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Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

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World Journal of Gastroenterology 2022年第30期28卷 4152-4162页

作者： Hyo Seon Ryu chang Sik Yu Young Il Kim Jong Lyul lee Chan wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The emergence of restorative total proctocolectomy has significantly reduced the lifetime colorectal cancer risk associated with familial adenomatous polyposis(FAP).However,adenomas may develop in the ileal pouch over time and may even progress to *** evaluated the cumulative incidence,time to development,and risk factors associated with ileal pouch *** To evaluate the cumulative incidence,time to development,and risk factors associated with pouch *** In this retrospective,observational study conducted at a tertiary center,95 patients with FAP who underwent restorative proctocolectomy at our center between 1989 and 2018 were consecutively *** mean follow-up period was 88 *** Pouch adenomas were found in 24(25.3%)patients,with a median time of 52 mo to their first *** adenomas were detected in most patients(95.9%).There were no high-grade dysplasia or *** the 24 patients with pouch adenomas,13 had all detected adenomas *** the 13 patients who underwent complete adenoma removal,four(38.5%)developed *** 11(45.8%)patients with numerous polyps within the pouch,seven(63.6%)exhibited progression of pouch *** cumulative risks of pouch adenoma development at 5,10,and 15 years after pouch surgery were 15.2%,29.6%,and 44.1%,*** colorectal polyposis(with more than 1000 polyps)was a significant risk factor for pouch adenoma development(hazard ratio,2.49;95% confidence interval:1.04-5.96;P=0.041).CONCLUSION Pouch adenomas occur at a fairly high rate in association with FAP after restorative proctocolectomy,and a high colorectal polyp count is associated with pouch adenoma development.

关键词： Adenomatous polyposis coli Familial adenomatous polyposis Adenoma Intestinal polyps Proctocolectomy,restorative Ileal pouch anal anastomosis

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A new strengthening mechanism driven by disruptive shear and solute segregation during warm rolling in 1.4 GPa class 12.5 wt% Al added-FeMnC ultra-lightweight steel

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Journal of Materials Science & Technology 2023年第26期157卷 174-188页

作者： Chiwon Kim Hyun-Uk Hong Joonoh Moon Bong Ho lee Seong-Jun Park chang-Hoon lee Department of Materials Convergence and System Engineering Changwon National University 20 Changwondaehak-roChangwonGyeongnam 51140Republic of Korea Advanced Analysis Team Daegu Gyeongbuk Institute of Science and Technology 333 Technojungang-daeroDaegu42988Republic of Korea Ferrous Alloy Department Korea Institute of Materials Science 797 ChangwondaeroChangwonGyeongnam 51508Republic of Korea

Novel strengthening of Fe-29.1Mn-12.5Al-1.35C-4.95Cr steel achieved by warm rolling was *** solution-treated steel consisted of aγ-matrix containing nano-sizedκ-carbide((Fe,Mn)_(3) AlC)and elongated prior ferrite,which was transformed into FeAl-type B2 and Fe_(3) Al-type D0_(3) *** solution-treated steel exhibited poor strain hardening owing to glide softening associated withκ-carbide shearing by ***,after warm rolling with a reduction ratio of 30%at 300℃,the yield and tensile strengths significantly increased from 917 to 1300 MPa and 1025 to 1419 MPa,*** tensile test conducted at 300℃to simulate warm rolling exhibited serrated flows,indicating dy-namic strain aging(DSA).Atom probe tomography exhibited that the C atoms inκ-carbide were swept away along the slip direction by disruptive shear during rolling at 300℃.The swept C atoms along the slip direction interacted strongly with dislocations at 300℃,with repeated pinning and breakaway of dislocations from the C *** contributed to significant strengthening owing to the formation of a solute-rich atmosphere after warm *** results of the tensile tests at 300℃indicated that the de-gree of strengthening was proportional to the pre-strain *** strength of 1.4 GPa can be achieved with good ductility(17%elongation)by warm *** novel warm-rolling strengthening method ex-pedites the potential application of Fe-29.1Mn-12.5Al-1.35C-4.95Cr as a 1.4 GPa class ultra-lightweight steel.

关键词： FeMnAlC Cr addition κ-carbide Dynamic strain aging Strengthening

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Utilizing hybrid faradaic mechanism via catalytic and surface interactions for high-performance flexible energy storage system

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能源化学:英文版 2023年第8期83卷 541-548,I0013页

作者： Dong-Gyu lee Hyeonggeun Choi Yeonsu Park Min-Cheol Kim Jong Bae Park Suok lee Younghyun Cho wook Ahn A-Rang Jang Jung Inn Sohn John Hong Young-Woo lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Division of Physics and Semiconductor Science Dongguk University-SeoulSeoul 04620Republic of Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Republic of Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Improving the capacitance and energy density is a significant challenge while developing practical and flexible energy storage system(ESS).Redox mediators(RMs),as redox-active electrolyte additives,can provide additional energy storing capability via electrochemical faradaic contribution on electrodes for high-performance flexible ***,determining effective material combinations between electrodes and RMs is essential for maximizing surface faradaic redox reactions for energy-storage *** this study,an electrode-RM system comprising heterostructured hybrid(carbon fiber(CF)/MnO_(2)) faradaic electrodes and iodine RMs(I-RMs) in a redox-active electrolyte is *** CF/MnO_(2)with the 1-RMs(CF/MnO_(2)-I) induces dominant catalytic faradaic interaction with the I-RMs,significantly enhancing the surface faradaic kinetics and increasing the overall energy-storage *** CF/MnO_(2)-I ESSs show a 12.6-fold(or higher) increased volumetric energy density of 793.81 mWh L^(-1)at a current of 10 μA relative to ESSs using CF/MnO_(2)without I-RMs(CF/MnO_(2)).Moreover,the CF/MnO_(2)-I retains 93.1% of its initial capacitance after 10,000 cycles,validating the excellent ***,the flexibility of the ESSs is tested at different bending angles(180° to 0°),demonstrating its feasibility for flexible and high-wear ***,CF/MnO_(2)electrodes present a practical material combination for high-performance flexible energy-storage devices owing to the catalytic faradaic interaction with I-RMs.

关键词： Energy storage system Redox mediators Faradaic electrodes Catalytic interactions Mechanical stability

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CNN Accelerator Using Proposed Diagonal Cyclic Array for Minimizing Memory Accesses

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Computers, Materials & Continua 2023年第8期76卷 1665-1687页

作者： Hyun-wook Son Ali AAl-Hamid Yong-Seok Na Dong-Yeong lee Hyung-Won Kim Department of Electronics College of Electrical and Computer EngineeringChungbuk National UniversityCheongju28644Korea Department of Electrical Engineering College of EngineeringAl-Azhar UniversityCairo11651Egypt

This paper presents the architecture of a Convolution Neural Network(CNN)accelerator based on a newprocessing element(PE)array called a diagonal cyclic array(DCA).As demonstrated,it can significantly reduce the burden of repeated memory accesses for feature data and weight parameters of the CNN models,which maximizes the data reuse rate and improve the computation ***,an integrated computation architecture has been implemented for the activation function,max-pooling,and activation function after convolution calculation,reducing the hardware *** evaluate the effectiveness of the proposed architecture,a CNN accelerator has been implemented for You Only Look Once version 2(YOLOv2)-Tiny consisting of 9 ***,the methodology to optimize the local buffer size with little sacrifice of inference speed is presented in this *** implemented the proposed CNN accelerator using a Xilinx Zynq ZCU102 Ultrascale+Field Programmable Gate Array(FPGA)and ISE Design *** FPGA implementation uses 34,336 Look Up Tables(LUTs),576 Digital Signal Processing(DSP)blocks,and an on-chip memory of only 58 KB,and it could achieve accuracies of 57.92% and 56.42% mean Average Precession@0.5 thresholds for intersection over union(mAP@0.5)using quantized 16-bit and 8-bit full integer data manipulation with only 0.68% as a loss for 8-bit version and computation time of 137.9 and 69 ms for each input image respectively using a clock speed of 200 *** speeds are expected to be doubled five times using a clock speed of 1GHz if implemented in a silicon System on Chip(SoC)using a sub-micron process.

关键词： CNN accelerator systolic array memory optimization YOLOv2-tiny mAP@0.5

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Flash‑Induced High‑Throughput Porous Graphene via Synergistic Photo‑Effects for Electromagnetic Interference Shielding

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纳微快报:英文版 2023年第11期15卷 1-18页

作者： Jin Soo lee Jeong‑wook Kim Jae Hee lee Yong Koo Son Young Bin Kim Kyoohee Woo Chanhee lee Il‑Doo Kim Jae Young Seok Jong Won Yu Jung Hwan Park Keon Jae lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea Department of Printed Electronics Nano‑Convergence Manufacturing Systems Research DivisionKorea Institute of Machinery and Materials(KIMM)156 Gajeongbuk‑RoYuseong‑GuDaejeon 34103Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology232 Gongneung‑roNowon‑guSeoul 01811Republic of Korea Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61 Daehak‑roGumiGyeongbuk 39177Republic of Korea

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference(EMI)shielding materials in future mobility and wearable applications to prevent signal noise,transmission inaccuracy,system malfunction,and health ***,we report on the synthesis of lightweight and flexible flash-induced porous graphene(FPG)with excellent EMI shielding *** broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films,forming 5×10 cm^(2)-size porous graphene with a hollow pillar structure in a few *** resulting material demonstrated low density(0.0354 g cm^(−3))and outstanding absolute EMI shielding effectiveness of 1.12×10^(5) dB cm^(2) g^(−1).The FPG was characterized via thorough material analyses,and its mechanical durability and flexibility were confirmed by a bending cycle ***,the FPG was utilized in drone and wearable applications,showing effective EMI shielding performance for internal/external EMI in a drone radar system and reducing the specific absorption rate in the human body.

关键词： Porous graphene Flash lamp Photo-pyrolysis High-throughput Electromagnetic interference shielding

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Ethical and legal implications of gene editing in plant breeding:a systematic literature review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期24卷 1093-1105页

作者： Siti Hafsyah IDRIS Nurzatil Sharleeza MAT JALALUDDIN lee Wei chang Faculty of Law Universiti Teknologi MARAJalan Sarjana 1/2Shah Alam 40450SelangorMalaysia Centre for Research in Biotechnology for Agriculture(CEBAR) Level 3Research Management and Innovation ComplexUniversiti MalayaKualaLumpur50603Malaysia Centre for Civilisational Dialogue Level 1High Impact Research BuildingUniversiti MalayaKuala Lumpur 50603Malaysia

Biotechnology policies and regulations must be revised and updated to reflect the most recent advances in plantbreeding technology. New Plant Breeding Techniques(NPBT) such as gene editing have been applied to address the myriad of challenges in plant breeding, while the use of NPBT as emerging biotechnological tools raises legal and ethical concerns. This study aims to highlight how gene editing is operationalized in the existing literature and examine the critical issues of ethical and legal issues of gene editing for plant breeding. We carried out a systematic literature review(SLR) to provide the current states of ethical and legal discourses surrounding this topic. We also identified critical research priority areas and policy gaps that must be addressed when designing the future governance of gene editing in plant breeding.

关键词： Systematic literature review Gene editing Plant breeding Ethical and legal issues Consequentialism Virtue ethics principles

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Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung Kim Ki wook Kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho lee Hyeon Jeong Oh Hye Seung lee Young Suk Park Sang-Hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho Kim Ji-Won Kim Jin Won Kim Keun-wook lee Won chang Ji HoonPark Yoon Jin lee Kyoung Ho lee Young Hoon Kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P < 0.001).Cancer of the gastric body(P < 0.001) and diffuse-type histology(P < 0.001) were more common in females than in *** trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival

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Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae Hoon lee Seo Young Park Yejong Park Woohyung lee Ki Byung Song Dae wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

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Biomass seaweed-derived n itrogen self-doped porous carb on anodes for sodium-ion batteries:Insights into the structure and electrochemical activity

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Journal of Energy Chemistry 2022年第1期31卷 286-295,I0008页

作者： Chenrayan Senthil Jae Woo Park Nitheesha Shaji Gyu Sang Sim chang Woo lee Department of Chemical Engineering(Integrated Engineering)&Center for the SMART Energy Platform College of EngineeringKyung Hee University1732 Deogyeong-daeroCihuengYonginGyeonggi 17104South Korea

Sustainable transformation and efficient utilization of biomasses and their derived materials are environ-mentally as well as economically compliant *** seaweed-derived nitrogen self-doped porous carbon with tailored surface area and pore structures are prepared through carb on izatio n and *** in fluence of carb on ization temperature on morphology,surface area,and heteroatom dopants are investigated to optimize sodium-ion storage ***-derived nitrogen selfdoped activated carbon(SAC)as anode materials for sodium-ion batteries exhibits remarkable reversible capacity of 303/192 mAh g^(-1) after 100/500 cycles at current densities of 100/200 mA g^(-1) respectively,and a good rate *** interconnected and porous conducting nature along with the heteroatom dopant role in creating defective sites and charge stabilization are favorable for ion storage and diffusion and electron transport,indicating the electrodes can offer improved electrochemical *** addition,post-mortem analysis of the cycled carbon electrodes through ex-situ tools demonstrates the sodium-ion storage mechanism.

关键词： Biomass Heteroatom self-doping Porous carbon Anode Sodium-ion batteries Post-mortem ex-situ analysis

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Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon:A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2266-2272页

作者： Hyeon Seok Baek Sang wook Kim Soo Teik lee Ho Sung Park Seung Young Seo Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju-si 56445Jeollabuk-doSouth Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjusi 56445Jeollabuk-doSouth Korea

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)accounts for about 0.25%of colorectal cancer ***,synchronous LCNEC and adenocarcinoma coexistence in the colon is very *** are usually aggressive and have a poor ***,colorectal LCNEC patients complain of abdominal symptoms such as pain,diarrhea or hematochezia because it is often diagnosed as an advanced disease that accompanies metastatic *** SUMMARY We describe a case of relatively asymptomatic synchronous LCNEC and colon adenocarcinoma.A 62-year-old male patient visited our hospital due to anemia detected by a local health *** did not complain of melena,hematochezia or abdominal *** examination was unremarkable and his abdomen was soft,nontender and nondistended with no palpable *** tests revealed anemia with hemoglobin 5.1 g/*** revealed an ulcerofungating lesion in the ascending colon and about a 1.5 cm-sized large sessile polyp in the sigmoid *** biopsy of the ascending colon lesion revealed the ulcerofungating mass that was LCNEC and endoscopic mucosal resection at the sigmoid colon lesion showed a large polypoid lesion that was *** liver,lung,bone and lymph nodes metastasis was found on chest/abdominal computed tomography and positron emission *** patient was diagnosed with advanced colorectal LCNEC with liver,lung,bone and lymph node metastasis(stage IV)and synchronous colonic adenocarcinoma *** this case,no specific symptom except anemia was observed despite the multiple *** patient refused systemic chemotherapy and was discharged after *** We report a case of silent LCNEC of the colon despite the advanced state and synchronous adenocarcinoma.

关键词： Large cell neuroendocrine carcinoma Colon Synchronous Adenocarcinoma Case report

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