagenase which can specificlly degrade the collagenΙandΙΙΙ,intervening the TME,can increase the perfusion and uptake of therapeutic macromolecules in tumor including the immunoglobulin（Ig G）.To achieve the goal that making more Mab molecules to the tumor parenchyma for better antitumor effect,we usedΙ-collagenase to degrade the collagen in tumor,intervening the *** chose Trastuzumab（Herceptin）as the model *** is a humanized Ig G1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein（HER-2）indicated for HER-2overexpressing breast cancer or metastatic *** combined theΙ-collagenase,Herceptin and PLGA-PE

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基于蚁群算法的石化项目应急路径规划研究

工业安全与环保 2012年第9期38卷 63-65页

作者：叶继红黄长生浙江海洋学院石油化工学院浙江舟山316004 中国地质大学工程学院武汉430074 武汉地质调查中心武汉430205

蚁群算法是一种智能仿生优化算法,实际运用仿真模拟时具有良好的寻优性和高效性。将蚁群算法与石化项目的路径规划结合,借鉴蚁群算法解决旅行商问题TSP的思路并将之运用于应急路径规划,利用MATLAB仿真软件,以某石化项目的应急路径规划... 详细信息

蚁群算法是一种智能仿生优化算法,实际运用仿真模拟时具有良好的寻优性和高效性。将蚁群算法与石化项目的路径规划结合,借鉴蚁群算法解决旅行商问题TSP的思路并将之运用于应急路径规划,利用MATLAB仿真软件,以某石化项目的应急路径规划为实例,较好地实现了有关应急路径模拟图,可为有关石化项目的安全规划提供借鉴和参考。

关键词：蚁群算法石化项目应急路径安全规划仿真模拟