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Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

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Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun Lee Min-Kyu Lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon Na chang-bun yoon SeKwon Oh Tae-Sik Jang Hyun-Do Jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv Sam S.yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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Herbal medicine use in Republic of Korea to alleviate side effects of COVID-19 vaccines:A cross-sectional study

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Journal of Integrative Medicine 2023年第4期21卷 361-368页

作者： Hae-chang yoon Department of Public Health Graduate School of Kyungpook National UniversityDaegu 41944Republic of Korea

Objective:Coronavirus disease 2019(COVID-19)has spread worldwide,and several virus variants have *** are administered to help prevent the *** Republic of Korea,most people take herbal *** study investigated the use of herbal medicine to counter the side effects of COVID-19 ***:This cross-sectional study was conducted using an online ***-square tests were used to determine differences in the use of herbal medication according to sociodemographic *** two-sample and paired t-tests were performed to examine the effect and satisfaction of herbal medicine use for countering the side effects of COVID-19 ***-way analysis of variance was used to determine vaccine-related ***:A total of 233 and 181 participants received the first and second doses of COVID-19 vaccines,*** majority of herbal medicine users were in their thirties,had a bachelor’s degree,suffered from side effects of vaccination,and received Vaxzevria for their first COVID-19 vaccine dose and Comirnaty for their second *** herbal medicine group had a higher satisfaction level of postvaccination side effects than the non-herbal medicine group(P<0.0001).The numeric rating scale scores for vaccination side effects were lower among participants who took herbal medication to alleviate those symptoms(P<0.0001).The most commonly used herbal formula was ***:A third of participants receiving COVID-19 vaccines used herbal medication to counter the side effects of *** use of herbal medicine was associated with age,education level,vaccine brand,and whether side effects of vaccination *** medication use was associated with greater satisfaction compared to vaccine recipients not using herbal medication.

关键词： COVID-19 vaccines Herbal medicine Side effects Republic of Korea

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A THREE-PARAMETER FAULT-DETECTION SOFTWARE RELIABILITY MODEL WITH THE UNCERTAINTY OF OPERATING ENVIRONMENTS

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Journal of Systems Science and Systems Engineering 2017年第1期26卷 121-132页

作者： Kwang yoon Song In Hong chang Hoang Pham Department of Computer Science and Statistics Chosun University Gwangju 62022 Korea Department of Industrial and Systems Engineering Rutgers University NJ 08855-8018 USA

As requirements for system quality have increased, the need for high system reliability is also increasing. Soflnvare systems are extremely important, in terms of enhanced reliability and stability, for providing high quality services to customers. However, because of the complexity of software systems, soft-ware development can be time-consuming and expensive. Many statistical models have been developed in the past years to estimate soflnvare reliability. In this paper, we propose a new three-parameter fault-detection software reliability model with the uncertainty of operating environments. The explicit mean value function solution for the proposed model is presented. Examples are presented to illustrate the goodness-of-fit of the proposed model and several existing non-homogeneous Poisson process （NHPP） models based on three sets of failure data collected from software applications. The results show that the proposed model fits significantly better than other existing NHPP models based on three criteria such as mean squared error （MSE）, predictive ratio risk （PRR）, and predictive power （PP）.

关键词： Nonhomogeneous Poisson process ratio risk predictive power fault detection software reliability mean squared error predictive

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Purification of Astaxanthin from Laminaria japonica by Ionic Liquid-based Monolithic Cartridge

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Chemical Research in Chinese Universities 2012年第3期28卷 406-409页

作者： yoon chang-hwan ROW Kyung-ho Department of Chemical Engineering Inha UniversityIncheon 402-751Korea

An effective and accurate method was developed for the extraction of astaxanthin from Laminariajapo- nica with subsequent separation by ionic liquid-based monolithic cartridge. The optimized extraction conditions in- cluding extraction solvent（ethanol）, extraction time（90 min） and ultrasonic power（75 W） were obtained by systema- tical investigation. Chromatographic analysis was performed on a C18 column with ultraviolet（UV） detection at 476 nm, and a solution consisting of methanol/acetonitrile/H2O/dichloromethane（83：6：6：5, volume ratio） was used as the mobile phase at a flow rate of 0.7 mL/min. After ionic liquid-based monolithic solid phase extraction, 17.82 μg/g as- taxanthin was obtained from Laminaria japonica. This ionic liquid-based monolithic cartridge exhibits high affinity and selectivity for astaxanthin, and it can be potentially used as the stationary phase of high performance liquid chromatography（HPLC）.

关键词： Laminariajaponica Astaxanthin Extraction Ionic liquid Cartridge

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Challenges and opportunities for using formate to store, transport, and use hydrogen

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Journal of Energy Chemistry 2020年第2期29卷 216-224页

作者： Katarzyna Grubel Hyangsoo Jeong chang Won yoon Tom Autrey Pacific Northwest National Laboratory 902 Battelle Boulevard.P.O.Box 999.Richland.WA 99352.United States Center for Hydrogen and Fuel Cell Research Korea Institute of Science and Technology(KIST).5 Hwarang-ro 14-gil.Seongbuk-gu.Seoul 02792Republic of Korea Divison of Energy and Environment Technology KIST SchoolKorea University of Science and Technology5 Hwarung-ro 14-gil.Seongbuk-guSeoul 02792.Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee University26 Kyungheedae-ro.Dongdaemun-guSeoul 02447Republic of Korea

In this perspective article,the synthesis and thermodynamic properties of aqueous solutions of formate salts(FS,HCO2-)are described in relationship to the concept of *** physiochemical properties of solid FS,aqueous formate solutions,and aqueous bicarbonate solutions set the limitations for storage capacity,deliverable capacity,and usable H2capacity of these H2carriers,*** parameters will help in the design of systems that use H2carriers for storage and transport of H2for fuel cell power ***,as well as admixtures with formic acid(FA,H2CO2),have potential to address the goals outlined in the *** of Energy’s H2@scale initiative to store in chemical bonds a significant quantity of energy(hundreds of megawatts)obtained from large scale renewable resources.

关键词： Hydrogen carriers Formate salts Bicarbonate salts Thermodynamics

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AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability

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World Journal of Gastroenterology 2010年第30期16卷 3731-3742页

作者： yoon Mee Yang chang Yeob Han yoon Jun Kim Sang Geon Kim Inno- vative Drug Research Center for Metabolic and Inflammatory Disease College of PharmacySeoul National UniversitySeoul 151-742South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea

The adenosine monophosphate-activated protein kinase (AMPK) and p70 ribosomal S6 kinase-1 pathway may serve as a key signaling flow that regulates energy metabolism; thus, this pathway becomes an attractive target for the treatment of liver diseases that result from metabolic derangements. In addition, AMPK emerges as a kinase that controls the redox-state and mitochondrial function, whose activity may be modulated by antioxidants. A close link exists between fuel metabolism and mitochondrial biogenesis. The relationship between fuel metabolism and cell survival strongly implies the existence of a shared signaling network, by which hepatocytes respond to challenges of external stimuli. The AMPK pathway may belong to this network. A series of drugs and therapeutic candidates enable hepatocytes to protect mitochondria from radical stress and increase cell viability, which may be associated with the activation of AMPK, liver kinase B1, and other molecules or components. Consequently, the components downstream of AMPK may contribute to stabilizing mitochondrial membrane potential for hepatocyte survival. In this review, we discuss the role of the AMPK pathway in hepatic energy metabolism and hepatocyte viability. This information may help identify ways to prevent and/or treat hepatic diseases caused by the metabolic syndrome. Moreover, clinical drugs and experimental therapeutic candidates that directly or indirectly modulate the AMPK pathway in distinct manners are discussed here with particular emphasis on their effects on fuel metabolism and mitochondrial function.

关键词： Adenosine monophosphate-activated protein kinase Cell survival Energy metabolism Fatty liver Insulin resistance Glycogen synthase kinase 3β p70 ribosomal S6 kinase-1

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An Advanced Probabilistic Neural Network for the Design of Breakwater Armor Blocks

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China Ocean Engineering 2007年第4期21卷 597-610页

作者： Dookie KIM Dong Hyawn KIM Seongkyu chang Gil Lim yoon Department of Civil and Environmental Engineering Kunsan National UniversityKunsanJeonbukKorea Department of Ocean System Engineering Kunsan National UniversityKunsanJeonbukKorea Coastal Engineering Research Department KORDIAnsanGyeonggiKorea

In this study, an advanced probabilistic neural network （APNN） method is proposed to reflect the global probability density function （PDF） by summing up the heterogeneous local PDF which is automatically determined in the individual standard deviation of variables. The APNN is applied to predict the stability number of armor blocks of breakwaters using the experimental data of＇ van der Meet, and the estimated results of the APNN are compared with those of an empirical formula and a previous artificial neural network （ANN） model. The APNN shows better results in predicting the stability number of armor bilks of breakwater and it provided the promising probabilistic viewpoints by using the individual standard deviation in a variable.

关键词： breakwater armor block stability number multivariate gaussian distribution classigication artificial neural network (ANN) advanced probabilistic neural network (APNN)

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Surface effects of hybrid vibration-assisted femtosecond laser system for micro-hole drilling of copper substrate

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中国有色金属学会会刊：英文版 2012年第S3期22卷 801-807页

作者： Jung-Kyu PARK Ji-Woon yoon Myung-chang KANG Sung-Hak CHO Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The ultrafast laser based hybrid machining system was studied and a novel approach was demonstrated to improve laser machining quality on metals by vibrating the optical objective lens with a low frequency (500 Hz) and various displacements (0-16.5 μm) during a femtosecond laser machining *** laser used in this experiment is an amplified Ti:sapphire femtosecond (10-15 s) laser system that generates 100 femtosecond pulses having an energy of 3.5 mJ/pulse with a 5 kHz repetition rate at a central wavelength of 790 *** is found that both the wall surface finish of the machined structures and the aspect ratio obtained using the frequency vibration assisted laser machining are improved compared with those derived via laser machining without vibration assistance.

关键词： femtosecond laser hybrid machining vibration-assisted machining surface roughness aspect ratio

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Effect of pectic oligosaccharide on probiotic survival and physicochemical properties of hydrogel beads for synbiotic encapsulation of Lactobacillus bulgaricus

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Food Bioscience 2023年第1期51卷 490-497页

作者： Ye-eun Lee Yu-Ra Kang yoon Hyuk chang Department of Food and Nutrition And Bionanocomposite Research CenterKyung Hee UniversitySeoul02447South Korea

The present study was carried out to evaluate the effects of different concentrations of pectic oligosaccharide(POS)on the physicochemical properties of Lactobacillus bulgaricus(***)loaded-synbiotic hydrogel beads and the survival of *** methoxyl(LM)pectin-resistant starch(RS)hydrogel beads,named RS beads,were coated/filled with different concentrations of POS:0.8%(RS-POS0.8 beads),1.0%(RS-POS1.0 beads),and 1.2%(RS-POS1.2 beads).POS treatment resulted in smooth beads with less surface dent by hydrogen bonding between RS beads and POS,which was confirmed by SEM and XRD *** encapsulation efficiency of RS beads and RS-POS beads ranged from 90.40%to 92.03%.In simulated gastric fluid(SGF)and bile salt solution,free *** completely died but *** encapsulated in RS-POS1.2 beads only slightly *** indicates that RS-POS1.2 beads exhibited higher protective effects on *** under SGF condition and bile ***,considering the relatively higher storage stability of *** loaded in RS-POS1.2 beads,the present results suggest that RS beads coated/filled with POS could be used for synbiotic encapsulation,protection,and delivery of probiotics.

关键词： Pectic oligosaccharide Synbiotic encapsulation Hydrogel bead Probiotic

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