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Chinese Science Bulletin 2002年第20期47卷 1711-1713页

作者： GU Qincui wu changcheng CHEN Shouxi HUANG Yong State Key Laboratory of Polymer Physics and Chemistry Center for Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080China Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of ChemistryChinese Academy of SciencesGuangzhou 510650China

Two decoration techniques, solidification-induced band texture decoration and focal-conic texture decoration, have been established to exhibit the director field of disclinations in a low-molar-mass methacrylate liquid crystal. The disclinations with strength s=1/2 and s=±1 are observed by the two decoration methods. For the solidification-induced band texture decoration, the molecular orientation is perpendicular to the direction of the band. While for focal-conic texture decoration, it has been proved by the results of IR dichroism that the direction of the director is parallel to the direction of the focal-conic. Therefore, the sketch map of the molecular director filed can be mapped according to the morphological pattern of the solidification-induced band texture or focal-conic texture.

关键词： decoration disclination solidification-induced band texture focal-conic texture liquid crystal.

Perspective on the application of genome sequencing for monkeypox virus surveillance

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Virologica Sinica 2023年第2期38卷 327-333页

作者： Yuda Chen changcheng wu Ruhan A Li Zhao Zhongxian Zhang Wenjie Tan School of Public Health Baotou Medical CollegeBaotou014040China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China

Monkeypox virus(MPXV),a DNA virus belonging to the Orthopoxvirus genus,causes a self-limiting zoonotic disease known as *** human monkeypox infection was first recorded in a 9-month-old child in the Republic of Congo in the 1970s(Ladnyj et al.,1972).For a long time,mpox was mainly prevalent in the humid forests of Central Africa and parts of West Africa(Kabugae and El Zowalaty,2019).In recent years,MPXV has been spread to other countries through trade and *** 2003,a group of rare pets carrying MPXV was exported from Africa to the United States,and an outbreak of animal-to-human transmission occurred(Di Giulio and Eckburg,2004).In 2018,two cases of mpox were confirmed in travelers from Nigeria to the United Kingdom and one case was confirmed in Israel(Vaughan et al.,2018;Erez et al.,2019).Then,in 2019,one case was confirmed in Singapore(Ng et al.,2019).The outbreak of mpox in multiple non-endemic countries in North America and Europe started in May 2022(WHO,2022b).On July 23,2022,the WHO declared MPXV a Public Health Emergency of International Concern(PHEIC)(WHO,2022a).As of March 5,2023,86,309 confirmed mpox cases have been reported from 107 countries/regions worldwide(WHO,2023).In the mainland of China,the first imported case was confirmed by the Chinese Center for Disease Control and Prevention(Zhao et al.,2022),making this the fifth confirmed mpox infection in *** zoonotic mpox has been restricted in Africa but now it is back in the spotlight worldwide(Tan and Gao,2022).

关键词： fir mainland Israel

A review of occluded objects detection in real complex scenarios for autonomous driving

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Green Energy and Intelligent Transportation 2023年第3期2卷 65-77页

作者： Jiageng Ruan Hanghang Cui Yuhan Huang Tongyang Li changcheng wu Kaixuan Zhang Department of Materials and Manufacturing Beijing University of TechnologyBeijingChina Centre for Green Technology School of Civil and Environmental EngineeringUniversity of Technology SydneyNSW2007Australia

Autonomous driving is a promising way to future safe,efficient,and low-carbon ***-time ac-curate target detection is an essential precondition for the generation of proper following decision and control ***,considering the complex practical scenarios,accurate recognition of occluded targets is a major challenge of target detection for autonomous driving with limited computational *** reveal the overlap and difference between various occluded object detection by sharing the same available sensors,this paper presents a review of detection methods for occluded objects in complex real-driving *** the rapid development of autonomous driving technologies,the research analyzed in this study is limited to the recent five *** study of occluded object detection is divided into three parts,namely occluded vehicles,pedes-trians and traffic *** paper provided a detailed summary of the target detection methods used in these three parts according to the differences in detection methods and ideas,which is followed by the comparison of advantages and disadvantages of different detection methods for the same ***,the shortcomings and limitations of the existing detection methods are summarized,and the challenges and future development prospects in this field are discussed.

关键词： Autonomous driving Occluded objects Object detection Vehicles Pedestrians Traffic signs

Rational design of Co nano-dots embedded three-dimensional graphene gel as multifunctional sulfur cathode for fast sulfur conversion kinetics

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Journal of Energy Chemistry 2021年第5期30卷 132-140页

作者： Tongtao Wan Shuming Liu changcheng wu Zhaoyang Tan Shuanglong Lin Xiaojie Zhang Zisheng Zhang Guihua Liu Hebei Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving Tianjin Key Laboratory of Chemical Process SafetySchool of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China College of Chemical Technology Shijiazhuang UniversityShijiazhuang 050035HebeiChina Department of Chemical and Biological Engineering University of OttawaOttawa KIN 6N5ONCanada

Lithium-sulfur(Li-S)batteries hold great promises to serve as next-generation energy storage devices because of their high theoretical energy density and environmental ***,the shuttle effect of the soluble lithium polysulfides(LiPS)and intrinsic insulating nature of sulfur lead to low sulfur utilization and coulombic efficiency,leading to poor cycling *** impeded charge transportation and retard LiPS catalytic conversion also endows the Li-S batteries with sluggish redox reaction,leading to unsatisfied rate *** this study,Co-based MOF material ZIF-67 is used as the precursor to prepare Co nano-dots decorated three-dimensional graphene aerogel as sulfur *** porous architecture establishes a highly conductive interconnected framework for fast charge/mass *** exposed Co nano-dots serve as active sites to strongly trap LiPS,which endows CoNDs@G with low decomposition energy barrier for fast LiPS conversion reaction and promote the completely Li2 S catalytic ***-S cells based on the Co-NDs@G cathode exhibits excellent cyclability and a high capacity retention rate of 91.1%in 100 *** strategy offers a new direction to design sulfur immobilizer for accelerated LiPS conversion kinetics of Li-S batteries.

关键词： Lithium-sulfur batteries Co nano-dots Graphene network Metal-organic framework High-loading cathodes

Synthesis of magnetic Pb/Fe_(3)O_(4)/SiO_(2) and its catalytic activity for propylene carbonate synthesis via urea and 1,2-propylene glycol

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Frontiers of Chemical Science and Engineering 2009年第2期3卷 215-218页

作者： Hualiang AN Xinqiang ZHAO Zhiguang JIA changcheng wu Yanji WANG Hebei Provincial Key Lab of Green Chemical Technology and High Efficient Energy Saving Hebei University of TechnologyTianjin 300130China

To facilitate the recovery of Pb/SiO_(2) catalyst,magnetic Pb/Fe_(3)O_(4)/SiO_(2) samples were prepared separately by emulsification,sol-gel and incipient impregnation *** catalyst samples were characterized by means of X-ray diffraction and N_(2) adsorption-desorption,and their catalytic activity was investigated in the reaction for synthesizing propylene carbonate from urea and 1,2-propylene *** the gelatin was applied in the preparation of Fe_(3)O_(4) at 60℃ and the pH value was controlled at 4 in the preparation of Fe_(3)O_(4)/SiO_(2),the Pb/Fe_(3)O_(4)/SiO_(2) sample shows good catalytic activity and *** the reaction conditions of a reaction temperature of 180℃,reaction time of 2h,catalyst percentage of 1.7 wt-% and a molar ratio of urea to PG of 1∶4,the yield of propylene carbonate attained was 87.7%.

关键词： Pb/Fe_(3)O_(4)/SiO_(2)magnetic particle urea 1 2-propylene glycol propylene carbonate

Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 89-97页

作者： Ke-Jia Shan changcheng wu Xiaolu Tang Roujian Lu Yaling Hu Wenjie Tan Jian Lu State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Sinovac Biotech Ltd. Beijing 100085China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100052China

The monkeypox virus(mpox virus,MPXV)epidemic in 2022 has posed a significant public health ***,the evolutionary principles of MPXV remain largely ***,we examined the evolutionary patterns of protein sequences and codon usage in *** first demonstrated the signal of positive selection in OPG027,specifically in the CladeⅠlineage of ***,we discovered accelerated protein sequence evolution over time in the variants responsible for the 2022 ***,we showed strong epistasis between amino acid substitutions located in different *** codon adaptation index(CAI)analysis revealed that MPXV genes tended to use more non-preferred codons compared to human genes,and the CAI decreased over time and diverged between clades,with CladeⅠ>Ⅱa andⅡb-A>Ⅱ*** the decrease in fatality rate among the three groups aligned with the CAI pattern,it remains unclear whether this correlation was coincidental or if the deoptimization of codon usage in MPXV led to a reduction in fatality *** study sheds new light on the mechanisms that govern the evolution of MPXV in human populations.

关键词： Mpox virus Positive selection OPG027 Accelerated evolution Codon usage bias

On the origin and continuing evolution of SARS-CoV-2

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National Science Review 2020年第6期7卷 1012-1023页

作者： Xiaolu Tang changcheng wu Xiang Li Yuhe Song Xinmin Yao Xinkai wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu State Key Laboratory of Protein and Plant Gene Research Center for Bioinformatics School of Life Sciences Peking University CAS Key Laboratory of Molecular Virology & Immunology Institut Pasteur of Shanghai Chinese Academy of Sciences Center for Biosafety Mega-Science Chinese Academy of Sciences University of Chinese Academy of Sciences School of Life Sciences Shanghai University NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College

The SARS-Co V-2 epidemic started in late December 2019 in wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains *** findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19).

关键词： SARS-CoV-2 virus molecular evolution population genetics

The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2

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Science China(Life Sciences) 2020年第10期63卷 1608-1611页

作者： Tao Li Xiaolu Tang changcheng wu Xinmin Yao Yirong Wang Xuemei Lu Jian Lu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyCenter for Excellence in Animal Evolution and GeneticsChinese Academy of SciencesKunming 650223China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China

Dear Editor,The coronavirus disease 2019(COVID-19)caused by the SARS-CoV-2 coronavirus has become a global *** SARS-CoV-2 genome has a similarity of 96.2%to that of RaTG13,a bat SARS-CoV-2-related coronavirus detected in Rhinolophus affinis(Paraskevis et al.,2020;Zhou et al.,2020).The SARS-CoV-2 genome also has 85.5%−92.4%sequence similarity to SARS-CoV-2-related coronaviruses from Malayan pangolins that have been seized in anti-smuggling operations in southern China(Guangdong-Pangolin(GD-Pangolin-CoV)and Guangxi-Pangolin(GX-Pangolin-CoV)genomes)(Liu et al.,2019;Lam et al.,2020).

关键词： al. similarity operations

Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

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Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui Xing Chunhua Wang Mengjun Tang changcheng wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

Facile cyclic ammonium salt with the smallest size for high performance electric double layer capacitors

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Chinese Chemical Letters 2019年第6期30卷 1269-1272页

作者： Chao Wang Jing Wang Xiang Xiao Guobin Zhong Shijia wu Kaiqi Xu Wei Zhao Wei Su Jie Zeng Baojun wu Weili Zhang changcheng wu Zhiqiang Shi Electric Power Research Institute of Guangdong Power Grid Co. Ltd. Guangzhou 510080 China Tianjin Key Laboratory of Advanced Fibers and Energy Storage College of Materials Science and Engineering Tianjin Polytechnic University Tianjin 300387 China

The smallest cyclic ammonium salt reported to date, N,N-dimethylpyrrolidinium tetrafluoroborate (P11-BF4), was successively synthesized using a synthesis route without metal ions and halogen ions, then investigated as the electrolyte with Propylene carbonate in EDLCs. The electrochemical characteristics of EDLCs assembled by 1 mol/L P11-BF4/PC paired with activated carbon electrodes were compared to traditional electrolytes. P11-BF4 has proven to have superior voltage resistance by using cyclic voltammetry and constant current charge-discharge testing. Moreover, P11-BF4 exhibits a more brilliant rate performance due to its high conductivity. These results demonstrate that P11-BF4 is an ideal electrolyte to improve the energy density and power density of supercapacitors.

关键词： N N-Dimethylpyrrolidinium tetrafluoroborate Cyclic ammonium salt Electrical conductivity Supercapacitor Rate performance