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A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis

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Asian Pacific Journal of Tropical Medicine 2020年第7期13卷 301-307页

作者： Tsung-Hang kuo Chia-chang Chuang Chin-Chung Tseng Ming-Yuan Hong Sheng-Hsiang Lin Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainan 70403 Department of emergency National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Department of Internal Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Department of Public Health College of MedicineNational Cheng Kung UniversityTainan 70403

Objective:To identify the febrile characteristics and clinical presentations associated with fatality in hospitalized adult patients with dengue virus(DENV)***:A total of 289 adult hospitalized patients with laboratoryconfirmed DENV infections were examined,of which 22 were fatal and 267 were non-fatal.A comparison of the clinical and laboratory characteristics was retrospectively conducted of the deceased and surviving *** logistic regression and receiver operating characteristic curve analysis were performed to identify predictors of ***:Fatal patients exhibited significantly more comorbidities,particularly renal and cardiac comorbidities,and they were,in general,older than control individuals(P<0.0001).The results of logistic regression analysis showed that febrile duration of less than four days before arriving in the Emergency Department(OR=5.34;95%CI:1.39–20.6),episode of hypotension in the Emergency Department(OR=6.95;95%CI:2.40–20.1),and comorbidity with congestive heart failure(OR=11.26;95%CI:2.31–54.79)were all significantly associated with inpatient fatality due to DENV *** ROC curve analysis indicated that the final prognostic model yielded an area under the curve of 0.87(95%CI:0.79–0.97)for ***:The aforementioned clinical findings may help clinicians predict fatality among adult inpatients with DENV infection.

关键词： Dengue Hospitalized patient Adult Fatality Febrile duration Hypotension

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Analysis and design of a smart card based authentication protocol

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第12期14卷 909-917页

作者： kuo-Hui YEH kuo-Yu TSAI Jia-Li HOU Department of Information Management National Dong Hwa University Department of Management Information Systems Hwa Hsia Institute of Technology

Numerous smart card based authentication protocols have been proposed to provide strong system security and robust individual privacy for communication between parties these days. Nevertheless, most of them do not provide formal analysis proof, and the security robustness is doubtful. chang and Cheng(2011) proposed an efficient remote authentication protocol with smart cards and claimed that their proposed protocol could support secure communication in a multi-server environment. Unfortunately, there are opportunities for security enhancement in current schemes. In this paper, we identify the major weakness, i.e., session key disclosure, of a recently published protocol. We consequently propose a novel authentication scheme for a multi-server environment and give formal analysis proofs for security guarantees.

关键词： Authentication Privacy Security Smart card

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Processing Chinese hand-radicals activates the medial frontal gyrus A functional MRI investigation

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Neural Regeneration Research 2013年第20期8卷 1837-1843页

作者： Qing-Lin Wu Yu-Chen Chan Joseph P.Lavallee Hsueh-Chin Chen kuo-En chang Yao-Ting Sung Department of Educational Psychology and Counseling Taiwan Normal University Institute of Learning Sciences Tsing Hua University School of Education and Applied Linguistics Ming Chuan University Graduate Institute of Information and Computer Education Taiwan Normal University

Embodied semantics theory asserts that the meaning of action-related words is neurally represented through networks that overlap with or are identical to networks involved in sensory-motor processing. While some studies supporting this theory have focused on Chinese characters, less attention has been paid to their semantic radicals. Indeed, there is still disagreement about whether these radicals are processed independently. The present study investigated whether radicals are processed separately and, if so, whether this processing occurs in sensory-motor regions. Materials consisted of 72 high-frequency Chinese characters, with 18 in each of four categories： hand-action verbs with and without hand-radicals, and verbs not related to hand actions, with and without hand-radicals. Twenty-eight participants underwent functional MRI scans while reading the characters. Compared to characters without hand-radicals, reading characters with hand-radicals activated the right medial frontal gyrus. Verbs involving hand-action activated the left inferior parietal lobule, possibly reflecting integration of information in the radical with the semantic meaning of the verb. The findings may be consistent with embodied semantics theory and suggest that neural representation of radicals is indispensable in processing Chinese characters.

关键词： neural regeneration neuroimaging functional MRI hand-radical radical representation Chinese character recognition embodied semantics semantic function Chinese learning grants-supported paper neuroregeneration

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Hematemesis as the initial complication of pancreatic adenocarcinoma directly invading the duodenum: A case report

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World Journal of Gastroenterology 2005年第5期11卷 767-769页

作者： Yueh-Hung Lin Chih-Yen Chen Chih-Ping Chen Tien-Yin kuo Full-Young chang Shou-Dong Lee Division of Gastroenterology Department of Medicine Taipei Veterans General Hospital and School of MedicineNational Yang-Ming UniversityTaipeiTaiwanChina Department of HealthTao-Yuan General Hospital Tao-Yuan TaiwanChina Division of Gastroenterology

Pancreatic carcinoma is a debilitating disease and carries a poor prognosis. It is a rare cause of upper gastrointestinal bleeding, even though pancreas, stomach, duodenum and jejunum are adjacent organs. The incidence of pancreatic adenocarcinoma directly invading the gastrointestinal tract leading to gastrointestinal hemorrhage is very low, and most of them present with melena and hematochezia. Here, we describe one unique case manifesting characteristically severe and unremitting hematemesis as an initial presentation of pancreatic adenocarcinoma. This tumor directly invaded the duodenal mucosa as a bleeding protruding tumor mass. Our MEDLINE search has confirmed that this is the first reported case with an initial manifestation of hematemesis from pancreatic adenocarcinoma in *** adenocarcinoma directly invading duodenum complicated by hemorrhage can be a rare cause of hematemesis, and clinicians should be reminded of it while they are making differential diagnosis.

关键词： Pancreatic adenocarcinoma Duodenum tumor Hematemesis Neoplasm invasiveness

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Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 1-9页

作者： Ching-hung LIN Huang-chun LIEN Fu-chang HU Yen-shen LU Sung-hsin kuo Ling-chu WE San-lin YOU Ann-lii CHENG King-jen chang Department of Oncology National Taiwan University Hospital Taiwan Taipei 10016 Department of Pathology National Taiwan University Hospital Taiwan Taipei 10016 National Center of Excellence for General Clinical Trial and Research National Taiwan University Hospital Taiwan Taipei 1001 6 Graduate Institute of Epidemiology College of Public Health National Taiwan University Taiwan Taipei 10055 Department of Surgery National Taiwan University Hospital Taiwan Taipei 10016

Objective： To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods： Patients with stages Ⅰ-Ⅲ breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor （ER） and progesterone receptor （PR） was evaluated by immu- nohistochemistry （IHC）. A fractionated score （F score）, the percentage of positive-staining nuclei （0=none, 1=1%-10% 2= 11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%）, was assigned to each case. The dichotomized scoring method defines an F score 〉1 as positive. The prognostic values of both scores were compared by multiple Cox＇s proportional hazard models of disease-free survival （DFS） and overall survival （OS）. Results： Four hundred and six- teen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox＇s proportional hazard models. Conclusion： Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

关键词： Breast cancer Fractionated evaluation Estrogen receptor Progesterone receptor

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Endometriosis coexisting with dermoid cyst in a single ovary： a case report

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Chinese Medical Journal 2011年第4期124卷 627-630页

作者： CHEN Tsai-chuan kuo Hsu-tung SHYU Shin-kuo CHU Chih-ping chang Tien-chang Department of Obstetrics and Gynecology Lin-Shin Medical Corporation Lin-Shin Hospital Department of Family Medicine Lin-Shin Medical Corporation Lin-Shin Hospital Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 408 TaiwanChina Department of Anatomical Pathology Lin-Shin Medical Corporation Lin-Shin Hospital chang Tien-chang General Clinic Taichung 408 TaiwanChina

Endometriosis coexisting with a dermoid cyst of the ovary is extraordinarily rare, although these both benign conditions are said to be common in women in the reproductive age group. There are only two previous case reports, which is evident from our literature review from January 1960 through January 2010. Acute abdomen is one of the greatest diagnostic challenges and easily ignored by the clinicians to exclude the possibility of gynecologic illness. A 35-year-old woman was referred by the doctor in Family clinic. She experienced a three-day period of severe right lower abdominal pain and intermittent vomiting. Ultrasonography identified a bilocular, cystic, hypoechoic, and hyperechoic tumor, 7 cm×6 cm×6 cm in the right adnexal region. Laparoscopic cystectomy was performed under the impression of ovarian cyst with torsion or hemorrhage. The frozen section was benign and appendiceal status was adequate. Histopathologic examination described an ovarian cyst composed of endometrial-type lining with stroma cells （endometriosis） and benign terotoma tissue with plenty of skin appendages and sebaceous glands. We report this unusual and interesting ovarian mass to remind physicians that the usage of the Endobag after cystectomy, the benefits on minimizing operative time, spilled opportunity, and postoperative complications. Laparoscopic techniques for large ovarian masses might be considered. The experience of the surgeon is also very important to prevent misdiagnosis or complication. Further follow up is mandatory for this simultaneous finding of ovarian endometriosis with coincidental dermoid cyst as a separate pathology in single ovary of such a nature. It also presents a challenge to the clinicians and to the pathologists.

关键词： endometriosis dermoid cyst cystectomy endobag

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Wet‑Spinning Knittable Hygroscopic Organogel Fibers Toward Moisture‑Capture‑Enabled Multifunctional Devices

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Advanced Fiber Materials 2023年第2期5卷 588-602页

作者： chang Zhang Peng Xiao Dong Zhang Feng Ni Jincui Gu Qingquan Liu Shiao‑Wei kuo Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China School of Chemical Sciences University of Chinese Academy of ScienceBeijing 100049People’s Republic of China Department of Chemical Biomolecular and Corrosion EngineeringThe University of AkronAkron 44325USA Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China Department of Material and Optoelectronic Science Center of Crystal ResearchNational Sun YatSen UniversityKaohsiung 804TaiwanChina

Atmospheric moisture exploitation is emerging as a promising alternative to relieve the shortage of freshwater and *** to exploit hygroscopic materials featuring flexibility,programmability,and accessibility are crucial to portable and adaptable ***,current two-dimensional(2D)or three-dimensional(3D)-based hygroscopic materials are dif-ficult to adapt to diverse irregular surfaces and meet breathability,which severely hinders their wide applications in wearable and programmable ***,hygroscopic organogel fibers(HOGFs)were designed via a wet-spinning *** achieved fibers were composed of the hydrophilic polymeric network,hygroscopic solvent,and photothermal/antibacterial Ag nanoparticles(AgNPs),enabling hygroscopic capacity,photothermal conversion,and *** to the good knittable feature,the HOGFs can be readily woven to adjusted 2D textiles to function as an efficient self-sustained solar evaporator of 4-layer woven HOGF device with a saturated moisture capacity of 1.63 kg m^(-2) and water-releasing rate of 1.46 kg m^(-2) h^(-1).Furthermore,the 2D textile can be applied as a wearable dehumidification device to efficiently remove the evaporative moisture from human skin to maintain a comfortable *** can reduce the humidity from 90 to 33.4%within 12.5 *** addition,the introduction of AgNPs can also endow the HOGFs with antibacterial features,demonstrat-ing significant potential in personal healthcare.

关键词： Hygroscopic organogel fibers Knittable and wearable Atmospheric moisture sorption Solar-enabled evaporation Antibacterial dehumidification device

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CRKL在肝内胆管癌中的表达及对癌细胞增殖和侵袭的影响

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中国现代普通外科进展 2024年第9期27卷 684-688页

作者：阔文蕾鲍昕悦常景博孙祺魏利敏西安交通大学第一附属医院普通外科陕西西安710061

目的:研究激酶样基因CT10调节因子(CRKL)在肝内胆管癌(ICC)中的表达,及其对胆管癌细胞增殖与侵袭的影响。方法:采用qRT-PCR技术检测ICC组织和癌旁组织中CRKL的转录水平;利用免疫组织化学技术检测ICC组织和癌旁组织中CRKL的表达,分析其... 详细信息

目的:研究激酶样基因CT10调节因子(CRKL)在肝内胆管癌(ICC)中的表达,及其对胆管癌细胞增殖与侵袭的影响。方法:采用qRT-PCR技术检测ICC组织和癌旁组织中CRKL的转录水平;利用免疫组织化学技术检测ICC组织和癌旁组织中CRKL的表达,分析其与临床病理特征的关系;通过siRNA技术抑制QBC939细胞中CRKL的表达,采用Western blot检测CRKL沉默对AKT及ERK信号通路的影响;MTT实验、细胞克隆形成实验及Transwell实验用于分析CRKL对ICC细胞的增殖和侵袭能力的影响。结果:ICC组织内CRKL表达上调,不同肿瘤大小、淋巴结转移及TNM分期等临床病理特征的ICC,其CRKL表达差异有统计学意义(P<0.05)。细胞实验显示,抑制CRKL后,AKT和ERK的磷酸化水平显著下降,ICC细胞的增殖和侵袭能力明显减弱(P<0.05)。结论:CRKL通过AKT和ERK信号途径促进肿瘤细胞的生长与侵袭,这可能为ICC的靶向治疗提供新的分子靶标和方向。

关键词：肝内胆管癌 CRKL 细胞增殖侵袭 AKT信号通路 ERK信号通路

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实测与卫星观测德基水库水质变化

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水科学进展 2012年第4期23卷 549-554页

作者：章国威真理大学休闲游憩事业学系台湾台南72147

德基水库集水区的气候条件适合温带水果及高冷蔬菜、茶叶的种植,德基水库集水区上游遍布果园、菜园与茶园。因此,每逢大雨来临时,大量的残留肥料常遭冲刷至水库中。这些残留的肥料中含有大量的氮、磷等营养盐,足以提供水库微生物的生长... 详细信息

德基水库集水区的气候条件适合温带水果及高冷蔬菜、茶叶的种植,德基水库集水区上游遍布果园、菜园与茶园。因此,每逢大雨来临时,大量的残留肥料常遭冲刷至水库中。这些残留的肥料中含有大量的氮、磷等营养盐,足以提供水库微生物的生长繁殖所需,也因此造成水库中二角多甲藻的大量繁殖,进而形成藻华现象。研究使用Landsat TM卫星数据,搭配传统监测模式,以监督式影像分类法分析与监测德基水库1995年的藻华现象。研究结果显示,以Landsat TM卫星数据监测德基水库的藻华现象,其准确率可达87.5%以上。由影像分类的结果可得知,德基水库二角多甲藻之藻华现象发生较严重的时期为夏天,而冬天则较为轻微。此现象发生的原因,应与集水区上游的农业经营模式息息相关。此外,德基水库藻华现象发生的区域及其程度也经由实地调查与卫星影像监测,一一获得证实。

关键词：德基水库藻华卫星遥测监督式影像分类 Landsat TM

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Rare finding of primary aortoduodenal fistula on single-photon emission computed tomography/computed tomography of gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7162-7169页

作者： Chun-Liang kuo Ching-Fu Chen Wen-Ko Su Rong-Hsin Yang Yu-Hong chang Department of Nuclear Medicine Hsinchu Mackay Memorial HospitalHsinchu 30071TaiwanChina Department of Gastroenterology Hsinchu Mackay Memorial HospitalHsinchu 30071TaiwanChina Department of Radiology Hsinchu Mackay Memorial HospitalHsinchu 30071TaiwanChina

BACKGROUND Primary aortoduodenal fistula is a rare cause of gastrointestinal(GI)bleeding consisting of abnormal channels between the aorta and GI tract without previous vascular intervention that results in massive intraluminal *** SUMMARY A 67-year-old man was hospitalized for coffee ground vomiting,tarry stools,and colic abdominal *** was repeatedly admitted for active GI bleeding and hypovolemic *** and spontaneously stopped bleeders were undetectable on multiple GI endoscopy,angiography,computed tomography angiography(CTA),capsule endoscopy,and ^(99)mTc-labeled red blood cell(RBC)*** patient received supportive treatment and was discharged without signs of ***,he was re-admitted for bleeder *** CTA after a bleed revealed a small aortic aneurysm at the renal level contacting the fourth portion of the duodenum.A ^(99)mTc-labeled RBC singlephoton emission CT(SPECT)/CT scan performed during bleeding symptoms revealed active bleeding at the duodenal *** to his clinical symptoms(intermittent massive GI bleeding with hypovolemic shock,dizziness,dark red stool,and bloody vomitus)and the abdominal CTA and ^(99)mTc-labeled RBC SPECT/CT results,we suspected a small aneurysm and an aortoduodenal *** duodenal excision and duodenojejunal anastomosis were performed.A 7-mm saccular aneurysm arising from the anterior wall of the abdominal aorta near the left renal artery was *** intravascular stenting of the abdominal aorta was performed and his symptoms *** Our findings suggest that ^(99)mTc-labeled RBC SPECT/CT scanning can aid the diagnosis of a rare cause of active GI bleeding.

关键词： Gastrointestinal active bleeding Computed tomography angiography 99mTc-labeled red blood cell scan Singlephoton emission computed tomography/computed tomography Primary aortoduodenal fistula Case report

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