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Effect of Antibiotic Treatment on Toxin Production by Alexandrium tamarense

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Biomedical and Environmental Sciences 2003年第4期16卷 340-347页

作者： chang-HAI wang, yi-YUN wang, yiNG-yiNG SUN, AND XIAN-TANG XIEDepartment of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, China Department of Bioengineering Dalian University of Technology Dalian 116024 Liaoning Chin

Objective Impact of the presence of bacteria associated with a marine dinoflagellate, Alexandrium tamarense CI01, on the growth and toxin production of the algae in batch culture was investigated. Methods Pronounced changes in the activities of the algal culture were observed when the culture was treated with different doses of a mixture of penicillin and streptomycin. Results In the presence of antibiotics at the initial concentration of 100 u/mL in culture medium, both algal growth and toxin yield increased markedly. When the concentration of antibiotics was increased to 500 u/mL, the microalgal growth was inhibited, but resumed in a few days to eventually reach the same level of growth and toxin production as at the lower dose of the antibiotics. When the antibiotics were present at a concentration of 1 000 u/mL, the algal growth was inhibited permanently. Conclusions The results indicate that antibiotics can enhance algal growth and toxin production not only through their inhibition of the growth and hence competition for nutrients, but also through their effects on the physiology of the algae.

关键词： Alexandrium tamarense Harmful algal bloom Antibiotic Toxin Saxitoxin

Slip flow in an annular sector duct using radial eigenfunctions

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Theoretical & Applied Mechanics Letters 2014年第3期4卷 30-34页

作者： chang yi wang Departments of Mathematics and Mechanical Engineering Michigan State UniversityEast Lansing Michigan 48824 USA

The fully developed slip flow in an annular sector duct is solved by expansions of eigenfunctions in the radial direction and boundary collocation on the straight sides. The method is efficient and accurate. The flow field for slip flow differs much from that of no-slip flow. The Poiseuille number increases with increased inner radius, opening angle, and decreases with slip.

关键词： slip flow radial eigenfunctions annular sector duct

Aging precipitation behavior and properties of Al-Zn-Mg-Cu-Zr-Er alloy at different quenching rates

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Transactions of Nonferrous Metals Society of China 2022年第4期32卷 1070-1082页

作者： yi-chang wang Xiao-dong WU Lu YUE Ming-xing GUO Ling-fei CAO International Joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Shenyang National Laboratory for Materials Science Chongqing UniversityChongqing 400044China

The effect of quenching rate on the aging precipitation behavior and properties of Al-Zn-Mg-Cu-Zr-Er alloy was *** scanning electron microscopy,transmission electron microscopy,and atom probe tomography were used to study the characteristics of clusters and precipitates in the *** quench-inducedηphase and a large number of clusters are formed in the air-cooled alloy with the slowest cooling rate,which contributes to an increment of hardness by 24%(HV 26)compared with that of the water-quenched ***,the aging hardening response speed and peak-aged hardness of the alloy increase with the increase of quenching ***,the water-quenched alloy after peak aging also has the highest strength,elongation,and corrosion resistance,which is due to the high driving force and increased number density of aging precipitates,and the narrowed precipitate free zones.

关键词： Al-Zn-Mg-Cu-Zr-Er alloy quenching rate aging treatment precipitate strengthening

急性冠脉综合征患者细胞色素P450的2C19基因多态性与氯吡格雷抗血小板作用及其预后的关系研究

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中国全科医学 2017年第21期20卷 2583-2589页

作者：石琳常奕王斌航天中心医院心脏中心北京市100049 北京大学人民医院心脏中心北京市100044 河北中医学院中西医结合学院河北省石家庄市050200 汕头大学医学院第一附属医院心血管内科广东省汕头市515041

背景临床上氯吡格雷的治疗效果普遍存在个体差异,这与患者种族相关并受其基因型影响。目的探讨急性冠脉综合征患者细胞色素P450的2C19(CYP2C19)基因多态性与氯吡格雷抗血小板作用及其预后之间的关系,以期为以基因分型为指导的个体化抗... 详细信息

背景临床上氯吡格雷的治疗效果普遍存在个体差异,这与患者种族相关并受其基因型影响。目的探讨急性冠脉综合征患者细胞色素P450的2C19(CYP2C19)基因多态性与氯吡格雷抗血小板作用及其预后之间的关系,以期为以基因分型为指导的个体化抗血小板治疗提供依据。方法选取2012年3—12月在航天中心医院心脏中心住院治疗的急性冠脉综合征患者98例为研究对象。入院后给予患者氯吡格雷单次负荷剂量300 mg而后75 mg/d口服,或直接给予75 mg/d常规剂量口服。分别检测患者入院时、治疗3 d后血小板聚集率,血小板抑制率,氯吡格雷抵抗情况。采用Taqman-PCR技术检测患者CYP2C19基因型,根据CYP2C19基因检测结果,按照是否携带突变基因A将患者分为野生型组(第5外显子G681A位点和第4外显子G636A位点均无突变基因A,34例)和突变型组(第5外显子G681A位点或第4外显子G636A位点有突变基因A,64例)。随访患者主要心血管不良事件(MACEs)发生情况。结果 CYP2C19*2基因型和CYP2C19*3基因型均符合Hardy-Weinberg平衡定律(P>0.05),提示本研究纳入的样本具有较好的群体代表性。不同CYP2C19*2基因型患者入院时血小板聚集率比较,差异无统计学意义(P>0.05)。CYP2C19*2中,GA基因型患者治疗3 d后血小板聚集率大于GG基因型(P0.05)。CYP2C19*3中,GG、GA基因型患者治疗3 d后血小板聚集率小于入院时血小板聚集率(P0.05)。结论急性冠脉综合征患者CYP2C19基因多态性与氯吡格雷抗血小板作用相关,含有CYP2C19第5外显子突变者服用常规剂量氯吡格雷后抗血小板作用减弱,预后较差,而第4外显子突变对患者预后影响相对较小。

关键词：急性冠状动脉综合征细胞色素P450酶系统多态性,单核苷酸血小板聚集抑制剂血小板聚集预后 CYP2C19 氯吡格雷

Exosomes as promising frontier approaches in future cancer therapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 28-33页

作者： Fatt-Yang Chew Chin-Hung Tsai Kuang-Hsi chang Yu-Kang chang Ruey-Hwang Chou yi-Jui Liu Department of Medical Imaging China Medical University HospitalTaichung 404TaiwanChina Department of Radiology School of MedicineChina Medical UniversityTaichung 404TaiwanChina Department of Cancer Center Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Chest Medicine Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402TaiwanChina Department of Medical Research Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Center for General Education China Medical UniversityTaichung 404TaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichung 404TaiwanChina Center for Molecular Medicine China Medical University HospitalTaichung 404TaiwanChina Department of Medical Laboratory and Biotechnology Asia UniversityTaichung 413TaiwanChina Department of Automatic Control Engineering Feng Chia UniversityTaichung 407TaiwanChina

In this editorial,we will discuss the article by Tang et al published in the recent issue of the World Journal of Gastrointestinal *** explored an innovative approach to enhancing gemcitabine(GEM)delivery and efficacy using human bone marrow mesenchymal stem cells(HU-BMSCs)-derived *** manufacture of GEM-loaded HU-BMSCs-derived exosomes(Exo-GEM)has been *** Tang et al’s study demonstrated that Exo-GEM exhibits enhanced cytotoxicity and apoptosis-inducing effects compared to free GEM,highlighting the potential of exosome-based drug delivery systems as a more effective and targeted approach to chemotherapy in pancreatic *** in vivo studies are required to confirm the safety and effectiveness of Exo-GEM before it can be considered for clinical use.

关键词： Mesenchymal stem cells Exosomes Gemcitabine Pancreatic cancer Apoptosis

白术内酯Ⅰ改善术后肠梗阻大鼠的肠功能、炎症反应、细菌移位及肠道屏障

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世界华人消化杂志 2024年第8期32卷 616-624页

作者：王一昌周应宁波市第六医院普外科浙江省宁波市315042

背景白术内酯Ⅰ(atractylenolideⅠ,AT-1)具有抗炎、抗氧化、抑制肠损伤和改善肠屏障功能的作用,但其对术后肠梗阻(postoperative ileus,POI)的影响和机制并不清楚.目的探讨AT-1对POI大鼠的肠功能、炎症反应、细菌移位及肠道屏障的影响... 详细信息

背景白术内酯Ⅰ(atractylenolideⅠ,AT-1)具有抗炎、抗氧化、抑制肠损伤和改善肠屏障功能的作用,但其对术后肠梗阻(postoperative ileus,POI)的影响和机制并不清楚.目的探讨AT-1对POI大鼠的肠功能、炎症反应、细菌移位及肠道屏障的影响,并探讨初步机制.方法60只泼累格·多雷雄性大鼠,分为5组:对照组、模型组、及低、中、高剂量AT-1干预组,每组12只.用摩擦肠管法构建POI大鼠模型,低、中、高剂量AT-1干预组分别在造模前1 h和造模后1-3 d通过尾静脉注射20、40和80 mg/kg AT-1,每天1次.肠推进实验评估肠推进功能,异硫氰酸酯-葡聚糖法检测肠通透性;苏木精-伊红染色观察小肠组织病理形态;生化分析仪计数外周血白细胞和粒细胞含量,酶联免疫吸附试验法检测血清中白细胞介素(interleukin,IL)-6、IL-1β、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、内毒素、脂多糖和D-乳酸水平;免疫组化检测肠组织中溶霉菌(Lysozyme)、绒毛蛋白(Villin)、闭锁小带蛋白1(zonula occludens protein 1,ZO-1)和密封蛋白(Claudin)表达分布情况;蛋白质免疫印迹法检测肠组织中核因子κB(nuclear factor kappa-B,NF-κB)相关蛋白表达.结果相比于对照组,模型组小肠绒毛断裂或脱落,隐窝丢失,肠推进功能降低,肠道通透性增加;相比于模型组,AT-1干预组小肠绒毛变长和隐窝增多,肠推进功能增高,肠道通透性降低.免疫组化结果显示,相比于对照组,模型组小肠组织中Lysozyme、Villin、ZO-1和Claudin表达降低,而AT-1干预组上述蛋白表达增高.生化检验结果显示,相比于对照组,模型组外周血中白细胞和中性粒细胞数增多,血清中IL-6、IL-1β、TNF-α、内毒素、脂多糖和D-乳酸水平增高;相比于模型组,AT-1干预组上述血液学指标均降低.蛋白质免疫印迹法检测结果显示,相比于对照组,模型组小肠组织中磷酸化(phospho,p)-P65/P65和磷酸化NF-κB抑制蛋白(phospho-inhibitor of NF-κB,p-IκB)/IκB的表达水平均升高;相比于模型组,AT-1干预组p-P65/P65和p-IκB/IκB的表达水平均降低.且以上结果均具有剂量效应.结论AT-1可有效抑制POI大鼠肠道损伤、炎症反应和NF-κB信号活性,同时维持肠屏障功能的完整性并阻止细菌移位.

关键词：白术内酯Ⅰ 术后肠梗阻大鼠肠功能细菌移位肠屏障功能炎症反应

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光电探测器相对光谱响应度标准

计量学报 1990年第1期11卷 1-6页

作者：王振常易庆祥王捷中国计量科学研究院

本文介绍光电探测器相对光谱响应度标准的实验装置、方法及测量结果。该装置以补偿型真空热电堆为参考基准,采用双光路替代法,全部测量过程自动化。总的不确定度为±(1.5～4.0)％。

关键词：光电探测器光谱响应度标准

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论电子证据的独立地位

法学论坛 2004年第1期19卷 66-74页

作者：常怡王健西南政法大学重庆400031

在《中华人民共和国民事证据法》的起草过程中,电子证据问题一直存在着较大的争议。本文在立足于电子证据与我国传统证据形式比较研究的基础上,针对电子证据地位的各种学说表达了自己的一些看法,并提出立法上的建议,以期确定电子证据的... 详细信息

在《中华人民共和国民事证据法》的起草过程中,电子证据问题一直存在着较大的争议。本文在立足于电子证据与我国传统证据形式比较研究的基础上,针对电子证据地位的各种学说表达了自己的一些看法,并提出立法上的建议,以期确定电子证据的独立证据地位,同时也希望借此文与关心电子证据立法工作的广大同仁交流意见,互相学习,促进我国民事证据立法工作的顺利、健康发展。

关键词：电子证据民事证据法证据种类

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羌塘地区壳内低阻层特征及初步认识

新疆石油地质 2001年第6期22卷 472-474页

作者：王宜昌王永涛中国石油勘探开发科学研究院遥感所北京100083 石油物探局河北涿州072700

在羌塘地区深达100km的大地电磁测深(MT)大剖面上,壳内低电阻层显示出不同面貌。南段以“Δ”块状体为特征;北段低阻层从-100km深处上升至近地表-10km处,呈巨大的蘑茹体。在平面等值线图上,北羌塘地区以大面积坳隆、东西分块为特征;南... 详细信息

在羌塘地区深达100km的大地电磁测深(MT)大剖面上,壳内低电阻层显示出不同面貌。南段以“Δ”块状体为特征;北段低阻层从-100km深处上升至近地表-10km处,呈巨大的蘑茹体。在平面等值线图上,北羌塘地区以大面积坳隆、东西分块为特征;南羌塘地区以条带状坳隆南北分带为主。研究结果认为,低电阻层与地形相关,这不仅旁证了有关低阻层解释的可靠性,同时说明北羌塘独特的块状高山区地貌是活跃的深部构造运动的表现。研究区地壳既非全是冷壳、也非全是热壳,应是冷壳、热壳呈楔块状相间,尤其是确旦错一带可能存在热柱。这对油气富集、形成、二次成因将有较大的影响。

关键词：羌塘地区地壳低电阻地层大地电磁测深