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Journal of Integrative Agriculture 2014年第2期13卷 299-309页

作者： XIA Zhe ZHANG Xin LIU Yang-yang JIA Zi-fang zhao Hai-hong LI Cheng-qi WANG qing-lian College of Life Sciences Henan Normal University Key Discipline Open Lab on Crop Molecular Breeding of Henan Institute of Higher Learning/Cotton Research Institute Henan Institute of Science and Technology

Segregation analysis of the mixed genetic model of major gene plus polygene was used to identify the major genes for cotton yield-related traits using six generations P1, P2, F1, B1, B2, and F2 generated from the cross of Baimian 1 x TM-1. In addition to boll size and seed index, the major genes for the other five traits were detected： one each for seed yield, lint percentage, boll number, lint index; and two for lint yield. Quantitative trait locus/loci （QTL） mapping was performed in the F2 and F2：3 populations of above cross through molecular marker technology, and a total of 50 QTL （26 suggestive and 24 significant） for yield-related traits were detected. Four common QTL were discovered： qLP-3b（F2）/qLP-3（F2：3） and qLP-19b （F2）/qLP-19（F2：3） for lint percentage, qBN-17（F2）/qBN-17（F2：3） for boll number, and qBS-26b（F2）/qBS-26（F2：3） for boll size. Especially, qLP- 3b（Fz）/qLP-3（F2：3）, not only had LOD scores 〉3 but also exceeded the permutation threshold （5.13 and 5.29, respectively）, correspondingly explaining 23.47 and 29.55% of phenotypic variation. This QTL should be considered preferentially in marker assisted selection （MAS）. Segregation analysis and QTL mapping could mutually complement and verify, which provides a theoretical basis for genetic improvement of cotton yield-related traits by using major genes （QTL）.

关键词： major gene segregation analysis QTL mapping yield-related traits upland cotton

Arabidopsis MADS-Box Transcription Factor AGL21 Acts as Environmental Surveillance of Seed Germination by Regulating ABI5 Expression

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Molecular Plant 2017年第6期10卷 834-845页

作者： Lin-Hui Yu Jie Wu Zi-Sheng Zhang Zi-qing Miao Ping-Xia zhao Zhen Wang Cheng-Bin Xiang School of Life Sciences University of Science and Technology of China Hefei Anhui Province 230027 China Shanghai Center for Plant Stress Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China

Seed germination is a crucial checkpoint for plant survival under unfavorable environmental conditions. Ab- scisic acid （ABA） signaling plays a vital role in integrating environmental information to regulate seed germination. It has been well known that MCMI/AGAMOUS/DEFICIENS/SRF （MADS）-box transcription factors are key regulators of seed and flower development in Arabidopsis. However, little is known about their functions in seed germination. Here we report that MADS-box transcription factor AGL21 is a negative regulator of seed germination and post-germination growth by controlling the expression of ABA-INSENSITIVE 5 （ABIb＇） in Arabidopsis. The AGL21-overexpressing plants were hypersensitive to ABA, salt, and osmotic stresses during seed germination and early post-germination growth, whereas ag121 mutants were less sensitive. We found that AGL21 positively regulated ABI5 expression in seeds. Consistently, genetic analyses showed that AGL21 is epistatic to ABI5 in controlling seed germination. Chromatin immunoprecipitation assays further demonstrated that AGL21 could directly bind to the ABI5 promoter in plant cells. Moreover, we found that AGL21 responded to multiple environmental stresses and plant hormones during seed germination. Taken together, our results suggest that AGL21 acts as a surveillance integrator that incorporates environmental cues and endogenous hormonal signals into ABA signaling to regulate seed germination and early post-germination growth.

关键词： MADS AGL21 seed germination ABA ABI5

CD5阳性弥漫大B细胞淋巴瘤患者的临床特征及预后分析

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中国实验血液学杂志 2024年第3期32卷 750-755页

作者：黄秀娟杨健魏小芳伏媛赵阳阳程明霞李青芬闫海龙冯友繁陕西省人民医院血液内科陕西西安710068 甘肃省人民医院肿瘤外科甘肃兰州730000 甘肃省人民医院血液科甘肃兰州730000 陕西省人民医院急诊外科陕西西安710068

目的:分析CD5阳性弥漫大B细胞淋巴瘤(DLBCL)患者的临床特征及预后影响因素。方法:回顾性分析自2013年1月至2020年1月甘肃省人民医院就诊的161例初治DLBCL患者的临床资料,根据CD5表达情况,将患者分为CD5+组和CD5-组,并对两组患者的临床... 详细信息

目的:分析CD5阳性弥漫大B细胞淋巴瘤(DLBCL)患者的临床特征及预后影响因素。方法:回顾性分析自2013年1月至2020年1月甘肃省人民医院就诊的161例初治DLBCL患者的临床资料,根据CD5表达情况,将患者分为CD5+组和CD5-组,并对两组患者的临床特征、预后生存进行统计学分析。结果:临床特征分析结果显示,CD5+组患者的中位年龄为62岁,高于CD5-组的56岁(P=0.048);CD5+组患者女性占比为62.96%,明显高于CD5-组的41.79%(P=0.043);CD5+组IPI评分>2分患者的比例为62.96%,高于CD5-组患者的40.30%(P=0.031)。生存分析结果显示,CD5+组的中位总生存期和无进展生存期分别为27(3-77)个月、31(3-76)个月,均短于CD5-组的30(5-84)个月、32.5(4-83)个月,比较差异有统计学意义(P=0.047,P=0.026)。单因素分析结果显示,高龄、CD5表达为阳性、初诊时存在三打击或双打击、较高的IPI评分及化疗过程中未使用利妥昔单抗是影响DLBCL患者预后的危险因素,进一步行Cox多因素回归分析结果显示,除高龄外以上均是独立危险因素。结论:CD5+DLBCL患者预后相对CD5-患者更差,此类患者多见于女性,高龄、IPI评分高,是一类特殊的DLBCL亚型。

关键词：弥漫大B细胞淋巴瘤 CD5 临床特征预后

经导管穿刺房间隔行二尖瓣瓣中瓣置换治疗二尖瓣生物瓣膜衰败1例

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中国介入心脏病学杂志 2024年第5期32卷 288-290页

作者：高政刘伟丽屈占军赵庆哲江磊青岛大学附属医院心血管外科山东青岛266000

近年来二尖瓣生物瓣膜的应用比例越来越高,发生瓣膜衰败的患者随之增加,严重影响患者生命质量,而再次开胸手术的高风险令许多二尖瓣衰败的患者失去再次手术的机会。随着介入手术在我国快速发展,经导管二尖瓣瓣中瓣置换术逐渐被广大瓣膜... 详细信息

近年来二尖瓣生物瓣膜的应用比例越来越高,发生瓣膜衰败的患者随之增加,严重影响患者生命质量,而再次开胸手术的高风险令许多二尖瓣衰败的患者失去再次手术的机会。随着介入手术在我国快速发展,经导管二尖瓣瓣中瓣置换术逐渐被广大瓣膜衰败患者所接受。本文介绍1例经导管穿刺房间隔路径的二尖瓣瓣中瓣置换术。通过术前CT详细评估制定手术计划,患者手术顺利,术后未发生并发症。对于二尖瓣生物瓣膜衰败的高危患者来说经导管二尖瓣瓣中瓣置换术不失为一种更好的替代方案。

关键词：二尖瓣置换瓣中瓣二尖瓣生物瓣衰败经导管经房间隔

小柴胡汤合香砂六君子汤对肝郁脾虚型慢性萎缩性胃炎患者胃黏膜病理积分改变与胃肠激素的影响

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广州中医药大学学报 2024年第9期41卷 2326-2332页

作者：刘明贺尹冬青张永青白皛莫晨许莉赵晶郭建堂冯书芳中国人民解放军总医院第三医学中心北京100039 首都医科大学附属北京安定医院北京100088

【目的】探讨小柴胡汤合香砂六君子汤对肝郁脾虚型慢性萎缩性胃炎(CAG)患者胃黏膜病理积分改变与胃肠激素的影响。【方法】将156例肝郁脾虚型CAG患者随机分为对照组和观察组,每组各78例。对照组给予常规西医治疗,观察组在对照组的基础... 详细信息

【目的】探讨小柴胡汤合香砂六君子汤对肝郁脾虚型慢性萎缩性胃炎(CAG)患者胃黏膜病理积分改变与胃肠激素的影响。【方法】将156例肝郁脾虚型CAG患者随机分为对照组和观察组,每组各78例。对照组给予常规西医治疗,观察组在对照组的基础上给予小柴胡汤合香砂六君子汤治疗,疗程为4周。观察2组患者治疗前后中医证候积分(胃脘胀痛、纳差便溏、四肢乏力、嗳气泛酸)、胃黏膜病理积分、胃肠激素[胃动素(MTL)、胃泌素(GAS)]水平的变化情况,比较2组患者的幽门螺旋杆菌(Hp)转阴率,评价2组患者的临床疗效和安全性。【结果】(1)治疗4周后,观察组的总有效率为93.59%(73/78),显著高于对照组的82.05%(64/78),组间比较,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的胃脘胀痛、纳差便溏、四肢乏力、嗳气泛酸等各项中医证候积分均较治疗前明显降低(P<0.05),且观察组的降低幅度均明显优于对照组(P<0.05)。(3)治疗后,2组患者的胃黏膜病理积分均较治疗前明显降低(P<0.05),且观察组的降低幅度明显优于对照组(P<0.01)。(4)治疗4周后,观察组的Hp转阴率为91.03%(71/78),明显高于对照组的75.64%(59/78),组间比较,差异有统计学意义(P<0.05)。(5)治疗后,2组患者的血清GAS水平均较治疗前明显降低(P<0.05),血清MTL水平均较治疗前明显升高(P<0.05);且观察组对血清GAS水平的降低幅度及对血清MTL水平的升高幅度均明显优于对照组(P<0.05)。(6)2组患者用药期间的血、尿、大便常规以及肾、肝功能和心电图等安全性指标均无明显异常,也均未出现头晕、皮疹、胸闷等不良反应,具有较高的安全性。【结论】小柴胡汤合香砂六君子汤对肝郁脾虚型GAS的治疗效果显著,可有效减轻患者临床症状与胃黏膜病理改变,促进Hp转阴,其作用机制可能与调节胃肠激素水平有关。

关键词：小柴胡汤香砂六君子汤肝郁脾虚型慢性萎缩性胃炎幽门螺旋杆菌转阴胃黏膜病理积分胃肠激素

绵羊妊娠早期lncRNA生物标志物的筛选与鉴定

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畜牧与兽医 2024年第11期56卷 1-9页

作者：常卫华杨富贵张桥桥王娟红倪国超赵影严光文西昌学院动物科学学院四川西昌615013 四川攀西动物疫病检测与防控实验室四川西昌615013 四川地方特色山羊重点实验室四川西昌615013

旨在探讨长链非编码RNA(lncRNA)在绵羊妊娠早期中的调控作用,研究其对绵羊生殖生理的调控机制。通过高通量技术对不同生理时期绵羊卵巢进行转录组测序,结合生物信息学获得差异lncRNA;利用顺式(cis)和反式(trans)关系探讨差异lncRNA靶基... 详细信息

旨在探讨长链非编码RNA(lncRNA)在绵羊妊娠早期中的调控作用,研究其对绵羊生殖生理的调控机制。通过高通量技术对不同生理时期绵羊卵巢进行转录组测序,结合生物信息学获得差异lncRNA;利用顺式(cis)和反式(trans)关系探讨差异lncRNA靶基因,对靶基因进行基因本体(GO)和京都基因与基因组百科全书(KEGG)通路分析,通过实时荧光定量PCR(RT-qPCR)研究lncRNA表达模式。结果:试验成功构建了绵羊妊娠早期RNA文库,每个样品平均产出11.50 G数据,并且每个样品与基因组平均比对率为93.88%;试验共检测到23219个差异基因,其中mRNA 418个,lncRNA 49个(已知17个,候选32个);对49个差异lncRNA通过cis和trans关系分析获得341个靶基因;GO和KEGG通路研究表明,5个lncRNA(LOC105612389、BGIG9940_27655、RPS28、BGIG9940_27548和BGIG9940_27563)在妊娠期表达显著或极显著升高(P<0.05或P<0.01),均参与早期胎儿发育及相关调控过程;RT-qPCR结果表明,5个lncRNA基因表达量达到一定临界值时,预示该母羊已经妊娠。提示:5个lncRNA单独或联合使用有望作为早期妊娠检查的候选生物标志物,对绵羊早期妊娠诊断及提高经济效益具有十分重要的意义。

关键词：高通量测序长链非编码RNA 生物标志物妊娠

The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy

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Asian Journal of Andrology 2011年第3期13卷 499-504,515页

作者： Rui-Yi Wu Guo-Min Wang Lei Xu Bo-Heng Zhang Ye-qing Xu zhao-Chong Zeng Bing Chen Department of Urology Zhongshan Hospital Fudan University Shanghai 200032 China Evidence-Based Medicine Center Fudan University Shanghai 200032 China Department of Radiotherapy Zhongshan Hospital Fudan University Shanghai 200032 China

The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound （HIFU） combined with （＋） low-dose external beam radiotherapy （LRT） as supplemental therapy for advanced prostate cancer （PCa） following hormonal therapy （HT）. Our definition of HIFU＋LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam radiotherapy （CRT）. We performed a prospective, controlled and non-randomized study on 120 patients with advanced PCa after HT who received HIFU, CRT, HIFU＋LRT and HT alone, respectively. CT/MR imaging showed the primary tumours and pelvic lymph node metastases visibly shrank or even disappeared after HIFU ＋LRT treatment. There were significant differences among four groups with regard to overall survival （OS） and disease-specific survival （DSS） curves （P=0.018 and 0.015）. Further comparison between each pair of groups suggested that the long-term DSS of the H IFU ＋ LRT group was higher than those of the other three groups, but there was no significant difference between the HIFU＋LRT group and the CRT group. Multivariable Cox＇s proportional hazard model showed that both HIFU＋LRT and CRT were independently associated with DSS （P=0.001 and 0.035） and had protective effects with regard to the risk of death. Compared with CRT, HIFU ＋LRT significantly decreased incidences of radiation-related late gastrointestinal （GI） and genitourinary （GU） toxicity grade ≥ II. In conclusion, long-term survival of patients with advanced PCa benefited from strengthening local control of primary tumour and reRional lymph node metastases after HT. As an alternative to CRT, HIFU＋LRT showed Rood efficacy and better safety.

关键词： complication high-intensity focused ultrasound hormonal therapy low-dose external beam radiotherapy prostate cancer survival rate

Time-resolved laser-induced breakdown spectroscopy of aluminum

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Optoelectronics Letters 2008年第5期4卷 369-370页

作者： LIU Xian-yun ZHANG Wei-jun WANG Zhen-ya HAO Li-qing HUANG Ming-qiang zhao Wen-wu LONG Bo zhao Wei Laboratory of Environment Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

We develop a system to measure the elemental composition of unprepared samples using laser-induced breakdown spec-troscopy (LIBS) in our laboratory,which can be used for the determination of elements in solids,liquids and aerosols. A description of the instrumentation,including laser,sample chamber and detection,is followed by a brief discussion. The time-resolved LIBS of aluminum at atmospheric pressure is presented. At the end,the possibilities and later uses of this technique are briefly discussed.

关键词：铝光谱学 LIBS 烟雾剂测试技术

Functional carbon materials for high-performance Zn metal anodes

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Journal of Energy Chemistry 2022年第12期75卷 135-153,I0005页

作者： Caiwang Mao Yuxin chang Xuanting zhao Xiaoyu Dong Yifei Geng Ning Zhang Lei Dai Xianwen Wu Ling Wang Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063009HebeiChina College of Chemistry&Environmental Science Hebei UniversityBaoding 071002HebeiChina School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000HunanChina Hebei Province Key Laboratory of Photocatalytic and Electrocatalytic Materials for Environment North China University of Science and TechnologyTangshan 063009HebeiChina

The realization of“carbon peak”and“carbon neutralization”highly depends on the efficient utilization of renewable energy *** reliable and low-cost electrochemical energy storage systems is an ever-growing demand for renewable energy *** available candidates,aqueous zinc-ion batteries(AZIBs)receive extensive researchers'attention because of their material abundance,high capacity,high safety,and environmental ***,the irreversible issues of Zn anode in terms of notorious dendric Zn growth,Zn corrosion/hydrogen evolution,and passivation significantly impede the commercialization of high-performance *** materials have advantages of large specific surface area,low cost,high electrical conductivity,controllable structure,and good *** application provides remedies for improving the comprehensive performance of Zn *** this review,the fundamentals and issues of Zn anodes,and the research progress with functional carbon materials for Zn anodes in recent years are *** major strategies are described in detail,including the use of carbon materials(carbon nanotubes,graphene,carbon fiber,metal-organic framework(MOF)derived host,etc.)as Zn plating/stripping substrates,as protective coating layers on Zn,and as electrolyte ***,the remaining challenges and perspectives of carbon materials in high-performance AZIBs are outlined.

关键词： Aqueous zinc-ion battery Carbon material Zn anodes Substrate Coating Additive

扎根教学目的和训练重心进行工科物理实验学科建设与改革

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实验室研究与探索 2010年第5期29卷 152-154页

作者：赵长青河海大学常州校区物理实验中心江苏常州213022

结合省教学示范中心建设经验提出扎根教学目的和实验项目的训练重心对内容体系、教学模式进行改革,另外对于本科生的科研训练也是教学过程的重要一环。

关键词：教学目的内容体系训练重心科研训练