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基于Amesim的往复杆输送系统建模与研究

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中国重型装备 2024年第3期 42-46,62页

作者：叶文军陶长城湖北汽车工业学院材料科学与工程学院湖北十堰442000

往复杆输送系统是汽车车身焊装生产线的主要输送系统形式之一。由于其升降运动一般采用电机和气缸共同驱动,力学模型相对复杂,常规方法难以建模和计算。目前设计人员主要按照工程经验及以往实例进行驱动装置选型和结构设计。本文基于Ame... 详细信息

往复杆输送系统是汽车车身焊装生产线的主要输送系统形式之一。由于其升降运动一般采用电机和气缸共同驱动,力学模型相对复杂,常规方法难以建模和计算。目前设计人员主要按照工程经验及以往实例进行驱动装置选型和结构设计。本文基于Amesim软件搭建了该系统模型,研究电机-气缸联合驱动方式下电机及气缸的计算选型、结构设计的新方法。结果表明,通过所搭建的模型能够准确计算双驱动方式下合理的气缸缸径、电机功率、扭矩等参数。与传统方法相比,应用该模型计算选型后的电机功率显著减小,在节省了生产线运行能耗的同时,结构尺寸也可进一步减小。

关键词：往复杆输送系统 Amesim 选型设计联合驱动强度分析

某SWC-BH型十字轴式万向联轴器强度与模态分析

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中国重型装备 2024年第1期 38-41页

作者：叶文军陶长城湖北汽车工业学院材料科学与工程学院湖北十堰442000 圣基恒信(十堰)工业装备技术有限公司湖北十堰442000

为了解某公司在白车身焊装生产线往复杆输送系统中所采用的SWC-BH型十字轴式万向联轴器能否在实际运行中满足使用要求,采用CATIA软件对十字轴式万向联轴器进行三维建模,利用有限元软件Abaqus/CAE中模态分析模块及静力学分析模块,按照其... 详细信息

为了解某公司在白车身焊装生产线往复杆输送系统中所采用的SWC-BH型十字轴式万向联轴器能否在实际运行中满足使用要求,采用CATIA软件对十字轴式万向联轴器进行三维建模,利用有限元软件Abaqus/CAE中模态分析模块及静力学分析模块,按照其实际使用工况,对十字轴式万向联轴器水平运输阶段进行结构强度分析与模态分析。结果表明,在水平运输阶段出现强制停机而导致十字轴式万向联轴器发生扭转急停现象时,联轴器上最大等效应力值达到了510.8 MPa,位于输出端十字轴承轴肩处,所有部件的最大等效应力值范围在159.3~510.8 MPa,除两端的十字轴承外,其余部件均没有超过其材料的许用应力;两端十字轴承轴肩处的应力已超过其材料的许用应力,会发生断裂,提出了一些失效原因及改进措施。在模态分析中,从联轴器的振型位移图可以发现,振动位移量最大值为7.374 mm,但该联轴器实际转动频率为11.6 Hz,小于第一阶固有频率13.826 Hz,可以有效避免共振,为十字轴式万向联轴器选型、设计及汽车主机厂实际操作提供了一定的帮助与借鉴。

关键词： SWC-BH型联轴器焊装生产线强度分析模态分析

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术前放疗降低中央型肝细胞癌患者肝切除术后复发风险的临床研究

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肿瘤研究与临床 2024年第2期36卷 81-87页

作者：陶常诚荣维淇吴凡王黎明吴健雄国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院肝胆外科北京100021

目的探讨术前放疗对肝切除术治疗的中央型肝细胞癌患者术后复发的影响。方法回顾性队列研究。回顾性收集2016年1月至2019年1月中国医学科学院北京协和医学院肿瘤医院接受手术治疗的142例中央型肝细胞癌患者临床病理资料。根据术前是否... 详细信息

目的探讨术前放疗对肝切除术治疗的中央型肝细胞癌患者术后复发的影响。方法回顾性队列研究。回顾性收集2016年1月至2019年1月中国医学科学院北京协和医学院肿瘤医院接受手术治疗的142例中央型肝细胞癌患者临床病理资料。根据术前是否接受放疗,将患者分为术前放疗组(30例)和单纯手术组(112例)。主要观察指标为无复发生存(RFS)及术中出血量、手术时间和术后并发症发生情况。采用Kaplan-Meier法进行生存分析,组间比较采用log-rank检验;通过标准化均数差(SMD)评价各因素两组间是否存在差异;采用Cox比例风险模型分析行肝切除术的中央型肝细胞癌患者RFS的影响因素;采用倾向得分匹配(PSM)、回归模型调整倾向得分(CAPS)以及逆概率加权(IPTW)方法研究暴露因素及混杂变量与RFS的关系;敏感性分析采用E值评估未测量混杂因素对结果的潜在影响。结果术前放疗组和单纯手术组中男性分别占96.7%(29/30)、87.5%(98/112),年龄分别为(55±10)岁和(54±12)岁。PSM法匹配前,两组间性别、丙型肝炎患者比例、丙氨酸氨基转移酶、血清清蛋白、甲胎蛋白、术后病理卫星结节、肿瘤数量均存在差异(均SMD>0.1)。共26对患者匹配成功,术前放疗组和单纯手术组匹配后基线特征均无差异(均SMD180 min患者比例分别为92.3%(24/26)和84.6%(22/26)(χ^(2)=0.75,P=0.385),术后轻度并发症发生率分别为100.0%(26/26)和92.3%(24/26)(χ^(2)=2.08,P=0.149),差异均无统计学意义。结论中央型肝细胞癌患者肝切除术前放疗安全、有效,具有减少术后复发的优势。

关键词：癌,肝细胞肝切除术放射疗法复发

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汽车焊装夹具智能设计研究

电焊机 2024年第1期54卷 55-61页

作者：袁吟啸陶长城徐华湖北汽车工业学院材料科学与工程学院湖北十堰442002

焊装夹具是汽车白车身焊装生产线的主体构成部分,其功能是对车身零件进行定位和夹紧,保证车身焊接的尺寸精度。传统的夹具设计方式需要大量的人力,设计周期较长。提出一种智能化焊装夹具设计思路,将耗时耗力的夹具结构设计过程自动化。... 详细信息

焊装夹具是汽车白车身焊装生产线的主体构成部分,其功能是对车身零件进行定位和夹紧,保证车身焊接的尺寸精度。传统的夹具设计方式需要大量的人力,设计周期较长。提出一种智能化焊装夹具设计思路,将耗时耗力的夹具结构设计过程自动化。以CATIA为平台,对焊装夹具的零件进行特征提取,把零件特征作为参数化设计中的主控参数,建立夹具零件的设计表。结合面向对象的知识表达方式,对夹具特征进行知识表达。使用python语言开发初步的自动设计程序,该程序在读取规范化后的夹具定位点信息(MCP)文件后,即可自动对焊装夹具进行结构设计。

关键词：焊装夹具参数化设计特征面向对象

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Novel Static Security and Stability Control of Power Systems Based on Artificial Emotional Lazy Q-Learning

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Energy Engineering 2024年第6期121卷 1713-1737页

作者： tao Bao Xiyuan Ma Zhuohuan Li Duotong Yang Pengyu Wang changcheng Zhou Digital Grid Research Institute Southern Power GridGuangzhou510000China

The stability problem of power grids has become increasingly serious in recent years as the size of novel power systems *** order to improve and ensure the stable operation of the novel power system,this study proposes an artificial emotional lazy Q-learning method,which combines artificial emotion,lazy learning,and reinforcement learning for static security and stability analysis of power ***,this study compares the analysis results of the proposed method with those of the small disturbance method for a stand-alone power system and verifies that the proposed lazy Q-learning method is able to effectively screen useful data for learning,and improve the static security stability of the new type of power system more effectively than the traditional proportional-integral-differential control and Q-learning methods.

关键词： Artificial sentiment static secure stable analysis Q-learning lazy learning data filtering

Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence

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Chinese Journal of Cancer Research 2020年第5期32卷 645-653页

作者： Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An changcheng tao Weihu Wang Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095USA Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing 102206China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Peritoneal Cancer Surgery Beijing Shijitan HospitalCapital Medical University BeijingBeijing 100038China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant ***:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control ***'outcome,adverse events,long-term recurrence and survival rates were ***:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin ***-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC.

关键词： Three-dimensional conformal radiotherapy recurrence long-term survival narrow-margin hepatectomy real-world evidence

Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a double-blind randomized controlled trial

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 834-847页

作者： Weiqi Rong Hui Xia Kai Zhang Yihan Zhang changcheng tao Fan Wu Liming Wang Hong Zhang Guiju Sun Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)BeijingChina Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjingChina Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjinChina

Background:Liver cancer as the main leading cancer has caused heavy burdens *** prognosis of liver cancer is closely related with postoperative nutrition *** oligopeptides(COPs)are protein hydrolysates produced by enzymatic treatments,which have shown potential bioactivities,such as inhibiting angiotensin I-converting enzyme,resisting lipid peroxidation and ***,the correlation between COPs and liver cancer patients is still unknown and the potential mechanism of COPs on liver cancer is unclear as *** aim of this study was to assess effects of 7-day intervention of COPs after surgery on liver function and serum metabolic profiles of liver cancer ***:Patients were assigned into COPs intervention group(n=50)and control group(n=91)for 7 *** were scheduled at 1st day and 7th day after liver resection surgery respectively,mainly including anthropometric,biochemical indexes and liquid chromatography-mass spectrometry(LC/MS)***:Seven-day supplementation of COPs on early post-surgery liver cancer patients down-regulated levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin and up-regulated prothrombin time activity and prealbumin ***/MS analysis revealed metabolic signatures including regulation of 16 metabolites,which was closely related with two metabolic pathways(nicotinate and nicotinamide metabolism,fatty acid metabolism).Conclusions:COPs supplementation has displayed the potentials on alleviating the injury of liver function and it may be due to regulation of fatty acid metabolism,nicotinate and nicotinamide metabolism,lipid peroxidation and anti-inflammatory *** researches are warranted in future to confirm the exact mechanisms.

关键词： Liver cancer corn oligopeptides supplementation metabolomics randomized controlled trial

The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 515-529,I0004页

作者： Liming Wang Yunhe Liu Weiqi Rong Fan Wu Weibo Yu Kan Liu Shengtao Lin Yiling Zheng Kai Zhang Tana Siqin changcheng tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Head and Neck Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCAUSA Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Surgical Oncology Fujian Provincial Hospital/Shengli Clinical Medical College of Fujian Medical UniversityFuzhouChina Laboratory of Cell and Molecular Biology&State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;***/ictrp.

关键词： Hepatocellular carcinoma(HCC) intraoperative electron radiotherapy(IOERT) microvascular invasion(MVI) relapse survival overall survival(OS)

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肝淋巴上皮瘤样癌的研究进展

中华肿瘤杂志 2020年第12期42卷 996-1000页

作者：陶常诚张凯荣维淇吴健雄国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肝胆外科100021

肝淋巴上皮瘤样癌(LELC)是一种罕见的肝癌亚型,具有独特的流行病学、病理学特征,特点是大量的淋巴细胞浸润,可分为淋巴上皮瘤样肝细胞癌(LEL-HCC)和淋巴上皮瘤样肝内胆管细胞癌(LEL-CC),其诊断主要依靠病理学方法,治疗以手术为主。肝LEL... 详细信息

肝淋巴上皮瘤样癌(LELC)是一种罕见的肝癌亚型,具有独特的流行病学、病理学特征,特点是大量的淋巴细胞浸润,可分为淋巴上皮瘤样肝细胞癌(LEL-HCC)和淋巴上皮瘤样肝内胆管细胞癌(LEL-CC),其诊断主要依靠病理学方法,治疗以手术为主。肝LELC预后良好,可能与大量淋巴细胞浸润有关。关于LELC的资料非常有限,仅有少量的病例报道和小型回顾性研究,还需要进一步深入研究。截至目前,已有67例LEL-HCC和34例LEL-CC在文献中报道。文章总结了肝LELC的流行病学、临床治疗、病理学特点以及研究前景。

关键词：肝肿瘤淋巴上皮瘤样癌研究进展