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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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储气库大功率往复式压缩机组振动整改分析

压缩机技术 2023年第3期 55-59页

作者：张斌常家喜李东肖强姚俊钱山大港油田天津储气库分公司天津300270 中国石油集团济柴动力有限公司成都压缩机分公司四川成都610100 中加压缩机撬及管道工程公司卡尔加里加拿大

大功率往复式压缩机组是储气库运营的核心设备,但容易发生振动。如果振动发生后不能及时消除,就会影响到储气库的正常运营。因此,对大功率往复式压缩机组进行有效的振动整改分析,尽快消除振动故障,是保证储气库安全运营的重要工作。以... 详细信息

大功率往复式压缩机组是储气库运营的核心设备,但容易发生振动。如果振动发生后不能及时消除,就会影响到储气库的正常运营。因此,对大功率往复式压缩机组进行有效的振动整改分析,尽快消除振动故障,是保证储气库安全运营的重要工作。以某储气库大功率往复式压缩机组的振动整改为例,说明了进行大功率往复式压缩机组振动整改分析的一般方法和步骤,为保证储气库压缩机组的安全运行和储气库的正常运营提供了技术参考。

关键词：储气库压缩机组振动整改 API 618脉动分析机械振动

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang Guo Di Lan Zirui jia Zhenguo Gao Xuetao Shi Mukun He Hua Guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

Non-artifact vector P- and S-wave separation for elastic reverse time migration

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Petroleum Science 2022年第6期19卷 2695-2710页

作者： xi-Yan Zhou Xu chang Yi-Bo Wang xiao-Tao Wen jia-Chun You chang Sun Key Laboratory of Earth Exploration and Information Techniques Chengdu University of TechnologyChengdu610059SichuanChina College of Geophysics Chengdu University of TechnologyChengdu610059SichuanChina Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Key Laboratory of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Elastic reverse time migration(RTM)uses the elastic wave equation to extrapolate multicomponent seismic data to the subsurface and separate the elastic wavefield into P-and S-waves.P-and S-wave separation is a necessary step in elastic RTM to avoid crosstalk between coupled ***,the current curl-divergence operator-based separation method has a polarity reversal problem in PS imaging,and vector separation methods often have separation artifacts at the interface,which affects the quality of the imaging *** propose a non-artifact P-and S-wave separation method based on the first-order velocity-strain *** equation is used for wavefield extrapolation and separation in the first-order staggered-grid finite-difference scheme,and the storage and calculation amounts are consistent with the classical first-order velocity-stress *** separation equation does not calculate the partial derivatives of the elastic parameters,and thus,there is no artifact in the separated Pand *** wavefield extrapolation,the dynamic characteristics of the reflected wave undergo some changes,but the transmitted wavefield is accurate;therefore,it does not affect the dynamic characteristics of the final migration *** numerical examples of 2 D simple models,part SEAM model,BP model,and 3 D 4-layer model,different wavefield separation methods and corresponding elastic RTM imaging results are *** found that the velocity-strain based elastic RTM can image subsurface structures well,without spike artifacts caused by separation artifacts,and without polarity reversal phenomenon of the PS imaging.

关键词： Multicomponent Elastic RTM P-and S-Wave separation Separation artifacts Decoupled velocity-strain equations

Photoluminescent nickel(Ⅱ)carbene complexes with ligand-to-ligand charge-transfer excited states

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Chinese Chemical Letters 2024年第1期35卷 357-360页

作者： Chun-Liang Hou jia-xi Song xiaoyong chang Yong Chen Key Laboratory of Photochemical Conversion and Optoelectronic Materials&CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

While nickel(II)complexes have been widely used as catalysts for carbon-carbon coupling reactions,the exploration of their photophysical and photochemical properties is still in the ***,a series of square-planar Ni(II)complexes[(diNHC)NiX2]bearing chelating benzimidazole-based bis(N-heterocyclic carbene)ligands and varying anionic coligands(1,X=Cl;2,X=Br;3,X=I)are synthesized and structurally *** solid state,both 1 and 2 exhibit orange-red photoluminescence under ambient *** photophysical and electrochemical measurements along with density functional theory(DFT)calculations reveal that the low-energy emissions can be attributed to singlet excited states with ligand-to-ligand charge-transfer(LLCT)*** work suggests that strong-field N-heterocyclic carbene ligands play a crucial role to achieve the luminescence of Ni(II)complexes.

关键词： Nickel(II)complexes N-Heterocyclic carbene Luminescence Ligand-to-ligand charge-transfer character Low-lying d-d excited states

Adjoint Functors and Representation Dimensions

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Acta Mathematica Sinica,English Series 2006年第2期22卷 625-640页

作者： chang chang xi School of Mathematical Sciences Beijing Normal University

We study the global dimensions of the coherent functors over two categories that are linked by a pair of adjoint functors. This idea is then exploited to compare the representation dimensions of two algebras. In particular, we show that if an Artin algebra is switched from the other, then they have the same representation dimension.

关键词： adjoint functor representation dimension global dimension tilting module group algebra

Microstructural evolution and constitutive models of 9CrMoCoB heatresistant steel during high-temperature deformation

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Journal of Iron and Steel Research International 2019年第11期26卷 1228-1239页

作者： Chao-hang jia Chen-xi Liu Yong-chang Liu Chong Li Hui-jun Li Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300354China

In order to research the hot deformation behavior of 9CrMoCoB heat-resistant steel,hot compression tests were performed over a wide range of temperatures from 850 to 1150℃ and strain rates from 0.01 to 10.00 s^-*** flow stress appears to increase with the decrease in deformation temperature and the increase in strain *** relationship between microstructural evolution and deformation parameters was studied,indicating that both low strain rate and high deformation temperature appear to promote the dynamic recrystallization,while excessively high temperature with low strain rate would result in the high non-uniformity of grain *** experimental stress-strain data was applied to calculate the material constants involved in the Arrhenius-type constitutive model and the modified Zerilli-Armstrong(MZA)model,and feasibility of these two models was *** results show that the MZA model is more accurate to predict the high-temperature flow behavior of the experimental steel than the Arrhenius-type constitutive equation.

关键词： 9CrMoCoB steel-Hot deformation behavior Dynamic recrystallization Arrhenius-type constitutive model Modified Zerilli-Armstrong model

Low-temperature heat conduction characteristics of diamond/Cu composite by pressure infiltration method

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Rare Metals 2013年第6期32卷 579-585页

作者： Hong Guo Guang-Zhong Wang xi-Min Zhang Fa-Zhang Yin Cheng-chang jia School of Materials and Engineering University of Science & Technology Beijing

In this paper,diamond/CuCr and diamond/CuB composites were prepared using the pressure infiltration *** physical property measurement system(PPMS)was adopted to evaluate the thermal conductivity of diamond/Cu and MoCu composites within the range of100–350 K,and a scanning electron microscope(SEM)was utilized to analyze the microstructure and fracture appearance of the *** research indicates that the thermal conductivity of diamond/Cu composite within the range of100–350 K is 2.5–3.0 times that of the existing MoCu material,and the low-temperature thermal conductivity of diamond/Cu composite presents an exponential relationship with the *** B element was added to a Cu matrix and a low-temperature binder was used for prefabricated elements,favorable interfacial adhesion,relatively high interfacial thermal conductivity,and favorable low-temperature heat conduction characteristics would be apparent.

关键词： Diamond/Cu composite Low-temperature thermal conductivity Pressure infiltration

Scheduling piece requests blindly and randomly for peer-to-peer live streaming

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The Journal of China Universities of Posts and Telecommunications 2010年第2期17卷 76-84页

作者： CHEN Yi-shuai CHEN chang-jia ZHAO Yong-xiang LI Chun-xi School of Electrical and Information Engineering Beijing Jiaotong University Beijing 100044 China

The design of piece scheduling algorithm is fundamental in mesh-based peer-to-peer （P2P） live streaming systems. This article regards the piece propagation process in P2P live streaming system as a conflict process, where peers compete to get the piece as soon as possible to meet the tight timing requirement of the live system. In this vision, the authors reduce the piece scheduling problem as a conflict resolution problem, and propose a blind random scheduling method to resolve it. The algorithm can be described as： 1） pieces are scheduled independently; 2） conflicts are resolved by the random back off algorithm. The theoretical analysis and simulation results prove that the algorithm scales well with the network size, and can obtain near-optimal in-time delivery of pieces. The algorithm is also easy to implement in the real-world system.

关键词： peer-to-peer live streaming conflict resolution exponential back off piece scheduling