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A pilot study of precision treatment for patients with lung cancer pain by Longteng Tongluo recipe(龙藤通络方) using serum genomics

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1006-1016页

作者： WU Ruixin FANG Qingliang GUAN Sisi WEI Xianglong SHAN Mengjun MAO Zhujun GONG Yabin XU Ling ZHOU Di dong changsheng Preclinical Department Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine School of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Department of Oncology Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Oncology the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Oncology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Cancer Institute of Traditional Chinese Medicine/Department of Oncology Longhua HospitalShanghai University of Traditional Chinese Medicine

OBJECTIVE: To investigate the efficacy of Longteng Tongluo recipe(龙藤通络方, LTTL) combined with threestep analgesia for the treatment of lung cancer pain, and the changes in serum miRNA expressions before-and after treatment with LTTL and its correlation with lung cancer pain. The possible mechanism underlying LTTL effects on the treatment of lung cancer pain was conducted. METHODS: The pilot study was conducted at the oncology ward of the Yueyang Hospital and the Longhua Hospital between March 2018 and October 2019. A prospective, single-blind, placebo controlled, randomized clinical trial of LTTL or placebo combined with three-step analgesia treatments were administered to 24 cancer pain patients diagnosed with lung cancer. Analgesic efficacy was investigated as the primary outcome. Equivalent morphine consumption and numerical rating scale(NRS) scores were used as the secondary outcome. In the present study, we utilized deep sequencing techniques to compare the differential miRNA expressions in serum samples obtained from two groups: the lung cancer pain treatment group(LTTL + three-step analgesia) and the control group(placebo + three-step analgesia). Next, we employed the target prediction database to investigate the target genes for differential miRNA expressions and Gene Ontology(GO) analysis along with Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis to examine the roles and the major biochemical and signaling pathways related to the differentially expressed target genes, respectively. RESULTS: LTTL treatment significantly reduces the NRS score(P = 0.021) as compared to those before treatment, along with significant reductions in the total morphine equivalent consumption(P = 0.007) and the average daily equivalent morphine consumption(P = 0.003) as opposed to the control group. The expressions of 31 miRNAs differed considerably between the two groups of patients( ≥ 2 times up-modulated or down-regulated between these groups, P < 0.05).

关键词： Longteng Tongluo recipe MicroRNA-chip Supporting information high-throughput nucleotide sequencing lung neoplasms neoplasm metastasis pain

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融西入中构建氢中医药学体系初探

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中国中医药现代远程教育 2024年第2期22卷 177-179页

作者：董昌盛于观贞上海中医药大学附属龙华医院肿瘤所上海200032 上海中医药大学附属龙华医院肿瘤科上海200032 浙江数字内容研究院数字医疗与人工智能实验室浙江绍兴312366

氢气作为来源于大自然的物质,在疾病防治方面已经起到一定作用。鉴于氢气在作用特点、理化属性、治病规律等方面高度符合中医学的特色,融西入中,开展氢气中药药理学、氢气复方配伍等研究,根据氢气对于具体疾病治疗效果进行中医学阐释并... 详细信息

氢气作为来源于大自然的物质,在疾病防治方面已经起到一定作用。鉴于氢气在作用特点、理化属性、治病规律等方面高度符合中医学的特色,融西入中,开展氢气中药药理学、氢气复方配伍等研究,根据氢气对于具体疾病治疗效果进行中医学阐释并挖掘氢中医药学的内涵和外延,对于中医学创新发展具有积极意义。

关键词：氢医学中医学氢中医学融西入中

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Pulsed Nd:YAG laser cladding of high silicon content coating on low silicon steel

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Journal of University of Science and Technology Beijing 2007年第4期14卷 321-326页

作者： Danyang dong changsheng Liu Bin Zhang Jun Miao Key Laboratory of the Ministry of Education of China for Anisotropy and Texture of Materials Northeastern University Shenyang 110004 China

A pulsed Nd：YAG （yttrium aluminum garnet） laser-based technique was employed to clad low silicon steel with preplaced Si and Fe mixed powders for high Si content. The surface morphology, microstructural evolution, phase composition, and Si distribution, within the obtained cladding coatings, were characterized by optical microscopy （OM）, field emission scanning electron microscopy （FE-SEM）, with associated energy dispersive spectroscopy （EDS）, transmission electron microscopy （TEM）, and X-ray diffraction （XRD）. The microhardness was also measured along the depth direction of the specimens, A crack- and pore-free cladding coating through excellent metallurgical bonding with the substrate was successfully prepared on low silicon steel by means of optimized single-track and multi-track laser cladding. The phases of the coating are a-Fe, T-Fe, and FeSi. The high microhardness of the lasercladding zone is considered as an increase in Si content and as the refined microstructure produced by the laser treatment. The Si contents of the cladding coatings were about 5.8wt% in the single-track cladding and 6.5wt% in the multi-track cladding, respectively.

关键词： silicon steel pulsed Nd:YAG laser cladding high silicon content coating microstructure microhardness

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富氢水对芳香中药茵陈产量及有效成分的影响

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香料香精化妆品 2024年第2期 1-7页

作者：董昌盛伍睿昕邓娅婷廖心怡于观贞上海中医药大学附属龙华医院中医肿瘤研究所上海200032 上海中医药大学附属龙华医院肿瘤科上海200032 上海中医药大学附属市中医医院治未病科上海200071 浙江数字内容研究院数字医疗与人工智能实验室浙江绍兴312366

为了研究富氢水对茵陈的影响,采用不同含量的富氢水浇灌及喷洒进行茵陈植株生长试验,并运用精准靶向-黄酮/酚类定性定量分析。试验第15天,与对照组相比,非饱和组的植株横径和体积明显增加,而饱和组无明显变化。第25天,不同含量富氢水组... 详细信息

为了研究富氢水对茵陈的影响,采用不同含量的富氢水浇灌及喷洒进行茵陈植株生长试验,并运用精准靶向-黄酮/酚类定性定量分析。试验第15天,与对照组相比,非饱和组的植株横径和体积明显增加,而饱和组无明显变化。第25天,不同含量富氢水组的植株横径和体积明显增加,非饱和组的湿重和干重明显增加(P<0.05)。不同含量富氢水组可下调或上调13个差异代谢物(P<0.05),且能上调天竺葵素-3-氯化葡萄糖苷等6个化合物的含量。研究发现富氢水能增加芳香中药茵陈产量,并通过增加有效成分含量提高茵陈质量。

关键词：氢中药学富氢水芳香中药茵陈有效成分

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基于网络药理学探讨《古今录验》续命汤治疗中风的机制

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山西中医药大学学报 2024年第2期25卷 202-213页

作者：杨伟丰云伍睿昕吴积海董昌盛河南省泌阳县人民医院河南泌阳463700 上海市闵行区梅陇社区卫生服务中心上海201104 上海中医药大学基础医学院上海201203 上海中医药大学研究生院上海201203 上海中医药大学附属龙华医院肿瘤科上海200032 上海市中医药研究院中医肿瘤研究所上海200032

目的:通过网络药理学方法探究《古今录验》续命汤治疗中风的潜在作用机制。方法:通过TCMSP数据库检索《古今录验》续命汤中麻黄、当归、桂枝、人参、杏仁、石膏、川芎、干姜、甘草的活性成分及作用靶点;以“cerebral infarction”为关... 详细信息

目的:通过网络药理学方法探究《古今录验》续命汤治疗中风的潜在作用机制。方法:通过TCMSP数据库检索《古今录验》续命汤中麻黄、当归、桂枝、人参、杏仁、石膏、川芎、干姜、甘草的活性成分及作用靶点;以“cerebral infarction”为关键词检索OMIM、GeneCards、NCBI数据库,进行有效的人类基因检索;利用Venny 2.1软件制作成分靶点与疾病靶点韦恩图,通过STRING数据库构建PPI网络图,并将其引入Cystoscape 3.8.0软件,使用网络分析(network analyzer)方法完成拓扑解析,采用度值(degree)排序方式选择得分超过平均值的靶点作为主要靶点,并启动MCODE模块进行基因组数据分析及核心靶点挑选。使用Cytoscape 3.8.0软件构建成分-疾病-靶点网络图,并进行拓扑分析,以degree值对成分进行排序。采用GO功能富集分析和KEEG通路富集分析对基因进行简单注释,采用R语言及cluster profiler包创建柱形图和气泡图以获取更精确的数据结果。结果:《古今录验》续命汤活性成分共有256个作用靶点,中风靶点1841个,成分与疾病交集靶点158个;运用PPI网络结构结合MCODE算法共筛选出续命汤治疗中风的10个基因簇和9个关键基因,包括胆碱能受体毒蕈碱1(CHRM1)、胱天蛋白酶9(CASP9)、信号传导及转录激活蛋白(STAT)、缺氧诱导因子(HIF)、氧化低密度脂蛋白受体1(OLR1)、UDP葡糖醛酸基转移酶1家族多肽A1(UGT1A1)、纤溶酶原激活因子(t-PA)、干扰素调节因子1(IRF1)、基质金属肽酶3(MMP3)等。GO功能富集分析共富集到2458条生物过程,174项分子功能,109项细胞组分;KEGG通路富集分析得到177条信号通路,续命汤主要通过活性成分槲皮素、木犀草素、山奈酚等与关键靶点结合,作用于血脂和动脉粥样硬化、糖尿病并发症中的衰老信号通路等,达到对脑卒中的有效治疗作用。结论:《古今录验》续命汤治疗中风表现出多元化、多样化的作用特点,通过网络药理学研究为基础理论研究及实践应用指明道路。

关键词：中风续命汤《古今录验》网络药理学作用机制

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Enhancing Site Style Tree Construction Algorithm

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Wuhan University Journal of Natural Sciences 2009年第2期14卷 129-133页

作者： ZHU Fuxi GONG changsheng YAO Haitao dong Wenyong School of Computer Wuhan University Wuhan 430072Hubei China

The World Wide Web has become a global information service center with a vast amount of news, advertisements, product and service information, and disparate information from diversi- fied sources. However, only a small portion of information is truly relevant and useful to the users who are seeking information on specific topics. In this paper, common relations among nodes are taken into consideration when constructing site style tree, and a new node type is introduced. Experimental results show that the proposed algorithm has higher precision and recall.

关键词： site style tree Web mining noise clean

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The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1984-1992页

作者： Lihui Li Wenjuan Zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang Yunjing Zhang Wenlian Chen changsheng dong Yanmei Zhang Mingsong Wang Wenyi Wei Lijun Jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Laboratory Medicine Huadong HospitalAffiliated to Fudan UniversityShanghaiChina Xinhua Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell ***,the regulatory mechanism of TNFAIP1 degradation remains largely *** the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)*** importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and ***,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in *** such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this ***,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of *** together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration.

关键词： TNFAIP1 CRL complex

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董昌盛运用芳香类中药治疗肺结节规律

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香料香精化妆品 2024年第2期 34-40页

作者：孙修桥伍睿昕楚晓符达马雨水张继亮韩睿钦董昌盛上海中医药大学附属龙华医院中医肿瘤研究所上海200032 上海中医药大学附属上海市中医医院治未病科上海200071 复旦大学附属上海市第五人民医院胸外科上海200240 上海交通大学医学院附属瑞金医院胰腺中心上海200025 北京同仁堂国药有限公司中国香港999077 中国医学科学院基础医学科学研究所重大疾病共性机制研究全国重点实验室北京100005 上海中医药大学附属龙华医院肿瘤科上海200032

通过运用R语言分析了2017年1月1日至2023年11月30日于上海中医药大学附属龙华医院董昌盛专家门诊收集、筛选到的治疗肺结节的中药处方,得到了处方583首,其中使用芳香类中药92味,使用频次前3的芳香类中药为当归、川芎、川牛膝;关联规则... 详细信息

通过运用R语言分析了2017年1月1日至2023年11月30日于上海中医药大学附属龙华医院董昌盛专家门诊收集、筛选到的治疗肺结节的中药处方,得到了处方583首,其中使用芳香类中药92味,使用频次前3的芳香类中药为当归、川芎、川牛膝;关联规则分析得到以柴胡、人参、肉桂为核心的芳香药物组合;聚类分析得到以枳术汤和四物汤为主的核心处方;相关性分析得出大枣-干姜、连翘-神曲等关联性药对。结果表明芳香类中药在肺结节的治疗中应用广泛,体现了董昌盛医师调元解毒、芳香化湿的治疗原则,为芳香类中药的运用拓展提供借鉴和参考。

关键词：董昌盛芳香类中药肺结节用药规律数据挖掘

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Identification of a novel microRNA function in alpaca skin

Identification of a novel microRNA function in alpaca skin

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中国畜牧兽医学会动物解剖学及组织胚胎学分会第十七次学术研讨会

作者： Ruiwen Fan Junming Bai Shanshan Yang changsheng dong College of Animal Science and Veterinary Medicine Shanxi Agricultural University

From the deep sequencing of alpaca skins with white and black coat color,we obtained 15 and 18 potentially novel miRNAs from the WA and BA skin libraries,*** those,a novel miRNA expressed differently in white and black alpaca skin(named miRNA-066).According to the target gene prediction,one of the target genes is melanophilin(MLPH),which plays important role in genesis in *** get the function of miRNA-066 in alpaca skin,miRNA was over expressed in melanocyte in *** expression level of miRNA-066 was tested by qRT-PCR and results showed it expressed *** expression level of MLPH,TYR,TYRPl,TRY and KIT protein were tested by western blotting,and the results showed that TYR,TYRPl and KIT protein were *** those results suggested that miRNA-066 might regulate melanogenesis.

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NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第11期22卷 959-965页

作者： Lisha ZHOU changsheng dong Zhuoming XU Xinran WANG Luyi ZHANG Siyuan CHEN Jiahao CHEN Yingying ZHU Department of Basic Medicine Medical CollegeTaizhou UniversityTaizhou 318000China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Lung cancer,which is exacerbated by environmental pollution and tobacco use,has become the most common cause of cancer-related deaths worldwide,with a five-year overall survival rate of only 19%(Siegel et al.,2020;Yang et al.,2020;Yu and Li,2020).Nearly 85%of lung cancers are non-small cell lung cancers,of which lung adenocarcinoma is the most common subtype accounting for 50%of non-small cell lung cancer *** present,radiotherapy is the primary therapeutic modality for lung cancer at different stages,with significant prolongation of survival time(Hirsch et al.,2017;Bai et al.,2019;Shi et al.,2020).

关键词： al. lung resistance

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