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Scientific statement of the Chinese Society of Cardiology(CSC) on using of renin angiotensin system blockers in patients with cardiovascular disease and COVID-19

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Journal of Geriatric Cardiology 2020年第5期17卷 241-242页

作者： Ya-Ling HAN Yu-Ming LI chang-sheng ma the Editorial Board of Chinese Journal of Cardiology 无不详 the Chinese Society of Cardiology

The coronavirus disease 2019(COVID-19), which is caused by SARS-CoV-2, has become a worldwide public health crisis. Published clinical data from China and other countries have shown a much higher risk of developing COVID-19 and dying from the disease among the elderly, especially among those who had preexisting hypertension, cardiovascular diseases(CVD) and diabetes mellitus[1].

关键词： Angiotensin converting enzyme Cardiovascular disease COVID-19 Scientific statement

Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 548-552页

作者： Xin DU Jun-ping KANG Jia-hui WU Qiang LV Chao-shu TANG chang-sheng ma Cardiovascular Division Beijing Anzhen Hospital Copital Medical University Beijing 100029 China Department of Physiology and Pathophysiology School of Basic Medical Sciences Peking University Beijing 100083 China

Objective:Percutaneous coronary intervention(PCI) triggers an acute inflammatory response,while sirolimus is known to have anti-inflammatory properties;the inflammatory system response to PCI after sirolimus-eluting stent placement remains *** purpose of this study is to determine the changes in high sensitive C-reactive protein(hs-CRP) and apelin after PCI procedure and drug-eluting stent implantation in patients with and without reduced left ventricular systolic ***:Forty-eight consecutive patients undergoing PCI at the Beijing Anzhen Hospital between July and September 2006 were ***-eluting stents were employed in all *** samples were drawn immediately before and 24 h after the *** hs-CRP and apelin levels were determined by enzyme ***:Paired t-test revealed a significant increase in both hs-CRP and apelin post-procedure(P=0.006 and Pmal ventricular function [(46.8±10.8) vs.(72.0±8.4) pg/ml,Pmal left ventricular systolic function 24 h after the PCI procedure [(86.7±11.6) vs.(85.1±6.1) pg/ml,P=0.72].Conclusions:hs-CRP and apelin levels increased after PCI and sirolimus-eluting stent *** with impaired left ventricular systolic function had significantly lower baseline apelin levels,which increased significantly after PCI.

关键词： High sensitive C-reactive protein (hs-CRP) Apelin Percutaneous colonary intervention (PCl)

Association of frailty with in-hospital outcomes in elderly patients with heart failure

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World Journal of Clinical Cases 2021年第36期9卷 11208-11219页

作者： Yun-Peng Kang Li-Ying Chen Jia-Jia Zhu Wen-Xian Liu chang-sheng ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijing 100029China

BACKGROUND Frailty is prevalent in elderly patients with cardiovascular ***,the association between frailty and in-hospital outcomes for elderly patients with heart failure and reduced ejection(HFrEF)remains *** To evaluate the predictive efficacy of frailty,compared with pre-frailty,for adverse events in these *** Elderly patients(≥60 years)with HFrEF were *** was evaluated with the Fried phenotype criteria,and physical performance was evaluated based on handgrip strength and the short physical performance battery(SPPB).The composite incidence of adverse events,including all-cause death,multiple organ failure,cardiac shock,and malignant arrhythmia,during hospitalization was *** Overall,252 elderly individuals with HFrEF[mean age:69.4±6.7 years,male:169(67.0%)]were *** hundred and thirty-five(53.6%)patients were frail and 93(36.9%)were *** patients were older,more likely to be female,to have a lower blood pressure,and to present with left ventricular thrombosis(P allmale gender(OR=0.422),aging(OR=1.090),poor cardiac functional class(OR=2.167),frailty(OR=2.379),and lower handgrip strength(OR=1.106)were independent predictors of in-hospital adverse events(P allmay be associated with poor in-hospital outcomes for elderly patients with *** influence of frailty on long-term prognosis in these patients deserves further investigation.

关键词： Heart failure with reduced ejection fraction Frailty Elderly Adverse events

The Use of Direct Oral Anticoagulants for Prevention of Stroke and Systemic Embolic Events in East Asian Patients with Nonvalvular Atrial Fibrillation

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Cardiovascular Innovations and Applications 2018年第B07期3卷 215-226页

作者： chang-sheng ma Department of Cardiology Beijing AnZhen HospitalCapital Medical UniversityBeijingChina

As patients in East Asia age,the prevalence of age-related and chronic disease,including nonvalvular atrial fibrillation,may *** warfarin has been the primary choice of anticoagulant for the prevention of stroke and systemic embolic events,the use of direct oral anticoagulants(DOACs)is *** do not require monitoring of the international normalized ratio to determine the optimal dose,and have a lower potential for food and drug interactions,improved benefi t-risk profiles,and a quicker onset and offset of action relative to *** pivotal phase 3 trials for each of the DOACs– dabigatran,rivaroxaban,apixaban,and edoxaban– included at least some East Asian ***,several clinical trials were conducted specifically for East Asian *** review discusses patterns and predictors of anticoagulant use in East Asian patients with nonvalvular atrial fibrillation,summarizes current guideline recommendations for East Asian patients,details the primary results demonstrating the safety and efficacy of DOACs in East Asian patients relative to non– East Asian patients,provides real-world data supporting the phase 3 testing results,and addresses the clinical profile of DOACs in East Asian populations,including patients at high risk of stroke.

关键词： anticoagulant direct oral anticoagulant East Asia stroke

Atrial Fibrillation Ablation： Indications, Outcomes, Complications, and Future Directions

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Chinese Medical Journal 2017年第16期130卷 1891-1893页

作者： Xue-Yuan Guo chang-sheng ma Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Atrial fibrillation （AF） is the most common type of cardiac arrhythmia which affects 33 million individuals worldwide？ It is associated with many adverse outcomes, including stroke, dementia, heart failure （HF）, and mortality. Based on a growing body of evidence illustrating its efficacy and safety, catheter ablation （CA） has become an important treatment strategy for symptomatic AF. Most centers have progressively moved from performing paroxysmal AF to more complex long-standing persistent AF or patients with more comorbidities.

关键词： Atrial Fibrillation Catheter Ablation Complications Indications Ovtcomes

Geriatric cardiology and the Great Wall International Congress of Cardiology 2015

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Journal of Geriatric Cardiology 2016年第4期13卷 279-281页

作者： Nanette K Wenger chang-sheng ma Emory University School of Medicine Atlanta GA USA Department of Cardiology Beij'ing Anzhen Hospital Capital Medical University Beijing China

The burgeoning geriatric population worldwide has resulted in an unprecedented challenge to the cardiology community. Cardiovascular disease is the major cause of morbidity and mortality in the elderly population, but its recognition and management are characteristically confounded by substantial comorbidities, polypharmacy, and other complexities of care, not encountered in younger cardiac patients.

关键词： Acute coronary syndrome GWICC 2015 ST- elevation myocardial infarction The elderly

Atrial Fibrillation Ablation:Indications,New Advances,and Complications

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Cardiovascular Innovations and Applications 2016年第B02期1卷 165-168页

作者： chang-sheng ma,MD Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityChao Yang DistrictBeijingChina

Atrial fibrillation(AF)is the most common cardiac arrhythmia affecting millions of people worldwide with increasing incidence and *** catheter ablation has evolved as the treatment of choice for both paroxysmal and persistent *** studies have been reported on catheter ablation as the first-line treatment for paroxysmal AF and different strategies for persistent *** technologies such as contact-force sensing catheters and cryoballoon have been recently used and the procedure carries the risk of complications like hematoma,arteriovenous fistula,cardiac tamponade,pulmonary vein stenosis,atrio-esophageal fistula and death.

关键词： atrial fi brillation catheter ablation major complications

Culprit vessel only versus ＂one-week＂ staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2015年第3期12卷 226-231页

作者： Li-Xiang ma Zhen-Hua LU Le WANG Xin DU chang-sheng ma Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beo'ing China

Objective To explore the impact of a ＂one-week＂ staged muhivessel percutaneous coronary intervention （PCI） versus culprit-only PCI on deaths and major adverse cardiac events （maCE）. Methods We retrospectively analyzed 447 patients with multivessel disease who experienced a ST-segment elevation myocardial infarction （STEMI） within 12 h before undergoing PCI between July 26, 2008 and Septem- ber 25, 201 l. After completion of PCI in the infarct artery, 201 patients still in the hospital agreed to undergo PCI in non-infarct arteries with more than 70% stenosis for a ＂one-week＂ staged multivessel PCI. A total of 246 patients only received intervention for the culprit vessel. Follow-up ended on September 9, 2014. This study examined the differences in deaths from any cause （i.e., cardiac and noncardiac） and maCE between the two treatment groups. Results Compared to a culprit-only PCI treatment approach, the ＂one-week＂ staged multivessel PCI was strongly associated with greater benefits for 55-month all cause death [41 （16.7%） vs. 13 （6.5%）, P = 0.004] and maCE [82 （33.3%） vs. 40 （19.9%）, P = 0.002] rates. In addition, there were significant differences in the number of myocardial infarctions [43 （17.5%） vs. 20 （10.0%）, P = 0.023], coronary-artery bypass grafting [CABG; 20 （8.1%） vs. 6 （3.0%）, P = 0.021], and PCI [31 （12.6%） vs. 12 （6.0%）, P - 0.018]. Patients undergoing culprit-only PCI compared to ＂one-week＂ PCI had the same number of stent thrombosis events [7 （2.8%） vs. 3 （1.5%）, P - 0.522]. Conclusions Compared to a culprit-only PCI treatment approach, ＂one-week＂ staged multi-vessel PCI was a safe and effective selection for STEMI and multi-vessel PCL

关键词： ST-segment elevation myocardial infarction Percutaneous coronary intervention Multivessel revascularization

Chinese Guidelines for the Diagnosis and management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： chang-sheng ma Shu-Lin WU Shao-Wen LIU Ya-Ling HAN Chinese Society of Cardiology Chinese Medical Association Heart Rhythm Committee of Chinese Society of Biomedical Engineering Beijing Anzhen Hospital Capital Medical University Guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart Rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis