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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong cui Wei Chen Li Du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Progress on the glassy-crystal laminates:From design,microstructure to deformation and future solutions

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Journal of Materials Science & Technology 2024年第5期172卷 113-144页

作者： Yu Chen Ronggao cui Jun Shen Gang Wang College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Department of Motor Design Business Weichai New Energy Technology Co.Ltd.Weifang 261061China Guangdong Key Laboratory of Electromagnetic Control and Intelligent Robots Shenzhen UniversityShenzhen 518060China Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghai 200444China

The development of new design strategies to create innovative structural materials,refine existing ones,and achieves compatible combinations of strength and plasticity remains a worldwide *** alloys,such as shape memory alloys(SMAs),bulk metallic glasses(BMGs),high entropy alloys(HEAs),and heterogeneous pure metals such as Cu,have excellent mechanical responses,but they still fall short of meeting all the requirements of structural materials due to specific flaws,such as lack of tensile de-formation for BMGs and low yielding strength for *** address these shortcomings,proposals such as integrating glassy matrices and crystallized alloys,such as HEAs/SMAs,have been ***,these solutions have unresolved issues,such as the challenging control of B2 phase formation in BMG ***,glass-crystal(A/C)laminated alloys with alternating layers have been reported to exhibit improved mechanical properties and activated work-hardening behaviors,but they still face press-ing issues such as bonding interfaces and unknown deformation *** review focuses on design routes such as the selection of alloy components and processing techniques,exploration of micro-structural evolution and deformation modes with an increase in strain,and future solutions to address pressing and unsolved *** prominent advantages include diversified deformation mechanisms,such as deformation twinning,martensitic phase transformation,and precipitation hardening,as well as tuned interactive reactions of shear bands(SBs)near the A/C ***,this review provides a promising pathway to design and develop structural materials in the materials field community.

关键词： Glassy-crystal laminates Bulk metallic glasses High entropy alloys Shape memory alloys Microstructure Deformation mechanisms Future solutions

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Distributed user pairing and effective computation offloading in aerial edge networks

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Chinese Journal of Aeronautics 2024年第4期37卷 378-390页

作者： Wei LIANG Shuhui WEN Lixin LI Jingjing cui School of Electronics and Information Northwestern Polytechnical UniversityXi’an CN710072China The State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an CN710126China School of Electronics and Computer Science University of SouthamptonSouthampton SO167NSUK

Future Sixth-Generation (6G) mobile communication networks extremely require the global connectivity and the ground Base Stations (BSs) are difficult to develop in some specific areas,such as mountainous ***,the aerial networks are the key framework for the future communications,in which the aerial vehicle could act as the access ***,Mobile Edge Computing (MEC) is also essential to enhance the data processing capabilities of aerial *** this paper,we study a comprehensive communication-computation resource management problem for jointly optimizing user pairing,power and time allocation in the MEC aided Cognitive Radio (CR) aerial networks,namely CR-MEC aerial ***,this multilevel optimization problem could be decomposed into the user pairing and power allocation as well as time allocation *** the conceived CR-MEC aerial networks,we propose a User Pairing and Computation Offloading Management Algorithm (UPCOMA) based on three-sided matching theory,aiming to minimize the system’s energy *** the first step of UPCOMA,multiple Primary Users (PUs) and Cognitive Users (CUs) on the ground negotiate to each other with the suitable power allocation coefficients and construct the stable user ***,the stable user pairs would match to a high altitude platform who act as the base station,which is for appropriately allocating Transmission Time Slots (TSs) at the second step of ***,a hybrid offloading mode is proposed in our conceived networks in order to support ground users to offload their tasks adaptively according to their individual ***,the simulation results reveal that the relative performance of UPCOMA is close to that of the Brute-Force Search Algorithm (BFSA) with low ***,the hybrid offloading mode with less energy consumption supports much more ground user pairs to offload tasks compared to the binary mode.

关键词： Aerial edge computing Binary offloading Cognitive radio Hybrid offloading Resource management

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Cognitive Navigation for Intelligent Mobile Robots:A Learning-Based Approach With Topological Memory Configuration

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1933-1943页

作者： Qiming Liu Xinru cui Zhe Liu Hesheng Wang Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China MoE Key Laboratory of Artificial Intelligence AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Automation Key Laboratory of System Control and Information Processing of Ministry of EducationKey Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Engineering Research Center of Intelligent Control and ManagementShanghai Jiao Tong UniversityShanghai 200240China

Autonomous navigation for intelligent mobile robots has gained significant attention,with a focus on enabling robots to generate reliable policies based on maintenance of spatial *** this paper,we propose a learning-based visual navigation pipeline that uses topological maps as memory *** introduce a unique online topology construction approach that fuses odometry pose estimation and perceptual similarity *** tackles the issues of topological node redundancy and incorrect edge connections,which stem from the distribution gap between the spatial and perceptual ***,we propose a differentiable graph extraction structure,the topology multi-factor transformer(TMFT).This structure utilizes graph neural networks to integrate global memory and incorporates a multi-factor attention mechanism to underscore elements closely related to relevant target cues for policy *** from photorealistic simulations on image-goal navigation tasks highlight the superior navigation performance of our proposed pipeline compared to existing memory *** validation through behavior visualization,interpretability tests,and real-world deployment further underscore the adapt-ability and efficacy of our method.

关键词： Graph neural networks(GNNs) spatial memory topological map visual navigation

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Reduction of dinitrogen to ammonia on doped three-atom clusters Nb_(2)M(M=Sc to Cu & Y to Ag)

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Rare Metals 2024年第8期43卷 3810-3818页

作者： Ran Cheng Chao-Nan cui Zhi-Xun Luo Beijing National Laboratory for Molecular Science(BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China

Catalytic reduction of dinitrogen to ammonia under mild conditions remains an attractive topic for the purpose of lowering energy ***-atom metal clusters have been proved an ideal model to explore highly efficient catalysts taking advantage of unique geometric/electronic structures and cooperative active *** a study of N2 activation and reduction on seventeen bimetallic Nb_2M(M=Sc to Cu,and Y to Ag) clusters was *** key processes for ammonia fixation(namely nitrogen activation,hydrogenation,and ammonia desorption) are fully studied,and three preferred systems(Nb_2Ni,Nb_2Rh and Nb_2Pd) are highlighted with outstanding catalytic *** d-σ and d-π~* orbital hybridizations between these metal clusters and N_(2) were demonstrated and the internal association with the N≡N bond activation was *** examining the ammonia synthesis on four chosen Nb_(2)M clusters(M=Fe,Ni,Rh and Pd),it can be elucidated that the distal pathway is more favorable than the alternative pathway in these *** work not only clarifies the N_(2) reduction on the bimetallic Nb_(2)M clusters,but also guides efficient bimetallic catalyst design.

关键词： Three-atom cluster catalysis Three-criteria strategy Nitrogen fixation Ammonia synthesis Theoretical calculations

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Re-entry rocket basic flow characteristics and thermal environment of different retro-propulsion modes

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Chinese Journal of Aeronautics 2024年第7期37卷 190-203页

作者： Yifei SU Peijie SUN Yangwen cui Guigao LE School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Shanghai Institute of Aerospace System Engineering Shanghai 200000China Southwest Institute of Technology and Engineering Chongqing 400039China

During the supersonic re-entry of multi-nozzle heavy rockets into the atmosphere,the basic flow state becomes increasingly complex due to the coupling effect between the retropropulsion plumes and the freestream.A numerical method using the hybrid Reynolds-Averaged Navier-Stokes and Large Eddy Simulation(RES)method and discrete coordinate method is developed to accurately estimate the thermal *** addition,finite rate chemical kinetics is used to calculate the afterburning *** numerical results agree well with wind tunnel data,which confirms the validity and accuracy of the numerical *** are conducted for the heavy carrier rocket re-entry from 53.1 km to 39.5 km altitude with 180°angle of attack by using three different Supersonic Retro-Propulsion(SRP)*** numerical results reveal that these three SRP flow fields are all Short Penetration Models(SPM).As the re-entry altitudes decrease,both the plume-plume interaction and the plume-freestream interaction become *** highest temperatures in the plume shear layers of the three SRP modes increase by 8.36%,7.33%and 6.92%respectively after considering afterburning reactions,and all occur at a reentry altitude of 39.5 *** the rocket re-enters the atmosphere,the maximum heat flux on the rocket base plate of three SRP modes stabilizes at 290,170 and 200 kW/m^(2) respectively,but the maximum heat flux on the side wall increases *** the altitude declines to 39.5 km,the extreme heat flux of the three modes increase by 84.16%,49.45%and 62.97%respectively compared to that at 53.1 km.

关键词： Re-entry rocket Multi-nozzle Supersonic retro propulsion Thermal environment Afterburning effect

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Experimental investigation of spectral evolution in flash radiation by hypervelocity impact on aluminum plates

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Defence Technology（防务技术） 2024年第7期37卷 96-110页

作者： Xing Chen Yonggang Lu Zhiwen Li Zhonghua cui Institute of Systems Engineering China Academy of Engineering PhysicsMianyang 621900SichuanChina Chongqing Qianwei Technology Group Co. LtdChongqing 401121China

In this study,a series of hypervelocity impact tests were carried out based on a two-stage light gas gun,and the sequence spectrum and radiation evolution data of the impact products under different impact conditions were *** diameter of the projectile is 3-5 mm,the impact velocity is 3.13-6.58 km/s,and the chamber pressure is 0.56-990 *** spectrum of ejected debris cloud in the 250-310 nm band were obtained using a transient spectral measurement system and a multi-channel radiometer measurement *** test results reveal that the flash radiation intensity increases as a power function with the kinetic energy of the ***,the peak value of the line spectrum decreases as the chamber vacuum degree increases,while the radiation width gradually *** line spectrum in the spectral characterization curve corresponds to the ejected debris clouds splitting phase,which does not produce significant line spectrum during material fragmentation and is dominated by the continuum spectrum produced by blackbody *** will appear one or three characteristic peaks in the flash radiation time curve,the first and second peaks correspond to the penetration phase and the third peak corresponds to the expansion phase of the ejected debris clouds on the time scale,the first and second peaks are more sensitive to the chamber vacuum degree,and when the pressure is higher than 99 Pa,the first and second characteristic peaks will *** radiant heat attenuation of the flash under different impact conditions is significantly different,the attenuation exponent has a power function relationship with the impact velocity and the chamber vacuum degree,while the attenuation exponent has a linear relationship with the diameter of the projectile,the specific expression of the attenuation exponent is obtained by *** findings from this research can serve as a valuable reference for remote diagnostic technologies based on flash radiation characte

关键词： Hypervelocity impact Flash radiation Evolution Spectral characteristics Damage evaluation

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Mangrove wetlands distribution status identification, changing trend analyzation and carbon storage assessment of China

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China Geology 2024年第1期7卷 1-11页

作者： chang Li Fu Wang Peng Yang Fei-cui Wang Yun-zhuang Hu Yan-lin Zhao Li-zhu Tian Rui-bin Zhao Tianjin Center(North China Center of Geoscience Innovation) China Geological Survey(CGS)Tianjin 300170China Tangshan Hydrological Survey and Research Center of Heibei Province Tangshan063000China Key Laboratory of Coast Geo-Environment China Geological SurveyCGSTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China

This research investigates the ecological importance,changes,and status of mangrove wetlands along China’s *** interpretation,geological surveys,and ISO clustering unsupervised classification methods are employed to interpret mangrove distribution from remote sensing images from 2021,utilizing ArcGIS software ***,the carbon storage capacity of mangrove wetlands is quantified using the carbon storage module of InVEST *** show that the mangrove wetlands in China covered an area of 278.85 km2 in 2021,predominantly distributed in Hainan,Guangxi,Guangdong,Fujian,Zhejiang,Taiwan,Hong Kong,and *** total carbon storage is assessed at 2.11×10^(6) t,with specific regional data *** since the 1950s reveal periods of increase,decrease,sharp decrease,and slight-steady increases in mangrove areas in *** important finding is the predominant replacement of natural coastlines adjacent to mangrove wetlands by artificial ones,highlighting the need for creating suitable spaces for mangrove *** study is poised to guide future mangroverelated investigations and conservation strategies.

关键词： Mangrove Wetland Carbon storage Ecological conservation ArcGIS software platform Restoration InVEST model Quantitative analysis Coastal zone of China

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Asymmetric Hydrogenation of Phenanthridines with Chiral Boranes

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Chinese Journal of Chemistry 2024年第6期42卷 631-635页

作者： Guangyu cui Xiangqing Feng Haifeng Du Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

The asymmetric hydrogenation of N-heteroarenes provides an efficient method for the synthesis of optically active cyclic secondary *** this paper,we described an asymmetric hydrogenation of phenanthridines using a chiral mono-alkene-derived borane.A variety of dihydrophenanthridines were furnished in high yields with up to 93%*** current catalytic system was very sensitive for the steric hindrance of *** substituents at one phenyl group of phenanthridines were required to obtain the high *** large substituents on the carbon of the C=N bonds would diminish the reactivity sharply.

关键词： Asymmetric catalysis Hydrogenation Nitrogen heterocycles Phenanthridines Frustrated Lewis pairs Chiral boranes

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RESTlogic: Detecting Logic Vulnerabilities in Cloud REST APIs

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Computers, Materials & Continua 2024年第2期78卷 1797-1820页

作者： Ziqi Wang Weihan Tian Baojiang cui School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing100876China

logical testing model and resource lifecycle information,generate test cases and complete parameters,and alleviate inconsistency issues through parameter *** again,we propose a method of analyzing test results using joint state codes and call stack information,which compensates for the shortcomings of traditional analysis *** will apply our method to testing REST services,including OpenStack,an open source cloud operating platform for experimental *** have found a series of inconsistencies,known vulnerabilities,and new unknown logical defects.

关键词： Cloud services RESTful API logic defects inconsistency issues

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